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1. 发明授权

US07153937B2 Mammalian cytokine-like factor 7 失效
公开(公告)号：US07153937B2
公开(公告)日：2006-12-26
申请号：US10253159
申请日：2002-09-24
申请人： Scott R. Presnell , Teresa Gilbert , Theresa Martinez , Ross C. Hoffman
发明人： Scott R. Presnell , Teresa Gilbert , Theresa Martinez , Ross C. Hoffman
IPC分类号： C07K14/52
CPC分类号： C07K14/52 , C07K2319/00 , C07K2319/02
摘要： Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.

2. 发明授权

US06642216B2 Isoprenoid pathway inhibitors for stimulating bone growth 有权
标题翻译：用于刺激骨生长的异戊二醛途径抑制剂
公开(公告)号：US06642216B2
公开(公告)日：2003-11-04
申请号：US09848839
申请日：2001-05-03
申请人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
发明人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
IPC分类号： A61K31665
CPC分类号： C07D215/14 , A23L33/10 , A61K31/00 , A61K31/192 , A61K31/22 , A61K31/225 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： Compounds of the formula wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C; Y is of the formula or a stereoisomer thereof, wherein R1 is substituted or unsubstituted alkyl; each R2 is independently H, hydroxy, alkoxy (1-6C) or lower alkyl (1-4C); R3 is H, hydroxy, or alkoxy (1-6C); or Y is of the formula wherein each n is 1, Z is N, K comprises a substituted or unsubstituted aromatic carbocyclic or heterocyclic ring system which may optionally be spaced from the linkage position shown in formula (7) by a linker of 1-2C, or in formula (7), Z may be spaced from the carbon bonded to X by ═CR6— wherein R6 is H or linear, branded or cyclic alkyl (1-6C), R5 is H or linear, branched or cyclic alkyl, and R′ represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C, promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. Also disclosed is a method to identify additional compounds which are inhibitors of enzymes in the isoprenoid scheme especially of HMG-CoA reductase which results in prenylation of proteins and in the synthesis of steroids or of inhibitors of their production which are useful in treating bone disorders.
摘要翻译：式（1）和（2）中的式（Ⅳ）化合物表示取代或未取代的2-6C的亚烷基，亚烯基或亚炔基接头; Y为其立体异构体，其中R 1为取代或每个R 2独立地是H，羟基，烷氧基（1-6C）或低级烷基（1-4C）; R 3是H，羟基或烷氧基（1-6C）; 或Y是每个n是1的烷基，其中Z是N，K包括取代或未取代的芳族碳环或杂环系统，其可以任选地与式（7）所示的连接位置与1-2C的连接体间隔开，或在式（7）中，Z可以与通过= CR 6键合到X的碳隔开，其中R 6是H或直链的，有品牌的或环状的烷基（1-6C），R 5是H或直链，支链或环状的烷基，R'表示1-6个C的阳离子H或取代或未取代的烷基，促进骨形成，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺损，转移性骨病，溶骨性骨病，整形后手术，假体后关节手术和牙后植入术。还公开了一种鉴定作为特异性HMG-CoA的异戊二烯方案中的酶抑制剂的其它化合物的方法导致蛋白质异戊烯化的还原酶在合成类固醇或其制备的抑制剂中可用于治疗骨骼疾病。

3. 发明授权

US6124299A Calcitonin mimetics 失效
公开(公告)号：US6124299A
公开(公告)日：2000-09-26
申请号：US28085
申请日：1998-02-23
申请人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. McKernan , Emma E. Moore
发明人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. McKernan , Emma E. Moore
IPC分类号： C07D295/08 , A61K31/495 , A61P19/08 , A61P19/10 , A61P43/00 , C07D295/096 , C07D295/20 , C07D295/215 , A61K31/415 , A61K31/55
CPC分类号： C07D295/096 , A61K31/495 , C07D295/215
摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.

4. 发明授权

US06395740B1 Calcitonin mimetics 失效
标题翻译：降钙素模拟物
公开(公告)号：US06395740B1
公开(公告)日：2002-05-28
申请号：US09616695
申请日：2000-07-14
申请人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. Mckernan , Emma E. Moore
发明人： Nand Baindur , Virender Labroo , Steven Stroop , Stephanie Beigel , Theresa Martinez , Charles R. Petrie , Mark W. Orme , Patricia A. Mckernan , Emma E. Moore
IPC分类号： A61K31495
CPC分类号： C07D295/096 , A61K31/495 , C07D295/215
摘要： Compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. Included among the calcitonin mimetics of the present invention are substituted piperazines. The calcitonin mimetics of the present invention are also useful in libraries and in assays for the determination of calcitonin receptor activity.
摘要翻译：描述了作为降钙素模拟物的化合物。这些化合物可用于治疗与骨吸收相关的疾病。本发明的降钙素模拟物中包括取代的哌嗪。本发明的降钙素模拟物也可用于文库和用于测定降钙素受体活性的测定中。

