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1. 发明授权

US09063137B2 Method and assay for detection of residues 有权
标题翻译：检测残留物的方法和测定
公开(公告)号：US09063137B2
公开(公告)日：2015-06-23
申请号：US12955331
申请日：2010-11-29
申请人： Steven J. Saul , Robert J. Markovsky , David W. Douglas
发明人： Steven J. Saul , Robert J. Markovsky , David W. Douglas
IPC分类号： G01N33/558 , G01N33/543
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/805 , Y10S436/828
摘要： Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
摘要翻译：本文描述的实施方案包括使用多个控制区捕获剂检测样品中的分析物的方法和测定。一些实施方案包括利用多个分析物结合物检测样品中的多种分析物和含有多个控制区捕获剂的对照区。在一些实施例中，多个控制区捕获剂在一个控制区内捕获多个粘合剂。通过将控制区信号与测试区信号进行比较来确定测试结果。

2. 发明授权

US09057724B2 Detecting a high molecular weight substance 有权
标题翻译：检测高分子量物质
公开(公告)号：US09057724B2
公开(公告)日：2015-06-16
申请号：US14118333
申请日：2012-05-23
申请人： Steven J. Saul
发明人： Steven J. Saul
IPC分类号： G01N33/558 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54393 , G01N33/543 , G01N33/54346 , G01N33/54366 , G01N33/558 , G01N33/585 , G01N2333/4713 , G01N2333/4731
摘要： Label complexes, lateral flow apparatus and methods of detecting a high molecular weight substance are shown and described. In one embodiment, the label complex includes an antispecies antibody and another antibody having sensitivity to both the antispecies antibody and to a control line capture agent, an antibody binding protein and a detectable component. Typically, the antibody binding protein may bind to a receptor for the analyte or to the anti-species antibody. In yet other embodiments, a lateral flow test strip includes the label complex and a solid support that traverses lateral flow of a liquid sample and provides a detectable signal.
摘要翻译：标记复合物，侧流装置和检测高分子量物质的方法被显示和描述。在一个实施方案中，标记复合物包括抗特异性抗体和对抗蚜虫抗体和对照线捕获剂，抗体结合蛋白和可检测组分都敏感的另一种抗体。通常，抗体结合蛋白可以结合分析物或抗物种抗体的受体。在另外的实施方案中，横向流动测试条包括标签复合物和穿过液体样品的侧向流动并提供可检测信号的固体支持物。

3. 发明申请

US20130295691A1 Method of Attaching a Ligand to a Test Strip 审中-公开
标题翻译：将配体连接到测试条的方法
公开(公告)号：US20130295691A1
公开(公告)日：2013-11-07
申请号：US13936902
申请日：2013-07-08
申请人： Steven J. Saul
发明人： Steven J. Saul
IPC分类号： G01N33/543
CPC分类号： G01N33/54353 , C07K5/06139 , G01N33/558
摘要： The invention features a method of attaching a ligand that has a free carboxyl group to a solid support by adding an amino group to the ligand to form a ligand-amino derivative, converting the ligand amino derivative to a ligand sulfhydryl derivative, attaching the ligand sulfhydryl derivative to a protein to form a ligand-linker-protein conjugate, and applying the ligand-linker-protein conjugate to the solid support. The method is particularly useful for immobilizing small molecule ligands having a free carboxyl group, such as cloxicillin, to a lateral-flow test strip, in order to make a detection zone on the test strip that exhibits a clear signal and enhanced sensitivity.
摘要翻译：本发明的特征在于通过向配体添加氨基以形成配体 - 氨基衍生物，将配体氨基衍生物转化成配体巯基衍生物，将配体巯基连接到具有游离羧基的配体与固体支持物的连接方法衍生物以形成配体 - 接头 - 蛋白质缀合物，并将配体 - 接头 - 蛋白质缀合物应用于固体支持物。该方法特别可用于将具有游离羧基的小分子配体如氯青霉素固定在横向流动测试条上，以便在测试条上形成具有清晰信号和增强的灵敏度的检测区。

