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1. 发明授权

US06914677B2 Device and method for optically measuring the concentration of a substance 失效
标题翻译：用于光学测量物质浓度的装置和方法
公开(公告)号：US06914677B2
公开(公告)日：2005-07-05
申请号：US10416845
申请日：2001-11-17
申请人： Lutz Mader , Thomas Böhme , Matthias Lau , Ulrich Künzelmann
发明人： Lutz Mader , Thomas Böhme , Matthias Lau , Ulrich Künzelmann
IPC分类号： G01N21/27 , G01N21/64 , G01N21/77 , G01N21/25
CPC分类号： G01N21/77 , G01N21/274 , G01N21/6428
摘要： The invention relates to a device and a method for optically measuring the concentrations of a substance contained in a fluid medium. With the solution according to the invention the accuracy of measurement is to be increased in accordance with the object over a greater period without any additional calibration measurements, and ageing of a fluorescent substance within a layer is to be taken into consideration, in particular, and the long-time drift of such a measurement system is to be reduced. To achieve this, a layer containing such a known fluorescent substance or layer system are employed in which fluorescence is excited. The fluorescence changes depending on a substance concentration or a pH-value, and the intensity varying correspondingly in time or phase shift of the fluorescent light is allowed to be measured with at least one optical detector with the known intensity or phase of the fluorescence exciting light. On that occasion, the exciting light is directed upon at least two areas being optically separated from each other of a layer containing a fluorescent substance or two equal layers each having a different excitation energy during the useful life, and measured values of fluorescence intensity, fluorescence decay times or phase shifts being locally and/or timely separated of both areas or layers are fed to an electronic comparative and correction value determination unit.
摘要翻译：本发明涉及用于光学测量流体介质中所含物质的浓度的装置和方法。利用根据本发明的解决方案，根据目标在更长的时间内增加测量精度，而无需任何额外的校准测量，并且特别地考虑层内的荧光物质的老化，以及这样的测量系统的长时间漂移将被减少。为了实现这一点，使用含有这种已知的荧光物质或层系统的层，其中激发荧光。荧光根据物质浓度或pH值而变化，并且使用具有已知的荧光激发光的强度或相位的至少一个光学检测器来测量荧光的时间或相移相应变化的强度。在这种情况下，激发光指向至少两个在使用寿命期间彼此光学分离的区域，其中包含荧光物质的层或两个相等的层具有不同的激发能量，并且荧光强度，荧光的测量值衰减时间或局部地和/或时间分离两个区域或层的相移被馈送到电子比较和校正值确定单元。

2. 发明授权

US06903216B2 Anthranilamides with heteroarylsulfonyl side chain, process of preparation, and use 有权
标题翻译：具有杂芳基磺酰侧链的邻氨基苯甲酰胺，制备方法和用途
公开(公告)号：US06903216B2
公开(公告)日：2005-06-07
申请号：US10166595
申请日：2002-06-12
申请人： Joachim Brendel , Thomas Böhme , Stefan Peukert , Heinz-Werner Kleemann
发明人： Joachim Brendel , Thomas Böhme , Stefan Peukert , Heinz-Werner Kleemann
IPC分类号： A61K31/42 , A61K31/4245 , A61K31/4402 , A61K31/47 , A61K31/472 , A61K31/497 , A61K45/06 , A61P9/06 , C07D213/70 , C07D215/36 , C07D217/02 , C07D261/10 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12
CPC分类号： C07D261/10 , A61K31/47 , A61K45/06 , C07D215/36 , C07D217/02 , C07D271/12 , C07D333/34 , C07D401/12 , C07D405/12 , A61K2300/00
摘要： This invention encompasses anthranilamides with heteroarylsulfonyl side chain, process for their preparation, their use as medicament or diagnostic aid, and pharmaceutical preparations containing them. Compounds of formula I, in which R1 to R7 have the meanings stated in the claims, act on the Kv1.5 potassium channel and inhibit a potassium current which is referred to as the ultra-rapidly activating delayed rectifier in the atrium of the human heart. They are therefore suitable as novel antiarrhythmic ingredients, such as for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutter.
摘要翻译：本发明包括具有杂芳基磺酰侧链的邻氨基苯甲酰胺，其制备方法，它们作为药物或诊断助剂的用途，以及含有它们的药物制剂。其中R 1至R 7具有权利要求中所述含义的式I化合物作用于Kv1.5钾通道并抑制在人心脏中心被称为超快速活化延迟整流剂的钾电流。因此，它们适合作为新的抗心律失常成分，例如用于治疗和预防心房心律失常，例如，心房颤动（AF）或心房扑动。

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