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1. 发明申请

US20070111286A1 Novel RAT calcium channel subunits and related probes, cell lines and methods 失效
标题翻译：新型RAT钙通道亚基和相关探针，细胞系和方法
公开(公告)号：US20070111286A1
公开(公告)日：2007-05-17
申请号：US11650813
申请日：2007-01-08
申请人： David Parker , Xianghong Xu , Afsheen Khawaja , Terrance Snutch
发明人： David Parker , Xianghong Xu , Afsheen Khawaja , Terrance Snutch
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： G01N33/502 , C07K14/705 , G01N33/5008 , G01N33/5023 , G01N33/6872 , G01N2500/10
摘要： Novel sequences for calcium channel α2δ-2 and α2δ-3 subunits are provided. Also provided are cell lines that express the novel calcium channel subunits of the invention. These cells may be used for identifying compounds capable of stimulating or inhibiting the activation of the calcium channels.
摘要翻译：提供了钙通道α2Δ-2和α2-Δ3亚基的新序列。还提供了表达本发明的新型钙通道亚基的细胞系。这些细胞可用于鉴定能够刺激或抑制钙通道活化的化合物。

2. 发明申请

US20060063775A1 Urea derivatives as calcium channel blockers 失效
标题翻译：尿素衍生物作为钙通道阻滞剂
公开(公告)号：US20060063775A1
公开(公告)日：2006-03-23
申请号：US11215064
申请日：2005-08-30
申请人： Hassan Pajouhesh , Hossein Pajouhesh , Yanbing Ding , Terrance Snutch
发明人： Hassan Pajouhesh , Hossein Pajouhesh , Yanbing Ding , Terrance Snutch
IPC分类号： A61K31/496 , A61K31/495 , C07D403/02
CPC分类号： C07D295/215 , C07D211/26 , C07D211/58 , C07D213/38 , C07D241/04 , C07D295/20 , C07D401/06 , C07D403/06 , C07D405/06
摘要： Urea derivatives which comprise piperidine or piperazine rings and further substitution are effective in ameliorating conditions characterized by unwanted calcium ion channel activity.
摘要翻译：包含哌啶或哌嗪环和进一步取代的尿素衍生物有助于改善以不需要的钙离子通道活性为特征的病症。

3. 发明申请

US20050227999A1 Diarylamine derivatives as calcium channel blockers 审中-公开
标题翻译：二芳基胺衍生物作为钙通道阻断剂
公开(公告)号：US20050227999A1
公开(公告)日：2005-10-13
申请号：US10928564
申请日：2004-08-27
申请人： Hassan Pajouhesh , Hossein Pajouhesh , Yanbing Ding , Terrance Snutch
发明人： Hassan Pajouhesh , Hossein Pajouhesh , Yanbing Ding , Terrance Snutch
IPC分类号： A61K31/495 , C07D241/04 , C07D43/02
CPC分类号： C07D241/04
摘要： Compounds which are derivatives of diarylamine substituted piperazine and amino-piperidine are useful in treating conditions mediated by calcium ion channel activity.
摘要翻译：作为二芳基胺取代的哌嗪和氨基哌啶的衍生物的化合物可用于治疗钙离子通道活性介导的病症。

4. 发明申请

US20050165065A1 N-type calcium channel blockers 失效
标题翻译： N型钙通道阻滞剂
公开(公告)号：US20050165065A1
公开(公告)日：2005-07-28
申请号：US10763974
申请日：2004-01-22
申请人： Hassan Pajouhesh , Hossein Pajouhesh , Yanbing Ding , Terrance Snutch
发明人： Hassan Pajouhesh , Hossein Pajouhesh , Yanbing Ding , Terrance Snutch
IPC分类号： A61K31/40 , A61K31/4439 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/30 , C07D401/06 , C07D43/02
CPC分类号： C07D207/273 , C07D207/14 , C07D207/16
摘要： The invention relates to novel 3-amino pyrrolidine derivatives, as well as methods for modulating calcium channel activity and for treating conditions associated with calcium channel function. In particular, the compounds generally contain at least one benzhydril moiety, and are useful in treating conditions which benefit from blocking calcium ion channels.
摘要翻译：本发明涉及新的3-氨基吡咯烷衍生物，以及调节钙通道活性和治疗与钙通道功能相关的病症的方法。特别地，化合物通常含有至少一个二苯甲基部分，并且可用于治疗受益于阻断钙离子通道的病症。

