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1. 发明授权

US08076324B2 Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them 有权
标题翻译：二（异）芳基环己烷衍生物，其制备方法，用途和包含它们的药物组合物
公开(公告)号：US08076324B2
公开(公告)日：2011-12-13
申请号：US12630537
申请日：2009-12-03
申请人： Thomas Bohme , Uwe Gerlach , Dirk Gretzke , Heinz-Werner Kleemann , Stefania Pfeiffer-Marek , Henning Vollert , Jean-Michel Altenburger , Sergio Mallart
发明人： Thomas Bohme , Uwe Gerlach , Dirk Gretzke , Heinz-Werner Kleemann , Stefania Pfeiffer-Marek , Henning Vollert , Jean-Michel Altenburger , Sergio Mallart
IPC分类号： A61P9/00 , A61P9/06 , A61K31/55 , A61K31/444 , A61K31/506 , A61K31/404 , A61K31/19 , A61K31/415 , A61K31/426 , A61K31/4184 , A61K31/44 , A61K31/343 , A61K31/4196 , C07C62/00 , C07D213/55 , C07D317/46 , C07D215/14 , C07D487/02 , C07D231/12 , C07D277/30 , C07D239/02 , C07D209/04 , C07D235/04
CPC分类号： C07D317/46 , C07B2200/07 , C07C62/32 , C07C62/34 , C07C255/46 , C07C311/08 , C07C317/46 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D209/18 , C07D213/30 , C07D213/46 , C07D213/55 , C07D213/57 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/02 , C07D217/16 , C07D231/12 , C07D231/16 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/84 , C07D233/90 , C07D235/06 , C07D235/16 , C07D249/08 , C07D277/24 , C07D277/30 , C07D305/04 , C07D305/06 , C07D333/24 , C07D401/12 , C07D405/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及式I的二（异）芳基环己烷衍生物，其中Ar1，Ar2，R1和R2具有权利要求中所示的含义。式I的化合物是抑制心肌中ATP敏感钾通道的有价值的药物活性化合物，并且适用于例如治疗心血管系统疾病如心律失常或心脏收缩力降低，例如，可能发生在冠心病，心功能不全或心肌病。特别是适用于预防心源性猝死。本发明还涉及用于制备式I化合物的方法和中间体，其用途和包含它们的药物组合物。

2. 发明申请

US20100204206A1 Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising them 有权
标题翻译：二（异）芳基环己烷衍生物，其制备方法，用途和包含它们的药物组合物
公开(公告)号：US20100204206A1
公开(公告)日：2010-08-12
申请号：US12630537
申请日：2009-12-03
申请人： Thomas BOHME , Uwe GERLACH , Dirk GRETZKE , Heinz-Werner KLEEMANN , Stefania PFEIFFER-MAREK , Henning VOLLERT , Jean-Michel ALTENBURGER , Sergio MALLART
发明人： Thomas BOHME , Uwe GERLACH , Dirk GRETZKE , Heinz-Werner KLEEMANN , Stefania PFEIFFER-MAREK , Henning VOLLERT , Jean-Michel ALTENBURGER , Sergio MALLART
IPC分类号： A61K31/55 , C07C62/00 , A61K31/19 , C07D213/55 , A61K31/44 , C07D317/46 , A61K31/343 , C07D215/14 , A61K31/47 , C07D213/62 , C07D249/08 , A61K31/4196 , C07D487/02 , C07D231/12 , A61K31/415 , C07D277/30 , A61K31/426 , A61K31/444 , C07D239/02 , A61K31/506 , C07D209/04 , A61K31/404 , C07D235/04 , A61K31/4184 , A61P9/00 , A61P9/06
CPC分类号： C07D317/46 , C07B2200/07 , C07C62/32 , C07C62/34 , C07C255/46 , C07C311/08 , C07C317/46 , C07C323/62 , C07C2601/02 , C07C2601/14 , C07D209/18 , C07D213/30 , C07D213/46 , C07D213/55 , C07D213/57 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/02 , C07D217/16 , C07D231/12 , C07D231/16 , C07D233/60 , C07D233/64 , C07D233/68 , C07D233/84 , C07D233/90 , C07D235/06 , C07D235/16 , C07D249/08 , C07D277/24 , C07D277/30 , C07D305/04 , C07D305/06 , C07D333/24 , C07D401/12 , C07D405/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Di(hetero)arylcyclohexane derivatives, their preparation, their use and pharmaceutical compositions comprising themThe present invention relates to di(hetero)arylcyclohexane derivatives of the formula I, in which Ar1, Ar2, R1 and R2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmaceutical active compounds which inhibit ATP-sensitive potassium channels in the heart muscle and are suitable, for example, for the treatment of disorders of the cardiovascular system such as arrhythmias or a decreased contractility of the heart, such as can occur, for example, in coronary heart disease, cardiac insufficiency or cardiomyopathies. In particular, they are suitable for the prevention of sudden cardiac death. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I, their use and pharmaceutical compositions comprising them.
摘要翻译：二（杂）芳基环己烷衍生物，其制备方法及用途及其组合物本发明涉及式I的二（异）芳基环己烷衍生物，其中Ar 1，Ar 2，R 1和R 2具有权利要求中所示的含义。式I的化合物是抑制心肌中ATP敏感钾通道的有价值的药物活性化合物，并且适用于例如治疗心血管系统疾病如心律失常或心脏收缩力降低，例如，可能发生在冠心病，心功能不全或心肌病。特别是适用于预防心源性猝死。本发明还涉及用于制备式I化合物的方法和中间体，其用途和包含它们的药物组合物。

