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1. 发明授权

US06306074B1 Method and apparatus for radiation treatment of a desired area in the vascular system of a patient 有权
标题翻译：辐射治疗患者血管系统中所需区域的方法和装置
公开(公告)号：US06306074B1
公开(公告)日：2001-10-23
申请号：US09304783
申请日：1999-05-04
申请人： Ron Waksman , Thomas D. Weldon , Raphael F. Meloul , Richard A. Hillstead , Jonathan J. Rosen , George K. Bonnoitt, Jr. , David S. Halpern , Charles E. Larsen , Ian R. Crocker
发明人： Ron Waksman , Thomas D. Weldon , Raphael F. Meloul , Richard A. Hillstead , Jonathan J. Rosen , George K. Bonnoitt, Jr. , David S. Halpern , Charles E. Larsen , Ian R. Crocker
IPC分类号： A61M2902
CPC分类号： A61M37/0069 , A61M25/0029 , A61M25/1002 , A61M25/1006 , A61M2025/0037 , A61M2025/0039 , A61M2025/004 , A61N5/1002 , A61N5/1007 , A61N2005/1003 , A61N2005/1005 , A61N2005/1008 , A61N2005/1023
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the intraluminal passageways of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's intraluminal passageways. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于将治疗元件（例如辐射源）通过导管递送到患者（例如冠状动脉）的管腔内通道中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间具有内腔，并且其直径足够小以插入病人的管腔内通道。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

2. 发明授权

US5330446A Wound treating device using an inflatable membrane and method for treating wounds 失效
标题翻译：使用充气膜的伤口治疗装置和治疗伤口的方法
公开(公告)号：US5330446A
公开(公告)日：1994-07-19
申请号：US899507
申请日：1992-06-16
申请人： Thomas D. Weldon , Charles E. Larsen
发明人： Thomas D. Weldon , Charles E. Larsen
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61F2/06 , A61M25/00 , A61M5/00
CPC分类号： A61B17/0057 , A61F2/06 , A61M25/10
摘要： A wound clotting device includes a tubular portion having a proximal end, a distal end and a lumen extending therebetween, an inflatable membrane associated with the distal end of the tubular portion and being moveable between a retracted position and an inflated position to form a balloon-like projection at the distal end when moved to the inflated position for treating a wound. A method for treating a wound by providing a wound-treating device, positioning the device in a location near the wound, moving an inflation membrane of the wound treating device to an inflated position near the wound, and removing the treating device is described. Finally, an alternate wound treating device having an inflatable membrane which is releasably carried at the distal end of the tubular portion and which is expelled to treat the wound is also described.
摘要翻译：伤口凝固装置包括管状部分，其具有近端，远端和在其间延伸的内腔，可膨胀的膜与管状部分的远端相关联并且可在缩回位置和充气位置之间移动以形成气囊 - 当移动到用于治疗伤口的充气位置时在远端处的类似突起。一种通过提供伤口处理装置来处理伤口的方法，将装置定位在伤口附近的位置，将伤口处理装置的充气膜移动到伤口附近的充气位置，并且去除处理装置。最后，还描述了具有可释放地携带在管状部分的远端并被排出以治疗伤口的可充气膜的替代伤口处理装置。

3. 发明授权

US5129882A Wound clotting device and method of using same 失效
标题翻译：绕线装置及其使用方法
公开(公告)号：US5129882A
公开(公告)日：1992-07-14
申请号：US634406
申请日：1990-12-27
申请人： Thomas D. Weldon , Charles Larsen
发明人： Thomas D. Weldon , Charles Larsen
IPC分类号： A61B17/12 , A61B17/00 , A61B17/03 , A61F2/06 , A61M25/00
CPC分类号： A61B17/0057 , A61F2/06 , A61M25/10
摘要： A wound clotting device is disclosed comprising a clotting device for dispensing a clotting agent onto a selected location in a patient while being retained adjacent to that location, comprising a tube having a proximal end portion and a distal end portion; means defining an inflation lumen in said tube extending between said proximal and distal end portions; inflatable retention means carried by said tube at said distal end portion for retaining said distal end at a selected location within the body of a living patient, said retention means being in fluid communication with said inflation lumen; means defining a second lumen in said tube extending between said proximal and distal end portions; means for receiving a quantity of clotting agent located within said second lumen; and means disposed within said second lumen for dispensing said clotting agent from said distal end of said second lumen to deposit said clotting agent at said selected location within a patient. A method for using such clotting device is also disclosed.

