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1. 发明申请

US20070264368A1 Carbohydrase inhibitors derived from fagaceous plants and use thereof 审中-公开
标题翻译：衍生自非物质植物的碳水解酶抑制剂及其用途
公开(公告)号：US20070264368A1
公开(公告)日：2007-11-15
申请号：US11662636
申请日：2005-06-03
申请人： Takahiro Tsujita
发明人： Takahiro Tsujita
IPC分类号： A61K36/49
CPC分类号： A61K36/49 , A23L33/105 , A61K2300/00
摘要： The present invention provides a plant-derived carbohydrase inhibitor, wherein the inhibitor is effective for preventing or alleviating diabetes, or preventing obesity, and foods, drinks, and medicines containing the same. The present invention is accomplished by use of an α-amylase inhibitor or an α-glucosidase inhibitor as a carbohydrase inhibitor that is extracted from an entire or a part of fagaceous plants using water, another polar solvent, or a mixture thereof. The present invention can also be accomplished by adding the carbohydrase inhibitor to a food or medical composition as an active ingredient for delaying saccharide digestion or absorption, suppressing a rise in postprandial blood glucose levels, or preventing obesity.
摘要翻译：本发明提供一种植物来源的糖酶抑制剂，其中所述抑制剂对于预防或减轻糖尿病，或预防肥胖有效，以及食品，饮料和含有该糖的酶的药物。本发明通过使用α-淀粉酶抑制剂或α-葡糖苷酶抑制剂作为糖水解酶抑制剂来完成，所述糖酶抑制剂是使用水，其它极性溶剂或其混合物从全身或部分异味植物中提取的。本发明还可以通过将糖酶抑制剂添加到食品或医药组合物中作为延缓糖消化或吸收的活性成分，抑制餐后血糖水平升高或预防肥胖的方法来实现。

2. 发明申请

US20070202205A1 Carbohydrase Inhibitors Derived From Chestnut And Use Thereof 审中-公开
标题翻译：来自栗子的碳水化合物抑制剂及其用途
公开(公告)号：US20070202205A1
公开(公告)日：2007-08-30
申请号：US11662638
申请日：2005-09-13
申请人： Takahiro Tsujita , Takeshi Takaku
发明人： Takahiro Tsujita , Takeshi Takaku
IPC分类号： A61K36/49
CPC分类号： A61K36/49 , A23L2/52 , A23L13/426 , A23L33/105
摘要： The present invention provides a plant-derived carbohydrase inhibitor, wherein the inhibitor is effective for preventing or alleviating diabetes, or preventing obesity, and foods, drinks, and medicines containing the same. The present invention is accomplished by use of an α-amylase inhibitor or an α-glucosidase inhibitor as a carbohydrase inhibitor that is extracted from astringent skins of a chestnut using ethanol or aqueous ethanol solution. The present invention can also be accomplished by adding the carbohydrase inhibitor to a food or medical composition as an active ingredient for delaying saccharide digestion or absorption, suppressing a rise in postprandial blood glucose levels or blood insulin levels, or preventing obesity.
摘要翻译：本发明提供一种植物来源的糖酶抑制剂，其中所述抑制剂对于预防或减轻糖尿病，或预防肥胖有效，以及食品，饮料和含有该糖的酶的药物。本发明通过使用α-淀粉酶抑制剂或α-葡糖苷酶抑制剂作为使用乙醇或乙醇水溶液从栗子的收敛皮肤中提取的糖酶抑制剂来实现。本发明还可以通过将糖酶抑制剂添加到食品或医药组合物中作为延缓糖消化或吸收的活性成分，抑制餐后血糖水平升高或血胰岛素水平或预防肥胖的方法来实现。

3. 发明申请

US20080220052A1 Body weight gain inhibitor 审中-公开
标题翻译：体重增加抑制剂
公开(公告)号：US20080220052A1
公开(公告)日：2008-09-11
申请号：US12149674
申请日：2008-05-06
申请人： Takahiro Tsujita , Takeshi Takaku , Naoyuki Yoshida
发明人： Takahiro Tsujita , Takeshi Takaku , Naoyuki Yoshida
IPC分类号： A61K9/68 , A61K38/02 , A61K9/00
CPC分类号： A61K38/10 , A23G1/44 , A23G3/44 , A23G4/14 , A23L2/52 , A23L33/18 , A23P10/28 , A23P10/30 , A23V2002/00 , A61K38/16 , A23V2200/332 , A23V2250/063 , A23V2250/156 , A23V2250/70 , A23V2250/5118 , A23V2250/5108 , A23V2250/54246 , A23V2250/628
摘要： The invention provides a body weight gain inhibitor, a fat amount gain inhibitor, a medicament for prevention and/or treatment of obesity, a food composition having inhibitory effect on body weight gain and a food composition having inhibitory effect on fat amount gain, each containing ε-polylysine or a salt thereof. In another aspect of the invention, the described compositions are useful for inhibiting body weight gain, inhibiting fat amount gain and preventing and/or treating obesity.
摘要翻译：本发明提供一种体重增加抑制剂，脂肪增加抑制剂，用于预防和/或治疗肥胖症的药物，对体重增加具有抑制作用的食物组合物和对脂肪量增加具有抑制作用的食物组合物，每种含有 ε-聚赖氨酸或其盐。在本发明的另一方面，所述的组合物可用于抑制体重增加，抑制脂肪增加并预防和/或治疗肥胖症。

