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1. 发明申请

US20230035578A1 CONTROLLED RELEASE OF COMPOUNDS 有权
公开(公告)号：US20230035578A1
公开(公告)日：2023-02-02
申请号：US17757536
申请日：2020-12-18
申请人： TECHNISCHE UNIVERSITAET MUENCHEN
发明人： Oliver LIELEG , Ceren KIMNA , Benjamin WINKELJANN
IPC分类号： A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
摘要： The present invention relates to a method for preparation of a functionalized surface comprising the steps: a) coating of a carrier with a least one polymer selected from a polyanionic or polycationic polymer, b) addition of at least one compound to the coated carrier of step a), c) exposing the at least one polyanionic or polycationic polymer on the coated carrier of step b) to an organic solvent, resulting in compaction of the at least one polyanionic or polycationic polymer and thereby encapsulating the at least one compound, d) reversible cross-linking of the at least one polyanionic or polycationic polymer of step c) with at least one cross-linker; e) removal of the organic solvent. Furthermore, the invention relates to a functionalized surface, a functionalized surface for use in medicine and a method for releasing a compound ex vivo.

2. 发明申请

US20220229054A1 COMBINATION OF REVERSIBLE AND IRREVERSIBLE CELL LABELING FOR ANALIZING RECEPTOR-LIGAND KOFF RATE 有权
公开(公告)号：US20220229054A1
公开(公告)日：2022-07-21
申请号：US17707726
申请日：2022-03-29
申请人： TECHNISCHE UNIVERSITAET MUENCHEN , JUNO THERAPEUTICS GMBH
发明人： Magdalena NAUERTH , Dirk BUSCH , Lothar GERMEROTH
IPC分类号： G01N33/557 , G01N33/566 , C12Q1/04 , G01N33/543 , G01N33/50 , C07K14/74 , C12N5/0783
摘要： The invention relates to a method of determining the dissociation rate constant (koff) of a receptor molecule R on a target cell using a combination of reversible and irreversible cell labeling. The invention further relates to a cell comprising such a receptor molecule R, wherein the cell has bound to it such a combination of cell labeling. The invention further relates to a kit and an apparatus useful in performing the methods of the invention. The invention further relates to a method of isolation a high-avidity T cell.

3. 发明授权

US10907140B2 Mutant beta-glucosidase variants with increased thermostability 有权
公开(公告)号：US10907140B2
公开(公告)日：2021-02-02
申请号：US15767066
申请日：2016-09-05
申请人： Technische Universitaet Muenchen
发明人： Vladimir Zverlov , Wolfgang Schwarz , Roman Prechtl , Benedikt Leis , Claudia Held , Wolfgang Liebl
IPC分类号： C12N9/42 , C12N15/86 , C12P19/14
摘要： A mutant β-glucosidase polypeptide exhibits enhanced thermostability and has the amino acid sequence: MAKFPRDFVWGTATSSYQIEGAVNEDGRTPSIWDTFSKTX1GKTYKGHT GDVACDHYHRYKEDVEILKEIGVKAYRFSIAWPRIFPEEGKYNPKGMDF YKKLIDELQKRDIX2PAATIYHWDLPQWAYDKGGGWLNRESIKWYVEYA TKLFEELGDAIPLWITHNEPWCSSILSYGIGEHAPGHKNYREALIAAHH ILLSHGEAVKAFREMNIKGSKIGITLNLTPAYPASEKEEDKLAAQYADG FANRWELDPIFKGNYPEDMMELYSKIIGEFDFIKEGDLETISVPIDFLG X3NYYTRSIVKYDEDSMLKAENVPGPGKRTEMGWEISPESLYDLLKRLD REYTKLPMYITENGAAFKDEVTEDGRVHDDERIEYIKEHLKAAAKFIGE GGNLKGYFVWSLMDNFEWAHGYSKRFGIVYVDYX4TQKRILKDSALWYK EVIX5DDGIED, wherein X1 is selected from E, P, T, M, A, S and G; X2 is selected from V, K, R and H; X3 is selected from I, L, M, P, T and A; X4 is selected from T, E, D, N, Q, M and P; and X5 is selected from L, R, K and H.

