专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090292002A1 NUCLEOTIDE AND AMINO ACID SEQUENCES RELATING TO RESPIRATORY DISEASES AND OBESITY 失效
标题翻译：与呼吸道疾病和肥胖相关的核酸和氨基酸序列
公开(公告)号：US20090292002A1
公开(公告)日：2009-11-26
申请号：US11690650
申请日：2007-03-23
申请人： TIM KEITH , Randall D. Little , Paul Van Eerdewegh , Josee Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： TIM KEITH , Randall D. Little , Paul Van Eerdewegh , Josee Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： A61K31/70 , A61P43/00 , C07H21/00 , C07H21/04 , C12N1/00 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/02 , C12Q1/68 , A61K48/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译：本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。还涉及调节所公开的基因或基因产物的活性的配体。此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

2. 发明申请

US20070009437A1 Intracellular trapping of radionuclides by enzyme-mediated reduction 审中-公开
标题翻译：通过酶介导的还原对细胞内捕获放射性核素
公开(公告)号：US20070009437A1
公开(公告)日：2007-01-11
申请号：US11390965
申请日：2006-03-28
申请人： Fangyu Peng , King Li , Sunil Pandit
发明人： Fangyu Peng , King Li , Sunil Pandit
IPC分类号： A61K51/00 , C12Q1/68
CPC分类号： C12N9/0067 , A61K48/005 , A61K51/025
摘要： Enzyme-mediated intracellular trapping of a radionuclide in a target cell is achieved by transfecting the target cell with a transgenic vector encoding a microbial hydrogenase expressible in the target cell and exposing the transfected target cell with a radionuclide. The transgenically expressed microbial hydrogenase catalyzes the reduction of the radionuclide. The reduced radionuclide becomes trapped intracellularly where its emissions can be detected in radioscintigraphy applications. In addition, emissions from an intracellularly trapped radionuclide can be cytotoxic to the cell and therefore useful in radiotherapy applications. As a reporter, a microbial hydrogenase encoding nucleic acid can be included in a vector along with a transgene, both under the control of the same promoter. The detection of emissions from intracellularly reduced and trapped radionuclide can be used to monitor transgene expression.
摘要翻译：通过用编码在靶细胞中可表达的微生物氢化酶的转基因载体转染靶细胞并用放射性核素暴露转染的靶细胞，实现靶细胞中放射性核素的酶介导的细胞内捕获。转基因表达的微生物氢化酶催化还原放射性核素。减少的放射性核素在细胞内被捕获，其中可以在放射线印迹应用中检测其排放。此外，来自细胞内捕获的放射性核素的排放物可能对细胞具有细胞毒性，因此可用于放射治疗应用。作为报告者，编码微生物氢化酶的核酸可以与转基因一起包含在载体中，两者都在同一启动子的控制下。检测来自细胞内减少和捕获的放射性核素的排放物可用于监测转基因表达。

3. 发明授权

US09528163B2 Reagents and methods for detecting HCV 有权
标题翻译：检测HCV的试剂和方法
公开(公告)号：US09528163B2
公开(公告)日：2016-12-27
申请号：US14127224
申请日：2012-06-20
申请人： Arejas Uzgiris , Sunil Pandit , Lance Palmer
发明人： Arejas Uzgiris , Sunil Pandit , Lance Palmer
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707
摘要： The present disclosure relates to oligonucleotide sequences for amplification primers and their use in performing nucleic acid amplifications of HCV, in particular regions that encode the NS3 polypeptide. In some embodiments the primers are used in nested PCR methods for the detection or sequencing of HCV NS3. The oligonucleotide sequences are also provided assembled as kits that can be used to amplify and detect or sequence HCV NS3.
摘要翻译：本公开涉及用于扩增引物的寡核苷酸序列及其在进行HCV的核酸扩增，特别是编码NS3多肽的区域中的用途。在一些实施方案中，引物用于巢式PCR方法用于HCV NS3的检测或测序。还提供寡核苷酸序列作为可用于扩增和检测或序列HCV NS3的试剂盒组装。

