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1. 发明授权

US09854966B2 System and method for using microsaccade dynamics to measure attentional response to a stimulus 有权
公开(公告)号：US09854966B2
公开(公告)日：2018-01-02
申请号：US14359235
申请日：2012-11-23
申请人： Jorge Otero-Millan , Stephen L. Macknik , Susana Martinez-Conde
发明人： Jorge Otero-Millan , Stephen L. Macknik , Susana Martinez-Conde
IPC分类号： A61B5/15 , A61B3/113 , A61B5/16 , A61B5/18 , A61B5/00
CPC分类号： A61B3/113 , A61B5/16 , A61B5/165 , A61B5/18 , A61B5/7246
摘要： A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.

2. 发明申请

US20160106358A1 SYSTEM AND METHOD FOR DETECTING NEUROLOGICAL DISEASE 有权
标题翻译：用于检测神经病的系统和方法
公开(公告)号：US20160106358A1
公开(公告)日：2016-04-21
申请号：US14893552
申请日：2014-04-23
申请人： Alexandre LANG , Mare VERNY , Stephen L. M. MACKNIK , Susana MARTINEZ-CONDE , Zoi KAPOULA
发明人： M. Stephen L. Macknik , Susana Martinez-Conde
IPC分类号： A61B5/00 , A61B3/00 , A61B3/113
CPC分类号： A61B5/4088 , A61B3/0025 , A61B3/0091 , A61B3/113 , A61B5/4842 , A61B5/4848
摘要： A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and infersaccatic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
摘要翻译：一种用于检测受试者的眼睛运动以用于诊断神经障碍的系统和方法。该方法包括跟踪受试者的眼睛运动，识别跟踪的眼睛运动中的微视野，以及表征所识别的微视野的微游泳动力学，以确定一个或多个参数，例如微视野方向，微风速度，微风速度，微距峰值速度 - 幅度关系，显微肌腱持续时间，以及心肌梗死时间间隔。该方法还包括将一个或多个确定的参数与相应的控制参数进行比较，评估比较以确定一个或多个确定的参数与相应的控制参数之间的差异，以及基于评估产生包括神经障碍诊断的报告。

3. 发明授权

US08721081B2 Method of detecting neurological disease 有权
标题翻译：检测神经系统疾病的方法
公开(公告)号：US08721081B2
公开(公告)日：2014-05-13
申请号：US13359828
申请日：2012-01-27
申请人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
发明人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
IPC分类号： A61B3/14 , A61B3/113
CPC分类号： A61B3/113 , A61B5/1103 , A61B5/4082 , A61B5/6821
摘要： A method and apparatus are provided for the differential diagnosis of a patient with progressive supranuclear palsy (PSP) from a patient with Parkinson's disease (PD). One method includes identifying a plurality of partially repetitive eye movements that over time define square wave jerks, each square wave jerk of the plurality of square wave jerks defined by a first horizontal saccadic movement that moves the eye away from a fixation target followed by a corrective saccadic movement towards the target shortly thereafter, measuring a vertical component associated with the plurality of square wave jerks, comparing the vertical component with a threshold value. PSP or PD is identified by comparison of the vertical component with the threshold value. In another embodiment, a patient's saccade rate is determined and compared to a threshold value, and PSP or PD is identified based upon the comparison of the saccade rate with the threshold value.
摘要翻译：提供了一种用于对来自患有帕金森病（PD）的患者的进行性核上麻痹（PSP）的患者的鉴别诊断的方法和装置。一种方法包括识别多个部分重复的眼睛运动，随着时间的推移，它们定义了方波波动，由第一水平扫视运动限定的多个方波跳动中的每个方波冲击使得眼睛远离固定目标，然后进行校正此后不久将朝着目标移动，测量与多个方波脉冲相关联的垂直分量，将垂直分量与阈值进行比较。通过垂直分量与阈值的比较来识别PSP或PD。在另一个实施例中，确定患者的扫视率并将其与阈值进行比较，并且基于扫视速率与阈值的比较来识别PSP或PD。

4. 发明申请

US20080175831A1 NEUROPROTECTION BY BLOOD FLOW STABILIZATION 审中-公开
标题翻译：通过血液流动稳定进行神经保护
公开(公告)号：US20080175831A1
公开(公告)日：2008-07-24
申请号：US11961835
申请日：2007-12-20
申请人： Stephen L. Macknik , Susana Martinez-Conde
发明人： Stephen L. Macknik , Susana Martinez-Conde
IPC分类号： A61K38/45 , A61K31/727 , A61K31/60 , A61K31/04 , A61K31/5575 , A61K31/4164 , A61K31/4375 , A61K31/19 , A61P3/10 , A61P25/28 , A61P7/02
CPC分类号： A61K31/04 , A61K31/19 , A61K31/4164 , A61K31/4375 , A61K31/5575 , A61K31/60 , A61K31/727 , A61K38/166 , A61K38/49 , A61K45/06 , A61K2300/00
摘要： A treatment is disclosed for alleviation or prevention of abnormal blood flow to various organs such as the eye, brain, kidneys, heart, feet and other tissues of organs with fine vascular networks that can lead to neurodegeneration as is seen in wet age-related macular degeneration (AMD), epilepsy and diabetes, in which an effective amount of a blood flow regulatory drug is administered to a subject in need of it. Illustrative blood flow regulatory drugs include anticoagulants and vasodilators, and their mixtures.
摘要翻译：公开了一种缓解或预防异常血液流向各种器官（如眼睛，脑部，肾脏，心脏，脚部和其他器官组织）的细小血管网络，可导致神经变性，如在湿性年龄相关性黄斑中所见退化（AMD），癫痫和糖尿病，其中向有需要的受试者施用有效量的血流调节药物。说明性血流调节药物包括抗凝血剂和血管舒张剂及其混合物。

