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1. 发明授权

US5534427A Pseudomonas fluorescens lipase 失效
标题翻译：荧光假单胞菌脂肪酶
公开(公告)号：US5534427A
公开(公告)日：1996-07-09
申请号：US923120
申请日：1992-07-31
申请人： Robert M. Johnston , Steven L. Goldberg , Paul M. Cino
发明人： Robert M. Johnston , Steven L. Goldberg , Paul M. Cino
IPC分类号： C12N9/20 , C12N15/55 , C12N15/70
CPC分类号： C12N9/20
摘要： Nucleic acid sequences, particularly DNA sequences, coding for all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the BamHI/HindIII insert of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 deposited with the American Type Culture Collection, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of a lipase of Pseudomonas fluorescens, wherein said lipase has the amino acid sequence encoded by the nucleotide sequence of the plasmid pRJ-Ltac1 from Escherichia coli BL21/pRJ-Ltac1 BamHI/HindIII insert of deposited with the American Type Culture Collection, and methods for producing these polypeptides.
摘要翻译：核酸序列，特别是DNA序列，其编码荧光假单胞菌的全部或部分脂肪酶，其中所述脂肪酶具有由来自大肠杆菌BL21 / P21的质粒pRJ-Ltac1的BamHI / HindIII插入片段的核苷酸序列编码的氨基酸序列，保藏在美国典型培养物保藏中心的pRJ-Ltac1，含有DNA序列的表达载体，含有表达载体的宿主细胞，以及利用这些材料的方法。本发明还涉及包含荧光假单胞菌的全部或部分脂肪酶的多肽分子，其中所述脂肪酶具有由大肠杆菌BL21 / pRJ-Ltac1 BamHI / HindIII插入片段的沉积的质粒pRJ-Ltac1的核苷酸序列编码的氨基酸序列美国典型培养物保藏中心，以及生产这些多肽的方法。

2. 发明授权

US09075505B2 Content feed user interface 有权
标题翻译：内容Feed用户界面
公开(公告)号：US09075505B2
公开(公告)日：2015-07-07
申请号：US13296178
申请日：2011-11-14
申请人： Steven L. Goldberg , Christopher Jason Wetherell , Mihai Parparita , Kevin David Fox
发明人： Steven L. Goldberg , Christopher Jason Wetherell , Mihai Parparita , Kevin David Fox
IPC分类号： G06F3/0482 , G06F3/0485
CPC分类号： G06F3/0482 , G06F3/0485
摘要： A content feed aggregator displays an ordered list of content items, including a selected item and a set of other items. The selected item is displayed in an expanded format while the other items are simultaneously displayed in a compact format. At least one respective item in compact format is displayed above the selected item and at least one respective item in compact format displayed below the selected item. In response to a user action for selecting a second item in the displayed list, the ordered list of content items is redisplayed with the second item displayed in the expanded format and the other items, including the first item, displayed in the compact format.
摘要翻译：内容馈送聚合器显示内容项目的有序列表，包括所选项目和一组其他项目。所选项目以扩展格式显示，而其他项目以紧凑格式同时显示。在所选项目之上显示至少一个紧凑格式的相应项目，并且在所选项目下方显示紧凑格式的至少一个相应项目。响应于用户选择所显示的列表中的第二项目的动作，以扩展格式显示的第二项目以及以紧凑格式显示的包括第一项目的其他项目重新显示内容项目的排序列表。

