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1. 发明申请

US20100105916A1 Processes for Preparing Donepezil 审中-公开
标题翻译：制备多奈哌齐的方法
公开(公告)号：US20100105916A1
公开(公告)日：2010-04-29
申请号：US12428677
申请日：2009-04-23
申请人： Raju Mahadev Kharatkar , Sachin Vinayakrao Pande , Nilesh Liladhar Bonde , Godfree Pavalu Fernandes , Sugata Chatterjee
发明人： Raju Mahadev Kharatkar , Sachin Vinayakrao Pande , Nilesh Liladhar Bonde , Godfree Pavalu Fernandes , Sugata Chatterjee
IPC分类号： C07D211/06
CPC分类号： C07D211/32
摘要： A process for preparing highly pure donepezil, particularly donepezil hydrochloride, is provided comprising hydrogenating compound 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methyl-piperidine or its hydrochloride salt with a noble metal catalyst or a derivative thereof, in the presence of at least one additive, wherein the additive contains at least one heteroatom, e.g., a sulfur, phosphorous, or nitrogen heteroatom.
摘要翻译：提供了制备高纯度多奈哌齐，特别是盐酸多奈哌齐的方法，其包括将贵金属氢化化合物1-苄基-4 - [（5,6-二甲氧基-1-茚满酮）-2-亚基]甲基 - 哌啶或其盐酸盐金属催化剂或其衍生物，在至少一种添加剂的存在下，其中所述添加剂含有至少一个杂原子，例如硫，磷或氮杂原子。

2. 发明授权

US5114967A Antibiotic alisamycin and its use 失效
标题翻译：抗生素ALISAMYCIN及其用途
公开(公告)号：US5114967A
公开(公告)日：1992-05-19
申请号：US639343
申请日：1991-01-10
申请人： Christopher M. M. Franco , Erra K. S. Vijayakumar , Sugata Chatterjee , Bimal N. Ganguli , Jurgen Blumbach , Herbert Kogler , Hans-Wolfram Fehlhaber
发明人： Christopher M. M. Franco , Erra K. S. Vijayakumar , Sugata Chatterjee , Bimal N. Ganguli , Jurgen Blumbach , Herbert Kogler , Hans-Wolfram Fehlhaber
IPC分类号： A61K31/335 , A61K31/336 , A61P31/04 , A61P33/10 , A61P35/00 , C07D303/32 , C07D303/46 , C12P17/02 , C12R1/465
CPC分类号： C12R1/04 , C07D303/46 , C12P17/02
摘要： Alisamycin, a compound of the formula I ##STR1## has an antibiotic, antitumor and antiparasitic action.

3. 发明授权

US5112806A Antibiotic, mersacidin, a process for the preparation thereof and the use thereof as a pharmaceutical 失效
标题翻译：抗生素，MERSACIDIN，其制备方法及其作为药物的用途
公开(公告)号：US5112806A
公开(公告)日：1992-05-12
申请号：US393953
申请日：1989-08-15
申请人： Sukumar Chatterjee , Sugata Chatterjee , Bimal N. Ganguli , Deepak K. Chatterjee , Rajendra K. H. Jani , Richard H. Rupp , Hans-Wolfram Fehlhaber , Herbert Kogler , Gerhard Seibert , Volker Teetz
发明人： Sukumar Chatterjee , Sugata Chatterjee , Bimal N. Ganguli , Deepak K. Chatterjee , Rajendra K. H. Jani , Richard H. Rupp , Hans-Wolfram Fehlhaber , Herbert Kogler , Gerhard Seibert , Volker Teetz
IPC分类号： C12N1/20 , A61K38/00 , A61P31/04 , C07K7/08 , C07K7/56 , C07K14/195 , C07K14/41 , C12P21/02 , C12P21/04 , C12R1/01 , C12R1/07
CPC分类号： C12P21/02 , C07K7/56 , A61K38/00 , Y10S435/832 , Y10S930/19
摘要： Mersacidin, a cyclic peptide of the formula I ##STR1## has antibiotic activity.
摘要翻译：梅沙替灵，式I的环肽具有抗生素活性，（I）具有抗生素活性。