5. 发明申请

US20050095678A1 Novel rat calcium channel subunits and related probes, cell lines and methods 失效
标题翻译：新型大鼠钙通道亚基及相关探针，细胞系及方法
公开(公告)号：US20050095678A1
公开(公告)日：2005-05-05
申请号：US10924081
申请日：2004-08-23
申请人： David Parker , Xianghong Xu , Afsheen Khawaja , Terrance Snutch
发明人： David Parker , Xianghong Xu , Afsheen Khawaja , Terrance Snutch
IPC分类号： C07K14/705 , C12N15/12 , G01N33/50 , G01N33/68 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/502 , C07K14/705 , G01N33/5008 , G01N33/5023 , G01N33/6872 , G01N2500/10
摘要： Novel sequences for calcium channel α2δ-2 and α2δ-3 subunits are provided. Also provided are cell lines that express the novel calcium channel subunits of the invention. These cells may be used for identifying compounds capable of stimulating or inhibiting the activation of the calcium channels.
摘要翻译：提供了钙通道α2Δ-2和α2-Δ3亚基的新序列。还提供了表达本发明的新型钙通道亚基的细胞系。这些细胞可用于鉴定能够刺激或抑制钙通道活化的化合物。

6. 发明申请

US20070185105A1 Calcium channel blockers 失效
标题翻译：钙通道阻滞剂
公开(公告)号：US20070185105A1
公开(公告)日：2007-08-09
申请号：US11601005
申请日：2006-11-16
申请人： Terrance Snutch , Gerald Zamponi
发明人： Terrance Snutch , Gerald Zamponi
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/445
CPC分类号： C07D295/185 , A61K31/4468 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5415 , C07D211/14 , C07D211/16 , C07D211/46 , C07D211/58 , C07D213/38 , C07D277/74 , C07D277/82 , C07D295/03 , C07D317/60 , C07D401/04 , C07D401/14
摘要： Compounds of the formula wherein m is 0, 1 or 2; wherein when m is 0, Z is O, when m is 1, Z is N, and when m is 2, Z is C; Y is H, OH, NH2, or an organic moiety of 1-20 C, optionally additionally containing 1-8 heteroatoms selected from the group consisting of N, P, O, S and halo; each 11 1 and 12 is independently 0-5; 13 is O or 1; each of R1, R2 and R3 is independently alkyl (1-6 C), aryl (6-10 C) or arylalkyl (7-16 C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or each of R1 and R2 may independently be halo, COOR, CONR2, CF3, CN or NO2, wherein R is H or lower alkyl (1-4 C) or alkyl (1-6 C); n is 0 or 1; X is a linker; with the proviso that Y is not a tropolone, a coumarin, or an antioxidant containing an aromatic group and with the further proviso that if 13 is 0, and either 11 and 12 is 0 or 1 and if R1 and/or R2 represent F in the para position, Z cannot be C or N; and are useful to treat pain. Libraries of these compounds can also be used to identify antagonists for other targets.
摘要翻译：下式的化合物其中m为0,1或2; 其中当m为0时，Z为O，当m为1时，Z为N，当m为2时，Z为C; Y是H，OH，NH 2或1-20C的有机部分，任选地另外含有1-8个选自N，P，O，S和卤素的杂原子; 每个1＆lt; 1＆gt; 1和1＆lt; 2＆gt;独立地为0-5; 1 3是O或1; R 1，R 2和R 3各自独立地为烷基（1-6C），芳基（6-10C）或芳基烷基（7-16C）任选地含有1-4个选自卤素，N，P，O和S的杂原子或者R 1和R 2各自的1-4个杂原子，可以独立地为卤素，COOR，CONR 2，CF 3，CN或NO 2，其中R为H或低级烷基（1-4 C）或（1-6C）烷基; n为0或1; X是一个连接子; 条件是Y不是托普洛尔，香豆素或含有芳族基团的抗氧化剂，进一步的条件是，如果1 <3>和0 <1> 和1 是0或1，如果R 1和/或R 2在对位表示F，则Z不能为C或N ; 并且可用于治疗疼痛。这些化合物的文库也可用于鉴定其他靶标的拮抗剂。

