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1. 发明授权

US5204327A Treatment of cerebral edema with ANP pharmaceutical compositions 失效
标题翻译：用ANP药物组合物治疗小儿EDEMA
公开(公告)号：US5204327A
公开(公告)日：1993-04-20
申请号：US435659
申请日：1989-11-13
申请人： Takao Kiyota , Shuichi Sugawara , Hiroshi Hayashi
发明人： Takao Kiyota , Shuichi Sugawara , Hiroshi Hayashi
IPC分类号： A61K38/00 , C07K14/58
CPC分类号： C07K14/58 , A61K38/00
摘要： A pharmaceutical composition and its use in the treatment of cerebral edema are provided wherein the composition comprises an atrial natriuretic peptide having an amino acid sequence of 28 amino acids and at least one pharmaceutically acceptable carrier, diluent or excipient.

2. 发明授权

US4409105A Dried, sterilized, gamma-globulin-fixed column and a process for preparing the same 失效
标题翻译：干燥，灭菌，γ-球蛋白固定柱及其制备方法
公开(公告)号：US4409105A
公开(公告)日：1983-10-11
申请号：US323338
申请日：1981-11-20
申请人： Hiroshi Hayashi , Takao Kiyota , Mitsuru Shibukawa
发明人： Hiroshi Hayashi , Takao Kiyota , Mitsuru Shibukawa
IPC分类号： G01N33/548 , A61K39/44 , A61L2/00 , A61L2/20 , A61M1/14 , A61M1/36 , G01N33/543 , B01J8/02
CPC分类号： A61M1/3679 , A61K39/44 , A61L2/0094 , A61L2/206 , Y10S530/868
摘要： A dried, sterilized column containing a carrier-fixed .gamma.-globulin capable of specifically combining with various harmful substances found in blood of patients suffering from certain diseases and acting as an antibody. The .gamma.-globulin fixed column according to the present invention has a prolonged storage stability, and an excellent activity and safety even after the storage for a prolonged period of time as compared with unsterilized columns. Therefore, the .gamma.-globulin fixed column according to the present invention may be advantageously used for medical instrument applications.
摘要翻译：一种干燥的无菌柱，其含有载体固定的γ-球蛋白，其能够与患有某些疾病的患者的血液中发现的各种有害物质特异性结合并作为抗体。根据本发明的γ-球蛋白固定柱具有延长的储存稳定性，即使在与未灭菌的柱相比长时间储存之后也具有优异的活性和安全性。因此，根据本发明的γ-球蛋白固定柱可有利地用于医疗仪器应用。

3. 发明授权

US4447355A Method for stabilizing a tumor necrosis factor and a stable aqueous solution or powder containing the same 失效
标题翻译：稳定肿瘤坏死因子的方法和含有该肿瘤坏死因子的稳定的水溶液或粉末
公开(公告)号：US4447355A
公开(公告)日：1984-05-08
申请号：US477866
申请日：1983-03-23
申请人： Hajimu Sakamoto , Takao Kiyota , Hiroshi Hayashi
发明人： Hajimu Sakamoto , Takao Kiyota , Hiroshi Hayashi
IPC分类号： A61K35/12 , A61K38/19 , A61K47/42 , C07G7/00
CPC分类号： A61K38/191 , A61K47/42 , Y10S514/97
摘要： A method for stabilizing a Tumor Necrosis Factor (TNF), which comprises adding at least one member selected from the group consisting of an albumin, a gelatin, a globulin, a protamine and a salt of protamine to an aqueous solution or powder containing TNF, and a stable aqueous solution or powder which contains TNF and an effective amount of such a protein. The aqueous solution or powder containing TNF can be stored for a prolonged period of time without losing its activity, and is stable on freezing, thawing, lyophilization or the like.
摘要翻译：一种稳定肿瘤坏死因子（TNF）的方法，其包括将选自白蛋白，明胶，球蛋白，鱼精蛋白和鱼精蛋白盐的至少一种添加到含有TNF的水溶液或粉末中，以及含有TNF和有效量的这种蛋白质的稳定的水溶液或粉末。含有TNF的水溶液或粉末可以长时间储存而不失去其活性，并且在冷冻，解冻，冻干等方面是稳定的。

