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    • 2. 发明授权
    • Method for enhancing the absorption and transport of lipid soluble
compounds using structured glycerides
    • 使用结构化甘油酯增强脂溶性化合物的吸收和运输的方法
    • US6013665A
    • 2000-01-11
    • US991503
    • 1997-12-16
    • Stephen J. DeMicheleTheresa W. LeePatrick Tso
    • Stephen J. DeMicheleTheresa W. LeePatrick Tso
    • A23D9/00A23D9/007A23L1/30A23L1/302A61K9/00A61K31/07A61K31/355A61K31/555A61K45/00A61K47/14A61P3/02C11C3/10A61K47/00
    • A23D9/00A23L33/115A23L33/12A23L33/15A61K31/07A61K31/355A61K47/14A61K9/0014C11C3/10A23V2002/00Y10S514/946
    • This invention relates to a method for enhancing the absorption of oil soluble (lipophilic) compounds such as oil soluble vitamins, hormones, nutrients and drugs in an animal. The inventive method comprises administering a lipophilic compound in conjunction with a structured glyceride component characterized in that at least 40% of the glyceride species have: (i) about 33 to 70 wt. % of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt. % of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48. This invention also relates to compositions suitable for administrating to an animal comprising a lipophilic compound and a structured glyceride component characterized in that at least 40% of the glyceride species have: (i) about 33 to 70 wt. % of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt. % of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48. The method and compositions of the invention are especially suited for animals that suffer from lipid malabsorption conditions such as Crohn's disease, Cystic fibrosis, and short bowel syndrome.
    • 本发明涉及一种用于增强动物体内油溶性(亲油性)化合物如油溶性维生素,激素,营养物和药物的吸收的方法。 本发明的方法包括与结构化的甘油酯组分联合施用亲脂性化合物,其特征在于至少40%的甘油酯物质具有:(i)约33至70重量% %的具有4至12个碳原子的酰基部分; (ii)约30至67wt。 %的具有多于12个碳原子的酰基部分; 本发明还涉及适用于向动物施用的组合物,其包含亲脂化合物和结构化甘油酯组分,其特征在于至少40%的甘油酯物质具有: (i)约33〜70重量% %的具有4至12个碳原子的酰基部分; (ii)约30至67wt。 %的具有多于12个碳原子的酰基部分; 和(iii)大于30且小于48的当量碳数。本发明的方法和组合物特别适用于患有例如克罗恩病,囊性纤维化和短肠综合征的脂质吸收不良的动物。