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1. 发明授权

US07211181B2 Photoelectrochemical molecular comb 失效
标题翻译：光电化学分子梳
公开(公告)号：US07211181B2
公开(公告)日：2007-05-01
申请号：US10365242
申请日：2003-02-12
申请人： Thomas G. Thundat , Thomas L. Ferrell , Gilbert M. Brown
发明人： Thomas G. Thundat , Thomas L. Ferrell , Gilbert M. Brown
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/305
摘要： A method, system, and apparatus are provided for separating molecules, such as biomolecules. The method, system, and apparatus utilize an electrochemical cell having at least to electrodes, one electrode comprising a photo-sensitive material capable of generating a photopotential. Molecules are moved through an electrolyte medium between the at least two electrodes based upon localized photopotentials.
摘要翻译：提供了一种分离分子的方法，系统和装置，例如生物分子。该方法，系统和装置利用至少具有电极的电化学电池，一个电极包括能够产生光致电位的光敏材料。基于局部的光电势，分子在至少两个电极之间移动通过电解质介质。

2. 发明授权

US06831747B2 Spectrometry and filtering with high rejection of stray light 失效
公开(公告)号：US06831747B2
公开(公告)日：2004-12-14
申请号：US10338614
申请日：2003-01-08
申请人： Thomas L. Ferrell , Thomas G. Thundat
发明人： Thomas L. Ferrell , Thomas G. Thundat
IPC分类号： G01N2155
CPC分类号： G01N21/553
摘要： A microoptoelectromechanical integrated spectrometer with a photonic element assembly having metal foil removably disposed on a first transparent substrate surface, the substrate having no foil on any other surface. A means is provided for directing source photons that are reflected from or transmitted through a sample, over a range of angles of incidence, into the transparent substrate and onto the metal foil such that source photons are incident at the Brewsters angle. A means is also provided for detecting an induced exponential field in the metal foil. A means is also provided for relating the induced exponential field to a known exponential field for the sample and determining the identity of the sample. The spectrometer performs ultraviolet-to-visible-to-infrared spectroscopy using photon tunneling and surface plasmon excitation.

3. 发明授权

US08110082B2 Photoelectrochemical molecular comb 有权
标题翻译：光电化学分子梳
公开(公告)号：US08110082B2
公开(公告)日：2012-02-07
申请号：US11731952
申请日：2007-04-02
申请人： Thomas G. Thundat , Thomas L Ferrell , Gilbert M. Brown
发明人： Thomas G. Thundat , Thomas L Ferrell , Gilbert M. Brown
IPC分类号： G01N27/453 , H01L31/00
CPC分类号： G01N27/305
摘要： A method, system, and apparatus are provided for separating molecules, such as biomolecules. The method, system, and apparatus utilize an electrochemical cell having at least two electrodes, one electrode comprising a photo-sensitive material capable of generating a photopotential. Molecules are moved through an electrolyte medium between the at least two electrodes based upon localized photopotentials.
摘要翻译：提供了一种分离分子的方法，系统和装置，例如生物分子。该方法，系统和装置利用具有至少两个电极的电化学电池，一个电极包括能够产生光电势的光敏材料。基于局部的光电势，分子在至少两个电极之间移动通过电解质介质。

4. 发明授权

US07090757B2 Photoelectrochemical molecular comb 失效
公开(公告)号：US07090757B2
公开(公告)日：2006-08-15
申请号：US10077633
申请日：2002-02-15
申请人： Thomas G. Thundat , Thomas L. Ferrell , Gilbert M. Brown
发明人： Thomas G. Thundat , Thomas L. Ferrell , Gilbert M. Brown
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/305
摘要： A method and apparatus for separating molecules. The apparatus includes a substrate having a surface. A film in contact with the surface defines a substrate/film interface. An electrode electrically connected to the film applies a voltage potential between the electrode and the substrate to form a depletion region in the substrate at the substrate/film interface. A photon energy source having an energy level greater than the potential is directed at the depletion region to form electron-hole pairs in the depletion region. At least one of the electron-hole pairs is separated by the potential into an independent electron and an independent hole having opposite charges and move in opposing directions. One of the electron and hole reach the substrate/film interface to create a photopotential in the film causing charged molecules in the film to move in response to the localized photovoltage.