5. 发明授权

US09763573B2 System and method for using microsaccade peak velocity as a measure of mental workload and fatigue 有权
公开(公告)号：US09763573B2
公开(公告)日：2017-09-19
申请号：US14359255
申请日：2012-11-23
申请人： Leandro Luigi Distasi , Stephen L. Macknik , Susana Martinez-Conde
发明人： Leandro Luigi Distasi , Stephen L. Macknik , Susana Martinez-Conde
IPC分类号： A61B3/113 , A61B5/00 , A61B5/16 , A61B5/18
CPC分类号： A61B3/113 , A61B5/16 , A61B5/165 , A61B5/18 , A61B5/7246
摘要： A system and method for determining a subject's level of fatigue. The method includes measuring microsaccadic eye movement dynamics of the subject, calculating a current microsaccade peak velocity from the measured microsaccadic eye movement dynamics, and comparing the current microsaccade peak velocity to a baseline microsaccade peak velocity. The method further includes determining the level of fatigue based on a difference between the current microsaccade peak velocity and the baseline microsaccade peak velocity.

6. 发明授权

US08348428B2 Method of detecting neurological disease 有权
标题翻译：检测神经系统疾病的方法
公开(公告)号：US08348428B2
公开(公告)日：2013-01-08
申请号：US12740008
申请日：2008-10-31
申请人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
发明人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
IPC分类号： A61B3/14
CPC分类号： A61B3/113 , A61B3/0091 , A61B5/4863
摘要： A method and apparatus are provided for characterizing square wave jerks in the eye movements of a person, which may provide a powerful tool in the differential diagnosis of oculomotor and neurological disease. The method includes the steps of a) providing a sequence of saccades, b) identifying pairs of consecutive saccades of the sequence, c) determining whether each saccade of each identified pair is opposite the direction of the other saccade and, if not, then discarding the pair, d) determining whether a magnitude of each saccade of each identified pair is comparable and, if not, then discarding the pair, e) determining whether the pair of saccades of each identified pair are temporally related by a predetermined time period and, if not, then discarding the pair and f) collecting any remaining pairs of saccades as square wave jerks.
摘要翻译：提供了一种用于表征人的眼睛运动中的方波脉冲的方法和装置，其可以在眼动和神经疾病的鉴别诊断中提供有力的工具。该方法包括以下步骤：a）提供一系列扫视，b）识别该序列的连续扫视对，c）确定每个识别的对的每个扫视是否与另一个扫视的方向相反，如果不是则丢弃所述对，d）确定每个识别的对的每个扫视的大小是否相当，如果不是则丢弃该对，e）确定每个识别的对的一对扫视是否在预定的时间段内暂时相关，如果没有，则丢弃该对，并且f）收集剩余的一对扫视作为方波冲击。

7. 发明授权

US07857452B2 Eye movements as a way to determine foci of covert attention 有权
标题翻译：眼睛运动是确定隐秘注意焦点的一种方式
公开(公告)号：US07857452B2
公开(公告)日：2010-12-28
申请号：US12199625
申请日：2008-08-27
申请人： Susana Martinez-Conde , Stephen L. Macknik , Jorge Otero-Millan
发明人： Susana Martinez-Conde , Stephen L. Macknik , Jorge Otero-Millan
IPC分类号： A61B3/00
CPC分类号： A61B3/113
摘要： A method and apparatus are provided for identifying the covert foci of attention of a person when viewing an image or series of images. The method includes the steps of presenting the person with an image having a plurality of visual elements, measuring eye movements of the subject with respect to those images, and based upon the measured eye movements triangulating and determining the level of covert attentional interest that the person has in the various visual elements.
摘要翻译：提供了一种方法和装置，用于在观看图像或一系列图像时识别人的注意的隐蔽焦点。该方法包括以下步骤：向人呈现具有多个视觉元素的图像，测量被摄体相对于那些图像的眼睛运动，并且基于测量的眼睛运动，三角测量和确定该人的隐蔽注意兴趣的水平有各种视觉元素。