4. 发明授权

US06821242B1 Method and apparatus for treating a desired area in the vascular system of a patient 有权
标题翻译：用于治疗患者血管系统中所需区域的方法和装置
公开(公告)号：US06821242B1
公开(公告)日：2004-11-23
申请号：US09468179
申请日：1999-12-21
申请人： Ron Waksman , Thomas D. Weldon , Ian R. Crocker
发明人： Ron Waksman , Thomas D. Weldon , Ian R. Crocker
IPC分类号： A61N500
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.
摘要翻译：描述了用于将治疗元件（例如辐射源）通过导管递送到患者（例如冠状动脉）的血管系统中用于抑制形成瘢痕组织的可能发生的装置和方法在球囊血管成形术后再狭窄。该装置包括细长的柔性导管，其具有近端部分和远端部分，其间延伸有内腔，并且具有足够小的直径以插入患者血管系统中的直径。一个或多个处理元件，例如包含放射性物质的胶囊或丸粒，可定位在内腔内并且在液体流过内腔的力的作用下在近端部分和远端部分之间移动。公开了一种使用这种装置的方法，包括与球囊血管成形术程序同时使用这种装置的方法。

5. 发明授权

US5980492A Vascular blood containment device 失效
标题翻译：血管收容装置
公开(公告)号：US5980492A
公开(公告)日：1999-11-09
申请号：US13748
申请日：1998-01-27
申请人： Jonathan J. Rosen , Richard A. Hillstead , Thomas D. Weldon , Charles E. Larsen , David O. Williams
发明人： Jonathan J. Rosen , Richard A. Hillstead , Thomas D. Weldon , Charles E. Larsen , David O. Williams
IPC分类号： A61M25/06 , A61M39/00 , A61M5/178
CPC分类号： A61M25/0693 , Y10S604/90
摘要： A blood containment, visualization and tactile confirmation device is provided for use with a vascular entry needle. The device includes a visualization channel and/or a compliant outer wall portion which indicates whether a needle connected to the device has entered a selected blood vessel. The visualization channel is optionally vented to the outside to allow displaced air to escape, but has a gas permeable member to prevent blood from escaping. Alternatively, the visualization channel is substantially sealed such that it is not significantly vented. Preferably, a compliant outer wall portion defining the visualization channel pulses with changes in blood pressure, thereby providing a tactile indication that the needle tip is properly positioned. The device has a guideway with a barrier of elastomeric material which prevents blood from passing therethrough, but which allows passage of an elongated medical instrument such as catheterization apparatus. A flange may optionally be disposed within the compliant membrane to prevent excess depression of the compliant membrane.
摘要翻译：提供血液容纳物，可视化和触觉确认装置用于血管入口针。该装置包括可视化通道和/或顺应性外壁部分，其指示连接到该装置的针是否已经进入选定的血管。可视化通道可选地排放到外部以允许排出的空气逸出，但是具有气体可渗透构件以防止血液逸出。或者，可视化通道基本上被密封，使得它不被显着地排出。优选地，限定可视化通道的顺应性外壁部分具有血压变化，从而提供针尖正确定位的触觉指示。该装置具有带有弹性体材料阻挡物的导轨，其阻止血液通过其中，但允许细长的医疗器械如导管插入装置通过。凸缘可以可选地设置在顺应性膜内以防止柔顺膜的过度凹陷。

6. 发明授权

US5820596A Vascular blood containment device 失效
标题翻译：血管收容装置
公开(公告)号：US5820596A
公开(公告)日：1998-10-13
申请号：US620922
申请日：1996-03-22
申请人： Jonathan J. Rosen , Richard A. Hillstead , Thomas D. Weldon , Charles E. Larsen , David O. Williams
发明人： Jonathan J. Rosen , Richard A. Hillstead , Thomas D. Weldon , Charles E. Larsen , David O. Williams
IPC分类号： A61M25/06 , A61M39/00 , A61M29/00
CPC分类号： A61M25/0693 , Y10S604/90
摘要： A blood containment, visualization and tactile confirmation device is provided for use with a vascular entry needle. The device includes a visualization channel and/or a compliant outer wall portion which indicates whether a needle connected to the device has entered a selected blood vessel. The visualization channel is vented to the outside to allow displaced air to escape, but has a gas permeable member to prevent blood from escaping. The visualization channel may have one, two, or more stages, with a first stage chamber which indicates initial penetration of a selected blood vessel, and a second stage chamber which fills more slowly and indicates that the needle remains positioned within the blood vessel. A third stage chamber with entrapped air which compresses slightly due to the heartbeat may also be used. Preferably, a compliant outer wall portion pulses with changes in blood pressure, thereby providing a tactile indication that the needle tip is properly positioned. The device has a guideway with a barrier of elastomeric material which prevents blood from passing therethrough, but which allows passage of an elongated medical instrument such as catheterization apparatus. A flange may also be disposed within the compliant membrane to prevent excess depression of the compliant membrane.
摘要翻译：提供血液容纳物，可视化和触觉确认装置用于血管入口针。该装置包括可视化通道和/或顺应性外壁部分，其指示连接到该装置的针是否已经进入选定的血管。可视化通道被排放到外部以允许排出的空气逸出，但是具有气体可渗透构件以防止血液逸出。可视化通道可以具有一个，两个或更多个阶段，其中第一阶段室指示所选择的血管的初始穿透，以及填充更慢并且指示针保持定位在血管内的第二阶段室。也可以使用具有夹带空气的第三级室，其由于心跳而略微压缩。优选地，顺应性外壁部分以血压变化脉冲，从而提供针尖正确定位的触觉指示。该装置具有带有弹性体材料阻挡物的导轨，其防止血液通过其中，但允许细长的医疗器械如导管插入装置通过。法兰也可以设置在柔顺膜内以防止顺应性膜的过度压低。