5. 发明授权

US06763705B1 High throughput microcantilever detector 失效
标题翻译：高通量微悬臂检测器
公开(公告)号：US06763705B1
公开(公告)日：2004-07-20
申请号：US10462249
申请日：2003-06-16
申请人： Thomas G. Thundat , Thomas L. Ferrell , Karolyn M. Hansen , Fang Tian
发明人： Thomas G. Thundat , Thomas L. Ferrell , Karolyn M. Hansen , Fang Tian
IPC分类号： G01N2700
CPC分类号： G01N33/54373 , G01N29/022 , G01N2291/012 , G01N2291/014 , G01N2291/0255 , G01N2291/0256 , G01N2291/106
摘要： In an improved uncoated microcantilever detector, the sample sites are placed on a separate semi-conducting substrate and the microcantilever element detects and measures the changes before and after a chemical interaction or hybridization of the sites by sensing differences of phase angle between an alternating voltage applied to the microcantilever element and vibration of the microcantilever element. In another embodiment of the invention, multiple sample sites are on a sample array wherein an array of microcantilever elements detect and measure the change before and after chemical interactions or hybridizations of the sample sites.
摘要翻译：在改进的未涂覆微悬臂梁检测器中，将样品位置放置在单独的半导体衬底上，并且微悬臂元件通过感测所施加的交流电压之间的相位角的差异来检测并测量化学相互作用或场地杂交之前和之后的变化到微型悬臂元件和微悬臂梁元件的振动。在本发明的另一个实施方案中，多个样品位点在样品阵列上，其中微悬臂梁元件的阵列在样品位点的化学相互作用或杂化之前和之后检测和测量变化。

6. 发明授权

US5018865A Photon scanning tunneling microscopy 失效
标题翻译：光子扫描隧道显微镜
公开(公告)号：US5018865A
公开(公告)日：1991-05-28
申请号：US260926
申请日：1988-10-21
申请人： Thomas L. Ferrell , Robert J. Warmack , Robin C. Reddick
发明人： Thomas L. Ferrell , Robert J. Warmack , Robin C. Reddick
IPC分类号： G01B11/30 , G01B9/04 , G01N21/00 , G01Q20/00 , G01Q60/18 , G02B6/04 , G02B6/26 , G02B21/00
CPC分类号： G01Q60/22 , B82Y20/00 , B82Y35/00 , G01B9/04 , G02B26/103 , G02B6/262 , Y10S977/862
摘要： A method and apparatus for photon scanning tunneling microscopy for examining a sample in a sample area on a surface at a subwavelength resolution is disclosed. The method comprises generating a near-field of photons at a surface containing a sample area. The near-field has an area that is larger than the sample area, and the near-field has an exponentially increasing intensity in a direction perpendicular to and towards the surface. The near-field is sampled with a probe which receives photons from that near-field that tunnel from the surface to the probe. The received photons are detected and a detector produces an output signal that is proportional to the number of photons received by the probe. The sample area is scanned with the probe in at least one direction parallel to the surface. While scanning, the probe may be maintained either at a position of a constant near-field intensity or at a position of constant distance from the surface. A photon scanning tunneling microscope for using the method is also disclosed.
摘要翻译：公开了一种用于光子扫描隧道显微镜的方法和装置，用于以亚波长分辨率检查表面上的样品区域中的样品。该方法包括在包含样品区域的表面上产生近场光子。近场具有大于样品面积的面积，并且近场在垂直于和朝向表面的方向上具有指数增加的强度。用一个探头对近场进行采样，该探头接收从表面到探头的那个近场的光子。检测到接收到的光子，并且检测器产生与探头接收的光子数成正比的输出信号。样品区域以平行于表面的至少一个方向用探头扫描。扫描时，可以将探头保持在恒定的近场强度的位置或距表面恒定的位置。还公开了一种使用该方法的光子扫描隧道显微镜。

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