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1. 发明授权

US09377470B2 Prognosis diagnosis method and prognosis diagnosis kit for sepsis or multiple organ failure 有权
标题翻译：脓毒症或多器官衰竭的预后诊断方法和预后诊断试剂盒
公开(公告)号：US09377470B2
公开(公告)日：2016-06-28
申请号：US13383565
申请日：2010-07-15
申请人： Takeshi Sugaya , Eisei Noiri , Kent Doi
发明人： Takeshi Sugaya , Eisei Noiri , Kent Doi
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6872 , G01N33/53 , G01N2800/26
摘要： Disclosed are: a prognosis diagnosis method which can diagnose the prognosis of a patient suffering from sepsis or sepsis-related multiple organ failure in a simple manner and with high accuracy and a prognosis diagnosis kit for use in the prognosis diagnosis method. The prognosis diagnosis method comprises: a first detection step of detecting a liver fatty acid-binding protein contained in urine collected from a subject with a specific antibody; a second detection step of treating the urine with a Redox reagent such as hemin and detecting a liver fatty acid-binding protein contained in the treated urine with the specific antibody; and a comparison step of comparing a detection value obtained in the first step with a detection value obtained in the second step. It is determined that the larger the detection value obtained in the second step compared to that in the first step, the worse the prognosis.
摘要翻译：公开了一种预测诊断方法，其可以以简单的方式和准确性诊断患有败血症或败血症相关多器官功能衰竭的患者的预后，以及用于预后诊断方法的预后诊断试剂盒。预后诊断方法包括：第一检测步骤，用特异性抗体检测从受试者收集的尿中所含的肝脏脂肪酸结合蛋白; 第二检测步骤，用氧化还原试剂如血红素处理尿液，并用特异性抗体检测处理的尿液中所含的肝脏脂肪酸结合蛋白; 以及将在第一步骤中获得的检测值与在第二步骤中获得的检测值进行比较的比较步骤。确定与第一步相比，第二步获得的检测值越大，预后越差。

2. 发明申请

US20120135433A1 PROGNOSIS DIAGNOSIS METHOD AND PROGNOSIS DIAGNOSIS KIT FOR SEPSIS OR MULTIPLE ORGAN FAILURE 有权
标题翻译：预防诊断方法和预防诊断工具包用于缝合或多器官失败
公开(公告)号：US20120135433A1
公开(公告)日：2012-05-31
申请号：US13383565
申请日：2010-07-15
申请人： Takeshi Sugaya , Eisei Noiri , Kent Doi
发明人： Takeshi Sugaya , Eisei Noiri , Kent Doi
IPC分类号： G01N33/566
CPC分类号： G01N33/6872 , G01N33/53 , G01N2800/26
摘要： Disclosed are: a prognosis diagnosis method which can diagnose the prognosis of a patient suffering from sepsis or sepsis-related multiple organ failure in a simple manner and with high accuracy and a prognosis diagnosis kit for use in the prognosis diagnosis method. The prognosis diagnosis method comprises: a first detection step of detecting a liver fatty acid-binding protein contained in urine collected from a subject with a specific antibody; a second detection step of treating the urine with a Redox reagent such as hemin and detecting a liver fatty acid-binding protein contained in the treated urine with the specific antibody; and a comparison step of comparing a detection value obtained in the first step with a detection value obtained in the second step. It is determined that the larger the detection value obtained in the second step compared to that in the first step, the worse the prognosis.
摘要翻译：公开了一种预测诊断方法，其可以以简单的方式和准确性诊断患有败血症或败血症相关多器官功能衰竭的患者的预后，以及用于预后诊断方法的预后诊断试剂盒。预后诊断方法包括：第一检测步骤，用特异性抗体检测从受试者收集的尿中所含的肝脏脂肪酸结合蛋白; 第二检测步骤，用氧化还原试剂如血红素处理尿液，并用特异性抗体检测处理的尿液中所含的肝脏脂肪酸结合蛋白; 以及将在第一步骤中获得的检测值与在第二步骤中获得的检测值进行比较的比较步骤。确定与第一步相比，第二步获得的检测值越大，预后越差。