4. 发明申请

US20110070127A1 Method and Assay for Detection of Residues 审中-公开
标题翻译：方法和检测残留物检测
公开(公告)号：US20110070127A1
公开(公告)日：2011-03-24
申请号：US12955331
申请日：2010-11-29
申请人： Steven J. Saul , Robert J. Markovsky , David W. Douglas
发明人： Steven J. Saul , Robert J. Markovsky , David W. Douglas
IPC分类号： G01N33/53
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/805 , Y10S436/828
摘要： Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
摘要翻译：本文描述的实施方案包括使用多个控制区捕获剂检测样品中的分析物的方法和测定。一些实施方案包括利用多个分析物结合物检测样品中的多种分析物和含有多个控制区捕获剂的对照区。在一些实施例中，多个控制区捕获剂在一个控制区内捕获多个粘合剂。通过将控制区信号与测试区信号进行比较来确定测试结果。

5. 发明授权

US07863057B2 Method and assay for detection of residues 有权
标题翻译：检测残留物的方法和测定
公开(公告)号：US07863057B2
公开(公告)日：2011-01-04
申请号：US12217729
申请日：2008-07-08
申请人： Steven J. Saul , Robert J. Markovsky , David W. Douglas
发明人： Steven J. Saul , Robert J. Markovsky , David W. Douglas
IPC分类号： G01N33/53
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/805 , Y10S436/828
摘要： Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
摘要翻译：本文描述的实施方案包括使用多个控制区捕获剂检测样品中的分析物的方法和测定。一些实施方案包括利用多个分析物结合物检测样品中的多种分析物和含有多个控制区捕获剂的对照区。在一些实施例中，多个控制区捕获剂在一个控制区内捕获多个粘合剂。通过将控制区信号与测试区信号进行比较来确定测试结果。

6. 发明申请

US20100285610A1 Lateral Flow Test Kit and Method for Detecting an Analyte 有权
标题翻译：侧流测试套件和检测分析物的方法
公开(公告)号：US20100285610A1
公开(公告)日：2010-11-11
申请号：US12842484
申请日：2010-07-23
申请人： Steven J. Saul , Mark E. Tess , Robert J. Markovsky
发明人： Steven J. Saul , Mark E. Tess , Robert J. Markovsky
IPC分类号： G01N33/543
CPC分类号： G01N33/558 , Y10S435/97 , Y10S436/81
摘要： A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.
摘要翻译：一种检测试样中分析物的方法和装置。实施方案包括用于定量检测浓度范围内的分析物的方法。在一个实施方案中，该方法包括具有用于捕获标记的受体以提供可检测信号的多个测试区域的侧流测试条。

7. 发明授权

US07632928B2 Method and antibodies for detecting nitrofuran 有权
标题翻译：用于检测硝基呋喃的方法和抗体
公开(公告)号：US07632928B2
公开(公告)日：2009-12-15
申请号：US11583236
申请日：2006-10-18
申请人： Say-Jong Law , Stanley E. Charm , Steven J. Saul
发明人： Say-Jong Law , Stanley E. Charm , Steven J. Saul
IPC分类号： C07K1/13 , C07K1/04 , C07D263/02
CPC分类号： C07K16/44 , G01N33/9446 , G01N2333/906
摘要： An antibody and immunogen for generating an antibody to nitrofuran and/or nitrofuran metabolite such as tissue or protein bound nitrofuran metabolites. Nitrofurans and and/or nitrofuran metabolites in a biological sample can be detected by contacting the sample with the antibodies to form a complex that can be detected. The antibodies may also be incorporated into test kits for the detection of nitrofuran and/or nitrofuran metabolites.
摘要翻译：用于产生硝基呋喃和/或硝基呋喃代谢物的抗体和免疫原，例如组织或蛋白质结合的硝基呋喃代谢物。可以通过使样品与抗体接触以形成可检测的复合物来检测生物样品中的硝基呋喃和/或硝基呋喃代谢物。抗体也可以并入用于检测硝基呋喃和/或硝基呋喃代谢物的检测试剂盒中。

