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1. 发明申请

US20160025717A1 HYPOSIALYLATION DISORDERS 审中-公开
标题翻译：高血压病
公开(公告)号：US20160025717A1
公开(公告)日：2016-01-28
申请号：US14775507
申请日：2014-03-13
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER , EMORY UNIVERSITY
发明人： Marjan Huizing , William A. Gahl , Nuria Carrillo-Carrasco , Miao He , Xueli Li , Rong Jiang
IPC分类号： G01N33/53 , A61K45/06
CPC分类号： G01N33/5308 , A61K45/06 , G01N33/6893 , G01N2800/04
摘要： Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in a subject. These methods include measuring an amount of monosialylated Thomsen-Friedenreich (ST) antigen and measuring an amount of non-sialylated Thomsen-Friedenreich antigen (T) in a biological sample, such as a serum or plasma sample from the subject, and determining the ratio of T to ST.
摘要翻译：公开了用于诊断腰酸症的方法。还公开了用于确定治疗剂用于治疗受试者中的唾液酸化障碍的有效性的方法。这些方法包括测量单唾液酸化Thomsen-Friedenreich（ST）抗原的量并测量生物样品中的非唾液酸化Thomsen-Friedenreich抗原（T）的量，例如来自受试者的血清或血浆样品，并确定比例的T到ST。

2. 发明申请

US20150209449A1 INTRALIPID AS A CONTRAST AGENT TO ENHANCE SUBSURFACE BLOOD FLOW IMAGING 审中-公开
标题翻译：作为对比剂的INTRALIPID，以增强表面血液流动成像
公开(公告)号：US20150209449A1
公开(公告)日：2015-07-30
申请号：US14414183
申请日：2013-07-12
申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER.
发明人： Yingtian Pan , Congwu Du , Hugang Ren , Nora Volkow
IPC分类号： A61K49/00 , A61B5/026
CPC分类号： A61B5/0261 , A61B5/004 , A61B5/0059 , A61B5/0275 , A61B5/0285 , A61K49/00 , A61K49/0004
摘要： The present invention provides a method of imaging blood vessels or blood flow in blood vessels in an animal comprising: (i) injecting a lipid solution into the bloodstream of the animal; (ii) imaging the blood vessels by an imaging method; and (iii) calculating the blood flow velocity in the blood vessels.
摘要翻译：本发明提供了一种对动物血管或血液流动进行成像的方法，包括：（i）将脂质溶液注射到动物的血液中; （ii）通过成像方法对血管成像; 和（iii）计算血管中的血流速度。

3. 发明公开

US20240009243A1 METHODS OF PREPARING T CELLS FOR T CELL THERAPY 审中-公开
公开(公告)号：US20240009243A1
公开(公告)日：2024-01-11
申请号：US18341692
申请日：2023-06-26
申请人： Kite Pharma, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Ser.
发明人： Arianne PEREZ , Marianna SABATINO , Steven A. ROSENBERG , Nicholas P. RESTIFO
IPC分类号： C12N5/0783
CPC分类号： C12N5/0636 , C12N2501/2307 , C12N2501/2315 , C12N2500/30
摘要： Provided herein are methods for delaying or inhibiting T cell maturation or differentiation in vitro for a T cell therapy, comprising contacting one or more T cells from a subject in need of a T cell therapy with an AKT inhibitor and at least one of exogenous Interleukin-7 (IL-7) and exogenous Interleukin-15 (IL-15), wherein the resulting T cells exhibit delayed maturation or differentiation. In some embodiments, the method further comprises administering the one or more T cells to a subject in need of a T cell therapy.

4. 发明申请

US20160333060A1 ANTI-VIRAL CNIDARINS 审中-公开
标题翻译：反传染媒介
公开(公告)号：US20160333060A1
公开(公告)日：2016-11-17
申请号：US15110156
申请日：2015-01-09
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER . . .
发明人： Barry R. O'Keefe , James B. McMahon , Koreen Ramessar , Chang-yun Xiong
IPC分类号： C07K14/435 , C07K16/18 , A61K38/17
CPC分类号： C07K14/43595 , A61K38/00 , A61K38/1767 , A61K48/00 , C07K14/435 , C07K16/18
摘要： An isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 1, 2, or 3, wherein the at least eight contiguous amino acids have anti-viral activity, as well as an isolated and purified nucleic acid molecule that encodes a polypeptide comprising at least eight contiguous amino acids of SEQ ID NO: 1, 2, or 3, wherein the at least eight contiguous amino acids have anti-viral activity, a vector comprising such an isolated and purified nucleic acid molecule, a host cell comprising the nucleic acid molecule, optionally in the form of a vector, a method of producing an antiviral polypeptide or conjugate thereof, the anti-viral polypeptide itself, a conjugate or fusion protein comprising the anti-viral polypeptide, and compositions comprising an effective amount of the anti-viral polypeptide or conjugate or fusion protein thereof. Further provided are methods of inhibiting prophylactically or therapeutically a viral infection of a host.
摘要翻译：分离和纯化的核酸分子，其编码包含SEQ ID NO：1,2或3的至少8个连续氨基酸的多肽，其中所述至少8个连续氨基酸具有抗病毒活性，以及分离和纯化的核酸分子，其编码包含SEQ ID NO：1,2或3的至少8个连续氨基酸的多肽，其中所述至少8个连续氨基酸具有抗病毒活性，包含这种分离和纯化的核酸的载体酸分子，包含核酸分子的宿主细胞，任选以载体的形式，产生抗病毒多肽或其缀合物的方法，抗病毒多肽本身，包含抗病毒多肽的缀合物或融合蛋白，以及包含有效量的抗病毒多肽或其结合物或其融合蛋白的组合物。还提供了预防性或治疗性地抑制宿主的病毒感染的方法。