5. 发明授权

US06376476B1 Isoprenoid pathway inhibitors for stimulating bone growth 有权
标题翻译：用于刺激骨生长的异戊二醛途径抑制剂
公开(公告)号：US06376476B1
公开(公告)日：2002-04-23
申请号：US09488380
申请日：2000-01-20
申请人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
发明人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
IPC分类号： A61K31665
CPC分类号： C07D215/14 , A23L33/10 , A61K31/00 , A61K31/192 , A61K31/22 , A61K31/225 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： Various embodiments of statin compounds are shown to enhance the formation of bone and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.
摘要翻译：他汀类化合物的各种实施方案被证明可增强骨的形成，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺损，转移性骨病，溶骨性骨病，整形外手术假体关节手术和牙植入后。

6. 发明授权

US6080779A Compositions and methods for stimulating bone growth 失效
标题翻译：用于刺激骨骼生长的组合物和方法
公开(公告)号：US6080779A
公开(公告)日：2000-06-27
申请号：US96957
申请日：1998-06-12
申请人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
发明人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
IPC分类号： A61K31/22 , A61K31/366 , A61K31/404 , A61K31/335 , A61K31/33 , A61K31/66
CPC分类号： A61K31/404 , A61K31/22 , A61K31/366
摘要： Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6 C;Y represents one or more carbocyclic or heterocyclic rings; when two or more rings are present in Y, they may optionally be fused; andR' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6 C; andthe dotted lines represent optional .pi.-bonds,promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. These compounds can be used in combination with other bone growth-promoting compounds and/or estrogens and/or bisphosphonates for this purpose.
摘要翻译：式（1）和（2）各自表示X为2-6的取代或未取代的亚烷基，亚烯基或亚炔基连接基的式 Y表示一个或多个碳环或杂环; 当Y中存在两个或更多个环时，它们可以任选地稠合; R'表示1-6个C的阳离子，H或取代或未取代的烷基; 虚线表示可选的pi-键，促进骨形成，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺陷，转移性骨病，溶骨性骨病，整形外手术假体关节手术和牙植入后。为了此目的，这些化合物可以与其它骨生长促进化合物和/或雌激素和/或二膦酸盐组合使用。

7. 发明申请

US20050272801A1 Isoprenoid pathway inhibitors for stimulating cartilage growth 审中-公开
标题翻译：用于刺激软骨生长的异戊二醛途径抑制剂
公开(公告)号：US20050272801A1
公开(公告)日：2005-12-08
申请号：US11167054
申请日：2005-06-24
申请人： Shirley Gasper , Robert West , Theresa Martinez , Kirk Robbins , Patricia McKernan , Nand Baindur , Virender Labroo , Gregory Mundy
发明人： Shirley Gasper , Robert West , Theresa Martinez , Kirk Robbins , Patricia McKernan , Nand Baindur , Virender Labroo , Gregory Mundy
IPC分类号： A23L1/30 , A61K31/00 , A61K31/192 , A61K31/22 , A61K31/225 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/4409 , A61K31/47 , A61K31/505 , A61K45/06 , A61P1/02 , A61P3/14 , A61P5/20 , A61P19/08 , A61P19/10 , C07D207/416 , C07D213/54 , C07D215/14
CPC分类号： C07D215/14 , A23L33/10 , A61K31/00 , A61K31/192 , A61K31/22 , A61K31/225 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： Compounds of the formula wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C; Y is of the formula or a stereoisomer thereof, wherein R1 is substituted or unsubstituted alkyl; each R2 is independently H, hydroxy, alkoxy (1-6C) or lower alkyl (1-4C); R3 is H, hydroxy, or alkoxy (1-6C); or Y is of the formula wherein each n is 1, Z is N, K comprises a substituted or unsubstituted aromatic carbocyclic or heterocyclic ring system which may optionally be spaced from the linkage position shown in formula (7) by a linker of 1-2C, or in formula (7), Z may be spaced from the carbon bonded to X by ═CR6— wherein R6 is H or linear, branded or cyclic alkyl (1-6C), R5 is H or linear, branched or cyclic alkyl, and R′ represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C, promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. Also disclosed is a method to identify additional compounds which are inhibitors of enzymes in the isoprenoid scheme especially of HMG-CoA reductase which results in prenylation of proteins and in the synthesis of steroids or of inhibitors of their production which are useful in treating bone disorders.
摘要翻译：式（1）和（2）中的X表示取代或未取代的2-6C的亚烷基，亚烯基或亚炔基接头; Y是下式或其立体异构体，其中R 1是取代或未取代的烷基; 每个R 2独立地是H，羟基，烷氧基（1-6C）或低级烷基（1-4C）; R 3是H，羟基或烷氧基（1-6C）; 或Y具有下式：其中每个n是1，Z是N，K包括取代或未取代的芳族碳环或杂环系统，其可以任选地与式（7）所示的连接位置间隔1-2- ，或式（7）中，Z可以与通过-CR 6键合到X的碳隔开，其中R 6是H或直链的，有品牌的或环状的烷基（ 1-6C）中，R 5是H或直链，支链或环状的烷基，R'表示阳离子，H或1-6C的取代或未取代的烷基，促进骨形成，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺损，转移性骨病，溶骨性骨病，整形外手术，假体后关节手术和牙后植入术。还公开了一种鉴定另外的化合物的方法，该化合物是类异戊二烯方案中尤其是HMG-CoA还原酶中的酶的抑制剂，其导致蛋白质的异戊烯化，以及合成类固醇或其生产抑制剂，其可用于治疗骨骼疾病。

