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1. 发明申请

US20130018339A1 Disposable Absorbent Article Design Utilizing Unbleached Pulp Fibers for the Absorbent Core 审中-公开
标题翻译：一次性吸收制品设计利用未漂白的纸浆纤维吸收芯
公开(公告)号：US20130018339A1
公开(公告)日：2013-01-17
申请号：US13181339
申请日：2011-07-12
申请人： Tom Kaiser , Steven D. Linton
发明人： Tom Kaiser , Steven D. Linton
IPC分类号： A61L15/56 , B23P17/00 , A61L15/22
CPC分类号： A61F13/49 , A61F13/534 , A61F2013/530007 , A61F2013/530481 , A61F2013/530708 , Y10T29/49801
摘要： Absorbent articles and methods for making absorbent articles incorporate unbleached fibers in an absorbing core. Example embodiments provide unbleached fibers which are totally chlorine free. Such unbleached fibers provide features and advantages not present or recognized over prior articles. According to one embodiment, a disposable absorbent article having a front waist region, a back waist region, and a crotch region located between the front and back waist regions, is provided. The disposable absorbent article includes a liquid pervious topsheet and a liquid impervious backsheet. Additionally, the disposable absorbent article includes an absorbent core disposed between at least a portion of the topsheet and bottom sheet. This absorbent core comprises a superabsorbent material and pulp material where at least a portion of the pulp material includes unbleached fibers having constituents which alter the performance properties of the absorbent core.
摘要翻译：用于制造吸收制品的吸收制品和方法在吸收芯中掺入未漂白的纤维。实施例提供完全无氯的未漂白纤维。这种未漂白的纤维提供了在现有物品上不存在或认可的特征和优点。根据一个实施例，提供一种具有前腰围区域，后腰区域和位于前后腰围区域之间的裆部区域的一次性吸收制品。一次性吸收制品包括液体可透过的顶片和不透液体的底片。此外，一次性吸收制品包括设置在顶片和底片的至少一部分之间的吸收芯。该吸收芯包括超吸收材料和纸浆材料，其中纸浆材料的至少一部分包括具有改变吸收芯性能的成分的未漂白纤维。

2. 发明授权

US07053056B2 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 有权
公开(公告)号：US07053056B2
公开(公告)日：2006-05-30
申请号：US09765105
申请日：2001-01-16
申请人： Donald S. Karanewsky , Robert J. Ternansky , Steven D. Linton , Thang Dinh
发明人： Donald S. Karanewsky , Robert J. Ternansky , Steven D. Linton , Thang Dinh
IPC分类号： C07K5/06
CPC分类号： C07D295/185 , C07B2200/07 , C07C237/22 , C07C317/50 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D295/135 , C07F9/3264
摘要： This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

3. 发明授权

US06610683B2 Treatment of infectious disease using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors 有权
标题翻译：使用白细胞介素-1β转换酶（ICE）/ CED-3家族抑制剂治疗传染病
公开(公告)号：US06610683B2
公开(公告)日：2003-08-26
申请号：US10007632
申请日：2001-11-13
申请人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewsky , Steven D. Linton , Xu Bai
发明人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewsky , Steven D. Linton , Xu Bai
IPC分类号： A61K3155
CPC分类号： A61Q17/00 , A01N1/0215 , A61K8/492 , A61K31/404 , A61K31/55 , A61K2800/75 , A61Q17/04 , C07K5/0202 , Y02A50/463
摘要： The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.
摘要翻译：本发明提供了通过抑制白细胞介素-1β转换酶（ICE）/ CED-3家族蛋白酶的活性来治疗感染性疾病或抑制与之相关的炎症或改善其症状的方法和组合物。还提供了可用于这些目的的组合物。本文提供了可用于本发明方法的示例性化合物。

4. 发明授权

US06444663B1 Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes 有权
公开(公告)号：US06444663B1
公开(公告)日：2002-09-03
申请号：US09730898
申请日：2000-12-05
申请人： Donald S. Karanewsky , Steven D. Linton
发明人： Donald S. Karanewsky , Steven D. Linton
IPC分类号： A61P910
摘要： This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.

5. 发明授权

US07183260B2 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 有权
标题翻译： C末端修饰的oxamyl二肽作为ICE / ced-3家族半胱氨酸蛋白酶的抑制剂
公开(公告)号：US07183260B2
公开(公告)日：2007-02-27
申请号：US10926800
申请日：2004-08-25
申请人： Donald S Karanewsky , Robert J Ternansky , Steven D Linton , Thang Dinh
发明人： Donald S Karanewsky , Robert J Ternansky , Steven D Linton , Thang Dinh
IPC分类号： C07K5/06
CPC分类号： C07D295/185 , C07B2200/07 , C07C237/22 , C07C317/50 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2603/74 , C07D295/135 , C07F9/3264
摘要： This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
摘要翻译：本发明涉及新型牛磺酰二肽ICE / ced-3家族抑制剂化合物。本发明还涉及含有这些化合物的药物组合物，以及这些组合物在治疗患有炎症，自身免疫和神经变性疾病的患者中的用途，用于预防缺血性损伤以及用于保护进行移植手术。

6. 发明授权

US06528506B2 Inhibition of apoptosis using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors 失效
标题翻译：使用白细胞介素-1β转换酶（ICE）/ CED-3家族抑制剂抑制细胞凋亡
公开(公告)号：US06528506B2
公开(公告)日：2003-03-04
申请号：US10083862
申请日：2002-02-25
申请人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewski , Steven D. Linton , Xu Bai
发明人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewski , Steven D. Linton , Xu Bai
IPC分类号： A61K3155
CPC分类号： A61K31/404 , A01N1/0226 , A61K38/55 , C07K5/0202
摘要： The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viablility of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.
摘要翻译：本发明提供了使用白细胞介素-1β转换酶（ICE）/ CED-3家族抑制剂扩增和增加造血细胞群的存活，延长移植器官的可行性以及增强生物生产的方法。本文提供了可用于本发明方法的示例性化合物。