3. 发明申请

US20100304478A1 METHOD FOR ISOLATING RENAL STEM/PROGENITOR CELLS, RENAL STEM/PROGENITOR CELLS AND THERAPEUTIC AGENT FOR RENAL DISEASE 审中-公开
标题翻译：用于分离肾脏干细胞/原核细胞，肾脏干细胞/祖细胞细胞和治疗药物治疗肾病的方法
公开(公告)号：US20100304478A1
公开(公告)日：2010-12-02
申请号：US12671474
申请日：2007-08-06
申请人： Takeshi Sugaya , Naoshi Shinozaki
发明人： Takeshi Sugaya , Naoshi Shinozaki
IPC分类号： C12N5/07 , C12N5/00
CPC分类号： C12N5/0687 , A61K35/12 , C12N5/0668
摘要： It is intended to provide a method for noninvasively isolating human renal stem/progenitor cells, an isolated renal stem/progenitor cells, a therapeutic agent for renal disease, mouse mesenchymal cells which can be used for isolating human renal stem/progenitor cells and a culture supernatant of the same. Renal stem/progenitor cells are isolated by primarily culturing cells contained in the urine of a patient having renal disease in a medium containing mouse mesenchymal cells identified by the deposition number of FERM ABP-10865 or a culture supernatant of the same, staining the obtained primarily cultured cells with Hoechst 33342 and separating a weak-positive or negative fraction.
摘要翻译：旨在提供一种用于非侵入性分离人肾干/祖细胞，分离的肾干/祖细胞，肾病治疗剂，可用于分离人肾干/祖细胞的小鼠间充质细胞和培养物上清液相同。通过在包含小鼠间充质细胞的培养基中培养包含在具有肾脏疾病的患者的尿液中的细胞来分离肾干细胞/祖细胞，所述培养基通过FERM ABP-10865的沉积数或其培养物上清液鉴定，染色所得到的主要用Hoechst 33342培养细胞并分离弱阳性或阴性部分。

4. 发明申请

US20100068694A1 METHOD, REAGENT AND KIT FOR MALARIA TESTING 有权
标题翻译：用于疟疾测试的方法，试剂和试剂盒
公开(公告)号：US20100068694A1
公开(公告)日：2010-03-18
申请号：US12405060
申请日：2009-03-16
申请人： Takeshi Sugaya , Eisei Noiri , Yoshitsugu Matsumoto
发明人： Takeshi Sugaya , Eisei Noiri , Yoshitsugu Matsumoto
IPC分类号： C12Q1/00
CPC分类号： G01N33/56905 , G01N2333/445 , Y02A50/58
摘要： The present invention provides a method for malaria testing which enables testing for the presence of malaria infection and the extent of the infection in a convenient manner; and a reagent or kit which can be used in the method. The method for malaria testing according to the present invention includes the step of detecting a liver-type fatty acid binding protein present in urine collected from a subject animal. The extent of infection is determined to be higher when a larger amount of the liver-type fatty acid binding protein is present in a test sample.
摘要翻译：本发明提供了一种疟疾检测方法，能够以方便的方式检测疟疾感染的存在和感染程度; 以及可用于该方法的试剂或试剂盒。根据本发明的疟疾测试方法包括检测从受试动物收集的尿液中存在的肝型脂肪酸结合蛋白的步骤。当在测试样品中存在更多量的肝型脂肪酸结合蛋白时，感染程度被确定为更高。

5. 发明申请

US20070243560A1 Method for examining kidney diseases 审中-公开
标题翻译：检查肾脏疾病的方法
公开(公告)号：US20070243560A1
公开(公告)日：2007-10-18
申请号：US11812334
申请日：2007-06-18
申请人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
发明人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347
摘要： Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results which may be very important information for diagnosis of prognosis of kidney disease, that has been very difficult in the past. Based on test results obtained by the present method, it may be possible to select a suitable method for treatment of kidney disease with taking into consideration risks as to the prognosis, etc. Besides, the present method can be applied to, in addition to the kidney tissue samples, urine samples as well, so that the examination procedure can be simple and efficient.
摘要翻译：用于检查肾脏疾病的方法，其包括检测来自肾组织的脂肪酸结合蛋白，其存在于不包括啮齿动物的哺乳动物收集的标本中。通过本方法，可以获得可能是诊断肾脏疾病预后的非常重要的信息的测试结果，这在过去是非常困难的。根据本方法得到的检测结果，考虑到预后的风险等，可以选择合适的肾病治疗方法。此外，本方法除了可以应用于肾组织样本，尿液样本，使检查程序简单有效。