7. 发明申请

US20050089961A1 Class of alpha2delta calcium channel subunits 失效
标题翻译： α2delta钙通道亚基类
公开(公告)号：US20050089961A1
公开(公告)日：2005-04-28
申请号：US10918602
申请日：2004-08-12
申请人： David Parker , Xianghong Xu , Afsheen Khawaja , Janette Mezeyova , Terrance Snutch
发明人： David Parker , Xianghong Xu , Afsheen Khawaja , Janette Mezeyova , Terrance Snutch
IPC分类号： C07H21/04 , C07K14/465 , C07K14/705 , C12N15/12
CPC分类号： C07K14/465
摘要： A new class of α2δ subunits which function in calcium ion channels is described. This class is avian derived.
摘要翻译：描述了在钙离子通道中起作用的新类型的α2 N 3亚基。这个类是禽类衍生的。

8. 发明申请

US20070207523A1 Mammalian t-type calcium channels 失效
标题翻译：哺乳动物t型钙通道
公开(公告)号：US20070207523A1
公开(公告)日：2007-09-06
申请号：US11649451
申请日：2007-01-03
申请人： Terrance Snutch , David Baillie
发明人： Terrance Snutch , David Baillie
IPC分类号： C12P21/00 , C07H21/02 , C07H21/04 , C12N15/63 , C12N5/06 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00
摘要： Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the α1G, α1H and α1I subunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human cells, and the development of cell lines which express the novel calcium channels of the invention. These cells may be used for identifying compounds capable of acting as agonists or antagonists to the calcium channels.
摘要翻译：三种类型的哺乳动物（确定的人和大鼠序列）的序列和部分序列我们已经标记为α1G1，α1H和α1的T型钙通道亚基，提供SUB> 1I 亚基。了解这些钙通道的顺序允许来自人细胞的完整序列的定位和回收，以及表达本发明的新型钙通道的细胞系的发展。这些细胞可用于鉴定能够作为钙通道的激动剂或拮抗剂的化合物。

9. 发明申请

US20070178553A1 Mammalian T-type calcium channels 失效
标题翻译：哺乳动物T型钙通道
公开(公告)号：US20070178553A1
公开(公告)日：2007-08-02
申请号：US11649452
申请日：2007-01-03
申请人： Terrance Snutch , David Baillie
发明人： Terrance Snutch , David Baillie
IPC分类号： C12P21/06 , C07H21/04 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the α1G, α1H and α1I subunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human cells, and the development of cell lines which express the novel calcium channels of the invention. These cells may be used for identifying compounds capable of acting as agonists or antagonists to the calcium channels.
摘要翻译：三种类型的哺乳动物（确定的人和大鼠序列）的序列和部分序列我们已经标记为α1G1，α1H和α1的T型钙通道亚基，提供SUB> 1I 亚基。了解这些钙通道的顺序允许来自人细胞的完整序列的定位和回收，以及表达本发明的新型钙通道的细胞系的发展。这些细胞可用于鉴定能够作为钙通道激动剂或拮抗剂的化合物。

10. 发明申请

US20050014748A1 N-type calcium channel blockers 失效
标题翻译： N型钙通道阻滞剂
公开(公告)号：US20050014748A1
公开(公告)日：2005-01-20
申请号：US10856921
申请日：2004-05-28
申请人： Hassan Pajouhesh , Terrance Snutch , Hossein Pajouhesh , Yanbing Ding
发明人： Hassan Pajouhesh , Terrance Snutch , Hossein Pajouhesh , Yanbing Ding
IPC分类号： A61K31/4025 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P9/00 , A61P25/00 , C07D207/09 , C07D413/02 , C07D417/02 , C07
CPC分类号： C07D207/09
摘要： Compounds that are derivatives of 3-aminomethyl-pyrrolidine generally containing at least one benzhydril moiety are useful in treating conditions which benefit from blocking calcium ion channels.
摘要翻译：通常含有至少一个二苯甲基部分的3-氨基甲基吡咯烷的衍生物的化合物可用于治疗受阻于钙离子通道的病症。

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