7. 发明授权

US5195990A Coronary catheter 失效
标题翻译：冠状导管
公开(公告)号：US5195990A
公开(公告)日：1993-03-23
申请号：US757684
申请日：1991-09-11
申请人： Thomas D. Weldon
发明人： Thomas D. Weldon
IPC分类号： A61M25/00
CPC分类号： A61M25/0041
摘要： The coronary catheter of the present invention has an elongated tubular member or shaft, with a proximal end portion and the distal end portion. The distal end portion terminates in a tip end portion. In accordance with the present invention, the distal end portion of the catheter is curved in three dimensions and cooperative with the shape of the human aortic arch so as to automatically place the tip end of the catheter into proximity with the right coronary ostium as the distal end portion passes over the aortic arch and into the ascending aorta.

8. 发明授权

US06994665B2 Method and apparatus for treating a desired area in the vascular system of a patient 失效
公开(公告)号：US06994665B2
公开(公告)日：2006-02-07
申请号：US10817549
申请日：2004-04-02
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61M3/00
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

9. 发明授权

US06503185B1 Method and apparatus for treating a desired area in the vascular system of a patient 有权
公开(公告)号：US06503185B1
公开(公告)日：2003-01-07
申请号：US09469082
申请日：1999-12-21
申请人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
发明人： Ron Waksman , Thomas D. Weldon , Richard A. Hillstead , Jonathan J. Rosen , Charles E. Larsen , Ian R. Crocker , Raphael F. Meloul
IPC分类号： A61N500
CPC分类号： A61M25/1002 , A61M25/0028 , A61M25/003 , A61M25/0032 , A61M25/1006 , A61M2025/0034 , A61N5/1002 , A61N5/1007
摘要： Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the vascular system of a patient, such as a coronary artery, for inhibiting the formation of scar tissue such as may occur in restenosis following balloon angioplasty. The apparatus includes an elongated flexible catheter tube having proximal and distal end portions, with a lumen extending therebetween, and a diameter sufficiently small for insertion in to a patient's vascular system. One or more treating elements, such as a capsule or pellet containing radioactive material, is positionable within the lumen and movable between the proximal and distal end portions under the force of liquid flowing through the lumen. A method for using such apparatus, including a method for using such apparatus simultaneously with a balloon angioplasty procedure, is disclosed.

10. 发明授权

US5746414A Fluid access and flow control valve 失效
公开(公告)号：US5746414A
公开(公告)日：1998-05-05
申请号：US668537
申请日：1996-06-21
申请人： Thomas D. Weldon , Charles E. Larsen , Jonathan J. Rosen
发明人： Thomas D. Weldon , Charles E. Larsen , Jonathan J. Rosen
IPC分类号： F16K3/28 , A61M5/168 , A61M39/26 , F16K3/32 , F16K7/02 , F16L29/02
CPC分类号： F16K7/02 , A61M39/26 , A61M5/16877
摘要： A flow control valve is described comprised of first and second rigid members and a resilient single or multi stage valve element disposed between the rigid members. A fluid flow path is defined through the rigid members and through or around the valve element to provide a continuous flow path through the valve. The rigid members are movable relative to each other between a first position and a second position. The valve element is sufficiently compressed by the rigid members when they are in the first position so as to close the flow path through or around the valve element. The valve element is sufficiently relaxed when the rigid members are in the second position to allow fluid flow through the flow path through or around the valve element.

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