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1. 发明申请

US20140051752A1 Treatment of Obesity Using Non-Daily Administration of 6-O-(4-Dimethylaminoethoxy) Cinnamoyl Fumagillol 有权
公开(公告)号：US20140051752A1
公开(公告)日：2014-02-20
申请号：US13990271
申请日：2011-11-29
申请人： Thomas E. Hughes
发明人： Thomas E. Hughes
IPC分类号： A61K31/336
CPC分类号： A61K31/336 , A61K9/0019
摘要： The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of e.g, a MetAP-2 inhibitor.

2. 发明申请

US20120322867A1 Methods of Treating an Overweight or Obese Subject 有权
公开(公告)号：US20120322867A1
公开(公告)日：2012-12-20
申请号：US13568800
申请日：2012-08-07
申请人： Thomas E. Hughes , James E. Vath
发明人： Thomas E. Hughes , James E. Vath
IPC分类号： A61K31/336 , A61P3/04
CPC分类号： A61K31/336 , A61K31/4015 , A61K31/439 , A61K45/06
摘要： The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.

3. 发明申请

US20120014907A1 USE OF SUBSTITUTED CYANOPYRROLIDINES AND COMBINATION PREPARATIONS CONTAINING THEM FOR TREATING HYPERLIPIDEMIA AND ASSOCIATED DISEASES 审中-公开
标题翻译：使用替代的CYANOPRROLIDINES和组合制剂，用于治疗高脂血症和相关疾病
公开(公告)号：US20120014907A1
公开(公告)日：2012-01-19
申请号：US13245226
申请日：2011-09-26
申请人： David Grenville Holmes , Thomas E. Hughes
发明人： David Grenville Holmes , Thomas E. Hughes
IPC分类号： A61K31/738 , A61K31/616 , A61K31/555 , A61K31/455 , A61P9/10 , A61K31/40 , A61P9/00 , A61P3/06 , A61P39/06 , A61K31/785 , A61K31/405
CPC分类号： A61K31/401 , A61K31/40 , A61K45/06 , A61K2300/00
摘要： Disclosed are methods and compositions for the treatment of hyperlipidemia and conditions associated therewith, such as CHD, ischemic stroke, restenosis after angioplasty, peripheral vascular disease, intermittent claudication, myocardial infarction (e.g. necrosis and apoptosis), dyslipidemia and post-prandial lipemia. The methods include administration of a therapeutically effective amount of a compound of formula (I), wherein R is substituted adamantly; and N is 0 to 3; in free form or in acid addition salt form, and a pharmaceutically acceptable carrier.
摘要翻译：公开了用于治疗高脂血症和与之相关的病症的方法和组合物，例如CHD，缺血性卒中，血管成形术后的再狭窄，外周血管疾病，间歇性跛行，心肌梗死（例如坏死和凋亡），血脂异常和餐后脂肪血症。所述方法包括施用治疗有效量的式（I）化合物，其中R是金刚烷取代的; N为0〜3; 游离形式或酸加成盐形式，和药学上可接受的载体。

4. 发明授权

US4849593A Microwave-activated heating element 失效
标题翻译：微波激活加热元件
公开(公告)号：US4849593A
公开(公告)日：1989-07-18
申请号：US29663
申请日：1987-03-24
申请人： Thomas E. Hughes , Calvin L. Seals
发明人： Thomas E. Hughes , Calvin L. Seals
IPC分类号： A45D1/04 , A45D1/20 , A45D2/36 , A45D4/16 , A47J39/02 , A61F7/02 , H05B6/64
CPC分类号： A61F7/02 , A45D1/04 , A45D1/20 , A45D2/36 , A45D4/16 , H05B6/64 , A61F2007/0242
摘要： A heating element for retaining heat applied by reaction with high-frequency microwave radiation is provided in various forms. In one form, the heating element includes a multi-layered cartridge having a center core for dissipating heat, a layer of material reactive to microwave radiation for retaining heat and an outer layer of paper for substantially sealing the cartridge, yet permitting heat to radiate in use from the cartridge. In another form, the heating element has multiple layers formed of a rubber and cellular material for retaining water, the multiple layers being disposed about a central core of wax material. In a still further form, the heating element may comprise clay disposed within a covering, the clay containing minerals or aromatics, depending upon its use. In all such heating elements, the materials comprising the elements are reactive to high-frequency microwave radiation to retain heat and radiate such retained heat upon application for their intended purposes.This application is a continuation-in-part of application Ser. No. 918,729, filed Oct. 14, 1986, now U.S. Pat. No. 4,743,726 issued May 10, 1988.
摘要翻译：以各种形式提供用于保持通过与高频微波辐射反应而施加的热的加热元件。在一种形式中，加热元件包括具有用于散热的中心芯的多层盒，可反应用于保留热的微波辐射的材料层和用于基本上密封盒的外层纸，同时允许热辐射从墨盒使用。在另一种形式中，加热元件具有由用于保持水的橡胶和多孔材料形成的多层，多层围绕蜡材料的中心芯设置。在另一种形式中，取决于其用途，加热元件可以包括布置在覆盖物内的粘土，含有矿物质或芳族化合物的粘土。在所有这样的加热元件中，包含这些元件的材料对高频微波辐射是有反应性的，以便在施加其预期目的时保持热量并辐射这种保留的热量。该应用程序是应用程序Ser的部分继续。 1986年10月14日提交的美国专利第918,729号。 1988年5月10日授权的第4,743,726号。

