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1. 发明申请

US20080234521A1 CRYSTAL FORMS OF ASTAXANTHIN 有权
标题翻译：阿司匹林的晶体形式
公开(公告)号：US20080234521A1
公开(公告)日：2008-09-25
申请号：US12032281
申请日：2008-02-15
申请人： Steve LEIGH , Mathew Louis Steven Leigh , Peter Van Hoogevest
发明人： Steve LEIGH , Mathew Louis Steven Leigh , Peter Van Hoogevest
IPC分类号： C07C45/61 , C07C49/713
CPC分类号： C07C403/24
摘要： Mixtures of specific crystal forms of astaxanthin and the individual crystal forms designated crystal Form I and II and disclosed together with methods for preparing said crystal Forms. Methods for preparing nutritional dosage forms including the disclosed astaxanthin crystal forms for the life science industry are also disclosed.
摘要翻译：特定晶体形式的虾青素和单独晶体的混合物形成指定的晶型I和II，并与制备所述晶形的方法一起公开。还公开了包括所公开的生命科学工业的虾青素晶体形式的营养剂型的方法。

2. 发明申请

US20050260145A1 Oil soluble compositions 审中-公开
标题翻译：油溶性组合物
公开(公告)号：US20050260145A1
公开(公告)日：2005-11-24
申请号：US10516019
申请日：2003-05-28
申请人： Steve Leigh , Mathew Leigh , Peter Hoogevest , Henricus Tiemessen
发明人： Steve Leigh , Mathew Leigh , Peter Hoogevest , Henricus Tiemessen
IPC分类号： A23K1/16 , A23K1/18 , A23L20060101 , A23L1/22 , A23L1/27 , A23L1/272 , A23L1/275 , A23L1/30 , A23L1/302 , A61K20060101 , A61K9/00 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/035 , A61K31/07 , A61K31/122 , A61K47/44 , A61P3/02 , C09B20060101 , C09B61/00 , C09B67/44 , A61K7/021
CPC分类号： C09B67/0083 , A23K20/179 , A23K50/80 , A23L5/42 , A23L5/44 , A23L27/00 , A23L33/105 , A23L33/15 , A61K9/0014 , A61K9/1652 , A61K47/44 , C09B61/00
摘要： A process is disclosed for the preparation of an oily solution of a carotenoid, particularly astaxanthin, a composition comprising at least one xanthophyll and at least one suitable solvent, particularly n-methyl-pyrrolidone, a composition comprising a carotenoid and a mixture of mono-, di- and triglycerides subjected to enzyme treatment, glycerolysis and/or fractionation, and a solid homogeneous mixture comprising one xanthophyll in a physiologically acceptable amount and at least one lipophilic dispersing agent. The process is useful, for example, in preparing nutrient or pharmaceutical compositions.
摘要翻译：公开了用于制备类胡萝卜素，特别是虾青素的油性溶液的方法，包含至少一种叶黄素和至少一种合适的溶剂，特别是N-甲基吡咯烷酮的组合物，包含类胡萝卜素和单 - 经过酶处理，甘油分解和/或分级分离的二甘油三酯和甘油三酸酯，以及包含一种生理上可接受量的叶黄素和至少一种亲脂性分散剂的固体均匀混合物。该方法例如在制备营养物或药物组合物中是有用的。

3. 发明授权

US08632832B2 Direct dissolution 有权
标题翻译：直接溶解
公开(公告)号：US08632832B2
公开(公告)日：2014-01-21
申请号：US11984754
申请日：2007-11-21
申请人： Steve Leigh , Mathew Louis Steven Leigh , Peter Van Hoogevest
发明人： Steve Leigh , Mathew Louis Steven Leigh , Peter Van Hoogevest
IPC分类号： A23L1/27 , A47J39/00 , A23D7/00
CPC分类号： C09B61/00 , A23K20/158 , A23K20/179 , A23K40/20 , A23K40/25 , A23K50/80 , A23L5/44 , A23L33/105 , A23L33/115 , A23L33/15 , A23L33/155 , A23P10/35 , A23V2002/00 , Y02A40/818 , Y02P20/13 , A23V2250/211 , A23V2200/224 , A23V2250/186 , A23V2250/156
摘要： The present disclosure describes a method for the continuous dissolution of e.g. crystalline astaxanthin or canthaxanthin suspension in oil, by applying heat for a predetermined period using an in-line or optionally batch wise-process, followed by cooling the heated solution with an oil phase or heat exchanger. The resulting oil solution may be used as such or added directly to feed components which are turned into feed compositions by extrusion, compaction or granulation. Alternatively the oil solution is spray coated or directly loaded to extruded or compacted pellets and granulates. The disclosure avoids using formulated carotenoids prepared by known multi-step production methods requiring solvents, solvent removal, cooling and emulsification with an aqueous phase or precipitation and recovery steps. Thus the present invention is a more economical, efficient and environmentally friendly method to add nutrients and colorants to feed compositions instead of using colloid dispersed particulate hydrocolloid compositions.
摘要翻译：本公开描述了用于连续溶解的方法。结晶的虾青素或角黄素悬浮液在油中，通过使用在线或任选的分批方法施加热量预定的时间，然后用油相或热交换器冷却加热的溶液。得到的油溶液可以原样使用或直接加入通过挤出，压实或造粒转化成进料组合物的进料组分。或者，油溶液被喷涂或直接装载到挤出或压实的颗粒和颗粒中。本公开避免使用通过已知的多步骤生产方法制备的配制的类胡萝卜素，其需要溶剂，溶剂去除，冷却和用水相或沉淀和回收步骤乳化。因此，本发明是一种更经济，有效和环境友好的添加营养物和着色剂到饲料组合物而不是使用胶体分散的颗粒状水胶体组合物的方法。