3. 发明授权

US08230361B2 Content feed user interface 有权
标题翻译：内容Feed用户界面
公开(公告)号：US08230361B2
公开(公告)日：2012-07-24
申请号：US11863207
申请日：2007-09-27
申请人： Steven L. Goldberg , Christopher Jason Wetherell , Mihai Parparita , Kevin David Fox
发明人： Steven L. Goldberg , Christopher Jason Wetherell , Mihai Parparita , Kevin David Fox
IPC分类号： G06F3/048
CPC分类号： G06F3/0482 , G06F3/0485
摘要： A content feed aggregator displays an ordered list of content items, including a selected item and a set of other items. The selected item is displayed in an expanded format while the other items are simultaneously displayed in a compact format. At least one respective item in compact format is displayed above the selected item and at least one respective item in compact format displayed below the selected item. In response to a user action for selecting a second item in the displayed list, the ordered list of content items is redisplayed with the second item displayed in the expanded format and the other items, including the first item, displayed in the compact format.
摘要翻译：内容馈送聚合器显示内容项目的有序列表，包括所选项目和一组其他项目。所选项目以扩展格式显示，而其他项目以紧凑格式同时显示。在所选项目之上显示至少一个紧凑格式的相应项目，并且在所选项目下方显示紧凑格式的至少一个相应项目。响应于用户选择所显示的列表中的第二项目的动作，以扩展格式显示的第二项目和包含以紧凑格式显示的第一项目的其他项目重新显示内容项目的排序列表。

4. 发明授权

US07730082B2 Remote module incorporation into a container document 有权
标题翻译：将远程模块整合到容器文档中
公开(公告)号：US07730082B2
公开(公告)日：2010-06-01
申请号：US11298930
申请日：2005-12-12
申请人： Adam Sah , Dylan Parker , Christopher H. Rohrs , Jessica Lynn Gray , Steven L. Goldberg
发明人： Adam Sah , Dylan Parker , Christopher H. Rohrs , Jessica Lynn Gray , Steven L. Goldberg
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06Q30/02
摘要： A system and method for serving content in a container document. The system comprises a container server that identifies one or more modules for use with a container document, receives a module specification from a remote server, and serves the container document including module data based on the module specification. The module specification comprises a content element and one or more optional preference elements that enable the container server to provide preferences to the module.
摘要翻译：一种用于在容器文档中提供内容的系统和方法。该系统包括识别用于容器文档的一个或多个模块的容器服务器，从远程服务器接收模块规范，并且基于模块规范对包含模块数据的容器文档进行服务。模块规范包括内容元素和一个或多个可选首选元素，其使容器服务器能够向模块提供偏好。

5. 发明授权

US07119188B2 N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor 失效
标题翻译： N-苄氧羰基（N-CBZ） - 保护酶，并用于此
公开(公告)号：US07119188B2
公开(公告)日：2006-10-10
申请号：US10453418
申请日：2003-06-03
申请人： Venkata B. Nanduri , Ramesh N. Patel , Steven L. Goldberg , Robert M. Johnston
发明人： Venkata B. Nanduri , Ramesh N. Patel , Steven L. Goldberg , Robert M. Johnston
IPC分类号： C07H21/04 , C12N9/14 , C12N1/20 , C12N15/00
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants and fragments thereof, that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides, and variants, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及分离或重组的N-苄氧羰基脱保护酶多肽及其变体和片段，其催化从苄氧羰基保护的氨基酸和醇中除去苄氧羰基。还涉及编码N-苄氧羰基脱保护酶多肽及其变体及其片段的分离的核酸以及包含这些核酸的载体和宿主细胞。本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用该多肽的方法。

6. 发明授权

US06800477B2 Stereoselective reduction of substituted acetophenone 有权
标题翻译：取代苯乙酮的立体选择性还原
公开(公告)号：US06800477B2
公开(公告)日：2004-10-05
申请号：US10092263
申请日：2002-03-06
申请人： Ramesh Patel , Animesh Goswami , Linda N. Chu , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Mary Jo Donovan , K. David Mirfakhrae
发明人： Ramesh Patel , Animesh Goswami , Linda N. Chu , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Mary Jo Donovan , K. David Mirfakhrae
IPC分类号： C12P4100
CPC分类号： C12P7/22 , Y10S435/911 , Y10S435/938
摘要： The present invention is directed to novel stereoselective processes for the preparation of (S)-1-arylethanols by the reduction of the corresponding keto group containing compounds by microorganisms. (S)-1-arylethanols are useful as intermediates in the synthesis of compounds that are inhibitors of &ggr;-secretase useful in the treatment of Alzheimer's disease.
摘要翻译：本发明涉及通过微生物还原相应的含有酮基的化合物来制备（S）-1-芳基乙醇的新的立体选择性方法。（S）-1-芳基乙醇可用作合成作为可用于治疗阿尔茨海默病的γ-分泌酶的抑制剂的化合物的中间体。

