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1. 发明申请

US20090274668A1 Combined Regulation of Neural Cell Production 审中-公开
标题翻译：神经细胞生产的综合调控
公开(公告)号：US20090274668A1
公开(公告)日：2009-11-05
申请号：US12504336
申请日：2009-07-16
申请人： Bradley G. Thompson , Samuel Weiss , Tetsuro Shingo
发明人： Bradley G. Thompson , Samuel Weiss , Tetsuro Shingo
IPC分类号： A61K35/12 , C12N5/00 , A61P25/00
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating neurodegenerative disease or medical conditions by producing neural cells. Thus, a combination of factors is used to achieve two steps: increasing the number of neural stem cells and instructing the neural stem cells to selectively become neurons or glial cells.
摘要翻译：本发明涉及在体外或体内选择性地产生包括神经元或神经胶质细胞的神经细胞的方法。还提供了通过产生神经细胞治疗或改善神经变性疾病或医学病症的方法。因此，使用因素的组合来实现两个步骤：增加神经干细胞的数量并指示神经干细胞选择性地成为神经元或神经胶质细胞。

2. 发明申请

US20080181873A1 PROLACTIN INDUCED INCREASE IN NEURAL STEM CELL NUMBERS 失效
标题翻译： PROLACTIN诱导增加神经干细胞数
公开(公告)号：US20080181873A1
公开(公告)日：2008-07-31
申请号：US12051240
申请日：2008-03-19
申请人： Tetsuro Shingo , Samuel Weiss
发明人： Tetsuro Shingo , Samuel Weiss
IPC分类号： A61K35/12 , C12N5/06 , A61P25/00 , A61K38/00
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions. In addition, since neural stem cells are a source for olfactory neurons, the present invention also provides methods of increasing olfactory neurons and enhancing olfactory functions.
摘要翻译：本发明提供了通过使用催乳素来增加神经干细胞数量或神经发生的方法。该方法可以在体内实施以获得更多的原位神经干细胞，其又可产生更多的神经元或神经胶质细胞以补偿丢失或功能失调的神经细胞。该方法也可以在体外实施以在培养物中产生大量的神经干细胞。培养的干细胞可用于例如患有神经变性疾病或病症的患者或动物的移植治疗。此外，由于神经干细胞是嗅觉神经元的来源，本发明还提供增加嗅觉神经元和增强嗅觉功能的方法。

3. 发明授权

US07048934B2 Combined regulation of neural cell production 失效
公开(公告)号：US07048934B2
公开(公告)日：2006-05-23
申请号：US10231493
申请日：2002-08-30
申请人： Bradley G. Thompson , Samuel Weiss , Tetsuro Shingo
发明人： Bradley G. Thompson , Samuel Weiss , Tetsuro Shingo
IPC分类号： A61K38/00 , A61K38/16 , A61K38/18
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating neurodegenerative disease or medical conditions by producing neural cells. Thus, a combination of factors is used to achieve two steps: increasing the number of neural stem cells and instructing the neural stem cells to selectively become neurons or glial cells.

4. 发明申请

US20050148071A1 Production of tyrosine hydroxylase positive neurons 审中-公开
公开(公告)号：US20050148071A1
公开(公告)日：2005-07-07
申请号：US10985849
申请日：2004-11-10
申请人： Samuel Weiss , Tetsuro Shingo
发明人： Samuel Weiss , Tetsuro Shingo
IPC分类号： A61K38/18 , C12N5/0793 , A61K31/22 , A61K31/522 , C12N5/08
CPC分类号： C12N5/0619 , A61K38/1825 , C12N2501/01 , C12N2501/113 , C12N2501/35 , C12N2501/70 , C12N2501/815 , A61K2300/00
摘要： The present invention relates to a method of producing neurons that express the enzyme tyrosine hydroxylase (TH) by subjecting neural stem cells to FGF-1, a protein kinase A activator, a protein kinase C activator, and dopamine/L-DOPA. Surprisingly, when forskolin is used as a protein kinase A activator, it requires only low levels of FGF-1 and forskolin to efficiently produce TH positive neurons from fetal or adult neural stem cells. Also provided are compositions used to produce TH positive neurons and the resulting neural cell culture, as well as a method of treating disease or conditions which are associated with dopamine neuron loss or dysfunction.

