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1. 发明申请

US20050272162A1 Functional assay of high-density lipoprotein 失效
标题翻译：高密度脂蛋白的功能测定
公开(公告)号：US20050272162A1
公开(公告)日：2005-12-08
申请号：US11053123
申请日：2005-02-07
申请人： Alan Fogelman , Mohamad Navab , Susan Hama
发明人： Alan Fogelman , Mohamad Navab , Susan Hama
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N2800/044 , Y10T436/24
摘要： This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g., lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the inflammatory response associated with and characteristic of atherosclerotic plaque formation. Moreover it was a discovery of this invention that individuals vary in the ability of their HDL to afford such protection. Thus an assay of HDL protective and/or repair activity provides a highly effective assay for risk of atherosclerosis and its associated pathologies and such assays are provided herein.
摘要翻译：本发明提供对动脉粥样硬化或动脉粥样硬化风险的预后和/或诊断的新型测定。已经发现，高密度脂蛋白（HDL）或其组分可以防止脂质（例如LDL中存在的脂质）的氧化，并且还可以修复（减少）已经氧化的脂质，从而减少与动脉粥样硬化斑块相关的特征和炎症反应形成。此外，本发明的发现是，个体HDL提供这种保护的能力各不相同。因此，HDL保护和/或修复活性的测定提供了对动脉粥样硬化及其相关病理学的风险的高效测定，并且本文提供了此类测定。

2. 发明授权

US06596544B1 Functional assay of high-density lipoprotein 失效
标题翻译：高密度脂蛋白的功能测定
公开(公告)号：US06596544B1
公开(公告)日：2003-07-22
申请号：US09541468
申请日：2000-03-31
申请人： Alan M. Fogelman , Mohamad Navab , Susan Hama
发明人： Alan M. Fogelman , Mohamad Navab , Susan Hama
IPC分类号： G01N3392
CPC分类号： G01N33/573 , A61K48/00 , C12Q1/42 , G01N33/92 , G01N2500/10 , G01N2800/044 , Y10T436/24
摘要： This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g. lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the inflammatory response associated with and characteristic of atherosclerotic plaque formation. Moreover it was a discovery of this invention that individuals vary in the ability of their HDL to afford such protection. Thus an assay of HDL protective and/or repair activity provides a highly effective assay for risk of atherosclerosis and its associated pathologies and such assays are provided herein.
摘要翻译：本发明提供对动脉粥样硬化或动脉粥样硬化风险的预后和/或诊断的新型测定。发现高密度脂蛋白（HDL）或其组分可以防止脂质（例如存在于LDL中的脂质）的氧化，并且还可以修复（减少）已经氧化的脂质，从而减少与动脉粥样硬化斑块形成相关的特征和炎性反应。此外，本发明的发现是，个体HDL提供这种保护的能力各不相同。因此，HDL保护和/或修复活性的测定提供了对动脉粥样硬化及其相关病理学的风险的高效测定，并且本文提供了此类测定。

3. 发明授权

US07250304B2 Functional assay of high-density lipoprotein 失效
标题翻译：高密度脂蛋白的功能测定
公开(公告)号：US07250304B2
公开(公告)日：2007-07-31
申请号：US11053123
申请日：2005-02-07
申请人： Alan M Fogelman , Mohamad Navab , Susan Hama
发明人： Alan M Fogelman , Mohamad Navab , Susan Hama
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N2800/044 , Y10T436/24
摘要： This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g., lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the inflammatory response associated with and characteristic of atherosclerotic plaque formation. Moreover it was a discovery of this invention that individuals vary in the ability of their HDL to afford such protection. Thus an assay of HDL protective and/or repair activity provides a highly effective assay for risk of atherosclerosis and its associated pathologies and such assays are provided herein.
摘要翻译：本发明提供对动脉粥样硬化或动脉粥样硬化风险的预后和/或诊断的新型测定。已经发现，高密度脂蛋白（HDL）或其组分可以防止脂质（例如LDL中存在的脂质）的氧化，并且还可以修复（减少）已经氧化的脂质，从而减少与动脉粥样硬化斑块相关的特征和炎症反应形成。此外，本发明的发现是，个体HDL提供这种保护的能力各不相同。因此，HDL保护和/或修复活性的测定提供了对动脉粥样硬化及其相关病理学的风险的高效测定，并且本文提供了此类测定。

4. 发明授权

US06869568B2 Functional assay of high-density lipoprotein 失效
标题翻译：高密度脂蛋白的功能测定
公开(公告)号：US06869568B2
公开(公告)日：2005-03-22
申请号：US10455243
申请日：2003-06-05
申请人： Alan M. Fogelman , Mohamad Navab , Susan Hama
发明人： Alan M. Fogelman , Mohamad Navab , Susan Hama
IPC分类号： A61K48/00 , C12Q1/42 , G01N33/573 , G01N33/92 , G01N21/77
CPC分类号： G01N33/573 , A61K48/00 , C12Q1/42 , G01N33/92 , G01N2500/10 , G01N2800/044 , Y10T436/24
摘要： This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g. lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the inflammatory response associated with and characteristic of atherosclerotic plaque formation. Moreover it was a discovery of this invention that individuals vary in the ability of their HDL to afford such protection. Thus an assay of HDL protective and/or repair activity provides a highly effective assay for risk of atherosclerosis and its associated pathologies and such assays are provided herein.
摘要翻译：本发明提供对动脉粥样硬化或动脉粥样硬化风险的预后和/或诊断的新型测定。发现高密度脂蛋白（HDL）或其组分可以防止脂质（例如存在于LDL中的脂质）的氧化，并且还可以修复（减少）已经氧化的脂质，从而减少与动脉粥样硬化斑块形成相关的特征和炎性反应。此外，本发明的发现是，个体HDL提供这种保护的能力各不相同。因此，HDL保护和/或修复活性的测定提供了对动脉粥样硬化及其相关病理学的风险的高效测定，并且本文提供了此类测定。

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