4. 发明授权

US07501118B2 Human gene relating to respiratory diseases and obesity 失效
标题翻译：与呼吸系统疾病和肥胖相关的人类基因
公开(公告)号：US07501118B2
公开(公告)日：2009-03-10
申请号：US10670184
申请日：2003-09-24
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josée Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josée Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： A61K39/395 , A61K39/44 , C07K16/18 , C07K17/00
CPC分类号： C12N9/6489 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q1/6883 , C12Q2600/156
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译：本发明涉及包含人染色体20p13-p12的基因和由这些基因编码的蛋白质的分离的核酸。包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

5. 发明授权

US07205146B1 Nucleotide and amino acid sequences relating to respiratory diseases and obesity 失效
标题翻译：与呼吸系统疾病和肥胖相关的核苷酸和氨基酸序列
公开(公告)号：US07205146B1
公开(公告)日：2007-04-17
申请号：US10021698
申请日：2001-10-22
申请人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： C12N5/10 , C12N15/70 , C12N1/20 , C12N1/00 , C07H21/04
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译：本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。还涉及调节所公开的基因或基因产物的活性的配体。此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。

6. 发明授权

US06737519B1 Human genes relating to respiratory diseases and obesity 失效
标题翻译：与呼吸系统疾病和肥胖相关的人类基因
公开(公告)号：US06737519B1
公开(公告)日：2004-05-18
申请号：US09627465
申请日：2000-07-28
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： C07H2104
CPC分类号： C07K16/18 , C07K14/47 , C07K2317/24
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译：本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

7. 发明授权

US06683165B1 Human gene relating to respiratory diseases and obesity 失效
标题翻译：与呼吸系统疾病和肥胖相关的人类基因
公开(公告)号：US06683165B1
公开(公告)日：2004-01-27
申请号：US09548797
申请日：2000-04-13
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josée Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josée Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： C07H1900
CPC分类号： C12N9/6489 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q1/6883 , C12Q2600/156
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 20p13-p12 and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译：本发明涉及包含人染色体20p13-p12的基因和由这些基因编码的蛋白质的分离的核酸。包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

8. 发明申请

US20140134605A1 Reagents and methods for detecting HCV 有权
标题翻译：检测HCV的试剂和方法
公开(公告)号：US20140134605A1
公开(公告)日：2014-05-15
申请号：US14127224
申请日：2012-06-20
申请人： Arejas Uzgiris , Sunil Pandit , Lance Palmer
发明人： Arejas Uzgiris , Sunil Pandit , Lance Palmer
IPC分类号： C12Q1/70
CPC分类号： C12Q1/707
摘要： The present disclosure relates to oligonucleotide sequences for amplification primers and their use in performing nucleic acid amplifications of HCV, in particular regions that encode the NS3 polypeptide. In some embodiments the primers are used in nested PCR methods for the detection or sequencing of HCV NS3. The oligonucleotide sequences are also provided assembled as kits that can be used to amplify and detect or sequence HCV NS3.
摘要翻译：本公开涉及用于扩增引物的寡核苷酸序列及其在进行HCV的核酸扩增，特别是编码NS3多肽的区域中的用途。在一些实施方案中，引物用于巢式PCR方法用于HCV NS3的检测或测序。还提供寡核苷酸序列作为可用于扩增和检测或序列HCV NS3的试剂盒组装。

9. 发明申请

US20130039914A1 NOVEL HUMAN GENES RELATING TO RESPIRATORY DISEASES AND OBESITY 审中-公开
公开(公告)号：US20130039914A1
公开(公告)日：2013-02-14
申请号：US13405525
申请日：2012-02-27
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： A61K39/395 , A61P11/06 , C07K16/46 , C07K16/18 , C07K17/00
CPC分类号： C07K16/18 , C07K14/47 , C07K2317/24
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.

10. 发明授权

US07928200B1 Human genes relating to respiratory diseases and obesity 失效
标题翻译：与呼吸系统疾病和肥胖相关的人类基因
公开(公告)号：US07928200B1
公开(公告)日：2011-04-19
申请号：US12180184
申请日：2008-07-25
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , C07K14/47 , C07K2317/24
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译：本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式