7. 发明授权

US07087418B2 Pichia pastoris formate dehydrogenase and uses therefor 有权
标题翻译：毕赤酵母甲酸脱氢酶，用于此
公开(公告)号：US07087418B2
公开(公告)日：2006-08-08
申请号：US10320300
申请日：2002-12-16
申请人： Steven L. Goldberg , Paul M. Cino , Ramesh N. Patel , Venkata B. Nanduri , Robert M. Johnston
发明人： Steven L. Goldberg , Paul M. Cino , Ramesh N. Patel , Venkata B. Nanduri , Robert M. Johnston
IPC分类号： C12N9/04 , C12N15/00 , C12N1/20 , C07H21/04
CPC分类号： C12N9/0004 , C12Q1/26 , G01N2333/04
摘要： This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及催化甲酸氧化成二氧化碳并同时将烟酰胺腺嘌呤二核苷酸（NAD +）还原为还原形式（NADH）的重组巴斯德毕赤酵母甲酸脱氢酶（FDH）酶。还涉及编码巴斯德毕赤酵母多肽的分离的核酸及其片段和变体，以及包含这些核酸的载体和宿主细胞。进一步相关的是分离的重组巴斯德毕赤酵母FDH多肽及其片段和变体，以及特异性结合巴斯德毕赤酵母多肽，片段或变体的抗体。本发明还涉及获得分离的巴斯德毕赤酵母FDH核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用巴斯德毕赤酵母FDH的方法。

8. 发明授权

US06929935B2 Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof 失效
标题翻译：氧化葡糖杆菌2-酮还原酶及其应用
公开(公告)号：US06929935B2
公开(公告)日：2005-08-16
申请号：US10320104
申请日：2002-12-16
申请人： Venkata B. Nanduri , Robert M. Johnston , Steven L. Goldberg , Paul M. Cino , Ramesh N. Patel
发明人： Venkata B. Nanduri , Robert M. Johnston , Steven L. Goldberg , Paul M. Cino , Ramesh N. Patel
IPC分类号： C12N1/21 , C12N9/02 , C12Q1/26 , C12Q1/32 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/0004 , C12Q1/26 , C12Q1/32 , G01N2333/04
摘要： This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to G. oxydans 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated G. oxydans 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using G. oxydans 2-ketoreductase in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及可用于合成手性醇的新型氧化葡糖杆菌2-酮还原酶。还涉及编码G.oxydans 2-酮还原酶的分离的核酸及其酶片段及其变体，以及包含这些核酸的载体和宿主细胞。进一步相关的是分离的G.oxydans 2-酮还原酶多肽及其片段和变体，以及特异性结合G.oxydans 2-酮还原酶多肽，片段或变体的抗体。本发明还涉及获得分离的G.oxydans 2-酮还原酶核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用G.oxydans 2-酮还原酶的方法。

9. 发明授权

US06515170B1 Enzymatic oxidative deamination process 有权
公开(公告)号：US06515170B1
公开(公告)日：2003-02-04
申请号：US09843226
申请日：2001-04-26
申请人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
发明人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
IPC分类号： C07C3200
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

10. 发明授权

US07696328B2 N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor 失效
标题翻译： N-苄氧羰基（N-CBZ） - 保护酶，并用于此
公开(公告)号：US07696328B2
公开(公告)日：2010-04-13
申请号：US12150544
申请日：2008-04-28
申请人： Venkata B. Nanduri , Ramesh N. Patel , Steven L. Goldberg , Robert M. Johnston
发明人： Venkata B. Nanduri , Ramesh N. Patel , Steven L. Goldberg , Robert M. Johnston
IPC分类号： C07K16/00 , C07K16/40 , C07K16/46 , C07K14/00 , C07K5/00
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using the polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及催化从苄氧羰基保护的氨基酸和醇中除去苄氧羰基的分离的或重组的N-苄氧羰基脱保护酶多肽。还涉及编码其N-苄氧羰基脱保护酶多肽的分离的核酸，以及包含这些核酸的载体和宿主细胞。本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用该多肽的方法。

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