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1. 发明授权

US4552751A Long-lasting multi-layered film preparation 失效
标题翻译：持久的多层膜制备
公开(公告)号：US4552751A
公开(公告)日：1985-11-12
申请号：US312458
申请日：1981-10-19
申请人： Kohji Inaba , Seiei Sasatani , Tatsushi Koide , Tamio Nanya
发明人： Kohji Inaba , Seiei Sasatani , Tatsushi Koide , Tamio Nanya
IPC分类号： A61K9/02 , A61K9/70 , A61K31/557 , A01N25/26 , A01N25/34
CPC分类号： A61K9/7092 , A61K31/557
摘要： The present invention provides multi-layered film preparations which comprise one or more water soluble polymer bases, one or more water insoluble polymer bases, one or more plasticizers and one or more prostaglandins, and optionally contain one or more organic acids, and they are composed of at least two drug release controlling layers and one or more drug storing layers. The multi-layered film preparations of the present invention are characterized by that the prostaglandin(s) containing therein exhibit the desired long-lasting release patterns at the concentration required for therapeutic purpose.
摘要翻译：本发明提供了多层膜制剂，其包含一种或多种水溶性聚合物基质，一种或多种水不溶性聚合物基质，一种或多种增塑剂和一种或多种前列腺素，并且任选地含有一种或多种有机酸，并且它们组成的至少两个药物释放控制层和一个或多个药物储存层。本发明的多层膜制剂的特征在于，其中含有的前列腺素以治疗目的所需的浓度显示出期望的持久释放模式。

2. 发明授权

US4483846A Long-lasting three-layered pharmaceutical film preparations 失效
标题翻译：持久的三层药膜制剂
公开(公告)号：US4483846A
公开(公告)日：1984-11-20
申请号：US464174
申请日：1983-02-07
申请人： Tatsushi Koide , Seiei Sasatani , Kohji Inaba
发明人： Tatsushi Koide , Seiei Sasatani , Kohji Inaba
IPC分类号： A61K31/557 , A61K9/70 , A61K45/08 , A01N25/26 , A01N25/34
CPC分类号： A61K9/7053 , A61K9/7092
摘要： The present invention provides new three-layered pharmaceutical film preparations which comprise one drug-storing middle layer composed of one or more (a) polyvinylpyrrolidone, (b) hydroxypropyl cellulose, (c) plasticizers and (d) organic acids, containing prostaglandin analogues, and two release-controlling layers on both sides of the said middle layer, composed of one or more (a) hydroxypropyl cellulose and (b) plasticizers, containing or not containing prostaglandin analogues, and which may release the drug at the desired concentration lastingly for an extended period of time, with great high biological availability, and can make this release "zero-order release", and further have improved the stability of the drug contained therein, and in which the form of the preparation is not retained at the administered site after administration.
摘要翻译：本发明提供新的三层药物膜制剂，其包含一种药物储存中间层，其由一种或多种（a）聚乙烯吡咯烷酮，（b）羟丙基纤维素，（c）增塑剂和（d）含有前列腺素类似物的有机酸组成，以及由所述中间层两侧的两个释放控制层，由一种或多种（a）羟丙基纤维素和（b）增塑剂组成，所述增塑剂含有或不含有前列腺素类似物，并且可以持续释放所需浓度的药物以用于延长的时间，具有很高的生物利用度，并且可以使这种释放“零次释放”，并且进一步改善了其中所含药物的稳定性，并且其中制剂形式不保留在给药管理后的网站。

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