6. 发明授权

US08034551B2 Method, reagent and kit for malaria testing 有权
标题翻译：用于疟疾测试的方法，试剂和试剂盒
公开(公告)号：US08034551B2
公开(公告)日：2011-10-11
申请号：US12405060
申请日：2009-03-16
申请人： Takeshi Sugaya , Eisei Noiri , Yoshitsugu Matsumoto
发明人： Takeshi Sugaya , Eisei Noiri , Yoshitsugu Matsumoto
IPC分类号： C12Q1/00 , G01N33/53
CPC分类号： G01N33/56905 , G01N2333/445 , Y02A50/58
摘要： The present invention provides a method for malaria testing which enables testing for the presence of malaria infection and the extent of the infection in a convenient manner; and a reagent or kit which can be used in the method. The method for malaria testing according to the present invention includes the step of detecting a liver-type fatty acid binding protein present in urine collected from a subject animal. The extent of infection is determined to be higher when a larger amount of the liver-type fatty acid binding protein is present in a test sample.
摘要翻译：本发明提供一种疟疾检测方法，能够以方便的方式检测疟疾感染的存在和感染程度; 以及可用于该方法的试剂或试剂盒。根据本发明的疟疾测试方法包括检测从受试动物收集的尿液中存在的肝型脂肪酸结合蛋白的步骤。当在测试样品中存在更多量的肝型脂肪酸结合蛋白时，感染程度被确定为更高。

7. 发明授权

US06403216B1 Moisture-absorbing/releasing synthetic fiber and fabric using the same 有权
标题翻译：水分吸收/释放合成纤维和使用其的织物
公开(公告)号：US06403216B1
公开(公告)日：2002-06-11
申请号：US09913024
申请日：2001-08-09
申请人： Masanori Doi , Takeshi Sugaya , Sueo Ohashi
发明人： Masanori Doi , Takeshi Sugaya , Sueo Ohashi
IPC分类号： D02F600
CPC分类号： D01F6/70 , D01F6/94 , Y10T428/2913 , Y10T428/2967
摘要： A synthetic fiber which is excellent in moisture-absorbing/releasing property and exhibits high elongation and high stretch recovery, characterized in that it has moisture absorption ratios of 0.5 to 4.0% by weight in environments of 20° C.×65% RH and that of 4.5% by weight or more in environments of 30° C.×90% RH, respectively, and also has a difference between the absorption ratios in both the environments of 4.0% by weight or more. The representative examples of such fibers include polyurethane synthetic fiber and polyether synthetic fiber. The synthetic fiber maintains a high strength at break of an elastic fiber component thereof also in the state of having absorbed moisture, is excellent in color fastness to rubbing, and can be used for manufacturing a stretch fiber fabric product excellent in comfort through blending with another fiber material. The synthetic fiber can be produced by incorporating a water absorption resin having a water absorption ratio in a range from 500 to 4000% by weight into an elastic fiber such as a polyurethane fiber or a polyurethane-urea fiber in a finely dispersed state in an amount in a range from 1 to 15% by weight relative to a fiber-forming polymer.
摘要翻译：一种吸水/脱模性优异，伸长率高，拉伸恢复性高的合成纤维，其特征在于，在20℃×65％RH的环境下，其吸湿率为0.5〜4.0重量％在30℃×90％RH的环境下分别为4.5重量％以上，并且在两个环境中的吸收比都为4.0重量％以上。这种纤维的代表性实例包括聚氨酯合成纤维和聚醚合成纤维。合成纤维在其吸收水分的状态下也保持其弹性纤维成分的高强度断裂，耐摩擦色牢度优异，可用于制造舒适性优异的拉伸纤维织物产品纤维材料。合成纤维可以通过将吸水率为500〜4000重量％的吸水性树脂以微细分散状态的聚氨酯纤维或聚氨酯 - 尿素纤维等弹性纤维的量加入，相对于成纤聚合物为1〜15重量％。