4. 发明申请

US20070003491A1 Body weight gain inhibitor 审中-公开
标题翻译：体重增加抑制剂
公开(公告)号：US20070003491A1
公开(公告)日：2007-01-04
申请号：US11476942
申请日：2006-06-29
申请人： Takahiro Tsujita , Takeshi Takaku , Naoyuki Yoshida
发明人： Takahiro Tsujita , Takeshi Takaku , Naoyuki Yoshida
IPC分类号： A61K38/16 , A61K38/10 , A61K9/68 , A61K47/00
CPC分类号： A61K38/10 , A23G1/44 , A23G3/44 , A23G4/14 , A23L2/52 , A23L33/18 , A23P10/28 , A23P10/30 , A23V2002/00 , A61K38/16 , A23V2200/332 , A23V2250/063 , A23V2250/156 , A23V2250/70 , A23V2250/5118 , A23V2250/5108 , A23V2250/54246 , A23V2250/628
摘要： The invention provides a body weight gain inhibitor, a fat amount gain inhibitor, a medicament for prevention and/or treatment of obesity, a food composition having inhibitory effect on body weight gain and a food composition having inhibitory effect on fat amount gain, each containing ε-polylysine or a salt thereof. In another aspect of the invention, the described compositions are useful for inhibiting body weight gain, inhibiting fat amount gain and preventing and/or treating obesity.
摘要翻译：本发明提供一种体重增加抑制剂，脂肪增加抑制剂，用于预防和/或治疗肥胖症的药物，对体重增加具有抑制作用的食物组合物和对脂肪量增加具有抑制作用的食物组合物，每种含有 ε-聚赖氨酸或其盐。在本发明的另一方面，所述的组合物可用于抑制体重增加，抑制脂肪增加并预防和/或治疗肥胖症。

5. 发明授权

US5411956A Lipolytic enzyme inhibitors 失效
标题翻译：脂解酶抑制剂
公开(公告)号：US5411956A
公开(公告)日：1995-05-02
申请号：US950773
申请日：1992-09-24
申请人： Toshiyuki Miyazaki , Hirofumi Motoi , Toshiaki Kodama , Taturo Maeda , Takahiro Tsujita , Hiromichi Okuda
发明人： Toshiyuki Miyazaki , Hirofumi Motoi , Toshiaki Kodama , Taturo Maeda , Takahiro Tsujita , Hiromichi Okuda
IPC分类号： C12N9/99 , A23K1/16 , A23L1/305 , A61K31/00 , A61K38/00 , A61P3/00 , A61P3/04 , A61P3/06 , A61P9/00 , A61P9/12 , A61P43/00 , A61K38/55 , C07K7/06
CPC分类号： A61K38/005 , A23K20/147 , A23L33/17
摘要： A lipolytic enzyme inhibitor is disclosed which comprises as an active ingredient at least one of a basic protein, a basic polypeptide and salt thereof. The inhibitor is useful as a dieting agent for the prevention of obesity and lipemia and as an additive for food and feed.
摘要翻译：公开了一种脂肪分解酶抑制剂，其包含碱性蛋白质，碱性多肽及其盐中的至少一种作为活性成分。该抑制剂可用作预防肥胖和脂肪血症的饮食剂以及作为食物和饲料的添加剂。

6. 发明授权

US5376640A Lipolytic enzyme inhibitors 失效
标题翻译：脂解酶抑制剂
公开(公告)号：US5376640A
公开(公告)日：1994-12-27
申请号：US973852
申请日：1992-11-09
申请人： Toshiyuki Miyazaki , Hirofumi Motoi , Toshiaki Kodama , Taturo Maeda , Takahiro Tsujita , Hiromichi Okuda
发明人： Toshiyuki Miyazaki , Hirofumi Motoi , Toshiaki Kodama , Taturo Maeda , Takahiro Tsujita , Hiromichi Okuda
IPC分类号： A23K1/16 , A23L1/305 , A61K38/00 , A61K37/02 , A61K37/64
CPC分类号： A61K38/005 , A23K20/147 , A23L33/17 , Y10S514/909
摘要： A method of inhibiting enzymatic hydrolysis of lipids in a mammal concerns orally administering an effective amount of a purothionin or an .epsilon.-polylysine of the formula: ##STR1## or a salt thereof, wherein n is a number of from 5 to 9, to a mammal in need thereof. Alternatively, the method concerns orally administering an .epsilon.-polylysine of the formula above or a salt thereof, wherein n is a number of from 4 to 30, to a mammal suffering from lipemia or obesity. The purothionin, .epsilon.-polylysine or salt thereof is a lipolytic enzyme inhibitor, useful as a dieting agent, an agent for the prevention of obesity and lipemia, and as an additive for food and feed.
摘要翻译：在哺乳动物中抑制脂质酶水解的方法涉及口服给予下列化学式的有效量的purothionin或ε-聚赖氨酸：其中n为5至9的数有需要的哺乳动物。或者，该方法涉及向患有脂血症或肥胖症的哺乳动物口服施用上述式ε-聚赖氨酸或其盐，其中n为4至30的数。作为止泻剂，预防肥胖和脂肪血症的药剂以及作为食品和饲料添加剂的抗氧化剂，ε-聚赖氨酸或其盐是脂解酶抑制剂。

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