4. 发明授权

US4988677A Macrolide antibiotic and its use as a medicinal agent 失效
标题翻译：大环内酯抗生素及其作为药剂的用途
公开(公告)号：US4988677A
公开(公告)日：1991-01-29
申请号：US89238
申请日：1987-08-25
申请人： Christopher M. M. Franco , Julia Gandhi , Sugata Chatterjee , Goukanapalli C. S. Reddy , Bimal N. Ganguli , Richard H. Rupp , Herbert Kogler , Hans-Wolfram Fehlhaber
发明人： Christopher M. M. Franco , Julia Gandhi , Sugata Chatterjee , Goukanapalli C. S. Reddy , Bimal N. Ganguli , Richard H. Rupp , Herbert Kogler , Hans-Wolfram Fehlhaber
IPC分类号： A61K31/70 , C07H15/26 , C07H17/08 , C12P19/58 , C12P19/62 , C12R1/465
CPC分类号： C07H17/08 , C12P19/62 , C12R1/465
摘要： The present invention relates to the macrolide antibiotic swalpamycin, to a microbiological process for its preparation, to a new microorganism strain Streptomyces species, and to the use of swalpamycin as a medicinal agent for the treatment of infections caused by bacteria, mycoplasmas and Actinomycetes.
摘要翻译：本发明涉及大环内酯类抗生素swalpamycin，其制备微生物方法，新型微生物链霉菌属物种，以及使用吐温霉素作为治疗由细菌，支原体和放线菌引起的感染的药剂。

5. 发明申请

US20110282074A1 Process for Preparing Substantially Pure Simvastatin 审中-公开
标题翻译：准备基本纯辛伐他汀的方法
公开(公告)号：US20110282074A1
公开(公告)日：2011-11-17
申请号：US12832263
申请日：2010-07-08
申请人： Sugata Chatterjee , Ajay Singh Rawat , Neeraj Kumar , Jetti Rajanikanth , Kundan Singh Shekhawat , Jigar H. Shah , P. Venkateswarlu
发明人： Sugata Chatterjee , Ajay Singh Rawat , Neeraj Kumar , Jetti Rajanikanth , Kundan Singh Shekhawat , Jigar H. Shah , P. Venkateswarlu
IPC分类号： C07D309/30
CPC分类号： C07D309/30 , Y02P20/55
摘要： This invention relates to an improved process for preparing substantially pure simvastatin (I), chemically known as (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2-H-pyran-2-yl]ethyl]-3 ,7-dimeth-yl-1,2,3,7,8,8a-Hexahydronaphthalen-1-yl2,2-dimethyl butanoate, which comprises of: a) treating lovastatin (II) with an alkali metal hydroxide in a chosen suitable alcoholic solvent followed by relactonization to obtain the diol lactone intermediate (III) in a single vessel. b) selective silylation of 4-hydroxy group of diol lactone intermediate (III) with a chosen suitable silylating reagent to obtain mono silylated intermediate diol lactone (IV). c) acylation of the mono silylated intermediate (IV) to form silylated simvastatin (V) Or optionally, preparing silylated simvastatin (V) starting from Lovastatin (II) without isolating diol lactone (III) and monosilylated diol lactone (IV) and d) finally, removal of the silyl protecting group on silylated simvastatin (V) followed by purification to provide substantially pure simvastatin (I).
摘要翻译：本发明涉及用于制备基本上纯的辛伐他汀（I）的改进方法，其化学方法称为（1S，3R，7S，8S，8aR）-8- [2 - [（2R，4R）-4-羟基-6-氧代四氢 -2-H-吡喃-2-基]乙基] -3,7-二甲基-1,2,3,7,8,8a-六氢萘-1-基2,2,2-二甲基丁酸酯，其包含：a ）用碱金属氢氧化物在选择的合适的醇溶剂中治疗洛伐他汀（II），然后进行重组，以在单个容器中获得二醇内酯中间体（III）。 b）用选择的合适的甲硅烷基化试剂选择甲硅烷基化二醇内酯中间体（III）的4-羟基，得到单甲硅烷基化中间体二醇内酯（IV）。 c）单甲硅烷基化中间体（IV）的酰化形成甲硅烷基化辛伐他汀（V）或任选地，从洛伐他汀（II）开始制备不分离二醇内酯（III）和单甲硅烷基化二醇内酯（IV）的甲硅烷基化辛伐他汀（V）最后，除去甲硅烷基化辛伐他汀（V）上的甲硅烷基保护基，然后纯化，得到基本上纯的辛伐他汀（I）。

