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1. 发明授权

US11529440B2 Delivery of hydrophobic active agent particles 有权
公开(公告)号：US11529440B2
公开(公告)日：2022-12-20
申请号：US16847272
申请日：2020-04-13
申请人： Surmodics, Inc.
发明人： Joram Slager , Toni M. Heyer , David E. Babcock
IPC分类号： A61L29/08 , A61L29/16 , A61L29/14 , A61K31/337 , A61K31/713 , A61K47/34 , A61M25/10 , C12N15/113 , A61K9/50
摘要： Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, the invention includes a drug delivery coating including a polymeric layer. The polymeric layer can include a hydrophilic outer surface. The coating can also include a matrix contacting the hydrophilic outer surface. The matrix can include a particulate hydrophobic therapeutic agent and a cationic agent. The polymeric layer can further include a hydrophilic polymer having pendent photoreactive groups and a photo-crosslinker including two aryl ketone functionalities. Other embodiments are also included herein.

2. 发明申请

US20220219194A1 COATING APPLICATION SYSTEM AND METHODS FOR COATING ROTATABLE MEDICAL DEVICES 有权
公开(公告)号：US20220219194A1
公开(公告)日：2022-07-14
申请号：US17571095
申请日：2022-01-07
申请人： Surmodics, Inc.
发明人： Ralph A. Chappa
IPC分类号： B05D1/00 , A61L29/16 , A61L31/16 , A61M25/10
摘要： Embodiments herein relate to a system for coating rotatable medical devices and related methods. In an embodiment, a coating system for coating rotatable medical devices is included. The coating system can include a rotation mechanism, wherein the rotation mechanism is configured to mount and rotate a rotatable medical device. The coating system can also include a fluid applicator unit. The fluid applicator unit can include a rotating retention sleeve, the rotating retention sleeve defining a channel, wherein the rotatable medical device fits within the channel. The fluid applicator unit can also include a retention sleeve drive mechanism, wherein the retention sleeve drive mechanism is configured to rotate the rotating retention sleeve. The coating system can also include an inner collar, wherein the inner collar fits within the channel of the rotating retention sleeve. Other embodiments are also included herein.

3. 发明申请

US20220211917A1 LUBRICIOUS COATING FOR MEDICAL DEVICE 有权
公开(公告)号：US20220211917A1
公开(公告)日：2022-07-07
申请号：US17700212
申请日：2022-03-21
申请人： Surmodics, Inc.
发明人： Mike Militello
IPC分类号： A61L29/08 , A61L29/14
摘要： Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including an acrylic acid polymer, an acrylamide copolymer comprising at least one photoreactive group, and a cross-linking agent comprising at least two photoreactive groups. The coating can be used on a catheter surface to facilitate its movement in the body.

4. 发明申请

US20210330343A1 SYSTEMS, DEVICES AND METHODS FOR CONTROLLED VESSEL LESION DISSECTION 有权
公开(公告)号：US20210330343A1
公开(公告)日：2021-10-28
申请号：US16483370
申请日：2019-06-05
申请人： SURMODICS, INC.
发明人： David Meerkin , Raphael BENARY , Yoav SHAKED
IPC分类号： A61B17/3207 , A61B17/221
摘要： Systems, devices and methods for treating a stenosed vessel or heart valve are disclosed. In some embodiments, a cutting/scoring assembly/device for treating a stenosed vessel/heart valve is provided and includes a main, elongated scoring sleeve or element with multiple longitude wires arranged at a distal end. A distal end of the elongated element is proximal to the multiple longitude wires which, when used in conjunction with a balloon catheter, is used to for, according to some embodiments, localized controlled longitudinal vessel incision.

5. 发明申请

US20210260255A1 LOW PARTICULATE LUBRICIOUS COATING WITH VINYL PYRROLIDONE AND ACIDIC POLYMER-CONTAINING LAYERS 有权
公开(公告)号：US20210260255A1
公开(公告)日：2021-08-26
申请号：US17316244
申请日：2021-05-10
申请人： Surmodics, Inc.
发明人： David E. Babcock , Timothy M. Kloke , Joseph S. McGonigle
IPC分类号： A61L29/14 , A61L29/08 , C10M169/04 , C10M107/42 , A61L29/04 , C10M107/48 , C10M177/00 , C10M107/46 , C10M107/50 , B05D7/00 , C10M107/28 , C10M135/36
摘要： Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 μm or greater) which is very desirable for in vivo use.

