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    • 4. 发明授权
    • Tricyclic compound and medical use thereof
    • 三环化合物及其医疗用途
    • US08273761B2
    • 2012-09-25
    • US12448094
    • 2007-12-07
    • Osamu UchikawaTatsuki KoikeTakafumi TakaiYasutaka Hoashi
    • Osamu UchikawaTatsuki KoikeTakafumi TakaiYasutaka Hoashi
    • C07D491/048A61K31/4355
    • C07D491/04C07D491/14
    • The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa to Xe are each a carbon atom or a nitrogen atom, m is 0 to 2, and ring A to ring C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
    • 本发明提供由下式表示的化合物,其中R 1是任选具有取代基的烃基,任选具有取代基的氨基,任选具有取代基的羟基或任选具有取代基的杂环基,R2是 氢原子或任选具有取代基的烃基,R 3是氢原子,卤素原子,任选具有取代基的烃基,任选具有取代基的氨基,任选具有取代基的羟基或任选具有取代基的巯基, 取代基,Xa〜Xe各自为碳原子或氮原子,m为0〜2,环A〜环C各自为任选具有取代基的环,或其盐,可用作试剂 用于预防或治疗与褪黑素的作用相关的疾病等。