4. 发明申请

US20200062817A1 CRETION-COMPETENT MUTEINS OF THE HUMAN IL-27 ALPHA-SUBUNIT 审中-公开
公开(公告)号：US20200062817A1
公开(公告)日：2020-02-27
申请号：US16609726
申请日：2018-05-04
申请人： TECHNISCHE UNIVERSITAET MUENCHEN
发明人： Matthias FEIGE , Stephanie MUELLER
IPC分类号： C07K14/54 , A61P37/06
摘要： The present invention refers to a secretion-competent mutein of the α-subunit of human Interleukin 27 and to a human heterodimeric Interleukin 27. The present invention further refers to a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the α-subunit of human Interleukin 27 or the human heterodimeric Interleukin 27, to a host cell containing a nucleic acid molecule comprising a nucleotide sequence encoding a secretion-competent mutein of the α-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27. The invention also refers to an immune modulator comprising a secretion-competent mutein of the α-subunit of human Interleukin 27 or of the human heterodimeric Interleukin 27, to the respective use thereof as well as to a method of producing said secretion-competent muteins and to a secretion-incompetent mutein of the α-subunit of mouse Interleukin 27 and a secretion-competent mutein of the β-subunit of mouse Interleukin 27.

5. 发明申请

US20190340729A1 DEPTH SUPER-RESOLUTION FROM SHADING 审中-公开
公开(公告)号：US20190340729A1
公开(公告)日：2019-11-07
申请号：US16400584
申请日：2019-05-01
申请人： Technische Universitaet Muenchen
发明人： Bjoern HAEFNER , Yvain Quéau , Thomas Moellenhoff , Daniel Cremers
IPC分类号： G06T3/40 , G06T5/50 , G06T7/507 , G06T7/10
摘要： A method for determining a high-resolution depth map of a scene, the method comprising: obtaining a low-resolution depth map of the scene, obtaining a high-resolution image of the scene, initializing an estimated reflectance map, an estimated lighting vector and an estimated depth map, wherein the estimated depth map is in high-resolution, iteratively simultaneously updating the estimated reflectance map, the estimated lighting vector, and the estimated depth-map, wherein updating the estimated depth map is partially based on the high-resolution image, and determining the high-resolution depth map based on the iteratively updated estimated depth-map.

6. 发明申请

US20190173375A1 ELECTRONIC AMPLIFIER FOR AMPLIFYING AN INPUT SIGNAL 审中-公开
公开(公告)号：US20190173375A1
公开(公告)日：2019-06-06
申请号：US16266723
申请日：2019-02-04
申请人： TECHNISCHE UNIVERSITAET MUENCHEN
发明人： BERNHARD LEHMEYER , AMINE MEZGHANI , JOSEF NOSSEK
IPC分类号： H02M1/34 , H02M1/088 , H02M7/537 , H03F3/217
CPC分类号： H02M1/34 , H02M1/088 , H02M7/537 , H03F3/2171 , H03F3/2173
摘要： An electronic amplifier for amplifying an input signal has a branching node, a supply branch, a balance branch, an auxiliary branch and a load branch. All of the branches are connected in parallel to each other relative to the branching node and a reference potential. The supply branch supplies a DC voltage to the branching node. The balance branch absorbs and/or storing electric energy. A current supply device supplies a DC current. The control switch, the current valve and the current source are in different branches. The control switch, in a pass current state, establishes a current flow from the supply branch into either the auxiliary branch or the balance branch. In the block current state, current flows from the current supply device to the balancing device. The supply, balance and auxiliary branches provide an amplified signal to the load, controlled only by the input signal at the control switch.

