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1. 发明授权

US08597625B2 Volume up shampoos II 有权
标题翻译：增加洗发水II
公开(公告)号：US08597625B2
公开(公告)日：2013-12-03
申请号：US13000120
申请日：2009-06-19
申请人： Franciscus Derks , Stephen Foster , Robert Lochhead , Adarsh Maini , Dirk Weber
发明人： Franciscus Derks , Stephen Foster , Robert Lochhead , Adarsh Maini , Dirk Weber
IPC分类号： A61K8/81
CPC分类号： A61K8/85 , A61Q5/02 , A61Q5/06 , A61Q5/12
摘要： The invention relates to aqueous compositions comprising an anionic surfactant and a hyperbranched polyesteramide comprising at least one secondary amide bond and having at least one quarternized amine end-group. The compositions, in particular in the form of shampoo preparations are suited for increasing the volume of hair treated therewith. Furthermore, such compositions provide styling attributes and increase the wet-combability of hair.
摘要翻译：本发明涉及包含阴离子表面活性剂和包含至少一个仲酰胺键并且具有至少一个季铵化胺末端基团的超支化聚酯酰胺的含水组合物。组合物，特别是洗发剂制剂的形式适合于增加用其处理的头发的体积。此外，这样的组合物提供造型属性并增加头发的湿润性。

2. 发明申请

US20130309238A1 SIGNAL TRANSDUCTION PATHWAY MODULATION 审中-公开
标题翻译：信号传输路径调制
公开(公告)号：US20130309238A1
公开(公告)日：2013-11-21
申请号：US13885491
申请日：2011-11-15
申请人： Joerg Mattes , Paul Stephen Foster , Adam Collison , Luke Hatchwell
发明人： Joerg Mattes , Paul Stephen Foster , Adam Collison , Luke Hatchwell
IPC分类号： A61K39/395 , A61K31/135 , A61K31/7088
CPC分类号： A61K39/3955 , A61K31/135 , A61K31/7088 , A61K31/7105 , C12N15/113 , G01N2500/10 , G01N2800/122 , G01N2800/24 , G01N2800/50
摘要： Provided herein are methods and compositions for modulating signal transduction pathways by regulating the expression and/or activity of Midline-1, enabling the inhibition of airways inflammation, the inhibition of airways hyperresponsiveness, the inhibition of rhinovirus-associated inflammation, and reductions in cytokine and chemokine release. Methods and compositions disclosed herein facilitate the treatment and prevention of conditions associated with airway inflammation, airway tissue remodelling and rhinovirus-associated inflammation and symptoms, manifestations and exacerbations thereof, in particular of allergic diseases such as allergic airways diseases including asthma.
摘要翻译：本文提供了通过调节Midline-1的表达和/或活性来调节信号转导途径的方法和组合物，其能够抑制气道炎症，抑制气道高反应性，抑制鼻病毒相关炎症和减少细胞因子和趋化因子释放。本文公开的方法和组合物有助于治疗和预防与气道炎症，气道组织重塑和鼻病毒相关的炎症及其症状，表现和恶化相关的病症，特别是过敏性疾病如过敏性气道疾病（包括哮喘）。

3. 发明授权

US08288358B2 Therapeutic targets and molecules 失效
标题翻译：治疗靶点和分子
公开(公告)号：US08288358B2
公开(公告)日：2012-10-16
申请号：US12593066
申请日：2008-03-26
申请人： Paul Stephen Foster , Joerg Mattes
发明人： Paul Stephen Foster , Joerg Mattes
IPC分类号： C12N15/11 , C07H21/04
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention provides methods and compositions for treating or preventing inflammation or an inflammatory condition in a subject, comprising administering to the subject an effective amount of at least one antagonist of one or more miRNA upregulated in inflammatory disease conditions and response to allergen challenge. The invention also provides methods for diagnosing inflammatory conditions based on miRNA expression profile signatures.
摘要翻译：本发明提供用于治疗或预防受试者的炎症或炎性病症的方法和组合物，其包括向所述受试者施用有效量的一种或多种在炎性疾病病症中上调的miRNA的至少一种拮抗剂和对变应原攻击的反应。本发明还提供了基于miRNA表达谱特征来诊断炎性病症的方法。