4. 发明授权

US4880915A Method for purifying a physiologically active substance produced by recombinant DNA technique 失效
标题翻译：纯化通过重组DNA技术生产的生理活性物质的方法
公开(公告)号：US4880915A
公开(公告)日：1989-11-14
申请号：US799509
申请日：1985-11-19
申请人： Junichi Kajihara , Takao Kiyota , Hiroshi Hayashi
发明人： Junichi Kajihara , Takao Kiyota , Hiroshi Hayashi
IPC分类号： C12N15/09 , A61K38/17 , C07K1/16 , C07K1/22 , C07K14/525 , C12N15/28 , C12P21/00 , C12P21/02 , C12R1/19
CPC分类号： C07K14/525 , Y10S530/828
摘要： An aqueous solution containing a physiologically active substance, which is produced by recombinant DNA technique and which has cytotoxic activity against L-M cells and is capable of inducing hemorrhagic necrosis of transplanted Meth A sarcoma in the BALB/c mouse, can be effectively, efficiently purified by column chromatography using a column packed with a dye-bonded crosslinked agarose gel.
摘要翻译：含有生理活性物质的水溶液可以通过重组DNA技术生产并且具有针对LM细胞的细胞毒活性并且能够诱导BALB / c小鼠中移植的Meth A肉瘤的出血性坏死的水溶液可有效地通过柱层析，使用填充有染料键合的交联琼脂糖凝胶的柱。

5. 发明授权

US4452918A Totally porous activated gel 失效
标题翻译：全多孔活性凝胶
公开(公告)号：US4452918A
公开(公告)日：1984-06-05
申请号：US374369
申请日：1982-05-03
申请人： Takateru Uchida , Kohji Noguchi , Takao Kiyota
发明人： Takateru Uchida , Kohji Noguchi , Takao Kiyota
IPC分类号： C12N9/00 , B01J20/26 , B01J20/291 , C08F8/00 , C08F8/12 , C12N11/08 , B32B3/00 , C08F226/00
CPC分类号： B01J20/291 , B01J20/26 , C08F8/12 , B01J2220/54 , C08F2810/20 , Y10S521/905 , Y10T428/2982
摘要： A totally porous activated gel which comprises a matrix of a totally porous crosslinked copolymer comprising as main components vinyl alcohol monomer units and crosslinkable monomer units and having a specific surface area of 5 to 1000 m.sup.2 /g and an reactive group linked to said matrix by a covalent bond. The present activated gel is very useful for effectively separating bio-substances due to the peculiar behavior of the reactive group of the activated gel. The activated gel is rigid, and is excellent in mechanical strength, resistance to chemicals, high pH, low pH, high temperature and low temperature, and is very effective in specific adsorption of bio-substances. The activated gel can be subjected to freeze-drying sterilization, heat sterilization and radiation sterilization, so that it can be utilized for the medical treatment by extracorporeal perfusion of, for example, blood.
摘要翻译：一种全多孔活性凝胶，其包含全部多孔交联共聚物的基质，其包含作为主要组分的乙烯醇单体单元和可交联单体单元，并且具有5至1000m 2 / g的比表面积和与所述基质连接的反应性基团共价键。由于活化凝胶的反应性基团的特殊行为，本发明的活化凝胶对于有效分离生物物质非常有用。活化凝胶是刚性的，机械强度，耐化学品，高pH，低pH，高温和低温都是优异的，对生物物质的特异性吸附是非常有效的。活化凝胶可以进行冷冻干燥灭菌，加热灭菌和放射线灭菌，从而可以通过例如血液的体外灌注来用于医疗。

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