7. 发明申请

US20140107605A1 Combined Leg Cuff and Leg Gather 审中-公开
标题翻译：组合腿袖和腿聚集
公开(公告)号：US20140107605A1
公开(公告)日：2014-04-17
申请号：US14054244
申请日：2013-10-15
申请人： Charles F. Schroer, JR. , Steven D. Linton
发明人： Charles F. Schroer, JR. , Steven D. Linton
IPC分类号： A61F13/494
CPC分类号： A61F13/49413 , A61F13/49017 , A61F13/515
摘要： A disposable absorbent article, such as a diaper having a pair of waist sections, a crotch section disposed between the waist sections, a liquid pervious topsheet, a liquid impervious backsheet, an absorbent core disposed between the topsheet and the backsheet, a leg cuff attached to the topsheet at least in part parallel to a longitudinal axis at a first attachment region, a leg gather section which runs along an outer edge region of the crotch section, wherein the leg gather section comprises an outer boundary and an inner boundary, wherein the outer boundary is defined by the edge of the crotch region and the inner boundary is defined by the first leg cuff attachment region; and wherein the leg gather region and leg cuff are attached together at least in part at a second attachment region.
摘要翻译：一次性吸收性物品，例如具有一对腰部的尿布，设置在腰部之间的裆部，液体可透过的顶片，不透液体的底片，设置在顶片和底片之间的吸收芯，至少部分地平行于第一附接区域处的纵向轴线的顶片，沿着裆部的外缘区域延伸的腿部褶皱部分，其中腿部收缩部分包括外边界和内边界，其中，外边界由裆区的边缘限定，内边界由第一腿箍连接区限定; 并且其中所述腿部褶皱区域和所述腿箍至少部分地连接在第二附接区域。

8. 发明申请

US20100190688A1 Tetrapeptide analogs 审中-公开
标题翻译：四肽类似物
公开(公告)号：US20100190688A1
公开(公告)日：2010-07-29
申请号：US11632441
申请日：2005-07-12
申请人： Bin Chao , Thomas L. Deckwerth , Paul S. Furth , Steven D. Linton , Alfred P. Spada , Brett R. Ullman , Michael I. Weinhouse
发明人： Bin Chao , Thomas L. Deckwerth , Paul S. Furth , Steven D. Linton , Alfred P. Spada , Brett R. Ullman , Michael I. Weinhouse
IPC分类号： A61K38/14 , C07C271/10 , A61K31/22 , C07D207/00 , A61K31/40 , C07D209/42 , A61K31/404 , C07D263/04 , A61K31/421 , C07D277/06 , A61K31/426 , C07D211/86 , A61K31/45 , C07D223/12 , A61K31/55 , C07D277/60 , A61K31/428 , C07D223/32 , A61K31/551 , C07D487/06 , C07D243/10 , C07D209/96 , C07C237/22 , A61K31/16 , A61K31/704 , A61K31/407 , A61K31/519 , A61K31/5365 , A61K31/427 , A61K31/397 , A61K31/357 , A61K31/70 , A61K31/475 , A61P35/00
CPC分类号： C07D207/16 , A61K38/00 , C07D207/22 , C07D207/24 , C07D207/273 , C07D209/42 , C07D209/44 , C07D211/76 , C07D213/64 , C07D233/10 , C07D263/06 , C07D277/06 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/1008 , Y02A50/411 , Y02A50/414
摘要： Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.
摘要翻译：提供了用于治疗过度增殖性疾病如癌症的化合物，组合物和方法。

9. 发明授权

US06693096B2 Treatment of inflammation-associated disorders using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors 有权
标题翻译：使用白细胞介素-1β转换酶（ICE）/ CED-3家族抑制剂治疗炎症相关疾病
公开(公告)号：US06693096B2
公开(公告)日：2004-02-17
申请号：US10208729
申请日：2002-07-29
申请人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewsky , Steven D. Linton , Xu Bai
发明人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewsky , Steven D. Linton , Xu Bai
IPC分类号： A61K3155
CPC分类号： A61Q17/00 , A01N1/0215 , A61K8/492 , A61K31/404 , A61K31/55 , A61K2800/75 , A61Q17/04 , C07K5/0202 , Y02A50/463
摘要： The present invention provides methods and compositions for preventing and treating inflammation-associated disorders or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.
摘要翻译：本发明提供了通过抑制白细胞介素-1β转换酶（ICE）/ CED-3家族蛋白酶的活性来预防和治疗炎症相关疾病或改善其症状的方法和组合物。还提供了可用于这些目的的组合物。本文提供了可用于本发明方法的示例性化合物。

10. 发明授权

US06531467B2 Inhibition of inflammation using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors 失效
公开(公告)号：US06531467B2
公开(公告)日：2003-03-11
申请号：US09982123
申请日：2001-10-16
申请人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewsky , Steven D. Linton , Xu Bai , Dominic F. Montisano , David Higgins
发明人： Lawrence C. Fritz , Kevin J. Tomaselli , Donald S. Karanewsky , Steven D. Linton , Xu Bai , Dominic F. Montisano , David Higgins
IPC分类号： A61K3155
CPC分类号： A61K31/404 , A01N1/0226 , A61K8/492 , A61K38/55 , A61K2800/75 , A61Q19/00 , C07K5/0202
摘要： The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.

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