3. 发明申请

US20050137200A1 Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use 有权
公开(公告)号：US20050137200A1
公开(公告)日：2005-06-23
申请号：US11052959
申请日：2005-02-08
申请人： Joachim Brendel , Thomas Bohme , Stefan Peukert , Heinz-Werner Kleemann
发明人： Joachim Brendel , Thomas Bohme , Stefan Peukert , Heinz-Werner Kleemann
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/4402 , A61K31/47 , A61K31/472 , A61K31/497 , A61K45/06 , A61P9/06 , C07D213/70 , C07D215/36 , C07D217/02 , C07D261/10 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K31/495 , A61K31/4965 , A61K31/50
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.

4. 发明授权

US06357202B1 Device for supplying package sleeves to a filling machine for filling liquid foodstuffs into multi-layer composite packages 有权
标题翻译：用于将包装袋供应到用于将液体食品填充到多层复合包装中的灌装机的装置
公开(公告)号：US06357202B1
公开(公告)日：2002-03-19
申请号：US09297338
申请日：1999-08-04
申请人： Jens Bauer , Jorg Berger , Thomas Bohme , Franz-Willi Spelten
发明人： Jens Bauer , Jorg Berger , Thomas Bohme , Franz-Willi Spelten
IPC分类号： B65B728
CPC分类号： B65B43/126
摘要： A device capable of transporting package sleeves in an upright position, from any of several filling lines to one or more filling machines, wherein said several filling lines are aligned parallel to each other. The device utilizes a manipulator capable of linear travel in a direction perpendicular to the plane of alignment of the filling lines, a swiveling unit for moving the package sleeves in a direction transverse to the direction of travel of the manipulator unit, and a gripper unit for gripping the package sleeves. The gripper unit is capable of supplying horizontal force to the package sleeves to enable their transport in an upright position. The gripper unit also has means to clamp to the loading magazine of the filling machine and to cause the horizontal transfer of the package sleeves thereto. By use of the present device, semi-automatic or automatic loading of package sleeves to one or more filling machines is possible.
摘要翻译：一种能够将直立位置的包装袋从多个填充线中的任一个输送到一个或多个灌装机的装置，其中所述多个填充线彼此平行排列。该装置使用能够在垂直于填充线的对准平面的方向上线性行进的操纵器，用于沿横向于操纵器单元的行进方向移动包装套筒的旋转单元，以及用于夹紧包装袖子。夹具单元能够向包装套筒提供水平力，以使其能够在直立位置运输。夹持器单元还具有夹紧到填充机的装载仓的装置并且使得包装套筒向其水平传递。通过使用本装置，可以将包装套筒半自动或自动装载到一个或多个灌装机。

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