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1. 发明授权

US07273703B2 Detection of mutations 有权
标题翻译：检测突变
公开(公告)号：US07273703B2
公开(公告)日：2007-09-25
申请号：US10501032
申请日：2003-01-09
申请人： Anne Lunden , Leif Andersson , Stefan Marklund
发明人： Anne Lunden , Leif Andersson , Stefan Marklund
IPC分类号： C12Q1/68 , C07H21/04 , C12N9/06 , C12P21/06
CPC分类号： C12N9/0073
摘要： The present invention relates to a polypeptide which is a flavin-containing monooxygenase 3 (FMO3), wherein said FMO3 is a polypeptide comprising at least a sequence having at least 85% identity with the polypeptide sequence SEQ ID NO: 15, in particular to a polypeptide which is a functionally altered mutant of flavin-containing mono oxygenase 3 (FMO3) leading to a buildup of trimethylamine in an animal. Further, the invention relates to nucleic acid sequences encoding said polypeptide, and to the complements of such nucleic acid sequences. Such nucleic acid sequences and fragments thereof may be useful e.g. as primers. The invention further relates to various methods for determining the presence in e.g. a nucleic acid sample of a nucleic acid sequence encoding a mutated FMO3 polypeptide.
摘要翻译：本发明涉及一种多肽，其是含黄素的单加氧酶3（FMO3），其中所述FMO3是至少包含与多肽序列SEQ ID NO：15具有至少85％同一性的序列的多肽，特别是与多肽，其是功能性改变的含黄素的单加氧酶3（FMO3）的突变体，导致动物中三甲胺的积累。此外，本发明涉及编码所述多肽的核酸序列以及这些核酸序列的互补序列。这样的核酸序列及其片段可以是有用的。作为引物。本发明进一步涉及用于确定例如存在的各种方法。编码突变FMO3多肽的核酸序列的核酸样品。

2. 发明授权

US07858369B2 Expression constructs expressing Prkag3 失效
标题翻译：表达构建表达Prkag3
公开(公告)号：US07858369B2
公开(公告)日：2010-12-28
申请号：US11744590
申请日：2007-05-04
申请人： Leif Andersson , Stefan Marklund
发明人： Leif Andersson , Stefan Marklund
IPC分类号： C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C12N9/1205 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/108 , A01K2267/03 , A01K2267/0362 , C12N15/8509 , C12N2830/008
摘要： Transgenic non-human animals that express the γ3 subunit of PRKAG are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention, or diagnosis of diseases related to energy metabolism, including obesity, dyslipidemia, insulin resistance syndrome, and type 2 diabetes.
摘要翻译：描述了表达PRKAG的γ3亚基的转基因非人动物，以及使用转基因非人动物作为改善治疗，预防或诊断与能量代谢有关的疾病的模型的方法，包括肥胖，血脂异常，胰岛素耐药综合征和2型糖尿病。

3. 发明申请

US20060147910A1 Detection of mutations 有权
标题翻译：检测突变
公开(公告)号：US20060147910A1
公开(公告)日：2006-07-06
申请号：US10501032
申请日：2003-01-09
申请人： Anne Lunden , Leif Andersson , Stefan Marklund
发明人： Anne Lunden , Leif Andersson , Stefan Marklund
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/06
CPC分类号： C12N9/0073
摘要： The present invention relates to a polypeptide which is a flavin-containing monooxygenase 3 (FMO3), wherein said FMO3 is a polypeptide comprising at least a sequence having at least 85% identity with the polypeptide sequence SEQ ID NO: 15, in particular to a polypeptide which is a functionally altered mutant of flavin-containing mono oxygenase 3 (FMO3) leading to a buildup of trimethylamine in an animal. Further, the invention relates to nucleic acid sequences encoding said polypeptide, and to the complements of such nucleic acid sequences. Such nucleic acid sequences and fragments thereof may be useful e.g. as primers. The invention further relates to various methods for determining the presence in e.g. a nucleic acid sample of a nucleic acid sequence encoding a mutated FMO3 polypeptide.
摘要翻译：本发明涉及一种多肽，其是含黄素的单加氧酶3（FMO3），其中所述FMO3是至少包含与多肽序列SEQ ID NO：15具有至少85％同一性的序列的多肽，特别是与多肽，其是功能性改变的含黄素的单加氧酶3（FMO3）的突变体，导致动物中三甲胺的积累。此外，本发明涉及编码所述多肽的核酸序列以及这些核酸序列的互补序列。这样的核酸序列及其片段可以是有用的。作为引物。本发明进一步涉及用于确定例如存在的各种方法。编码突变FMO3多肽的核酸序列的核酸样品。

4. 发明授权

US06849401B1 Methods for determining coat color genotypes in pigs 有权
标题翻译：确定猪的外壳颜色基因型的方法
公开(公告)号：US06849401B1
公开(公告)日：2005-02-01
申请号：US09550605
申请日：2000-04-17
申请人： Leif Andersson , Stefan Marklund , James Kijas , Maria Moller , Richard Wales
发明人： Leif Andersson , Stefan Marklund , James Kijas , Maria Moller , Richard Wales
IPC分类号： C12N15/09 , C12Q1/68 , C07H21/04 , C12P19/34 , G01N33/53
CPC分类号： C12Q1/6876 , C12Q2600/124 , C12Q2600/156
摘要： Methods for determining coat color genotypes in pigs are provided. In particular, these methods are based on determining whether a mutation is/is not present at one or more exon/intron splice sites of the KIT gene. Kits for carrying out such methods are also described.
摘要翻译：提供了确定猪皮肤色素基因型的方法。特别地，这些方法基于确定KIT基因的一个或多个外显子/内含子剪接位点上是否存在突变。还描述了用于执行这些方法的套件。