4. 发明申请

US20090145248A1 DISSOLUTION COMPOSITION FOR EXAMINING DRUG SOLUBILITY 有权
标题翻译：用于检查药物溶解性的溶解组合物
公开(公告)号：US20090145248A1
公开(公告)日：2009-06-11
申请号：US12084806
申请日：2006-11-10
申请人： Steve Leigh , Matthew Louis Steven Leigh , Peter Van Hoogevest , Daniel Streich , Jacques Quinton
发明人： Steve Leigh , Matthew Louis Steven Leigh , Peter Van Hoogevest , Daniel Streich , Jacques Quinton
IPC分类号： G01N33/15
CPC分类号： G01N33/15 , Y10S514/937 , Y10S514/943
摘要： There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.
摘要翻译：描述了固体组合物或检查药物溶解度，其包含胆汁盐和磷脂，任选地含有适于制备肠培养基的缓冲组分，其模拟禁食和进食状态下肠液的组成。

5. 发明申请

US20060286169A1 Lipophilic compositions 审中-公开
标题翻译：亲油性组合物
公开(公告)号：US20060286169A1
公开(公告)日：2006-12-21
申请号：US10545416
申请日：2004-02-13
申请人： Mathew Leigh , Peter Van Hoogevest , Jacques Quinton , Steve Leigh
发明人： Mathew Leigh , Peter Van Hoogevest , Jacques Quinton , Steve Leigh
IPC分类号： A61K9/14
CPC分类号： A61K9/1652 , A61K9/146 , A61K9/4866
摘要： There is described dry compositions comprising lipophilic compounds associated with low viscosity grades of water insoluble polymer and optionally hydrophilic agent/s associated either as monomolecular or amorphous complexes. There is also described a method of preparing said lipophilic polymer complexes from a solution or homogeneous dispersion employing either water miscible or immiscible organic solvents. The lipophilic polymer complex is precipitated from the solution comprising a water miscible solvent by dilution with water, separating out the precipitated complex, washing, drying and conversion to oral and topical dosage forms. The lipophilic polymer complex may also be prepared by solvent removal involving spray drying or vacuum drying under elevated temperatures using either water miscible or water immiscible solvents. The compositions are characterised by improved dissolution and solubility of the associated compound in aqueous medium.
摘要翻译：描述了包含与低粘度等级的水不溶性聚合物相关的亲脂性化合物和任选的作为单分子或无定形络合物缔合的亲水剂的干组合物。还描述了使用水可混溶或不混溶的有机溶剂的溶液或均匀分散体制备所述亲脂性聚合物复合物的方法。通过用水稀释，从包含水混溶性溶剂的溶液中沉淀亲脂性聚合物络合物，分离出沉淀的复合物，洗涤，干燥和转化为口服和局部剂型。亲脂性聚合物复合物也可以通过溶剂去除制备，包括喷雾干燥或在高温下使用水混溶或水不混溶的溶剂进行真空干燥。组合物的特征在于相关化合物在水性介质中的溶解和溶解度得到改善。