8. 发明申请

US20080160538A1 Lateral Flow Test Kit and Method for Detecting an Analyte 有权
标题翻译：侧流测试套件和检测分析物的方法
公开(公告)号：US20080160538A1
公开(公告)日：2008-07-03
申请号：US11883784
申请日：2006-02-16
申请人： Steven J. Saul , Mark E. Tess , Robert J. Markovsky
发明人： Steven J. Saul , Mark E. Tess , Robert J. Markovsky
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10S435/97 , Y10S436/81
摘要： A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.
摘要翻译：一种检测试样中分析物的方法和装置。实施方案包括用于定量检测浓度范围内的分析物的方法。在一个实施方案中，该方法包括具有用于捕获标记的受体以提供可检测信号的多个测试区域的侧流测试条。

9. 发明授权

US07097983B2 Method for detecting the presence of an analyte in a sample 有权
标题翻译：用于检测样品中分析物的存在的方法
公开(公告)号：US07097983B2
公开(公告)日：2006-08-29
申请号：US09961998
申请日：2001-09-24
申请人： Robert J. Markovsky , Cheryl A. Boyer , Stanley E. Charm , Paul R. Donahue , Yael Agi Glickman , Steven J. Saul , Joan L. Scheemaker , Richard T. Skiffington , Shefali B. Trivedi , Eliezer Zomer
发明人： Robert J. Markovsky , Cheryl A. Boyer , Stanley E. Charm , Paul R. Donahue , Yael Agi Glickman , Steven J. Saul , Joan L. Scheemaker , Richard T. Skiffington , Shefali B. Trivedi , Eliezer Zomer
IPC分类号： G01N33/53 , G01N31/00 , G01N33/558
CPC分类号： G01N33/558 , A23D9/00 , A23K10/30 , A23K20/158 , C11B3/001 , C11B7/00 , C11C1/04 , C11C3/10 , C11C3/123 , C12N9/0083 , C12N15/8216 , C12N15/8222 , C12N15/8234 , C12N15/8247 , G01N33/537 , G01N33/54366 , G01N2201/0221 , Y10S435/805 , Y10S435/97 , Y10T436/10 , Y10T436/105831
摘要： The invention features a method of determining whether one or more members of an analyte family are present in a sample. The method makes use of a test zone binder, e.g., a receptor that can bind one or a plurality of analytes within an analyte family, the analytes family defined by similar structural binding sites. Members of an analyte family can have different detection level requirements and, therefore, additional analyte binders can be employed to adjust test sensitivity for a subset of the analytes in the analyte family individually, so that each analyte can be detected only if it is present in the sample above a predetermined threshold.
摘要翻译：本发明的特征在于确定样品中是否存在分析物族的一个或多个成员的方法。该方法利用测试区粘合剂，例如可以结合分析物家族内的一种或多种分析物的受体，即由相似结构结合位点定义的分析物族。分析物家族的成员可以具有不同的检测水平要求，因此，可以使用其他分析物结合剂来单独分析分析物家族中一部分分析物的测试灵敏度，以便每个分析物只有在存在于样品高于预定阈值。

10. 发明授权

US07824878B2 Sensitive method for detecting low levels of ATP 有权
标题翻译：检测低水平ATP的敏感方法
公开(公告)号：US07824878B2
公开(公告)日：2010-11-02
申请号：US12319602
申请日：2009-01-09
申请人： Stanley E. Charm , Cheryl B. Francisco , Robert J. Markovsky , Robert S. Salter , Steven J. Saul
发明人： Stanley E. Charm , Cheryl B. Francisco , Robert J. Markovsky , Robert S. Salter , Steven J. Saul
IPC分类号： C12Q1/66
CPC分类号： C12Q1/008 , C12Q1/66
摘要： Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to noise ratio. The maximum signal to noise ratio can be particularly useful with recombinant luciferase including recombinant Coleoptera luciferase.
摘要翻译：提供了使用荧光素 - 萤光素酶反应敏感检测样品中三磷酸腺苷（ATP）的方法。方面包括使用使信噪比最大化的pH组合物。对于包括重组鞘翅目荧光素酶的重组萤光素酶，最大信噪比对于特别有用。

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