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1. 发明授权

US08822699B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08822699B2
公开(公告)日：2014-09-02
申请号：US13223455
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： A61K31/42 , C07D263/30 , C07D413/02
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

2. 发明授权

US08349879B2 Tricyclic compound and pharmaceutical use thereof 有权
公开(公告)号：US08349879B2
公开(公告)日：2013-01-08
申请号：US13047363
申请日：2011-03-14
申请人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： A61K31/428 , C07D277/60
CPC分类号： A61K31/428 , A61K31/423 , C07D263/52 , C07D277/60 , C07D277/62 , C07D413/06
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.

3. 发明授权

US08318784B2 Tricyclic compound and pharmaceutical use thereof 有权
公开(公告)号：US08318784B2
公开(公告)日：2012-11-27
申请号：US13047363
申请日：2011-03-14
申请人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： A61K31/428 , C07D277/60
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.

4. 发明授权

US08273761B2 Tricyclic compound and medical use thereof 有权
标题翻译：三环化合物及其医疗用途
公开(公告)号：US08273761B2
公开(公告)日：2012-09-25
申请号：US12448094
申请日：2007-12-07
申请人： Osamu Uchikawa , Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
发明人： Osamu Uchikawa , Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
IPC分类号： C07D491/048 , A61K31/4355
CPC分类号： C07D491/04 , C07D491/14
摘要： The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa to Xe are each a carbon atom or a nitrogen atom, m is 0 to 2, and ring A to ring C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
摘要翻译：本发明提供由下式表示的化合物，其中R 1是任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的杂环基，R2是氢原子或任选具有取代基的烃基，R 3是氢原子，卤素原子，任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的巯基，取代基，Xa〜Xe各自为碳原子或氮原子，m为0〜2，环A〜环C各自为任选具有取代基的环，或其盐，可用作试剂用于预防或治疗与褪黑素的作用相关的疾病等。

5. 发明申请

US20120059030A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20120059030A1
公开(公告)日：2012-03-08
申请号：US13223455
申请日：2011-09-01
申请人： Tatsuki KOIKE , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki KOIKE , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： A61K31/437 , A61P25/28 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

6. 发明申请

US20110196003A1 TRICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF 有权
标题翻译：三氯化合物及其药物用途
公开(公告)号：US20110196003A1
公开(公告)日：2011-08-11
申请号：US13047363
申请日：2011-03-14
申请人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
发明人： Osamu Uchikawa , Tatsuki Koike , Yasutaka Hoashi , Takafumi Takai
IPC分类号： A61K31/428 , C07D277/62 , A61P25/00
CPC分类号： A61K31/428 , A61K31/423 , C07D263/52 , C07D277/60 , C07D277/62 , C07D413/06
摘要： The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.
摘要翻译：本发明提供下式表示的化合物，其可用作预防或治疗与褪黑激素或其盐等有关的疾病的药剂。

7. 发明授权

US08901309B2 Fused triazoles for the treatment or prophylaxis of mild cognitive impairment 有权
标题翻译：融合三唑用于治疗或预防轻度认知障碍
公开(公告)号：US08901309B2
公开(公告)日：2014-12-02
申请号：US13819239
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Takafumi Takai , Yuichi Kajita , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Takafumi Takai , Yuichi Kajita , Makoto Kamata
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性和/或优异的γ-分泌酶调节活性及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

8. 发明申请

US20130178497A1 FUSED TRIAZOLES FOR THE TREATMENT OR PROPHYLAXIS OF MILD COGNITIVE IMPAIRMENT 有权
标题翻译：用于治疗或预防小儿认知功能障碍的三叉神经痛
公开(公告)号：US20130178497A1
公开(公告)日：2013-07-11
申请号：US13819239
申请日：2011-09-01
申请人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
发明人： Tatsuki Koike , Minoru Nakamura , Yoshihide Tomata , Takafumi Takai , Yasutaka Hoashi , Yuichi Kajita , Tetsuya Tsukamoto , Makoto Kamata
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and/or a superior γ-secretase modulation activity, and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异的淀粉样蛋白β产生抑制活性和/或优异的γ-分泌酶调节活性的杂环衍生物及其用途。由式（I）表示的化合物或其盐，其中每个符号如本说明书中所定义。

9. 发明申请

US20120142672A1 HETEROCYCLIC COMPOUND AND USE THEREOF 审中-公开
标题翻译：杂环化合物及其用途
公开(公告)号：US20120142672A1
公开(公告)日：2012-06-07
申请号：US13383478
申请日：2010-07-12
申请人： Tatsuki Koike , Yasutaka Hoashi , Yoshihide Tomata
发明人： Tatsuki Koike , Yasutaka Hoashi , Yoshihide Tomata
IPC分类号： A61K31/55 , C07D487/04 , A61P25/00 , A61K31/5377 , A61P25/28 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a heterocycle derivative having a superior amyloid β production inhibitory activity and use thereof.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有优异淀粉样蛋白的杂环衍生物; 生产抑制活性及其用途。本发明涉及由式（I）表示的化合物：其中每个符号如本说明书中所定义，或其盐。

10. 发明授权

US08110585B2 Bicyclic compound and pharmaceutical use thereof 有权
标题翻译：双环化合物及其药物用途
公开(公告)号：US08110585B2
公开(公告)日：2012-02-07
申请号：US12451090
申请日：2008-04-25
申请人： Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
发明人： Tatsuki Koike , Takafumi Takai , Yasutaka Hoashi
IPC分类号： A61K31/416 , A61K31/428 , A61K31/437 , C07D231/54 , C07D277/64 , C07D471/04
CPC分类号： C07D231/56 , C07D275/04 , C07D277/64 , C07D285/14 , C07D471/04
摘要： The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
摘要翻译：本发明提供由下式表示的化合物：其中R 1为任选具有取代基的烃基，任选具有取代基的氨基，任选具有取代基的羟基或任选具有取代基的杂环基; R2是氢原子或任选具有取代基的烃基; Xa和Xb各自为C，N，O或S; Xc和Xd分别为C或N; m为0-2; n为1-3; 环A是任选具有取代基的5元环; 环B是任选具有取代基的6元环; 并且环C是任选具有取代基的3至5元环，条件是当Xa，Xc和Xd各自为C时，则Xb为N或S，或其盐，其可用作与褪黑素的作用有关的疾病的预防或治疗等。

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