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    • 2. 发明授权
    • Method for comparison of DNA base sequences
    • DNA碱基序列比较方法
    • US06662115B2
    • 2003-12-09
    • US09050010
    • 1998-03-30
    • Keiichi NagaiRyotaro IrieSusumu HiraokaNaoko Kasahara
    • Keiichi NagaiRyotaro IrieSusumu HiraokaNaoko Kasahara
    • G06F1900
    • G06F19/22
    • A method for comparing DNA base sequences by comparing similarities between two amino acid sequences translated from two DNA base sequences, respectively, includes (1) a step of dividing each of the first DNA base sequence and the second DNA base sequence into groups of successive three nucleotides each, translating each of these groups of nucleotides into an amino acid, and thereby obtaining a first amino acid sequence and a second amino acid sequence, and (2) a step of determining similarities between each amino acid of the first translated amino acid sequence and each amino acid of the second translated amino acid sequence in view of nucleotide insertions or deletions in the first and second DNA base sequence and amino acid insertions or deletions in the first and second translated amino acid sequence. The method is repeated by shifting the base sequences one base at a time.
    • 通过比较分别从两个DNA碱基序列翻译的两个氨基酸序列之间的相似性来比较DNA碱基序列的方法包括(1)将第一DNA碱基序列和第二DNA碱基序列中的每一个分成连续三个组的步骤 核苷酸各自将这些核苷酸组中的每一个转化成氨基酸,从而获得第一氨基酸序列和第二氨基酸序列,和(2)确定第一翻译氨基酸序列的每个氨基酸之间的相似性的步骤 考虑到第一和第二DNA碱基序列中的核苷酸插入或缺失以及第一和第二翻译氨基酸序列中的氨基酸插入或缺失,第二翻译氨基酸序列的每个氨基酸。 通过一次移位一个碱基来重复该方法。