4. 发明申请

US20070095157A1 Method and apparatus for analysis of elements in bulk substance 有权
标题翻译：散装物质元素分析方法和装置
公开(公告)号：US20070095157A1
公开(公告)日：2007-05-03
申请号：US11640546
申请日：2006-12-18
申请人： Clinton Lingren , David Cook , James Miller , Stephen Foster
发明人： Clinton Lingren , David Cook , James Miller , Stephen Foster
IPC分类号： G01N1/00
CPC分类号： G01T3/06 , G01N23/222 , G01N2223/0745
摘要： A substance analyzer utilizing Prompt Gamma Neutron Activation Analysis for identifying characteristics of a substance and method of manufacturing the same are disclosed. The analyzer is small enough to be portable and to allow its use in many applications where current analyzers cannot be utilized. The analyzer uses a neutron radiation source and a gamma-ray detector to activate the sample material and detect the prompt gamma rays emitted by the sample material. A novel housing for such an analyzer and method for making the housing are also described. Novel methods of operating such an analyzer including via a communications network are also disclosed. Also disclosed are data analysis methods that improve the accuracy and sensitivity of the results of such material analysis.
摘要翻译：公开了一种利用快速γ中子激活分析来鉴定物质特性的物质分析仪及其制造方法。分析仪足够小以便于携带，并允许其在许多不能使用电流分析仪的应用中使用。分析仪使用中子辐射源和伽马射线检测器来激活样品材料并检测样品材料发出的迅速伽马射线。还描述了一种用于这种分析器的新型外壳和用于制造外壳的方法。还公开了通过通信网络操作这种分析器的新颖方法。还公开了提高这种材料分析结果的准确性和灵敏度的数据分析方法。

5. 发明申请

US20160026986A1 SECURE BILLING SYSTEM FOR FUEL AND GAS SALES 审中-公开
标题翻译：燃料和气体销售的安全计费系统
公开(公告)号：US20160026986A1
公开(公告)日：2016-01-28
申请号：US14741732
申请日：2015-06-17
申请人： Stephen Foster , Kevin Peakman
发明人： Stephen Foster , Kevin Peakman
IPC分类号： G06Q20/20
CPC分类号： G06Q20/145
摘要： An improved billing system for the dispensing of fuel and gas products is described. The system is comprised of non-proprietary (off the shelf) components that can be controlled by the fuel and gas seller. This avoids the need to use proprietary systems offered by system vendors and results in capital and maintenance cost savings.
摘要翻译：描述了用于分配燃料和气体产品的改进的计费系统。该系统由可由燃料和燃气销售商控制的非专有（现成）组件组成。这避免了使用系统供应商提供的专有系统的需要，从而节省了资本和维护成本。

6. 发明申请

US20140096540A1 ZERO LOSS COOLDOWN OF CRYOGENIC PUMP 审中-公开
标题翻译：低压泵的零损失
公开(公告)号：US20140096540A1
公开(公告)日：2014-04-10
申请号：US14039781
申请日：2013-09-27
申请人： Stephen Foster
发明人： Stephen Foster
IPC分类号： F17C7/02
CPC分类号： F17C7/02 , F17C2221/033 , F17C2223/0161 , F17C2223/033 , F17C2225/0161 , F17C2225/035 , F17C2227/0142 , F17C2227/015
摘要： A system for cryogenic liquid delivery includes a cryogenic vacuum pump that operates to efficiently cool down the cryogenic delivery pump. The system is a no loss system that provides reduced cool down time at lower cost greater versatility and maintainability.
摘要翻译：用于低温液体输送的系统包括低温真空泵，其操作以有效地冷却低温输送泵。该系统是一种无损耗系统，可以降低成本，降低冷却时间，提高通用性和可维护性。

7. 发明申请

US20120230987A1 METHODS FOR TREATING CONDITIONS ASSOCIATED WITH C-FMS 有权
标题翻译：处理与C-FMS有关的条件的方法
公开(公告)号：US20120230987A1
公开(公告)日：2012-09-13
申请号：US13466850
申请日：2012-05-08
申请人： Kenneth Allan BRASEL , James F. SMOTHERS , Douglas Pat CERRETTI , Christopher MEHLIN , Jilin SUN , Stephen FOSTER
发明人： Kenneth Allan BRASEL , James F. SMOTHERS , Douglas Pat CERRETTI , Christopher MEHLIN , Jilin SUN , Stephen FOSTER
IPC分类号： A61K39/395 , A61P35/02 , A61P19/00 , A61P19/02 , A61P25/28 , A61P1/00 , A61P17/06 , A61P17/00 , A61P3/10 , A61P37/06 , A61P35/00 , A61P29/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K14/7153 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-1, reduce monocyte migration into tumors, and reduce the accumulation of tumor-associated macrophages.
摘要翻译：提供了结合人c-fms蛋白的抗原结合蛋白。还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。抗原结合蛋白可以抑制c-fms与CSF-1的结合，减少单核细胞迁移到肿瘤中，减少肿瘤相关巨噬细胞的积累。