5. 发明授权

US06844312B2 Production of tyrosine hydroxylase positive neurons 失效
标题翻译：生产酪氨酸羟化酶阳性神经元
公开(公告)号：US06844312B2
公开(公告)日：2005-01-18
申请号：US10118167
申请日：2002-04-09
申请人： Samuel Weiss , Tetsuro Shingo
发明人： Samuel Weiss , Tetsuro Shingo
IPC分类号： A61K38/18 , C12N5/0793 , A61K31/00 , A61K38/00
CPC分类号： C12N5/0619 , A61K38/1825 , C12N2501/01 , C12N2501/113 , C12N2501/35 , C12N2501/70 , C12N2501/815 , A61K2300/00
摘要： The present invention relates to a method of producing neurons that express the enzyme tyrosine hydroxylase (TH) by subjecting neural stem cells to FGF-1, a protein kinase A activator, a protein kinase C activator, and dopamine/L-DOPA. Surprisingly, when forskolin is used as a protein kinase A activator, it requires only low levels of FGF-1 and forskolin to efficiently produce TH positive neurons from fetal or adult neural stem cells. Also provided are compositions used to produce TH positive neurons and the resulting neural cell culture, as well as a method of treating disease or conditions which are associated with dopamine neuron loss or dysfunction.
摘要翻译：本发明涉及通过使神经干细胞经受FGF-1，蛋白激酶A激活剂，蛋白激酶C激活剂和多巴胺/ L-DOPA来产生表达酪氨酸羟化酶（TH）的神经元的方法。令人惊讶的是，当毛喉素用作蛋白激酶A激活剂时，仅需要低水平的FGF-1和毛喉素从胎儿或成体神经干细胞有效地产生TH阳性神经元。还提供了用于产生TH阳性神经元和所得神经细胞培养物的组合物，以及治疗与多巴胺神经元丧失或功能障碍相关的疾病或病症的方法。

6. 发明授权

US07884072B2 Prolactin induced increase in neural stem cell numbers 失效
标题翻译：催乳素诱导神经干细胞数增加
公开(公告)号：US07884072B2
公开(公告)日：2011-02-08
申请号：US12051240
申请日：2008-03-19
申请人： Tetsuro Shingo , Samuel Weiss
发明人： Tetsuro Shingo , Samuel Weiss
IPC分类号： A61K36/15 , A61K36/18 , C12N5/074 , C12N5/0797
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions. In addition, since neural stem cells are a source for olfactory neurons, the present invention also provides methods of increasing olfactory neurons and enhancing olfactory functions.
摘要翻译：本发明提供了通过使用催乳素来增加神经干细胞数量或神经发生的方法。该方法可以在体内实施以获得更多的原位神经干细胞，其又可产生更多的神经元或神经胶质细胞以补偿丢失或功能失调的神经细胞。该方法也可以在体外实施以在培养物中产生大量的神经干细胞。培养的干细胞可用于例如患有神经变性疾病或病症的患者或动物的移植治疗。此外，由于神经干细胞是嗅觉神经元的来源，本发明还提供增加嗅觉神经元和增强嗅觉功能的方法。