6. 发明申请

US20060128665A1 Marine lipid compositions 审中-公开
标题翻译：海洋脂质组成
公开(公告)号：US20060128665A1
公开(公告)日：2006-06-15
申请号：US10536450
申请日：2003-11-26
申请人： Steve Leigh , Elsa Kung , Peter Van Hoogevest , Henricus Tiemessen
发明人： Steve Leigh , Elsa Kung , Peter Van Hoogevest , Henricus Tiemessen
IPC分类号： A61K31/685 , A61K31/66 , C07F9/02
CPC分类号： A23D9/013 , A23J7/00 , A23K20/147 , A23K40/10 , A23K40/30 , A23K50/80 , A23L33/115 , A23L33/12 , A23L33/17 , A23V2002/00 , C11B1/10 , C11B1/104 , Y02A40/818 , A23V2200/224 , A23V2250/192 , A23V2250/182 , A23V2250/05 , A23V2250/1842
摘要： There is described marine phospholipids (MPL) compositions suitable for human, aquaculture applications comprising a dry composition comprising nutritional components selected from the group consisting of marine phospholipids, marine proteins and amino acid blends obtainable by fluid extraction of a dried marine raw material. The compositions have low amounts of neutral lipids and particularly low amounts of cholesterol and cholesterol esters. They may be used either as such in powder form and for preparing purified MPL compositions by ethanol extraction. Both forms may be used as nutritional supplements, ingredients for functional foods and to optimise the delivery and containment of nutritional components in multicomponent fish feed compositions. There is further described a blend of the purified, ethanol extracted MPL compositions mixed with marine, vegetable, microbial or MCT oils to form liquid preparations for hard or soft gel encapsulation. There is further described MPL concentrates comprising purified and clearly defined phospholipid types dispersed in hydrophilic medium which are nutritionally essential in larvae feed. Still further there is described MPL compositions in unit dosage forms as supplements to supply highly bioavailable omega-3 fatty acids for human use, optionally with biologically active compounds.
摘要翻译：描述了适用于人，水产养殖应用的海洋磷脂（MPL）组合物，其包含干组合物，其包含选自海洋磷脂，海洋蛋白质和通过干燥的海洋原料的流体萃取获得的氨基酸混合物的营养成分。组合物具有低量的中性脂质，特别是低量的胆固醇和胆固醇酯。它们可以以粉末形式使用，也可以通过乙醇提取制备纯化的MPL组合物。两种形式可以用作营养补充剂，功能食品的成分，并优化多组分鱼饲料组合物中营养成分的输送和遏制。进一步描述了与海洋，植物，微生物或MCT油混合的纯化的乙醇提取的MPL组合物的混合物，以形成用于硬或软凝胶包封的液体制剂。进一步描述了MPL浓缩物，其包含分散在亲水介质中的纯化和明确定义的磷脂类型，其在幼虫饲料中是营养必需的。此外，还描述了单位剂型中的MPL组合物作为补充剂，为人类提供高度生物可利用的ω-3脂肪酸，任选地具有生物活性化合物。

7. 发明授权

US08287907B2 Dissolution composition for examining drug solubility 有权
标题翻译：用于检查药物溶解度的溶出组合物
公开(公告)号：US08287907B2
公开(公告)日：2012-10-16
申请号：US12084806
申请日：2006-11-10
申请人： Steve Leigh , Matthew Louis Steven Leigh , Peter Van Hoogevest , Daniel Streich , Jacques Quinton
发明人： Steve Leigh , Matthew Louis Steven Leigh , Peter Van Hoogevest , Daniel Streich , Jacques Quinton
IPC分类号： A61K9/14 , A61K9/08 , A61K9/10 , A61K47/12 , A61K47/44 , G01N33/15
CPC分类号： G01N33/15 , Y10S514/937 , Y10S514/943
摘要： There are described solid compositions or examining drug solubility comprising bile salts and phospholipids, optionally containing buffer components suitable for preparation of intestinal media that simulate the composition of the intestinal fluids in fasted and fed states.
摘要翻译：描述了固体组合物或检查药物溶解度，其包含胆汁盐和磷脂，任选地含有适于制备肠培养基的缓冲组分，其模拟禁食和进食状态下肠液的组成。