6. 发明授权

US5162368A Butalactin and its use as pharmaceutical 失效
标题翻译： BUTALACTIN及其用作药物
公开(公告)号：US5162368A
公开(公告)日：1992-11-10
申请号：US563188
申请日：1990-08-06
申请人： Christopher M. M. Franco , Erra K. Vijayakumar , Sugata Chatterjee , Bimal N. Ganguli , Jurgen Blumbach
发明人： Christopher M. M. Franco , Erra K. Vijayakumar , Sugata Chatterjee , Bimal N. Ganguli , Jurgen Blumbach
IPC分类号： A61K31/34 , A61K31/365 , A61P31/00 , C07D407/06 , C12N1/20 , C12P17/16 , C12R1/465
CPC分类号： C07D407/06 , C12P17/162 , C12R1/465
摘要： Butalactin, a compound of the formula I ##STR1## can be produced by cultivation of Streptomyces species Y-86,36923. Butalactin has an antibiotic activity.

7. 发明授权

US5571701A Antibiotic, balhimycin, a process for its production and its use as pharmaceutical 失效
标题翻译：抗生素，巴利霉素，其生产过程及其用作药物
公开(公告)号：US5571701A
公开(公告)日：1996-11-05
申请号：US449543
申请日：1995-05-24
申请人： Suresh R. Nadkarni , Sugata Chatterjee , Mahesh V. Patel , Kalvanapuram R. Desikan , Erra K. S. Vijayakumar , Bimal N. Ganguli , Jurgen Blumbach , Hans-Wolfram Fehlhaber , Herbert Kogler
发明人： Suresh R. Nadkarni , Sugata Chatterjee , Mahesh V. Patel , Kalvanapuram R. Desikan , Erra K. S. Vijayakumar , Bimal N. Ganguli , Jurgen Blumbach , Hans-Wolfram Fehlhaber , Herbert Kogler
IPC分类号： A61K38/00 , C07K4/04 , C12P1/06 , C12P21/04 , C12N1/20 , C07K9/00 , A61K38/14
CPC分类号： C07K9/008 , C12P1/06 , A61K38/00 , Y10S930/19
摘要： Balhimycin, a compound of the molecular formula C.sub.66 H.sub.73 C1.sub.2 N.sub.9 0.sub.24, is a novel Glycopeptide antibiotic and has the following structure: ##STR1##
摘要翻译：分子式C66H73C12N9024的化合物Balhimycin是一种新型的糖肽抗生素，具有以下结构：

8. 发明授权

US5451570A Antibiotic, balhimycin, a process for its production and its use as pharmaceutical 失效
标题翻译：抗生素，巴利霉素，其生产过程及其用作药物
公开(公告)号：US5451570A
公开(公告)日：1995-09-19
申请号：US996936
申请日：1992-12-30
申请人： Suresh R. Nadkarni , Sugata Chatterjee , Mahesh V. Patel , Kalvanapuram R. Desikan , Erra K. S. Vijayakumar , Bimal N. Ganguli , Jurgen Blumbach , Hans-Wolfram Fehlhaber , Herbert Kogler
发明人： Suresh R. Nadkarni , Sugata Chatterjee , Mahesh V. Patel , Kalvanapuram R. Desikan , Erra K. S. Vijayakumar , Bimal N. Ganguli , Jurgen Blumbach , Hans-Wolfram Fehlhaber , Herbert Kogler
IPC分类号： A61K38/00 , C07K4/04 , C12P1/06 , A61K38/14 , A61K38/12 , C07K9/00
CPC分类号： C07K9/008 , C12P1/06 , A61K38/00 , Y10S930/19
摘要： Balhimycin, a compound of the molecular formula C.sub.66 H.sub.73 Cl.sub.2 N.sub.9 O.sub.24, is a novel Glycopeptide antibiotic and has the following structure (SEQ. ID. No. 1): ##STR1##
摘要翻译：分子式为C66H73Cl2N9O24的化合物巴尔霉素是新型的糖肽抗生素，具有以下结构（SEQ ID NO：1）：