5. 发明授权

US4093211A Combination jump rope and flexible exerciser 失效
标题翻译：组合跳绳和灵活运动
公开(公告)号：US4093211A
公开(公告)日：1978-06-06
申请号：US766053
申请日：1977-02-04
申请人： Thomas E. Hughes , Thomas E. Skornschek
发明人： Thomas E. Hughes , Thomas E. Skornschek
IPC分类号： A63B5/20 , A63B21/055 , A63B23/16 , A63B21/14 , A63B21/30
CPC分类号： A63B23/16 , A63B21/0004 , A63B21/0552 , A63B5/20 , A63B21/00061 , A63B21/00069 , A63B21/0442 , A63B21/0555 , A63B21/0557 , A63B21/1645 , A63B2208/0204 , A63B2208/0223
摘要： Exercising apparatus having a pair of handgrips connected to respective ends of an elastic, flexible member to form a jump rope. Suitable clamps are provided for releasably attaching the ends of the flexible member to the handgrips, while the handgrips themselves include handles provided with recesses and grooves for selectively receiving the flexible member and facilitating use of the apparatus as a chest exerciser, and the like. The handgrips are constructed around a torsion spring which permits the handgrips be employed as hand exercising devices.
摘要翻译：具有一对手柄的运动装置，其连接到弹性柔性构件的相应端部，以形成跳绳。提供了适当的夹具，用于将柔性构件的端部可释放地附接到手柄上，而手柄本身包括具有用于选择性地接收柔性构件并便于使用该装置作为胸部锻炼器等的凹部和凹槽的手柄。手柄围绕扭簧构成，其允许把手用作手动锻炼装置。

6. 发明授权

US08642650B2 Methods of treating an overweight or obese subject 有权
标题翻译：治疗超重或肥胖受试者的方法
公开(公告)号：US08642650B2
公开(公告)日：2014-02-04
申请号：US13133060
申请日：2009-12-04
申请人： Thomas E. Hughes , James E. Vath
发明人： Thomas E. Hughes , James E. Vath
IPC分类号： A01N43/20 , A01N43/24 , A61K31/335 , A01N37/12 , A01N37/44 , A61K31/24 , A01N37/02 , A61K31/22
CPC分类号： A61K31/336 , A61K31/4015 , A61K31/439 , A61K45/06
摘要： The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
摘要翻译：本发明一般涉及治疗超重或肥胖受试者以及治疗超重或肥胖相关病症的方法。在某些实施方案中，本发明提供了治疗超重或肥胖受试者的方法，包括施用MetAP2抑制剂，其中给药量基本上不调节血管发生。

