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1. 发明申请

US20060013885A1 Water soluble chitosan nanoparticle for delivering an anticancer agent and preparing method thereof 有权
标题翻译：用于递送抗癌剂的水溶性壳聚糖纳米颗粒及其制备方法
公开(公告)号：US20060013885A1
公开(公告)日：2006-01-19
申请号：US11128297
申请日：2005-05-13
申请人： Jae-Woon Nah , Teok Jung , Mi-Kyeong Jang , Young-Il Jeong
发明人： Jae-Woon Nah , Teok Jung , Mi-Kyeong Jang , Young-Il Jeong
IPC分类号： A61K9/14 , C08B37/08
CPC分类号： C08L5/08 , A61K9/5161 , A61K9/5192 , A61K47/36 , C08J3/12 , C08J3/14 , C08J2305/08
摘要： The present invention relates to a water soluble chitosan nanoparticle (WSC-NP) for delivering an anticancer agent and a preparing method thereof, more precisely, a water soluble chitosan nanoparticle for delivering an anticancer agent which has function of targeting on a wanted area by introducing a functional group in the location of highly reactive amine group and becomes an excellent gene carrier with the use of water soluble chitosan since the water soluble chitosan itself can combined with DNA having a negative electric charge(−) owing to the very strong positive electric charge(+) of its amine group, and a preparing method thereof. Therefore, a water-soluble chitosan nanoparticle for delivering an anticancer agent of the present invention can effectively envelope paclitaxel by introducing hydrophilic and hydrophobic groups in the position of highly reactive amine group of the water-soluble chitosan. A water soluble chitosan nanopaclitaxel prepared as the above has an excellent re-dispersion force, after freeze-drying, in distilled water and has an outstanding anticancer effect with its accumulation in tumor cells greater than that of the other anticancer agent carriers.
摘要翻译：本发明涉及用于递送抗癌剂的水溶性壳聚糖纳米粒子（WSC-NP）及其制备方法，更确切地说，涉及一种用于递送抗癌剂的水溶性壳聚糖纳米粒子，其具有通过引入在高反应性胺基的位置上的官能团，并且由于水溶性壳聚糖本身可以与具有负电荷（ - ）的DNA结合，因而具有非常强的正电荷（+）及其制备方法。因此，用于输送本发明的抗癌剂的水溶性壳聚糖纳米粒子可以通过在水溶性壳聚糖的高反应性胺基的位置引入亲水基团和疏水基团来有效地包裹紫杉醇。如上制备的水溶性壳聚糖纳米紫杉醇在蒸馏水中冷冻干燥后具有优异的再分散力，并且在肿瘤细胞中积累的抗肿瘤效果优于其它抗癌剂载体，具有优异的抗癌作用。

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