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1. 发明授权

US09133495B2 Hybrid suppressor tRNA for vertebrate cells 有权
标题翻译：用于脊椎动物细胞的杂交抑制子tRNA
公开(公告)号：US09133495B2
公开(公告)日：2015-09-15
申请号：US12440015
申请日：2007-09-07
申请人： Feng Tian , Thea Norman , Stephanie Chu
发明人： Feng Tian , Thea Norman , Stephanie Chu
IPC分类号： C12N15/85 , C12P21/02 , C12N9/00 , C12N15/11
CPC分类号： C12P21/02 , C12N9/93 , C12N15/11
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
摘要翻译：本发明提供用于生产翻译成分的组合物和方法，其扩展脊椎动物细胞中遗传编码氨基酸的数目。组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸的正交对。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。本发明提供具有翻译成分的脊椎动物细胞，例如正交氨基-tRNA合成酶（O-RS）和正交tRNA（O-tRNA）及其各自成分的对，其用于脊椎动物蛋白质生物合成机制以掺入非天然氨基在生长的多肽链中，在脊椎动物细胞中。

2. 发明授权

US08809511B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08809511B2
公开(公告)日：2014-08-19
申请号：US13006335
申请日：2011-01-13
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K17/08 , C07K14/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are compounds useful in the preparation non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are compound useful in the preparation of non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了可用于制备非天然氨基酸和多肽的化合物，其包括至少一种非天然氨基酸，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了可用于制备在翻译后进一步修饰的非天然氨基酸多肽的化合物，用于实现这些修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

3. 发明授权

US08557781B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 失效
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08557781B2
公开(公告)日：2013-10-15
申请号：US11925732
申请日：2007-10-26
申请人： Zhenwei Miao , Junjie Liu , Thea Norman
发明人： Zhenwei Miao , Junjie Liu , Thea Norman
IPC分类号： C07K7/00 , A61K38/04 , A61K38/18
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

4. 发明授权

US08420792B2 Suppressor tRNA transcription in vertebrate cells 有权
标题翻译：在脊椎动物细胞中抑制tRNA转录
公开(公告)号：US08420792B2
公开(公告)日：2013-04-16
申请号：US12440013
申请日：2007-09-07
申请人： Feng Tian , Thea Norman , Stephanie Chu
发明人： Feng Tian , Thea Norman , Stephanie Chu
IPC分类号： C07H21/04 , C12N15/85
CPC分类号： C12N15/85 , C12N9/93 , C12N15/11 , C12P21/02
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
摘要翻译：本发明提供用于生产翻译成分的组合物和方法，其扩展脊椎动物细胞中遗传编码氨基酸的数目。组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸的正交对。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

5. 发明授权

US08399614B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 失效
公开(公告)号：US08399614B2
公开(公告)日：2013-03-19
申请号：US11925735
申请日：2007-10-26
申请人： Zhenwei Miao , Junjie Liu , Thea Norman
发明人： Zhenwei Miao , Junjie Liu , Thea Norman
IPC分类号： C07K2/00 , C07K4/00 , C07C249/16
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

6. 发明授权

US08367612B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
公开(公告)号：US08367612B2
公开(公告)日：2013-02-05
申请号：US12613423
申请日：2009-11-05
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： A61K38/16 , A61K38/18 , A61K38/27
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides, are disclosed. The non-natural amino acids, by themselves or as a part of a polypeptide, can include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Methods for making, modifying, and purifying the non-natural amino acid polypeptides are also disclosed. Further, methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses, are disclosed.

7. 发明申请

US20130030160A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 有权
公开(公告)号：US20130030160A1
公开(公告)日：2013-01-31
申请号：US13528723
申请日：2012-06-20
申请人： Zhenwei MIAO , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei MIAO , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K1/107
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

8. 发明申请

US20120315686A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 有权
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的用途
公开(公告)号：US20120315686A1
公开(公告)日：2012-12-13
申请号：US13467870
申请日：2012-05-09
申请人： Zhenwei MIAO , Junjie Liu , Thea Norman
发明人： Zhenwei MIAO , Junjie Liu , Thea Norman
IPC分类号： C07K14/61 , C12N7/00 , C07K16/00 , C07K14/47 , C12N9/96
CPC分类号： C07K2/00 , C07C229/42 , C07K1/006
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但典型地具有至少一个芳族胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个烷基化胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

9. 发明授权

US08263740B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US08263740B2
公开(公告)日：2012-09-11
申请号：US12027130
申请日：2008-02-06
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C12P21/02 , C07K1/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides are disclosed. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typically have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. The non-natural amino acid polypeptides are further modified post-translationally. The non-natural amino acid polypeptides and modified non-natural amino acid polypeptides have many uses, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括多种可能的功能，但通常具有至少一个肟，羰基，二羰基和/或羟胺基团。非天然氨基酸多肽在翻译后进一步修饰。非天然氨基酸多肽和修饰的非天然氨基酸多肽具有许多用途，包括治疗，诊断和其他生物技术用途。

10. 发明授权

US08110553B2 Methods and compositions for the treatment of gastrointestinal disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合物
公开(公告)号：US08110553B2
公开(公告)日：2012-02-07
申请号：US12788979
申请日：2010-05-27
申请人： Mark G. Currie , Shalina Mahajan-Miklos , G. Todd Milne , Thea Norman
发明人： Mark G. Currie , Shalina Mahajan-Miklos , G. Todd Milne , Thea Norman
IPC分类号： A61K38/10
CPC分类号： C07K7/08 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其他病症和病症。

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