7. 发明申请

US20170078134A1 METHOD FOR DEMODULATION AND DEMODULATOR 有权
标题翻译：解调和解调器的方法
公开(公告)号：US20170078134A1
公开(公告)日：2017-03-16
申请号：US15361766
申请日：2016-11-28
申请人： TECHNISCHE UNIVERSITAET MUENCHEN
发明人： Josef A. NOSSEK , Manuel STEIN , Sebastian THEILER
IPC分类号： H04L27/38 , H04B17/20 , H04B1/00 , H04B1/06
CPC分类号： H04L27/38 , H04B1/0017 , H04B1/06 , H04B17/20
摘要： A method is provided for demodulation of an analog receive signal carrying information, wherein a number of more than two analog signals is formed from the receive signal in separate channels such that the receive signal is multiplied in each case by a period function, the phase thereof respectively differing in the channels, and wherein the multiple signals are each low-pass filtered.
摘要翻译：提供了一种用于解调携带信息的模拟接收信号的方法，其中在单独信道中从接收信号形成多于两个的模拟信号的数量，使得接收信号在每种情况下被乘以周期函数，其相位分别在通道中不同，并且其中多个信号各自被低通滤波。

8. 发明申请

US20160236077A1 METHOD AND SYSTEM FOR AUTOMATIC DISTRIBUTION AND SOLUTION OF TASKS 审中-公开
标题翻译：方法和系统的自动分配和解决方案的任务
公开(公告)号：US20160236077A1
公开(公告)日：2016-08-18
申请号：US14624407
申请日：2015-02-17
申请人： Technische Universitaet Muenchen
发明人： Maximilian Baust , Christoph Hennersperger , Nassir Navab
IPC分类号： A63F13/23 , A63F13/52 , A63F13/31 , H04L29/06
CPC分类号： A63F13/23 , A63F13/31 , A63F13/52 , G06F9/5027 , H04L67/38
摘要： A method for distributing tasks includes selecting at least one interactive process according to at least one task and transferring input data related to the at least one task to at least one server associated with the at least one interactive process. The input data is to be distributed to one or more clients configured to execute entities of the at least one interactive process. The method further includes collecting, from the at least one server associated with the at least one interactive process, one or more results of processing of respective entities of the at least one interactive process based on the input data on the one or more clients, and providing output data for the at least one task based on the collected one or more results.
摘要翻译：一种用于分发任务的方法包括根据至少一个任务选择至少一个交互过程，并将与至少一个任务有关的输入数据传送给与至少一个交互过程相关联的至少一个服务器。输入数据将被分配给被配置为执行至少一个交互过程的实体的一个或多个客户端。该方法还包括从至少一个与至少一个交互过程相关联的服务器中收集基于一个或多个客户端上的输入数据的至少一个交互过程的相应实体的一个或多个处理结果，以及基于所收集的一个或多个结果为所述至少一个任务提供输出数据。

9. 发明申请

US20150041662A1 METHOD FOR DETECTING RADIATION AND EXAMINATION DEVICE FOR THE RADIATION-BASED EXAMINATION OF A SAMPLE 有权
标题翻译：用于检测放射性和检验装置的方法，用于基于辐射的检验样品
公开(公告)号：US20150041662A1
公开(公告)日：2015-02-12
申请号：US14381982
申请日：2013-02-15
申请人： Helmholtz Zentrum Muenchen Deutsches Forschungszentrum fuer Gesundheit und Umwelt(GmbH) , Technische Universitaet Muenchen
发明人： Stefan Thalhammer , Markus Hofstetter , John Howgate , Martin Stutzmann
IPC分类号： G01T1/24 , G01N23/083
CPC分类号： G01T1/24 , G01N23/083
摘要： A method for detecting radiation during the examination of a sample (1) comprises the steps of generating the radiation, more particularly X-ray radiation or proton radiation, by means of a source device (10), passing the radiation through the sample (1), and detecting the radiation by means of at least one photoelectric solid-state detector (20) containing a photoconduction section having a predetermined response threshold and a potential well section for taking up free charge carriers. The solid-state detector (20) is a GaN- or GaAs-based semiconductor detector and the potential well section contains a two-dimensional electron gas (2DEG). A setting of the radiation is provided in such a way that the solid-state detector (20) is operated separately from the response threshold of the photoconduction section and in a sensitivity range of the potential well section. An examination device (100) is also described, said examination device being configured for an examination of a sample (1) using radiation, more particularly X-ray radiation or proton radiation.
摘要翻译：在检查样品（1）期间检测辐射的方法包括以下步骤：通过源装置（10）产生辐射，更具体地说是X射线辐射或质子辐射，使辐射通过样品（1）），并且通过至少一个包含具有预定响应阈值的光电导部分的光电固态检测器（20）和用于吸收空载电荷载体的势阱部分来检测辐射。固态检测器（20）是基于GaN或GaAs的半导体检测器，势阱部分包含二维电子气（2DEG）。提供辐射的设置，使得固态检测器（20）与光电导部分的响应阈值和势阱部分的灵敏度范围分开操作。还描述了检查装置（100），所述检查装置被配置为使用辐射，特别是X射线辐射或质子辐射来检查样品（1）。