7. 发明授权

US07604993B2 Combined regulation of neural cell production 失效
标题翻译：神经细胞生产的组合调节
公开(公告)号：US07604993B2
公开(公告)日：2009-10-20
申请号：US11343419
申请日：2006-01-30
申请人： Bradley G. Thompson , Samuel Weiss , Tetsuro Shingo
发明人： Bradley G. Thompson , Samuel Weiss , Tetsuro Shingo
IPC分类号： A61K38/00 , A61K38/16 , A61K38/18
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： This invention relates to a method of selectively producing neural cells, including neurons or glial cells, in vitro or in vivo. Also provided are methods of treating or ameliorating neurodegenerative disease or medical conditions by producing neural cells. Thus, a combination of factors is used to achieve two steps: increasing the number of neural stem cells and instructing the neural stem cells to selectively become neurons or glial cells.
摘要翻译：本发明涉及在体外或体内选择性地产生包括神经元或神经胶质细胞的神经细胞的方法。还提供了通过产生神经细胞治疗或改善神经变性疾病或医学病症的方法。因此，使用因素的组合来实现两个步骤：增加神经干细胞的数量并指示神经干细胞选择性地成为神经元或神经胶质细胞。

8. 发明申请

US20060148084A1 Effect of growth hormone and IGF-1 on neural stem cells 审中-公开
公开(公告)号：US20060148084A1
公开(公告)日：2006-07-06
申请号：US11366161
申请日：2006-03-01
申请人： Tetsuro Shingo , Samuel Weiss
发明人： Tetsuro Shingo , Samuel Weiss
IPC分类号： C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/1816 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： The present invention provides a method of increasing neural stem cell numbers by using growth hormone and/or IGF-1. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions.

9. 发明申请

US20120329714A1 Prolactin Induced Increase in Neural Stem Cell Numbers 审中-公开
标题翻译：催乳素诱导神经干细胞数增加
公开(公告)号：US20120329714A1
公开(公告)日：2012-12-27
申请号：US13535567
申请日：2012-06-28
申请人： Tetsuro Shingo , Samuel Weiss
发明人： Tetsuro Shingo , Samuel Weiss
IPC分类号： A61K38/27 , A61P25/16 , A61P25/14 , A61P25/28 , A61P25/00
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions. In addition, since neural stem cells are a source for olfactory neurons, the present invention also provides methods of increasing olfactory neurons and enhancing olfactory functions.
摘要翻译：本发明提供了通过使用催乳素来增加神经干细胞数量或神经发生的方法。该方法可以在体内实施以获得更多的原位神经干细胞，其又可产生更多的神经元或神经胶质细胞以补偿丢失或功能失调的神经细胞。该方法也可以在体外实施以在培养物中产生大量的神经干细胞。培养的干细胞可用于例如患有神经变性疾病或病症的患者或动物的移植治疗。此外，由于神经干细胞是嗅觉神经元的来源，本发明还提供增加嗅觉神经元和增强嗅觉功能的方法。

10. 发明授权

US08222212B2 Prolactin induced increase in neural stem cell numbers 失效
标题翻译：催乳素诱导神经干细胞数增加
公开(公告)号：US08222212B2
公开(公告)日：2012-07-17
申请号：US12981101
申请日：2010-12-29
申请人： Tetsuro Shingo , Samuel Weiss
发明人： Tetsuro Shingo , Samuel Weiss
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： C12N5/0623 , A61K35/12 , A61K38/2257 , A61K38/27 , A61K38/30 , A61K2300/00
摘要： The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions. In addition, since neural stem cells are a source for olfactory neurons, the present invention also provides methods of increasing olfactory neurons and enhancing olfactory functions.
摘要翻译：本发明提供了通过使用催乳素来增加神经干细胞数量或神经发生的方法。该方法可以在体内实施以获得更多的原位神经干细胞，其又可产生更多的神经元或神经胶质细胞以补偿丢失或功能失调的神经细胞。该方法也可以在体外实施以在培养物中产生大量的神经干细胞。培养的干细胞可用于例如患有神经变性疾病或病症的患者或动物的移植治疗。此外，由于神经干细胞是嗅觉神经元的来源，本发明还提供增加嗅觉神经元和增强嗅觉功能的方法。

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