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1. 发明授权

US07365181B2 Probes for chondrogenesis 失效
标题翻译：软骨形成探针
公开(公告)号：US07365181B2
公开(公告)日：2008-04-29
申请号：US10623914
申请日：2003-07-21
申请人： Thomas M. Hering , Brian Johnstone
发明人： Thomas M. Hering , Brian Johnstone
IPC分类号： C07H21/04
CPC分类号： G01N33/6887 , C07K14/47 , C07K14/4702 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.
摘要翻译：提供了细胞中检测和分期软骨形成的标记物。一方面，标记是分离的多核苷酸，以下称为CZF-1和CZF-2及其片段。在一个实施方案中，CZF-1多核苷酸包含SEQ ID NO.1所示的开放阅读框序列。在一个实施方案中，CZF-2多核苷酸包含SEQ ID NO：1所示的开放阅读框序列。在另一方面，标记是对CZF-1或CZF-2编码的蛋白质具有免疫特异性的抗体。提供了使用本标记鉴定已经开始分化成软骨细胞的细胞的方法。本发明还涉及CZ-1蛋白和CZ-2蛋白以及与CZF-1或CZF-2或其区域的编码序列互补的多核苷酸或寡核苷酸。

2. 发明授权

US06596855B2 Probes for chondrogenesis 失效
标题翻译：软骨形成探针
公开(公告)号：US06596855B2
公开(公告)日：2003-07-22
申请号：US09881578
申请日：2001-06-14
申请人： Thomas M. Hering , Brian Johnstone
发明人： Thomas M. Hering , Brian Johnstone
IPC分类号： C12N1512
CPC分类号： G01N33/6887 , C07K14/47 , C07K14/4702 , C07K2319/00 , C12Q1/6886 , C12Q2600/158
摘要： Markers for detecting and staging chondrogenesis in cells are provided. In one aspect the markers are isolated polynucleotides, referred to hereinafter as CZF-1 and CZF-2, and fragments thereof. In one embodiment, the CZF-1 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO.1. In one embodiment, the CZF-2 polynucleotide comprises the open reading frame sequence set forth in SEQ ID NO. 3. In another aspect the markers are antibodies, which are immunospecific for proteins encoded by CZF-1 or CZF-2. Methods which employ the present markers to identify cells that have begun to differentiate into chondrocytes are provided. The present invention also relates to the CZ-1 protein and the CZ-2 protein and to polynucleotides or oligonucleotides whose sequences are complementary to the coding sequences of CZF-1 or CZF-2, or regions thereof.
摘要翻译：提供了细胞中检测和分期软骨形成的标记物。一方面，标记是分离的多核苷酸，以下称为CZF-1和CZF-2及其片段。在一个实施方案中，CZF-1多核苷酸包含SEQ ID NO.1所示的开放阅读框序列。在一个实施方案中，CZF-2多核苷酸包含SEQ ID NO：1所示的开放阅读框序列。在另一方面，标记是对CZF-1或CZF-2编码的蛋白质具有免疫特异性的抗体。提供了使用本标记鉴定已经开始分化成软骨细胞的细胞的方法。本发明还涉及CZ-1蛋白和CZ-2蛋白以及与CZF-1或CZF-2或其区域的编码序列互补的多核苷酸或寡核苷酸。

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