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1. 发明授权

US4963128A Chest tube and catheter grid for intrathoracic afterload radiotherapy 失效
标题翻译：胸管和导管网格用于胸腔后负荷放疗
公开(公告)号：US4963128A
公开(公告)日：1990-10-16
申请号：US326733
申请日：1989-03-21
申请人： Thomas M. Daniel , Seung S. Hahn
发明人： Thomas M. Daniel , Seung S. Hahn
IPC分类号： A61M1/00 , A61M27/00 , A61M36/12 , A61N5/10
CPC分类号： A61N5/1007 , A61M1/008 , A61M27/00 , A61N2005/1012
摘要： An apparatus and method for intraoperative internal placement of an afterloading catheter tube grid for post-operative radiotherapy using a semi-rigid tube having inserted within a plurality of catheters which extends outwardly from the distal end of the semi-rigid tube for a predetermined distance and attaching these distally outward extending catheter tubes to a soft sheet so that the catheter tube maintain a parallel position to one another over the predetermined distance. The proximal ends of these catheter tubes extend outwardly from the proximal end of the semi-rigid tube and are located on the outside of the body. These proximal ends of the catheters are left open for loading of the radioactive material into these catheter tubes, while the distal ends are closed to prevent airleak and to stop the radioactive material. The soft sheet is provided with eyelets at each of the four corners, and these eyelets are used to secure the soft sheet with sutures to the inside of the cavity wall over the area intended for radiation therapy. A stiff cover cap is provided so as to cover the furled soft sheet, and this cover cap attaches to the distal end of the semi-rigid tube. This cover cap is removed when the present invention is inserted into the body cavity.
摘要翻译：一种用于术中内置放置用于术后放射治疗的后置导管管网格的装置和方法，其使用插入在从半刚性管的远端向外延伸预定距离的多个导管内的半刚性管，以及将这些远端向外延伸的导管连接到软片上，使得导管管在预定距离上保持彼此平行的位置。这些导管的近端从半刚性管的近端向外延伸并且位于身体的外侧。导管的这些近端保持开放，用于将放射性物质装载到这些导管中，而远端封闭以防止空气泄漏并停止放射性物质。软片在四个角中的每一个处设置有孔眼，并且这些孔眼用于将缝合的软片固定在用于放射治疗的区域上的腔壁内部。提供一个刚性的盖帽，以便覆盖卷发的软片，并且该盖帽附接到半刚性管的远端。当将本发明插入体腔时，该盖帽被去除。

2. 发明授权

US4899021A Latching switch 失效
标题翻译：锁定开关
公开(公告)号：US4899021A
公开(公告)日：1990-02-06
申请号：US185069
申请日：1988-04-22
申请人： Thomas M. Daniel
发明人： Thomas M. Daniel
IPC分类号： H01H13/62
CPC分类号： H01H13/62
摘要： A portable latching switch which has a switch body containing three cavities. An elongated cavity extends into the switch body for receiving an actuating member. The second and third cavities communicate with and extend transversely from the elongated cavity and contain latching members. An electrical switching member is responsive to movement of the latching member located in the second cavity. A locking member is contained in the third cavity whereby upon actuation of the electronic device a key is required for resetting of the latching member in the third cavity and subsequently of the actuating member.
摘要翻译：一种便携式闭锁开关，其具有包含三个空腔的开关体。细长的空腔延伸到开关主体中以接收致动构件。第二和第三空腔与细长空腔连通并横向延伸并包含闭锁构件。电切换构件响应位于第二腔中的闩锁构件的运动。锁定构件容纳在第三腔中，由此在电子装置致动时，需要一个钥匙来将闩锁构件在第三空腔中以及之后的致动构件复位。

3. 发明授权

US3486741A Impeller 失效
标题翻译：叶轮
公开(公告)号：US3486741A
公开(公告)日：1969-12-30
申请号：US3486741D
申请日：1968-02-06
申请人： MIDGETTE ERNST L , KATHERINE S DANIEL , THOMAS M DANIEL , MARJORIE E VAN NAME
发明人： MIDGETTE ERNST L
IPC分类号： B01F7/00 , B01F15/00 , C09B67/46 , B01F5/16 , B01F7/26
CPC分类号： B01F7/00241 , C09B67/0091

4. 发明授权

US4123427A Method for the purification of mycobacterial protein antigens and resulting product 失效
标题翻译：纯化分枝杆菌蛋白抗原及其产物的方法
公开(公告)号：US4123427A
公开(公告)日：1978-10-31
申请号：US708950
申请日：1976-07-27
申请人： Thomas M. Daniel
发明人： Thomas M. Daniel
IPC分类号： A61K39/04 , G01N33/531 , A23J1/06
CPC分类号： A61K39/04 , G01N33/531 , Y10S436/811 , Y10S530/806 , Y10S530/812 , Y10S530/813 , Y10S530/814 , Y10S530/823 , Y10S530/825
摘要： The subject invention is directed in general to a method of preparing an antigen using immunoabsorbent affinity chromotography particularly in cases where an antigen is used for the recognition and measurement of hypersensitivity and where antigenic specificity is desired as, for example, in hypersensitivity to tuberculin, histoplasmin, coccidioidin, and common inhalant allergens. More particularly, this invention consists of a method which includes the following steps: immunizing a suitable host animal, usually a goat, with a preparation containing the desired antigen, collecting antisera from the animal and selecting the most specific antisera; isolating the antibody containing gamma globulin from the selected antiserum; coupling the globulin to an inert substrate (usually agarose beads) by chemical bonding with cyanogen bromide to form an absorbent in which the antibody acts as ligand; using the absorbent to bind selectively the desired antigen in a crude mixture containing the antigen; eluting the antigen from the absorbent by breaking the antigen-antibody bond with urea, usually at 4 - 6 molar (also referred to as M in the specification) and about pH 7 - 9; and then recovering the eluted antigen and preparing it in a form suitable for its intended use. By this method a highly purified, improved tuberculin skin test reactant is produced from culture filtrate which is prepared by growing tubercle bacilli in a liquid, synthetic medium, collecting and sterilizing by filtration the liquid phase of this culture (alternatively a soluble extract of the bacillary mass may be used), and then processing this filtrate and purifying the antigen by the steps described.
摘要翻译：本发明总体上涉及使用免疫吸附剂亲和层析法制备抗原的方法，特别是在抗原用于识别和测量超敏反应的情况下，并且其中需要抗原特异性的情况下，例如对结核菌素，组织蛋白酶敏感性，球虫和常见的吸入性过敏原。更具体地，本发明包括以下步骤：用含有所需抗原的制剂免疫合适的宿主动物（通常为山羊），从动物采集抗血清并选择最具体的抗血清; 从所选择的抗血清中分离含有γ球蛋白的抗体; 通过与溴化氰化学键合将球蛋白偶联到惰性底物（通常是琼脂糖珠）上以形成其中抗体作为配体的吸收剂; 使用吸收剂选择性地结合含有抗原的粗混合物中的所需抗原; 通过用尿素（通常为4-6摩尔）（在本说明书中也称为M）和约pH7-9破坏抗原 - 抗体结合，从吸收剂中洗脱抗原; 然后回收洗脱的抗原并以适合其预期用途的形式制备。通过该方法，通过培养滤液产生高度纯化的改良的结核菌素皮肤试验反应物，培养滤液通过在液体，合成培养基中培养结核杆菌而制备，通过过滤该培养液的液相（或者可溶性细菌的提取物可以使用质量），然后通过所述步骤处理该滤液并纯化抗原。

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