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1. 发明授权

US5773286A Inner supported biocompatible cell capsules 失效
标题翻译：内支持的生物相容性细胞胶囊
公开(公告)号：US5773286A
公开(公告)日：1998-06-30
申请号：US449568
申请日：1995-05-24
申请人： Keith E. Dionne , Orion D. Hegre , Thomas R. Flanagan , Tyrone F. Hazlett , Edward J. Doherty
发明人： Keith E. Dionne , Orion D. Hegre , Thomas R. Flanagan , Tyrone F. Hazlett , Edward J. Doherty
IPC分类号： A61F2/02 , A61K9/00 , A61K35/12 , B01J13/02 , C12N5/00 , C12N5/071 , C12N11/00 , C12N11/04
CPC分类号： A61K9/0024 , A61F2/022 , B01J13/02 , C12N5/0012 , C12N5/0614 , A61K2035/128 , C12N2533/30
摘要： A biocompatible capsule for containing cells for implantation is prepared containing an inner support that provides tensile strength to the capsule. Cells within the capsule are suspended in a liquid medium or immobilized in a hydrogel or extracellular matrix material, and are surrounded by a semipermeable membrane across which biologically active molecules can be delivered from the capsule to surroundings or from the surroundings into the capsule. The inner support may be formed as an integral part of the capsule during a coextrusion process to form the capsule. Alternatively, the inner support may be a discrete component within a tube having top and bottom sealing fittings that are linked withing the tube by the support. The inner support may have external features such as flutes or a roughened or irregularly-shaped surface, and may be coated with cell-adhesive substance or a cell-viability-enhancing substance. The inner support may be a hollow tube having two channels, one communicating with a filling port that permits injecting cells through the support into the capsule and the other communicating with another port that allows gas to escape through the support as cells are introduced. The capsule may be made immunoisolatory by controlling membrane permselectivity or by substances in the membrane that reduce immune response, and may contain a tether for retrieval that can be formed integrally with the inner support.
摘要翻译：制备用于包含用于植入的细胞的生物相容性胶囊，其包含向胶囊提供拉伸强度的内部支撑物。胶囊内的细胞悬浮在液体培养基中或固定在水凝胶或细胞外基质材料中，并且被半透膜围绕，生物活性分子可以从该膜渗透到周围或周围环境或胶囊中。在共挤出过程中，内部支撑可以形成为胶囊的整体部分以形成胶囊。或者，内部支撑件可以是具有顶部和底部密封配件的管内的分立部件，其通过支撑件与管连接。内部支撑件可以具有外部特征，例如凹槽或粗糙或不规则形状的表面，并且可以涂覆有细胞粘附物质或细胞活力增强物质。内部支撑件可以是具有两个通道的中空管，一个与填充口连通，其允许将细胞通过支撑件注入到胶囊中，另一个与另一个端口连通，允许气体在引入电池时通过支撑件逸出。可以通过控制膜选择性或通过减少免疫应答的膜中的物质使胶囊免疫免疫，并且可以包含可与内支架一体形成的用于提取的系绳。

2. 发明授权

US5786216A Inner-supported, biocompatible cell capsules 失效
标题翻译：内支持，生物相容性细胞胶囊
公开(公告)号：US5786216A
公开(公告)日：1998-07-28
申请号：US337555
申请日：1994-11-10
申请人： Keith E. Dionne , Orion D. Hegre , Thomas R. Flanagan , Tyrone F. Hazlett , Edward J. Doherty
发明人： Keith E. Dionne , Orion D. Hegre , Thomas R. Flanagan , Tyrone F. Hazlett , Edward J. Doherty
IPC分类号： A61F2/02 , A61K9/00 , A61K35/12 , B01J13/02 , C12N5/00 , C12N5/071 , C12N11/04 , A61K9/52 , A61K9/50
CPC分类号： A61F2/022 , A61K9/0024 , B01J13/02 , C12N5/0012 , C12N5/0614 , A61K2035/128 , C12N2533/30
摘要： A biocompatible capsule for containing cells for implantation is prepared containing an inner support that provides tensile strength to the capsule. The capsule may be a tubular semipermeable membrane such as a hollow fiber membrane having both ends sealed. A rod shaped inner support extends through the lumen and ends of the rod are attached to sealed ends of the fiber. Prior to sealing one fiber end, cells are introduced into the lumen. Cells within the capsule may be suspended in a liquid medium or immobilized in a hydrogel or extracellular matrix material, and biologically active molecules can be delivered from the capsule to surroundings or from the surroundings into the capsule. The inner support may have external features such as flutes or a roughened or irregularly-shaped surface, and may be coated with cell-adhesive substance or a cell-viability-enhancing substance. The inner support may be a hollow tube having two channels, one communicating with a filling port that permits injecting cells through the support into the capsule and the other communicating with another port that allows gas to escape through the support as cells are introduced. Anti-inflammatory agents can be incorporated into the capsule membrane to reduce immune response, and angiogenic factors and cell growth factors may be used to stimulate cell culture. Post-coating of capsule can be used to provide a protective barrier against immunogens. A tether for capsule retrieval can be formed integral with the inner support.
摘要翻译：制备用于包含用于植入的细胞的生物相容性胶囊，其包含向胶囊提供拉伸强度的内部支撑物。胶囊可以是管状半透膜，例如具有两端密封的中空纤维膜。杆状内部支撑件延伸穿过内腔，杆的端部附接到纤维的密封端。在密封一个纤维端之前，将细胞引入管腔。胶囊内的细胞可以悬浮在液体培养基中或固定在水凝胶或细胞外基质材料中，并且生物活性分子可以从胶囊递送到周围环境或从周围环境进入胶囊。内部支撑件可以具有外部特征，例如凹槽或粗糙或不规则形状的表面，并且可以涂覆有细胞粘附物质或细胞活力增强物质。内部支撑件可以是具有两个通道的中空管，一个与填充口连通，其允许将细胞通过支撑件注入到胶囊中，另一个与另一个端口连通，允许气体在引入电池时通过支撑件逸出。可以将抗炎剂并入胶囊膜中以降低免疫应答，并且血管生成因子和细胞生长因子可用于刺激细胞培养。胶囊的后包衣可用于提供抵抗免疫原的保护性屏障。用于胶囊回收的系绳可以与内部支撑件一体形成。

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