8. 发明授权

US5919564A Elastic polyurethaneurea fiber 失效
标题翻译：弹性聚氨酯脲纤维
公开(公告)号：US5919564A
公开(公告)日：1999-07-06
申请号：US983477
申请日：1998-01-21
申请人： Takeshi Sugaya , Kazuhiko Naka
发明人： Takeshi Sugaya , Kazuhiko Naka
IPC分类号： D01F6/70 , D02G3/00 , C08G18/10
CPC分类号： D01F6/70 , Y10T428/2913
摘要： Disclosed is a polyurethaneurea elastic fiber composed of a polyurethaneurea obtained by a reaction of a polymer diol, organic diisocyanate, bifunctional amine mainly consisting of 75% or more of ethylenediamine and a monoamine; and incorporated therein a specific alkylsulfonate or sulfate having a specific hydrocarbon groups containing carbon atoms ranging from 6 to 20. The polyurethaneurea elastic fiber can exhibit a high breaking strength and high elongation at break, and therefore, can produce a fine denier polyurethaneurea elastic fiber. The fiber can provide a converting processing of elastic fiber under a high draft and at a higher processing speed.
摘要翻译： PCT No.PCT / JP96 / 02098 Sec。 371日期1998年1月21日 102（e）1998年1月21日PCT PCT 1996年7月25日PCT公布。出版物WO97 / 05309 日期1997年2月13日公开是由主要由75％以上的乙二胺和单胺组成的聚合物二醇，有机二异氰酸酯，双官能胺反应得到的聚氨酯脲组成的聚氨酯脲弹性纤维，并且在其中加入具有6至20个碳原子的特定烃基的特定烷基磺酸盐或硫酸盐。聚氨酯脲弹性纤维可以表现出高断裂强度和高断裂伸长率，因此可以生产出细旦尼尔聚氨酯脲弹性纤维。该纤维可以在高吃水和较高处理速度下提供弹性纤维的转化加工。

9. 发明授权

US07592148B1 Method for examining human kidney disease by detecting the fatty acid binding protein 有权
标题翻译：通过检测脂肪酸结合蛋白检测人肾脏疾病的方法
公开(公告)号：US07592148B1
公开(公告)日：2009-09-22
申请号：US09578693
申请日：2000-07-26
申请人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
发明人： Masaya Yamanouchi , Akiko Honda , Hiromi Hase , Takeshi Sugaya , Kenjiro Kimura
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/6893 , G01N2800/347
摘要： Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results, which may be very important information for diagnosis or prognosis of kidney disease that has been very difficult in the past. Based on test results obtained by the present method, it may be possible to select a suitable method for treatment of kidney disease with taking into consideration risks such as the prognosis, etc. Besides, the present method can be applied to, in addition to the kidney disease samples, urine samples as well, so that the examination procedure can be simple and efficient.
摘要翻译：用于检查肾脏疾病的方法，其包括检测来自肾组织的脂肪酸结合蛋白，其存在于不包括啮齿动物的哺乳动物收集的标本中。通过本方法，可以获得测试结果，这可能是过去非常困难的肾脏疾病的诊断或预后的非常重要的信息。根据本方法得到的检测结果，考虑到预后等风险，可以选择合适的肾脏疾病治疗方法。此外，本方法除了可以应用于肾脏疾病样本，尿液样本，使检查程序简单有效。

10. 发明授权

US06794154B1 Remedies for kidney diseases and method for screening the same 有权
标题翻译：肾脏疾病的治疗方法和筛查方法相同
公开(公告)号：US06794154B1
公开(公告)日：2004-09-21
申请号：US09979765
申请日：2001-11-27
申请人： Masaya Yamanouchi , Hiromi Hase , Akiko Honda , Takeshi Sugaya
发明人： Masaya Yamanouchi , Hiromi Hase , Akiko Honda , Takeshi Sugaya
IPC分类号： G01N3353
CPC分类号： C12N5/0686 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K31/00 , A61K31/336 , A61K31/41 , A61K31/425 , A61K31/4439 , A61K38/00 , C07K14/475 , C07K14/705 , C12N15/8509 , C12N2503/02 , C12N2510/04 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/92 , G01N2500/00 , G01N2500/10
摘要： The present invention provides a method for screening or identifying therapeutic or prophylactic agents for renal diseases, which comprises assaying a test substance for the activity of up-regulating the expression of fatty acid-binding protein (FABP), and novel mouse proximal renal tubular epithelial cell lines useful therein. The present invention also provides therapeutic or prophylactic agents for renal diseases comprising, as an active ingredient, an agent having activity of up-regulating FABP expression; agents for up-regulating the expression of FABP, and for treating or preventing renal diseases, which comprise a compound having activity of peroxisome proliferator-activated receptor (PPAR) agonist or carnitine palmitoyltransferase (CPT) inhibitor or the like.
摘要翻译：本发明提供了筛选或鉴定肾脏疾病的治疗或预防剂的方法，其包括测定测试物质以上调脂肪酸结合蛋白（FABP）表达的活性，以及新型小鼠近端肾小管上皮可用于其中的细胞系。本发明还提供了用于肾脏疾病的治疗剂或预防剂，其包含作为活性成分的具有上调FABP表达活性的药剂; 用于上调FABP表达的药物，以及用于治疗或预防肾脏疾病的药物，其包含具有过氧化物酶体增殖物激活受体（PPAR）激动剂或肉碱棕榈酰转移酶（CPT）抑制剂等的活性的化合物。

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