10. 发明申请

US20150023911A1 DEVICE-BASED METHODS FOR LOCALIZED DELIVERY OF CELL-FREE CARRIERS WITH STRESS-INDUCED CELLULAR FACTORS 审中-公开
标题翻译：基于设备的方法，用于通过应力诱导的细胞因子定位递送无细胞载体
公开(公告)号：US20150023911A1
公开(公告)日：2015-01-22
申请号：US14375038
申请日：2013-01-31
申请人： Technische Universitaet Muenchen-Kinikum Rechts Der Isar
发明人： Arndt Schilling , Ektoras Hadjipanayi , Hans-Guenther Machens
IPC分类号： C12N5/078 , C12M1/00 , C12M1/42 , A61K38/18 , A61K38/20
CPC分类号： C12N5/0641 , A61K35/12 , A61K38/00 , A61K38/18 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/2053 , A61L15/40 , A61L15/44 , A61L17/005 , A61L26/0057 , A61L26/0066 , A61L27/38 , A61L27/3895 , A61L27/54 , A61L31/005 , A61L31/16 , A61L2300/414 , C12M29/04 , C12M35/02 , C12M35/04 , C12M35/08 , C12N5/0634 , C12N5/0644 , C12N2500/02 , C12N2502/11 , C12N2502/1128 , C12N2502/115 , C12N2533/40 , C12N2533/54 , C12N2533/56
摘要： The present invention relates to an in vitro or ex vivo method of preparing a cell-free composition, said method comprising or consisting of (a) subjecting cells to stress; and (b) collecting factors produced, preferably secreted by said cells when subjected to said stress, thereby obtaining said cell-free composition; wherein said cells are comprised in or form at least one first carrier and said collecting is effected by means of at least one second carrier which second carrier(s) is/are cell-free and concomitantly present with and spatially distinct from said first carrier; and said collecting is effected using a device comprising or consisting of (i) said first carrier(s) which first carrier(s) comprise(s) said cells or is/are suitable to hold said cells; (ii) said second carrier(s) which is cell-free; and (iii) means of subjecting said cells in said first carrier to stress; wherein first carrier(s) and second carrier(s) are positioned such that factors secreted by said cells when subjected to stress are collected in said second carrier(s), wherein means are positioned between said first and second carrier which prevent any cells and/or pathogens present in (any of) said first carrier(s) from entering into said second carrier(s).
摘要翻译：本发明涉及一种制备无细胞组合物的体外或离体方法，所述方法包括或（a）使细胞受到应激; 和（b）收集所产生的因素，优选在受到所述应激时由所述细胞分泌，从而获得所述无细胞组合物; 其中所述细胞包含在或形成至少一个第一载体，并且所述收集通过至少一个第二载体进行，所述第二载体是无细胞的，并且与所述第一载体空间不同; 并且所述收集是使用包括或由（i）所述第一载体（第一载体）包含所述细胞或适合于保持所述细胞的装置来实现的; （ii）无细胞的所述第二载体; 和（iii）对所述第一载体中的所述细胞进行压力的装置; 其中定位第一载体和第二载体，使得当所述细胞经受应激时分泌的因子被收集在所述第二载体中，其中装置位于所述第一和第二载体之间，其防止任何细胞和存在于（任何一个）所述第一载体中的/或病原体进入所述第二载体。

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