9. 发明授权

US5271935A Antibiotic, cammunocin, a process for the preparation thereof, and the use thereof as a pharmaceutical 失效
标题翻译：抗生素，cammunocin，其制备方法及其作为药物的用途
公开(公告)号：US5271935A
公开(公告)日：1993-12-21
申请号：US850162
申请日：1992-03-13
申请人： Christopher M. M. Franco , Sugata Chatterjee , Erra K. S. Vijayakumar , Bimal N. Ganguli , Richard H. Rupp
发明人： Christopher M. M. Franco , Sugata Chatterjee , Erra K. S. Vijayakumar , Bimal N. Ganguli , Richard H. Rupp
IPC分类号： C12P1/06 , A61K35/74
CPC分类号： C12P1/06
摘要： Cammunocin, an active substance which can be obtained by cultivation of Streptomyces species Y-84,36210 (DSM 4329), has antibiotic and immunosuppressant activity.
摘要翻译：可通过培养链霉菌属种Y-84,36210（DSM 4329）获得的活性物质具有抗生素和免疫抑制剂活性。

10. 发明授权

US08093391B2 Process for the preparation of substantially pure palonosetron and its acid salts 失效
标题翻译：制备基本上纯粹的帕洛诺司琼及其酸式盐的方法
公开(公告)号：US08093391B2
公开(公告)日：2012-01-10
申请号：US12652090
申请日：2010-01-05
申请人： Sugata Chatterjee , Ajay Singh Rawat , Anil V. Pawar , Jetti Rajanikanth , Penigandla Venkateswarlu
发明人： Sugata Chatterjee , Ajay Singh Rawat , Anil V. Pawar , Jetti Rajanikanth , Penigandla Venkateswarlu
IPC分类号： C07D401/00 , C07D211/06 , C07D211/40 , C07D211/54 , C07D211/00 , A61K31/44 , A61K31/445 , A01N43/40
CPC分类号： C07D453/02
摘要： This invention relates to an improved and scalable process for the preparation of substantially pure palonosetron and its acid addition salts, in particular hydrochloride (I) which comprises of, (a) converting intermediate (IIa) as such or as its freebase (II) to a crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) via hydrogenation under pressure with an appropriately chosen hydrogenation catalyst in an suitable organic solvent. (b) making the resulting crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) substantially free from (II) or (IIa) via halogenation reaction. (c) Finally, converting the resulting diastereomeric palonosetron (VIII) or its hydrochloride (VIIIa) substantially free from intermediate (II) or (IIa) to the desired palonosetron hydrochloride (I) in substantially pure form via selective crystallization from a suitable single or mixture of organic solvents.
摘要翻译：本发明涉及一种用于制备基本上纯的帕洛诺司琼及其酸加成盐，特别是盐酸盐（I）的改进和可伸缩的方法，其包括（a）将本文中间体（IIa）或其游离碱（II）转化为通过在合适的有机溶剂中用适当选择的氢化催化剂在压力下氢化，用不同量的未转化的中间体（II）或（IIa）污染的非对映异构的帕洛诺司琼（VIII）或（VIIIa）的粗混合物。（b）通过卤化反应使所得到的非对映异构体帕洛诺司琼（VIII）或（VIIIa）的粗混合物被不同量的未转化的中间体（II）或（IIa）污染，基本上不含（II）或（IIa）。（c）最后，将基本上不含中间体（II）或（IIa）的所得非对映体帕洛诺司琼（VIII）或其盐酸盐（VIIIa）以基本上纯的形式通过选择性结晶从合适的单一或有机溶剂的混合物。

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