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1. 发明授权

US07399586B2 Modulation of biological signal transduction by RNA interference 失效
标题翻译：通过RNA干扰调节生物信号转导
公开(公告)号：US07399586B2
公开(公告)日：2008-07-15
申请号：US10444795
申请日：2003-05-23
申请人： Richard Klinghoffer , Stephen Patrick Lewis
发明人： Richard Klinghoffer , Stephen Patrick Lewis
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/03 , C12N15/00 , C07N21/04
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/3517 , C12N2310/53 , C12Y301/03048
摘要： Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that interfere with expression of members of the protein tyrosine phosphatase (PTP) class of enzymes that mediate signal transduction, and with certain MAP kinase kinases (MKK). In certain preferred embodiments siRNA modulate signal transduction pathways comprising SHP2, cdc14a/b, cdc25A/B/C, KAP, PTP-ε, PRL-3, CD45, dual specificity phosphatase-3 (DSP-3), MKK-4, and/or MKK-7. Modulation of PTP-mediated biological signal transduction has uses in diseases associated with defects in cell proliferation, cell differentiation and/or cell survival, such as metabolic disorders (including diabetes and obesity), cancer, autoimmune disease, infectious and inflammatory disorders and other conditions. The invention also provides siRNA polynucleotides that interfere with expression of chemotherapeutic target polypeptides, such as DHFR, thymidylate synthetase, and topoisomerase I.
摘要翻译：提供了与小干扰RNA（siRNA）多核苷酸相关的组合物和方法，涉及生物信号转导的调节。显示干扰介导信号转导的酶的蛋白酪氨酸磷酸酶（PTP）类成员和某些MAP激酶激酶（MKK）的成员的表达的siRNA多核苷酸。在某些优选实施方案中，siRNA调节包含SHP2，cdc14a / b，cdc25A / B / C，KAP，PTP-ε，PRL-3，CD45，双特异性磷酸酶-3（DSP-3），MKK-4和 /或MKK-7。 PTP介导的生物信号转导的调节在与细胞增殖，细胞分化和/或细胞存活缺陷相关的疾病中使用，例如代谢紊乱（包括糖尿病和肥胖症），癌症，自身免疫性疾病，感染性和炎症性疾病和其他病症。本发明还提供干扰化学治疗靶多肽如DHFR，胸苷酸合成酶和拓扑异构酶I的表达的siRNA多核苷酸。

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