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1. 发明申请

US20140328767A1 METHOD AND DEVICE FOR PRODUCING OPTIMIZED LIPID-BASED MICRO/NANO-BUBBLES 有权
标题翻译：用于生产优化的基于脂质的微孔/纳米泡沫的方法和装置
公开(公告)号：US20140328767A1
公开(公告)日：2014-11-06
申请号：US14248338
申请日：2014-04-09
申请人： Trust Bio-sonics Inc.
发明人： Chung-Hsin Wang
IPC分类号： A61K49/22 , B01F11/02 , B01F15/06 , B01F3/04
CPC分类号： A61K49/223 , A61K41/0028 , A61K49/22 , B01F3/04099 , B01F11/0266 , B01F15/06 , B01F2015/062 , B01F2215/0034 , B01F2215/0404
摘要： A method of producing lipid-based micro/nano bubbles includes steps of (a) preparing a lipid mixture including one or more first lipids with different phase transition temperature, and a second lipid bonding with a hydrophilic polymer moiety or molecules capable of getting across a lipid membrane and decreasing van der Waals forces between lipid bilayers; (b) emulsifying the lipid mixture with a solvent, to form a transparent lipid carrier solution; (c) placing the transparent lipid carrier solution in a closed vessel with halo-substituted hydrocarbon; (d) manipulating temperature of the transparent lipid carrier solution to be close to a main phase transition temperature thereof; and (e) agitating in a mechanical manner the vessel containing the transparent lipid carrier solution to form micro/nano bubbles within the closed vessel. This method contributes to form micro/nano bubbles with desired diameters in a way of optimal material utilization efficiency.
摘要翻译：制备基于脂质的微/纳米气泡的方法包括以下步骤：（a）制备包含一种或多种具有不同相变温度的第一种脂质的脂质混合物，以及与亲水性聚合物部分或能够穿过脂质膜和减少脂双层之间的范德华力; （b）用溶剂乳化脂质混合物，形成透明的脂质载体溶液; （c）将透明的脂质载体溶液置于具有卤代烃的密闭容器中; （d）将所述透明脂质载体溶液的温度控制在接近其主相变温度的温度; 和（e）以机械方式搅拌含有透明脂质载体溶液的容器，以在封闭容器内形成微/纳米气泡。该方法有助于以最佳材料利用效率的方式形成具有所需直径的微/纳米气泡。

2. 发明申请

US20210000448A1 COMPOSITION AND METHODS FOR SENSITIVE MOLECULAR ANALYSIS 有权
公开(公告)号：US20210000448A1
公开(公告)日：2021-01-07
申请号：US16980416
申请日：2019-03-13
申请人： Joshua RYCHAK , TRUST BIO-SONICS, INC.
发明人： Joshua Rychak , Shih-Tsung Kang , ChungHsin Wang
IPC分类号： A61B8/08 , A61B8/00 , A61K49/22 , G16H50/30
摘要： A method for ascertaining the presence of target-bound microbubbles in the context of ultrasound molecular imaging is taught. This method, referred to herein as dynamic scaling ultrasound molecular imaging, relies upon the time-varying behavior contrast agents within a region expressing a molecular imaging target and that within a reference region. Ultrasound contrast agents compositions that enable use of the method are also taught. The method is useful for the use of ultrasound molecular imaging in diagnosing and monitoring treatment.

3. 发明申请

US20200297874A1 METHOD AND DEVICE FOR PRODUCING OPTIMIZED LIPID-BASED MICRO/NANO-BUBBLES 审中-公开
公开(公告)号：US20200297874A1
公开(公告)日：2020-09-24
申请号：US16894794
申请日：2020-06-06
申请人： Trust Bio-sonics Inc.
发明人： Chung-Hsin Wang
IPC分类号： A61K49/22 , A61K41/00 , B01F3/04 , B01F11/02 , B01F15/06
摘要： A method of producing lipid-based micro/nano bubbles includes steps of (a) preparing a lipid mixture including one or more first lipids with different phase transition temperature, and a second lipid bonding with a hydrophilic polymer moiety or molecules capable of getting across a lipid membrane and decreasing van der Waals forces between lipid bilayers; (b) emulsifying the lipid mixture with a solvent, to form a transparent lipid carrier solution; (c) placing the transparent lipid carrier solution in a closed vessel with halo-substituted hydrocarbon; (d) manipulating temperature of the transparent lipid carrier solution to be close to a main phase transition temperature thereof; and (e) agitating in a mechanical manner the vessel containing the transparent lipid carrier solution to form micro/nano bubbles within the closed vessel. This method contributes to form micro/nano bubbles with desired diameters in a way of optimal material utilization efficiency.

4. 发明授权

US09687570B2 Method and device for producing optimized lipid-based micro/nano-bubbles 有权
公开(公告)号：US09687570B2
公开(公告)日：2017-06-27
申请号：US14248338
申请日：2014-04-09
申请人： Trust Bio-sonics Inc.
发明人： Chung-Hsin Wang
IPC分类号： A61K8/00 , A61K49/22 , A61K41/00 , B01F3/04 , B01F11/02 , B01F15/06
CPC分类号： A61K49/223 , A61K41/0028 , A61K49/22 , B01F3/04099 , B01F11/0266 , B01F15/06 , B01F2015/062 , B01F2215/0034 , B01F2215/0404
摘要： A method of producing lipid-based micro/nano bubbles includes steps of (a) preparing a lipid mixture including one or more first lipids with different phase transition temperature, and a second lipid bonding with a hydrophilic polymer moiety or molecules capable of getting across a lipid membrane and decreasing van der Waals forces between lipid bilayers; (b) emulsifying the lipid mixture with a solvent, to form a transparent lipid carrier solution; (c) placing the transparent lipid carrier solution in a closed vessel with halo-substituted hydrocarbon; (d) manipulating temperature of the transparent lipid carrier solution to be close to a main phase transition temperature thereof; and (e) agitating in a mechanical manner the vessel containing the transparent lipid carrier solution to form micro/nano bubbles within the closed vessel. This method contributes to form micro/nano bubbles with desired diameters in a way of optimal material utilization efficiency.

5. 发明申请

US20170274103A1 METHOD AND DEVICE FOR PRODUCING OPTIMIZED LIPID-BASED MICRO/NANO-BUBBLES 审中-公开
公开(公告)号：US20170274103A1
公开(公告)日：2017-09-28
申请号：US15604615
申请日：2017-05-24
申请人： TRust Bio-sonics Inc.
发明人： Chung-Hsin Wang
IPC分类号： A61K49/22 , A61K41/00 , B01F11/02 , B01F15/06 , B01F3/04
CPC分类号： A61K49/223 , A61K41/0028 , A61K49/22 , B01F3/04099 , B01F11/0266 , B01F15/06 , B01F2015/062 , B01F2215/0034 , B01F2215/0404
摘要： A method of producing lipid-based micro/nano bubbles includes steps of (a) preparing a lipid mixture including one or more first lipids with different phase transition temperature, and a second lipid bonding with a hydrophilic polymer moiety or molecules capable of getting across a lipid membrane and decreasing van der Waals forces between lipid bilayers; (b) emulsifying the lipid mixture with a solvent, to form a transparent lipid carrier solution; (c) placing the transparent lipid carrier solution in a closed vessel with halo-substituted hydrocarbon; (d) manipulating temperature of the transparent lipid carrier solution to be close to a main phase transition temperature thereof; and (e) agitating in a mechanical manner the vessel containing the transparent lipid carrier solution to form micro/nano bubbles within the closed vessel. This method contributes to form micro/nano bubbles with desired diameters in a way of optimal material utilization efficiency.

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