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1. 发明授权

US09861690B2 Ehrlichia ewingii proteins, nucleic acids, and methods of their use 有权
公开(公告)号：US09861690B2
公开(公告)日：2018-01-09
申请号：US15174643
申请日：2016-06-06
申请人： The Ohio State University Research Foundation
发明人： Yasuko Rikihisa
IPC分类号： A61K39/02 , A61K38/04 , G01N33/53 , C07K14/29 , C07K7/08 , G01N33/569 , G01N33/68 , A61K38/00 , A61K39/00
CPC分类号： A61K39/0233 , A61K38/00 , A61K38/04 , A61K2039/552 , A61K2039/575 , A61K2039/6031 , C07K7/08 , C07K14/29 , G01N33/53 , G01N33/56911 , G01N33/6854 , G01N2333/29 , G01N2469/20 , Y02A50/402
摘要： The novel omp-1 gene cluster encoding twenty one Ehrlichia ewingii (EE) proteins was isolated and sequenced completely. This invention relates to isolated E. ewinigii (EE) polypeptides, isolated polynucleotides encoding EE polypeptides, probes, primers, isolated antibodies and methods of their production, immunogenic compositions and vaccines, as well as methods of using the EE polypeptides, antibodies, probes, and primers for the purpose of diagnosis, therapy and production of vaccines against E. ewingii.

2. 发明授权

US09695153B2 Oligooxopiperazines for p53 reactivation 有权
公开(公告)号：US09695153B2
公开(公告)日：2017-07-04
申请号：US14160037
申请日：2014-01-21
申请人： New York University , The Ohio State University Research Foundation , The Regents of the University of Michigan
发明人： Paramjit S. Arora , Quintin Pan , Anna Mapp
IPC分类号： C07D403/06 , A61K31/496 , A61K45/06
CPC分类号： C07D403/06 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix αB of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1α. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R1, R2, R3, R4, and B are as defined herein).

3. 发明授权

US09605026B2 Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation 有权
公开(公告)号：US09605026B2
公开(公告)日：2017-03-28
申请号：US14160001
申请日：2014-01-21
申请人： New York University , The Ohio State University Research Foundation , The Regents of the University of Michigan
发明人： Paramjit S. Arora , Quintin Pan , Anna Mapp
IPC分类号： A61K38/08 , C07K7/64 , C07K7/56 , A61K33/24 , A61K45/06 , A61K38/00
CPC分类号： C07K7/64 , A61K33/24 , A61K38/00 , A61K38/08 , A61K45/06 , C07K7/56 , A61K2300/00
摘要： The present invention relates to peptidomimetics for reactivating p53. Methods of using the peptidomimetics are also disclosed.

4. 发明授权

US09568457B2 Thermal simulator 有权
标题翻译：热模拟器
公开(公告)号：US09568457B2
公开(公告)日：2017-02-14
申请号：US13920165
申请日：2013-06-18
申请人： The Ohio State University Research Foundation
发明人： Ahmed Yousef , David Kasler , Mohammad Shavezipur
IPC分类号： G01K3/00 , A23L1/32 , G01N33/08 , G01K13/12
CPC分类号： G01N25/00 , A23L15/35 , A23V2002/00 , G01K7/02 , G01K13/12 , G01N33/08
摘要： A thermal simulator simulates the thermal behavior of items such as eggs for which the actual internal temperature profile is difficult to measure. A yolk body simulates the egg yolk, an albumen body surrounds the yolk body and simulates the egg albumen, and a shell layer surrounds the albumen body to simulate the shell. The thermal properties of the materials forming the egg body, albumen body and shell layer are tuned to match the thermal properties of the egg yolk, egg albumen and egg shell. Thermometric devices are positioned within the egg body and egg albumen along with communication devices which process signals from the thermometric devices indicative of temperature and communicate these signals to a computer for further processing and display.
摘要翻译：热模拟器模拟实际内部温度曲线难以测量的物品（如鸡蛋）的热行为。蛋黄身体模拟蛋黄，一个蛋白体围绕蛋黄体，模拟蛋清蛋白，壳层围绕蛋白体模拟壳。调整形成蛋体，蛋白体和壳层的材料的热性能，以匹配蛋黄，蛋清蛋白和蛋壳的热性质。温度测量装置位于蛋体和蛋清蛋白内以及通信装置，其处理来自表示温度的温度测量装置的信号，并将这些信号传送到计算机用于进一步的处理和显示。