5. 发明申请

US20160145590A1 CYTOLETHAL DISTENDING TOXIN SUBUNIT B CONJUGATED OR FUSED TO BACILLUS ANTHRACIS TOXIN LETHAL FACTOR 有权
标题翻译：联合使用毒素亚硝酸盐B混合或加入到BACILLUS ANTHRACIS TOXIN LETHAL FACTOR
公开(公告)号：US20160145590A1
公开(公告)日：2016-05-26
申请号：US14898248
申请日：2014-06-19
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER
发明人： Christopher H. Bachran , Stephen H. Leppla
IPC分类号： C12N9/22 , A61K38/48 , A61K38/16 , A61K38/46 , C12N9/54 , C07K14/32
CPC分类号： C12N9/22 , A61K38/164 , A61K38/465 , A61K38/4886 , A61K47/6415 , C07K14/285 , C07K14/32 , C07K2319/55 , C12N9/54 , C12Y301/00 , C12Y301/21001 , C12Y304/24083
摘要： Disclosed is a protein comprising a cytolethal distending toxin subunit B (CdtB) conjugated or fused to a Bacillus anthracis toxin lethal factor (LF) or a functional portion of LF. Related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of treating or preventing cancer, and methods of inhibiting the growth of a target cell are also disclosed.
摘要翻译：公开了包含与炭疽杆菌毒素致死因子（LF）或LF功能部分共轭或融合的细胞致死性扩张毒素亚基B（CdtB）的蛋白质。还公开了相关嵌合分子以及相关核酸，重组表达载体，宿主细胞，细胞群，药物组合物，治疗或预防癌症的方法，以及抑制靶细胞生长的方法。

6. 发明申请

US20160024600A1 COINCIDENCE REPORTER GENE SYSTEM 审中-公开
标题翻译： COINCIDENCE报告基因系统
公开(公告)号：US20160024600A1
公开(公告)日：2016-01-28
申请号：US14775293
申请日：2013-03-15
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SER
发明人： James Inglese , Ken Chih-Chien Cheng , Samuel Hasson
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6897
摘要： Disclosed is a nucleic acid comprising a nucleotide sequence encoding (i) two or more reporters comprising a first reporter and a second reporter that is different from the first reporter; and (ii) one or more ribosomal skip sequences, wherein a ribosomal skip sequence is positioned between the first and second reporters, wherein the first and second reporters are stoichiometrically co-expressed from the nucleotide sequence and the nucleic acid does not comprise a cytomegalovirus-immediate early (CMV-IE) promoter. Also disclosed are methods of screening test compounds for ability to modulate a biological activity of interest using the nucleic acid, as well as related recombinant expression vectors, host cells, and populations of cells.
摘要翻译：公开了包含编码（i）两个或多个记者的核苷酸序列的核酸，其包含不同于第一报道员的第一报告人和第二报告者; 其中核糖体跳跃序列位于第一和第二报告基因之间，其中第一和第二报告子与核苷酸序列化学计量地共表达，并且核酸不包含巨细胞病毒 - 即时早期（CMV-IE）启动子。还公开了使用核酸以及相关重组表达载体，宿主细胞和细胞群体筛选测试化合物以调节感兴趣的生物活性的能力的方法。