8. 发明申请

US20110165107A1 Volume up shampoos 审中-公开
标题翻译：增容洗发水
公开(公告)号：US20110165107A1
公开(公告)日：2011-07-07
申请号：US12999740
申请日：2009-06-19
申请人： Franciscus Derks , Stephen Foster , Robert Lochhead , Adarsh Maini , Dirk Weber
发明人： Franciscus Derks , Stephen Foster , Robert Lochhead , Adarsh Maini , Dirk Weber
IPC分类号： A61K8/72 , A61Q5/02
CPC分类号： A61K8/72 , A61K8/85 , A61Q5/00 , A61Q5/02 , A61Q5/06 , A61Q5/12 , C08G69/44 , C08G83/005 , C08L101/005
摘要： The invention relates to aqueous compositions comprising an anionic surfactant and a hyperbranched polyesteramide having at least one quarternized amine end-group. The compositions, in particular in the form of shampoo preparations are suited for increasing the volume of hair treated therewith. Furthermore, such compositions provide styling attributes and increase the wet-combability of hair.
摘要翻译：本发明涉及包含阴离子表面活性剂和具有至少一个季铵化胺端基的超支化聚酯酰胺的含水组合物。组合物，特别是洗发剂制剂的形式适合于增加用其处理的头发的体积。此外，这样的组合物提供造型属性并增加头发的湿润性。

9. 发明申请

US20100113562A1 THERAPEUTIC TARGETS AND MOLECULES 失效
标题翻译：治疗目标和分子
公开(公告)号：US20100113562A1
公开(公告)日：2010-05-06
申请号：US12593066
申请日：2008-03-26
申请人： Paul Stephen Foster , Joerg Mattes
发明人： Paul Stephen Foster , Joerg Mattes
IPC分类号： A61K31/7052 , C07H21/00 , C07H21/02 , C12Q1/68 , A61P29/00 , A61P11/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2310/3521
摘要： The invention provides methods and compositions for treating or preventing inflammation or an inflammatory condition in a subject, comprising administering to the subject an effective amount of at least one antagonist of one or more miRNA upregulated in inflammatory disease conditions and response to allergen challenge. The invention also provides methods for diagnosing inflammatory conditions based on miRNA expression profile signatures.
摘要翻译：本发明提供用于治疗或预防受试者的炎症或炎性病症的方法和组合物，其包括向所述受试者施用有效量的一种或多种在炎性疾病病症中上调的miRNA的至少一种拮抗剂和对变应原攻击的反应。本发明还提供了基于miRNA表达谱特征来诊断炎性病症的方法。

10. 发明授权

US07521048B2 TRAIL receptor-2 polypeptides and antibodies 有权
标题翻译： TRAIL受体-2多肽和抗体
公开(公告)号：US07521048B2
公开(公告)日：2009-04-21
申请号：US11512051
申请日：2006-08-28
申请人： Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
发明人： Brian Gliniak , Xiao-Dong Yang , Sharon Wong-Madden , Ian Foltz , Xiao Feng , Alison Fitch , Stephen Foster , Randal R. Ketchem
IPC分类号： C12P21/08 , A61K39/00
CPC分类号： A61K39/39558 , A61K38/00 , C07K16/2878 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92
摘要： Polypeptides are provided. Antibodies or antigen binding domains are provided which bind such polypeptides. Also provided are methods of obtaining an antibody that binds tumor necrosis factor (TNF)-related apoptosis-inducing ligand (“TRAIL”) Receptor-2 (TR-2) comprising administering at least one of such polypeptides to an animal and obtaining an antibody that binds TR-2 from the animal. Antibodies reactive with TR-2 are provided. Also provided are cells producing antibodies reactive with TR-2, pharmaceutical compositions comprising antibodies reactive with TR-2, methods using antibodies reactive with TR-2, and kits comprising antibodies reactive with TR-2. Also provided are methods of decreasing or preventing binding of an antibody to TR-2 by administering such a polypeptide.
摘要翻译：提供多肽。提供结合这些多肽的抗体或抗原结合结构域。还提供了获得结合肿瘤坏死因子（TNF）相关的凋亡诱导配体（“TRAIL”）受体-2（TR-2）的抗体的方法，包括向动物施用至少一种这样的多肽并获得抗体其结合来自动物的TR-2。提供与TR-2反应的抗体。还提供产生与TR-2反应的抗体的细胞，包含与TR-2反应的抗体的药物组合物，使用与TR-2反应的抗体的方法，以及包含与TR-2反应的抗体的试剂盒。还提供了通过施用这样的多肽来降低或预防抗体与TR-2结合的方法。

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