5. 发明申请

US20160177316A1 Methods and Compositions for Increasing the Efficacy of Doxorubicin Treatment in the Treatmentof Prostate Related Disorders using miR-106b-25 Cluster 审中-公开
标题翻译：用于增加多柔比星治疗前列腺相关疾病使用miR-106b-25簇的功效的方法和组合
公开(公告)号：US20160177316A1
公开(公告)日：2016-06-23
申请号：US15062414
申请日：2016-03-07
申请人： The Ohio State University Research Foundation , The Government of the United States of America, as represented by the Secretary of the Department of
发明人： Carlo M. Croce , Stefan Ambs
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/1135 , C12N15/1137 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12N2320/31 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： Methods and compositions for the treatment of prostate associated disorders are disclosed.
摘要翻译：公开了用于治疗前列腺相关疾病的方法和组合物。

6. 发明申请

US20160177311A1 Methods and Compositions for the Treatment of Prostate Related Disorders using miR-106b 审中-公开
标题翻译：使用miR-106b治疗前列腺相关性疾病的方法和组合
公开(公告)号：US20160177311A1
公开(公告)日：2016-06-23
申请号：US15062407
申请日：2016-03-07
申请人： The Ohio State University Research Foundation , The Government of the United States of America, as represented by the Secretary of the Department of
发明人： Carlo M. Croce , Stefan Ambs
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/1135 , C12N15/1137 , C12N2310/113 , C12N2310/141 , C12N2320/30 , C12N2320/31 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： Methods and compositions for the treatment of prostate associated disorders are disclosed.
摘要翻译：公开了用于治疗前列腺相关疾病的方法和组合物。

7. 发明授权

US09297012B2 Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias 有权
公开(公告)号：US09297012B2
公开(公告)日：2016-03-29
申请号：US14829057
申请日：2015-08-18
申请人： The Ohio State University Research Foundation
发明人： Carlo M. Croce
IPC分类号： C12N15/11 , C12N15/113 , A61K31/713 , A61K31/7064
CPC分类号： C12N15/1137 , A61K31/7064 , A61K31/713 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2320/31 , C12Q1/6886 , G01N33/5041 , G01N33/57426 , G01N2800/52
摘要： Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.

8. 发明授权

US09174951B2 Glucose transporter inhibitors 有权
标题翻译：葡萄糖转运蛋白抑制剂
公开(公告)号：US09174951B2
公开(公告)日：2015-11-03
申请号：US14386127
申请日：2013-03-28
申请人： The Ohio State University Research Foundation
发明人： Ching-Shih Chen , Dasheng Wang , Samuel K. Kulp
IPC分类号： C07D277/34
CPC分类号： C07D277/34
摘要： Thiazolidinedione compounds and pharmaceutically acceptable salts thereof are described. The compounds can be used in methods of treating cancer in a subject by administering to the subject a therapeutically effective amount of the compound. The compounds can also be used in methods of inhibiting glucose uptake in a cell by contacting the cell with the compound.
摘要翻译：描述了噻唑烷二酮化合物及其药学上可接受的盐。该化合物可用于通过向受试者施用治疗有效量的化合物来治疗受试者的癌症的方法。化合物也可以用于通过使细胞与化合物接触来抑制细胞中葡萄糖摄取的方法。

9. 发明授权

US09139830B2 Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias 有权
标题翻译：用于诱导人急性白血病中EPHA7和ERK磷酸化失调的方法和组合物
公开(公告)号：US09139830B2
公开(公告)日：2015-09-22
申请号：US13916699
申请日：2013-06-13
申请人： The Ohio State University Research Foundation
发明人： Carlo M. Croce
IPC分类号： C12N15/11 , C12N15/113 , G01N33/574 , C12Q1/68 , G01N33/50
CPC分类号： C12N15/1137 , A61K31/7064 , A61K31/713 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2320/31 , C12Q1/6886 , G01N33/5041 , G01N33/57426 , G01N2800/52
摘要： Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.
摘要翻译：用于评估受试者病理状况的方法包括测量一个或多个标记，其中差异指示急性淋巴细胞白血病（ALL）或倾向于ALL，使用和组合物被公开。

10. 发明申请

US20150051255A1 GLUCOSE TRANSPORTER INHIBITORS 有权
标题翻译：葡萄糖输送机抑制剂
公开(公告)号：US20150051255A1
公开(公告)日：2015-02-19
申请号：US14386127
申请日：2013-03-28
申请人： The Ohio State University Research Foundation
发明人： Ching-Shih Chen , Dasheng Wang , Samuel K. Kulp
IPC分类号： C07D277/34
CPC分类号： C07D277/34
摘要： Thiazolidinedione compounds and pharmaceutically acceptable salts thereof are described. The compounds can be used in methods of treating cancer in a subject by administering to the subject a therapeutically effective amount of the compound. The compounds can also be used in methods of inhibiting glucose uptake in a cell by contacting the cell with the compound.
摘要翻译：描述了噻唑烷二酮化合物及其药学上可接受的盐。该化合物可用于通过向受试者施用治疗有效量的化合物来治疗受试者的癌症的方法。化合物也可以用于通过使细胞与化合物接触来抑制细胞中葡萄糖摄取的方法。

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