8. 发明申请

US20110244028A1 METHOD OF SOLUBILIZING BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：溶解生物活性化合物的方法
公开(公告)号：US20110244028A1
公开(公告)日：2011-10-06
申请号：US13121042
申请日：2009-09-28
申请人： Steve Leigh , Mathew Leuis Steven Leigh , Peter Van Hoogevest
发明人： Steve Leigh , Mathew Leuis Steven Leigh , Peter Van Hoogevest
IPC分类号： A61K9/127 , A61K31/5513 , A61K31/519 , A61K31/496 , A61K31/4164 , A61P43/00
CPC分类号： A61K47/24 , A61K9/1277
摘要： The invention describes a method of preparing lipid compositions by associating pH sensitive compounds which maybe weak acids, bases or amphoteric compounds with at least one ionisable or pH sensitive group and low water solubility into preformed and standardised lipid particles by pH manipulation. Drug association is carried out in situ by changing the pH of the aqueous medium to pH 6-8 wherein the compound spontaneously partitions into the lipid particles. Drug association may also be carried out by exploiting pH changes in the GI tract. The lipophilic compound is solubilised by the lipid particles and may be used as such for in-vitro and pharmacokinetic assessments or processed for oral, parenteral or topical therapy.
摘要翻译：本发明描述了一种制备脂质组合物的方法，其通过pH操作将pH敏感化合物（其弱酸，碱或两性化合物与至少一个可电离或pH敏感基团和低水溶性）结合到预先形成和标准化的脂质颗粒中。通过将水性介质的pH改变为pH6-8，原位进行药物缔合，其中化合物自发分配成脂质颗粒。也可以通过利用GI道中的pH变化来进行药物关联。亲脂性化合物被脂质颗粒溶解，并且可以原样用于体外和药代动力学评估或用于口服，肠胃外或局部治疗。

9. 发明授权

US07563935B2 Crystal forms of astaxanthin 有权
标题翻译：晶体形式的虾青素
公开(公告)号：US07563935B2
公开(公告)日：2009-07-21
申请号：US12032281
申请日：2008-02-15
申请人： Steve Leigh , Mathew Louis Steven Leigh , Peter Van Hoogevest
发明人： Steve Leigh , Mathew Louis Steven Leigh , Peter Van Hoogevest
IPC分类号： C07C45/00
CPC分类号： C07C403/24
摘要： Mixtures of specific crystal forms of astaxanthin and the individual crystal forms designated crystal Form I and II and disclosed together with methods for preparing said crystal Forms. Methods for preparing nutritional dosage forms including the disclosed astaxanthin crystal forms for the life science industry are also disclosed.
摘要翻译：特定晶体形式的虾青素和单独晶体的混合物形成指定的晶型I和II，并与制备所述晶形的方法一起公开。还公开了包括所公开的生命科学工业的虾青素晶体形式的营养剂型的方法。

10. 发明申请

US20080311267A1 Direct dissolution 有权
标题翻译：直接溶解
公开(公告)号：US20080311267A1
公开(公告)日：2008-12-18
申请号：US11984754
申请日：2007-11-21
申请人： Steve Leigh , Mathew Louis Steven Leigh , Peter Van Hoogevest
发明人： Steve Leigh , Mathew Louis Steven Leigh , Peter Van Hoogevest
IPC分类号： A23L1/275
CPC分类号： C09B61/00 , A23K20/158 , A23K20/179 , A23K40/20 , A23K40/25 , A23K50/80 , A23L5/44 , A23L33/105 , A23L33/115 , A23L33/15 , A23L33/155 , A23P10/35 , A23V2002/00 , Y02A40/818 , Y02P20/13 , A23V2250/211 , A23V2200/224 , A23V2250/186 , A23V2250/156
摘要： The present disclosure describes a method for the continuous dissolution of e.g. crystalline astaxanthin or canthaxanthin suspension in oil, by applying heat for a predetermined period using an in-line or optionally batch wise-process, followed by cooling the heated solution with an oil phase or heat exchanger. The resulting oil solution may be used as such or added directly to feed components which are turned into feed compositions by extrusion, compaction or granulation. Alternatively the oil solution is spray coated or directly loaded to extruded or compacted pellets and granulates. The disclosure avoids using formulated carotenoids prepared by known multi-step production methods requiring solvents, solvent removal, cooling and emulsification with an aqueous phase or precipitation and recovery steps. Thus the present invention is a more economical, efficient and environmentally friendly method to add nutrients and colourants to feed compositions instead of using colloid dispersed particulate hydrocolloid compositions.
摘要翻译：本公开描述了用于连续溶解的方法。结晶的虾青素或角黄素悬浮液在油中，通过使用在线或任选的分批方法施加热量预定的时间，然后用油相或热交换器冷却加热的溶液。得到的油溶液可以原样使用或直接加入通过挤出，压实或造粒转化成进料组合物的进料组分。或者，油溶液被喷涂或直接装载到挤出或压实的颗粒和颗粒中。本公开避免使用通过已知的多步骤生产方法制备的配制的类胡萝卜素，其需要溶剂，溶剂去除，冷却和用水相或沉淀和回收步骤乳化。因此，本发明是更经济，有效和环境友好的方法，以添加营养物和着色剂到饲料组合物而不是使用胶体分散的颗粒状水解胶体组合物。

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