7. 发明申请

US20150038463A1 COMPOSITIONS AND METHODS TO TREAT CARDIAC DISEASES 有权
标题翻译：组合物和治疗心脏病的方法
公开(公告)号：US20150038463A1
公开(公告)日：2015-02-05
申请号：US14338987
申请日：2014-07-23
申请人： University of Connecticut , The United States of America, as represented by the Secretary, Department of Health and Human Ser
发明人： Bruce Liang , Kenneth A. Jacobson
IPC分类号： C07F9/6561
CPC分类号： A61K31/675 , A61K31/683 , C07F9/65616
摘要： Phosphonate and phosphinate N-methanocarba derivatives of AMP including their prodrug analogs are described. MRS2339, a 2-chloro-AMP derivative containing a (N)-methanocarba(bicyclo[3.1.0]hexane) ring system in place of ribose, activates P2X receptors, ligand-gated ion channels. Phosphonate analogues of MRS2339 were synthesized using Michaelis-Arbuzov and Wittig reactions, based on the expectation of increased half-life in vivo due to the stability of the C—P bond. When administered to calsequestrin-overexpressing mice (a genetic model of heart failure) via a mini-osmotic pump (Alzet), some analogues significantly increased intact heart contractile function in vivo, as assessed by echocardiography-derived fractional shortening (FS) as compared to vehicle-infused mice. The range of carbocyclic nucleotide analogues for treatment of heart failure has been expanded.
摘要翻译：描述了膦酸盐和次膦酸盐，其包括其前体药物类似物的N-甲基碳酰胺衍生物。含有（N） - 甲烷卡巴（双环[3.1.0]己烷）环体系的代替核糖的2-氯-AMP衍生物MRS2339激活P2X受体，配体门控离子通道。基于由于C-P键的稳定性而增加的体内半衰期的期望，使用Michaelis-Arbuzov和Wittig反应合成MRS2339的膦酸酯类似物。当通过小型渗透泵（Alzet）将氯雷斯特林过度表达的小鼠（心力衰竭的遗传模型）施用时，一些类似物显着增加体内完整的心脏收缩功能，如通过超声心动图来源的分数缩短（FS）评估的，与车辆输注小鼠。用于治疗心力衰竭的碳环核苷酸类似物的范围已经扩大。

8. 发明申请

US20130330741A1 KITS FOR DETECTING AND MONITORING ENDOCRINE DISRUPTING CHEMICALS (EDCs) 有权
标题翻译：用于检测和监测内切蛋白质破坏化学品（EDCs）的试剂盒
公开(公告)号：US20130330741A1
公开(公告)日：2013-12-12
申请号：US13912071
申请日：2013-06-06
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Ser.
发明人： Gordon L. Hager , Diana A. Stavreva
IPC分类号： G01N21/64
CPC分类号： G01N33/5035 , C07K14/435 , C07K14/705 , C07K2319/60 , G01N21/6486 , G01N33/5014 , G01N33/68 , G01N33/743 , G01N2520/00
摘要： Described herein are compositions, a system, and kits for detection of endocrine disruptor chemicals (EDCs) in environmental samples, such as samples of water including but not limited to waste water treatment plant effluent, using a live-cell fluorescence-based nuclear translocation reporter system. Upon binding of a ligand to a fluorescent-labeled reporter protein, the protein (and therefore the fluorescence) is translocated in a ligand level-dependent manner from the cytoplasm to the nucleus of live mammalian cells; this translocation is detectable as diffuse (cytoplasmic) fluorescence converting to localized, brightly fluorescent nuclei. The described kits can be used to reliably detect very low levels of EDC contamination, including in high throughput analysis systems as described.
摘要翻译：本文描述的是用于检测环境样品中的内分泌干扰物质化学品（EDC）的组合物，系统和试剂盒，例如使用基于活细胞荧光的核移位报告基因的水包括但不限于废水处理植物废水系统。在将配体结合到荧光标记的报道蛋白上时，蛋白质（因此荧光）以配体水平依赖的方式从细胞质转移到活哺乳动物细胞的细胞核; 这种易位可检测为扩散（细胞质）荧光转化为局部的，明亮的荧光核。所描述的套件可用于可靠地检测非常低水平的EDC污染，包括在所述的高通量分析系统中。

9. 发明申请

US20190083647A1 VIRUS-LIKE PARTICLE CONJUGATES FOR DIAGNOSIS AND TREATMENT OF TUMORS 审中-公开
公开(公告)号：US20190083647A1
公开(公告)日：2019-03-21
申请号：US16143147
申请日：2018-09-26
申请人： Aura Biosciences, Inc. , The United States of America, as represented by the Secretary, Department of Health and Human Ser.
发明人： Elisabet de los Pinos , John Todd Schiller , Rhonda C. Kines , John MacDougall
IPC分类号： A61K47/69 , C07K16/32 , C07K16/08 , A61K39/12 , C12N7/00 , A61K41/00
摘要： The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.

10. 发明申请

US20190008899A1 TUMOR INFILTRATING LYMPHOCYTES AND METHODS OF THERAPY 审中-公开
公开(公告)号：US20190008899A1
公开(公告)日：2019-01-10
申请号：US15947688
申请日：2018-04-06
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , INTIMA BIOSCIENCE, INC. , The United States of America, as Represented by the Secretary, Department of Health and Human Ser
发明人： Branden MORIARITY , Beau WEBBER , Modassir CHOUDHRY , Steven A. ROSENBERG , Douglas C. PALMER , Nicholas P. RESTIFO
IPC分类号： A61K35/17 , A61K9/00 , A61P35/00 , C12N5/0783 , C07K14/725 , C07K14/715 , C12N15/90 , C12N9/22 , A61P31/00 , C12N15/79
摘要： Genetically modified compositions, such as non-viral vectors and tumor infiltrating lymphocytes, for the treatment of gastrointestinal cancer are disclosed. Disclosed are methods of utilizing a CRISPR system to generate genetically modified compositions. Also disclosed are the methods of making and using the genetically modified compositions for the treatment of gastrointestinal cancer.

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