8. 发明申请

US20150029462A1 SYSTEM AND METHOD FOR USING MICROSACCADE PEAK VELOCITY AS A MEASURE OF MENTAL WORKLOAD AND FATIGUE 有权
标题翻译：使用MICROSACCADE峰值速度作为精神工作和疲劳测量的系统和方法
公开(公告)号：US20150029462A1
公开(公告)日：2015-01-29
申请号：US14359255
申请日：2012-11-23
申请人： Leandro Luigi Distasi , Stephen L. Macknik , Susana Martinez-Conde
发明人： Leandro Luigi Distasi , Stephen L. Macknik , Susana Martinez-Conde
IPC分类号： A61B3/113 , A61B5/00 , A61B5/18
CPC分类号： A61B3/113 , A61B5/16 , A61B5/165 , A61B5/18 , A61B5/7246
摘要： A system and method for determining a subject's level of fatigue. The method includes measuring microsaccadic eye movement dynamics of the subject, calculating a current microsaccade peak velocity from the measured microsaccadic eye movement dynamics, and comparing the current microsaccade peak velocity to a baseline microsaccade peak velocity. The method further includes determining the level of fatigue based on a difference between the current microsaccade peak velocity and the baseline microsaccade peak velocity.
摘要翻译：用于确定受试者疲劳程度的系统和方法。该方法包括测量受试者的微型眼动作动力学，根据测量的微型眼动态动力学计算当前的微足迹峰值速度，并将当前的微潮流峰值速度与基线微潮流峰值速度进行比较。该方法还包括基于当前微消息峰值速度和基线微潮流峰值速度之间的差异来确定疲劳程度。

9. 发明申请

US20120238903A1 Method of Detecting Neurological Disease 有权
标题翻译：检测神经病的方法
公开(公告)号：US20120238903A1
公开(公告)日：2012-09-20
申请号：US13359828
申请日：2012-01-27
申请人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
发明人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
IPC分类号： A61B3/113
CPC分类号： A61B3/113 , A61B5/1103 , A61B5/4082 , A61B5/6821
摘要： A method and apparatus are provided for the differential diagnosis of a patient with progressive supranuclear palsy (PSP) from a patient with Parkinson's disease (PD). One method includes identifying a plurality of partially repetitive eye movements that over time define square wave jerks, each square wave jerk of the plurality of square wave jerks defined by a first horizontal saccadic movement that moves the eye away from a fixation target followed by a corrective saccadic movement towards the target shortly thereafter, measuring a vertical component associated with the plurality of square wave jerks, comparing the vertical component with a threshold value. PSP or PD is identified by comparison of the vertical component with the threshold value. In another embodiment, a patient's saccade rate is determined and compared to a threshold value, and PSP or PD is identified based upon the comparison of the saccade rate with the threshold value.
摘要翻译：提供了一种用于对来自患有帕金森病（PD）的患者的进行性核上麻痹（PSP）的患者的鉴别诊断的方法和装置。一种方法包括识别多个部分重复的眼睛运动，随着时间的推移，它们定义了方波波动，由第一水平扫视运动限定的多个方波跳动中的每个方波冲击使得眼睛远离固定目标，然后进行校正此后不久将朝着目标移动，测量与多个方波脉冲相关联的垂直分量，将垂直分量与阈值进行比较。通过垂直分量与阈值的比较来识别PSP或PD。在另一个实施例中，确定患者的扫视率并将其与阈值进行比较，并且基于扫视速率与阈值的比较来识别PSP或PD。

10. 发明申请

US20100277693A1 METHOD OF DETECTING NEUROLOGICAL DISEASE 有权
标题翻译：检测神经病的方法
公开(公告)号：US20100277693A1
公开(公告)日：2010-11-04
申请号：US12740008
申请日：2008-10-31
申请人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
发明人： Susana Martinez-Conde , Stephen L. Macknik , Xoana Troncoso , Jorge Otero-Millan
IPC分类号： A61B3/113
CPC分类号： A61B3/113 , A61B3/0091 , A61B5/4863
摘要： A method and apparatus are provided for characterizing square wave jerks in the eye movements of a person, which may provide a powerful tool in the differential diagnosis of oculomotor and neurological disease. The method includes the steps of a) providing a sequence of saccades, b) identifying pairs of consecutive saccades of the sequence, c) determining whether each saccade of each identified pair is opposite the direction of the other saccade and, if not, then discarding the pair, d) determining whether a magnitude of each saccade of each identified pair is comparable and, if not, then discarding the pair, e) determining whether the pair of saccades of each identified pair are temporally related by a predetermined time period and, if not, then discarding the pair and f) collecting any remaining pairs of saccades as square wave jerks.
摘要翻译：提供了一种用于表征人的眼睛运动中的方波脉冲的方法和装置，其可以在眼动和神经疾病的鉴别诊断中提供有力的工具。该方法包括以下步骤：a）提供一系列扫视，b）识别该序列的连续扫视对，c）确定每个识别的对的每个扫视是否与另一个扫视的方向相反，如果不是则丢弃所述对，d）确定每个识别的对的每个扫视的大小是否相当，如果不是则丢弃该对，e）确定每个识别的对的一对扫视是否在预定的时间段内暂时相关，如果没有，则丢弃该对，并且f）收集剩余的一对扫视作为方波冲击。

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