6. 发明授权

US11000632B2 Low particulate lubricious coating with vinyl pyrrolidone and acidic polymer-containing layers 有权
公开(公告)号：US11000632B2
公开(公告)日：2021-05-11
申请号：US14148339
申请日：2014-01-06
申请人： SurModics, Inc.
发明人： David E. Babcock , Timothy M. Kloke , Joseph S. McGonigle
IPC分类号： A61L29/14 , A61L29/08 , C10M169/04 , C10M107/42 , A61L29/04 , C10M107/48 , C10M177/00 , C10M107/46 , C10M107/50 , B05D7/00 , C10M107/28 , C10M135/36 , C10N20/00 , C10N50/00
摘要： Embodiments of the disclosure include lubricious coatings. In an embodiment the disclosure includes a lubricious coating for a medical device including first and second coated layers. The first coated layer is between the second coated layer and the device surface and includes a vinyl pyrrolidone polymer and a photo reactive group. The second coated layer is in direct contact with the first coated layer and is a top coating that includes an acrylic acid polymer. The second coated layer can optionally include photoreactive groups. The coating was found to have a very low number of particulates (e.g., 10 μm or greater) which is very desirable for in vivo use.

7. 发明授权

US10758719B2 Low-friction sealing devices 有权
公开(公告)号：US10758719B2
公开(公告)日：2020-09-01
申请号：US15838677
申请日：2017-12-12
申请人： Surmodics, Inc.
发明人： Charles Olson
IPC分类号： A61M39/06 , A61B17/34 , A61M39/00
摘要： Aspects herein relate to a low-friction septum for providing a leak-resistant seal for use in a vascular access device. In an embodiment, a device for vascular access hemostasis is included having an enclosure defining a cavity and configured to at least partially receive a medical device. The device can include a first seal portion and a second seal portion, the cavity disposed between the first seal portion and the second seal portion. The device can include a barrel in structural communication with the second seal portion, the second seal portion including a septum seal. The second seal portion can define two or more discrete portions, each separated by one or more split lines. The discrete portions can include a mating surface to interface with mating surfaces of other discrete portions. The mating surface can include a surface topology including raised portions and depressions. Other embodiments are also included herein.

8. 发明授权

US10524809B2 Insertable medical device system with plaque treatment portion and methods of using 有权
公开(公告)号：US10524809B2
公开(公告)日：2020-01-07
申请号：US15053526
申请日：2016-02-25
申请人： SurModics, Inc.
发明人： Charlie Olson
IPC分类号： A61B17/22 , A61B17/3207 , A61M25/10 , A61B17/32 , A61B17/00
摘要： The disclosure provides plaque treatment catheter assemblies for the treatment of arterial plaques and removal of clots. One assembly includes a second catheter tube movable within a first catheter tube, and an expansion member movable within the second tube. The second catheter tube has one or more distally-disposed and outwardly-expandable plaque treatment portion(s). Another assembly includes a catheter tube and at least one channel(s) within the catheter. The channel includes an elongate member with a distally-disposed plaque scoring or clot retrieval member. Optionally, the assembly includes an expandable member that can cause movement of the scoring member.

9. 发明授权

US10478201B2 Insertable medical device system with plaque treatment portion and methods of using 有权
公开(公告)号：US10478201B2
公开(公告)日：2019-11-19
申请号：US15053526
申请日：2016-02-25
申请人： SurModics, Inc.
发明人： Charlie Olson
IPC分类号： A61B17/22 , A61B17/3207 , A61M25/10 , A61B17/32 , A61B17/00
摘要： The disclosure provides plaque treatment catheter assemblies for the treatment of arterial plaques and removal of clots. One assembly includes a second catheter tube movable within a first catheter tube, and an expansion member movable within the second tube. The second catheter tube has one or more distally-disposed and outwardly-expandable plaque treatment portion(s). Another assembly includes a catheter tube and at least one channel(s) within the catheter. The channel includes an elongate member with a distally-disposed plaque scoring or clot retrieval member. Optionally, the assembly includes an expandable member that can cause movement of the scoring member.

10. 发明申请

US20190275209A1 ARTICLE COATINGS INCLUDING OLIGOMERIZED POLYPHENOL LAYER AND BIOLOGICAL METHODS OF USE 审中-公开
公开(公告)号：US20190275209A1
公开(公告)日：2019-09-12
申请号：US16272808
申请日：2019-02-11
申请人： Surmodics, Inc.
发明人： David E. Babcock , Sean Lundquist , Gary Opperman , Adriyn Torguson , Tim Jentz
IPC分类号： A61L29/08 , A61L27/34 , A61L29/06 , A61K31/7024 , G01N33/543 , A61L29/16
摘要： Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

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