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    • 4. 发明授权
    • Preparation of optically active ketones
    • 光学活性酮的制备
    • US4618710A
    • 1986-10-21
    • US417771
    • 1982-09-13
    • Henry RapoportThomas F. Buckley, III
    • Henry RapoportThomas F. Buckley, III
    • C07C271/06C07C307/02C07C311/00C07C125/065C07C125/067C07C143/74C07C143/78
    • C07C307/02C07C271/06C07C311/00
    • An optically active alpha-amino acid derivative having the formula: ##STR1## wherein: X is OH, Cl, Br, I, or OCOR.sub.3 ;Y is a radical selected to stabilize the alpha carbon atom of the alpha-amino acid derivative sufficiently to prevent significant change in symmetry thereof during replacement of X with an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl or alkynaryl radical, or such radical having one or more chemical constituents thereon; andR.sub.1 and R.sub.2 are different from one another and are each hydrogen or an alkyl, aryl, alkenyl, alkynyl, alkaryl, aralkyl, alkenaryl, or alkynaryl radical, or such radical having one or more non-protic chemical constituents thereon is conventionally synthesized from the corresponding alpha-amino acid. The ##STR2## portion of the above derivative is converted to a ketone functionality without racemization.
    • 具有下式的光学活性α-氨基酸衍生物:其中:X是OH,Cl,Br,I或OCOR3; Y是选择的基团,以充分稳定α-氨基酸衍生物的α碳原子,以防止在用烷基,芳基,烯基,炔基,烷芳基,芳烷基,烯芳基或炔烃基取代X时其对称性的显着变化,或 这种基团在其上具有一种或多种化学成分; 并且R 1和R 2彼此不同,并且各自为氢或烷基,芳基,烯基,炔基,烷芳基,芳烷基,烯芳基或炔烃基,或者其上具有一个或多个非质子化学成分的基团通常由 相应的α-氨基酸。 上述衍生物的部分转化为酮官能团而不外消旋化。