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1. 发明申请

US20070160600A1 Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations 有权
标题翻译：针对T细胞亚群特异性的单克隆和多克隆抗体的组合物和方法
公开(公告)号：US20070160600A1
公开(公告)日：2007-07-12
申请号：US11541958
申请日：2006-10-02
申请人： Mark Exley , Samuel Wilson , Steven Balk
发明人： Mark Exley , Samuel Wilson , Steven Balk
IPC分类号： A61K39/395 , C12Q1/70 , G01N33/567 , C12P21/06 , C12P21/04 , C12N5/06 , C07K16/28
CPC分类号： C07K16/2809 , A61K2035/124 , A61K2039/505 , A61K2039/5158 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K2317/31 , C07K2317/34 , C07K2317/50 , C07K2317/74 , C07K2317/76 , C12N5/0636 , C12N5/0646 , C12N2501/515 , C12N2501/599 , Y02A50/466
摘要： The invention provides compounds and methods for the ex vivo or in vivo expansion of NK T cells, CD1d-reactive T cells, and JαQ+ T cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
摘要翻译：本发明提供了NK T细胞，CD1d反应性T细胞和JalphaQ + T细胞的离体或体内扩增的化合物和方法及其活性的调节。这些化合物和方法具有诊断和治疗应用。

2. 发明申请

US20060002927A1 Use of anti-cd1 antibodies for the modulation of immune responses 有权
标题翻译：使用抗cd1抗体来调节免疫反应
公开(公告)号：US20060002927A1
公开(公告)日：2006-01-05
申请号：US10513109
申请日：2003-05-01
申请人： Mark Exley , Steven Balk , Simon Yue
发明人： Mark Exley , Steven Balk , Simon Yue
IPC分类号： A61K39/395
CPC分类号： C07K16/2833 , A61K2035/124 , A61K2039/505 , A61K2039/5158 , Y02A50/466
摘要： The invention provides methods for the administration of an anti-CD 1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.
摘要翻译：本发明提供了用于治疗或预防各种疾病如自身免疫性疾病，病毒感染，细菌感染，寄生虫感染，真核病原体感染，过敏，哮喘，炎性反应的抗CD 1抗体的方法病情，移植物抗宿主病，移植排斥反应，免疫缺陷病，自然流产，怀孕和癌症。

3. 发明授权

US06673586B2 Steroid hormone receptor interacting protein kinase 失效
标题翻译：类固醇激素受体相互作用蛋白激酶
公开(公告)号：US06673586B2
公开(公告)日：2004-01-06
申请号：US09765815
申请日：2001-01-19
申请人： Steven Balk
发明人： Steven Balk
IPC分类号： C12N912
CPC分类号： C12N9/1205
摘要： The present invention features a novel p21-activated kinase that interacts with steroid hormone receptors, the steroid hormone receptor interacting p21-activated kinase (PAKSI). In general, the invention provides methods of inhibiting hormone related cancers. More particularly, the present invention relates to inhibiting prostate cancer and breast cancer. The present invention further provides methods of activating the therapeutic effects of steroid hormone receptors, particularly the estrogen receptor. Alternatively, the present invention provides methods of diagnosing steroid hormone receptor-related diseases.
摘要翻译：本发明的特征在于一种新型的p21激活的激酶，其与类固醇激素受体（类固醇激素受体相互作用的p21激活的激酶（PAKSI））相互作用。通常，本发明提供抑制激素相关癌症的方法。更具体地，本发明涉及抑制前列腺癌和乳腺癌。本发明还提供激活类固醇激素受体，特别是雌激素受体的治疗作用的方法。或者，本发明提供诊断类固醇激素受体相关疾病的方法。

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