8. 发明授权

US6022887A Compositions and methods for stimulating bone growth 失效
标题翻译：用于刺激骨骼生长的组合物和方法
公开(公告)号：US6022887A
公开(公告)日：2000-02-08
申请号：US989862
申请日：1997-12-12
申请人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo
发明人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo
IPC分类号： A61K31/216 , A61K31/22 , A61K31/366 , A61K31/381 , A61K31/404 , A61K31/405 , A61P19/08 , A61P19/10 , A01N43/16 , C07D309/00
CPC分类号： A61K31/405 , A61K31/22 , A61K31/366 , A61K31/404
摘要： Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C;Y represents one or more carbocyclic or heterocyclic rings; when two or more rings are present in Y, they may optionally be fused; andR' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C; andthe dotted lines represent optional .pi.-bonds,promote bone formation and are thus usefull in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation.
摘要翻译：式（1）和（2）中的X表示取代或未取代的2-6C的亚烷基，亚烯基或亚炔基接头; Y表示一个或多个碳环或杂环; 当Y中存在两个或更多个环时，它们可以任选地稠合; 和R'表示1-6个C的阳离子，H或取代或未取代的烷基; 并且虚线代表可选的pi-键，促进骨形成，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺陷，转移性骨病，溶骨性骨病，整形后手术假体关节手术和牙植入后。

9. 发明授权

US5618837A PDGF antagonists III 失效
标题翻译： PDGF拮抗剂III
公开(公告)号：US5618837A
公开(公告)日：1997-04-08
申请号：US483216
申请日：1995-06-07
申请人： Charles E. Hart , Oliver J. McConnell , Robert R. West , Theresa Martinez
发明人： Charles E. Hart , Oliver J. McConnell , Robert R. West , Theresa Martinez
IPC分类号： A61K31/075 , A61K31/122 , A61K31/19 , A61K31/365 , A61P9/00 , A61K31/335 , A61K31/12
CPC分类号： A61K31/19 , A61K31/365
摘要： Methods for inhibiting intimal hyperplasia in the vasculature of mammals, including primates, are disclosed. The methods comprise administering to the mammal an effective amount of Brefeldin A or a derivative of Brefeldin A. The methods are useful in reducing intimal hyperplasia due to, for example, vascular injuries resulting from angioplasty, endarterectomy, reduction atherectomy or anastomosis of a vascular graft. The non-peptide PDGF antagonists Brefeldin A and its derivatives may optionally be administered coordinately with heparin, whereby the coordinately administered of non-peptide PDGF antagonist and heparin are combinatorially effective in inhibiting intimal hyperplasia.
摘要翻译：公开了抑制哺乳动物（包括灵长类动物）脉管系统内膜增生的方法。所述方法包括向哺乳动物施用有效量的布雷菲德菌素A或布雷菲德菌素A的衍生物。该方法可用于减少由于血管成形术，内膜切除术，血管移植术中的粥样斑块切除术或吻合口引起的血管损伤引起的内膜增生。非肽PDGF拮抗剂Brefeldin A及其衍生物可以任选地与肝素配位施用，由此协调施用非肽PDGF拮抗剂和肝素在抑制内膜增生中是组合有效的。

10. 发明授权

US07101907B2 Topical administration of statins for treatment of bone disorders 有权
标题翻译：用于治疗骨骼疾病的他汀类药物的局部给药
公开(公告)号：US07101907B2
公开(公告)日：2006-09-05
申请号：US10652159
申请日：2003-08-29
申请人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
发明人： Shirley R. Gasper , Robert R. West , Theresa Martinez , Kirk G. Robbins , Patricia A. McKernan , Nand Baindur , Virender M. Labroo , Gregory R. Mundy
IPC分类号： A61K31/335
CPC分类号： C07D215/14 , A23L33/10 , A61K31/00 , A61K31/192 , A61K31/22 , A61K31/225 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/405 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： The topical administration of statins for the treatment of bone disorders is disclosed.
摘要翻译：公开了用于治疗骨骼疾病的他汀类药物的局部给药。

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