7. 发明申请

US20090291791A1 TENSIONER ASSEMBLY WITH SEALED PULLEY 有权
标题翻译：带紧密螺丝的紧固件总成
公开(公告)号：US20090291791A1
公开(公告)日：2009-11-26
申请号：US12125398
申请日：2008-05-22
申请人： Christopher Ward , Thomas E. Hughes , Matthew B. Neal
发明人： Christopher Ward , Thomas E. Hughes , Matthew B. Neal
IPC分类号： F16H7/12 , F16H55/36
CPC分类号： F16H7/20 , F16C13/006 , F16C2361/63 , F16H2007/0865
摘要： A pulley assembly operable in connection with a tensioner assembly is provided for tensioning a belt. The pulley assembly includes one or more elements for sealing the pulley to protect the pulley assembly in harsh environments. For instance, the pulley assembly may include one or more shields for protecting the pulley from contaminants entering the interior of the pulley assembly that can lead to premature failure.
摘要翻译：提供可与张紧器组件连接操作的滑轮组件，用于张紧皮带。滑轮组件包括用于密封滑轮以在恶劣环境中保护滑轮组件的一个或多个元件。例如，滑轮组件可以包括一个或多个屏蔽件，用于保护滑轮免于进入滑轮组件内部的污染物，这可能导致过早的故障。

8. 发明授权

US5478988A Thermal exchange composition and articles for use thereof 失效
标题翻译：热交换组合物和用于其的制品
公开(公告)号：US5478988A
公开(公告)日：1995-12-26
申请号：US188428
申请日：1994-01-28
申请人： Thomas E. Hughes , R. Scott Sparkman
发明人： Thomas E. Hughes , R. Scott Sparkman
IPC分类号： A47J39/02 , A61F7/02 , F25D3/00 , H05B6/64 , H05B6/80
CPC分类号： A61F7/02 , A47J36/2494 , F25D3/00 , H05B6/64 , A61F2007/0242 , F25D2303/0822 , F25D2303/085 , F25D2331/804 , F25D2331/812 , Y10S99/14
摘要： A thermal exchange composition made from clay, glycol and/or water for retaining and slowly releasing hot and cold temperatures is provided. The composition can further include polyacrylamide, for mixing with water, and olivine. The composition can be incorporated and used in a variety of applications. For instance, the thermal exchange composition can be used in hot and cold packs for therapeutic treatment to sore areas of the body. Other articles incorporating the thermal exchange composition include food trays, stadium seats, and the like. A thermal delivery device is also provided. The thermal delivery device can be incorporated into a variety of articles, including toys and food containers.
摘要翻译：提供了由粘土，乙二醇和/或水制成的用于保持和缓慢释放热和冷温度的热交换组合物。该组合物可进一步包括聚丙烯酰胺，与水混合和橄榄石。该组合物可以并入并用于各种应用中。例如，热交换组合物可以用于冷热包装，用于治疗身体的疼痛区域。结合热交换组合物的其它制品包括食品托盘，体育场座椅等。还提供热输送装置。热输送装置可以并入到各种物品中，包括玩具和食品容器。

9. 发明授权

US4743726A Microwave activated heating element 失效
标题翻译：微波激活加热元件
公开(公告)号：US4743726A
公开(公告)日：1988-05-10
申请号：US918729
申请日：1986-10-14
申请人： Thomas E. Hughes , Calvin L. Seals
发明人： Thomas E. Hughes , Calvin L. Seals
IPC分类号： A45D1/04 , A45D1/20 , A45D2/36 , A45D4/16 , A47J39/02 , A61F7/02 , H05B6/64 , H05B6/80
CPC分类号： A61F7/02 , A45D1/04 , A45D1/20 , A45D2/36 , A45D4/16 , H05B6/64 , A61F2007/0242
摘要： A microwave activated heating element for exposure to high energy microwaves to heat the element includes a water saturated cellular core, water, heat and flame resistant rubber coated with high temperature lubricant, and a wax center core to absorb and store heat from the microwave heated water and rubber. The construction of the heating element may be accomplished in several forms such as concentrically wound, tubular, layered, and sectioned in particles, to conform to the specific design and use of the outer appliance.
摘要翻译：用于暴露于高能量微波以加热元件的微波激活加热元件包括水饱和的细胞芯，涂覆有高温润滑剂的水，耐热和耐火橡胶，以及用于吸收和储存来自微波加热水的热的蜡中心芯和橡胶。加热元件的结构可以以几种形式实现，例如同心缠绕，管状，分层和分段成颗粒，以符合外部设备的具体设计和使用。

10. 外观设计

USD256338S Range finder 失效
公开(公告)号：USD256338S
公开(公告)日：1980-08-12
申请号：US946836
申请日：1978-09-28
申请人： Charles E. Kester , Thomas E. Hughes
设计人： Charles E. Kester , Thomas E. Hughes

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