5. 发明申请

US20090197252A1 Detection of Mutations 审中-公开
标题翻译：检测突变
公开(公告)号：US20090197252A1
公开(公告)日：2009-08-06
申请号：US11852967
申请日：2007-09-10
申请人： Anne Lunden , Leif Andersson , Stefan Marklund
发明人： Anne Lunden , Leif Andersson , Stefan Marklund
IPC分类号： C12Q1/68
CPC分类号： C12N9/0073
摘要： The present invention relates to a polypeptide which is flavin-containing monooxygenase 3 (FMO3), wherein said FMO3 is a polypeptide comprising at least a sequence having at least 85% identity with the polypeptide sequence SEQ ID NO: 15, in particular to a polypeptide which is a functionally altered mutant of flavin-containing mono oxygenase 3 (FMO3) leading to a buildup of trimethylamine in an animal. Further, the invention relates to nucleic acid sequences encoding said polypeptide, and to the complements of such nucleic acid sequences. Such nucleic acid sequences and fragments thereof may be useful e.g. as primers. The invention further relates to various methods for determining the presence in e.g. a nucleic acid sample of a nucleic acid sequence encoding a mutated FMO3 polypeptide.
摘要翻译：本发明涉及含有黄素的单加氧酶3（FMO3）的多肽，其中所述FMO3是至少包含与多肽序列SEQ ID NO：15具有至少85％同一性的序列的多肽，特别是多肽其是功能性改变的含黄素的单加氧酶3的突变体（FMO3），导致动物中三甲胺的积聚。此外，本发明涉及编码所述多肽的核酸序列以及这些核酸序列的互补序列。这样的核酸序列及其片段可以是有用的。作为引物。本发明进一步涉及用于确定例如存在的各种方法。编码突变FMO3多肽的核酸序列的核酸样品。

6. 发明申请

US20070003956A1 APPROACHES TO IDENTIFYING GENETIC TRAITS IN ANIMALS 审中-公开
标题翻译：识别动物遗传物种的方法
公开(公告)号：US20070003956A1
公开(公告)日：2007-01-04
申请号：US11466968
申请日：2006-08-24
申请人： Max Rothschild , Stefan Marklund , Richard Robson , Ted Huiatt , Jeannine Helm , Tun-Ping Yu , Graham Plastow
发明人： Max Rothschild , Stefan Marklund , Richard Robson , Ted Huiatt , Jeannine Helm , Tun-Ping Yu , Graham Plastow
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： Disclosed herein are embodiments to screen an animal for the presence or absence of polymorphisms in the following gene: CKM, SCN4α, and LDHα.
摘要翻译：本文公开了筛选动物以下基因中存在或不存在多态性的实施方案：CKM，SCN4alpha和LDHalpha。

7. 发明授权

US5472691A Superoxide dismutase 失效
标题翻译：超氧化物歧化酶
公开(公告)号：US5472691A
公开(公告)日：1995-12-05
申请号：US125744
申请日：1993-09-24
申请人： Stefan Marklund , Thomas Edlund
发明人： Stefan Marklund , Thomas Edlund
IPC分类号： A61K38/44 , C07K16/40 , C12N9/02 , C12N15/53
CPC分类号： A61K38/446 , C07K16/40 , C12N9/0089
摘要： A superoxide dismutase originally found in extracellular body fluids and therefore termed extracellular superoxide dismutase (EC-SOD) is prepared by growing a cell line, preferably of mammalian origin, producing EC-SOD and recovering the EC-SOD secreted from the cells or by inserting a DNA sequence encoding EC-SOD into a suitable vector, introducing the recombinant vector into a host cell, growing the cell and recovering the EC-SOD produced.EC-SOD may be used for the prophylaxis or treatment of diseases or disorders associated with the presence or formation of superoxide radicals.
摘要翻译：最初在细胞外体液中发现的超氧化物歧化酶，因此称为细胞外超氧化物歧化酶（EC-SOD）是通过生长优选哺乳动物来源的细胞系产生EC-SOD并回收从细胞分泌的EC-SOD或通过插入将编码EC-SOD的DNA序列转化成合适的载体，将重组载体导入宿主细胞，培养细胞并回收产生的EC-SOD。 EC-SOD可用于预防或治疗与超氧自由基的存在或形成相关的疾病或病症。

8. 发明授权

US5366729A Non-glycosylated variants of extracellular superoxide dismutase (EC-SOD) 失效
标题翻译：细胞外超氧化物歧化酶（EC-SOD）的非糖基化变体
公开(公告)号：US5366729A
公开(公告)日：1994-11-22
申请号：US856077
申请日：1992-05-13
申请人： Stefan Marklund , Thomas Edlund
发明人： Stefan Marklund , Thomas Edlund
IPC分类号： C07K16/40 , C12N9/02 , C12N15/53 , A61K37/50 , C12N5/10
CPC分类号： C12N9/0089 , C07K16/40
摘要： Extracellular superoxide dismutase (EC-SOD) variants having the superoxide dismutating property of the native EC-SOD and having a modified (reduced or increased) binding to heparin as compared to recombinant EC-SOD C as well as compositions comprising such variants. The EC-SOD variants are polypeptides comprising: 1) amino acids 1-193 of native EC-SOD C and 2) an amino acid sequence which is based on, but different from amino acid moieties 194-222 of recombinant EC-SOD C, either by being truncated or prolonged at the C-terminal end or by having substituted or otherwise modified one or more amino acid moieties of the sequence. Another EC-SOD variant is one which differs from recombinant EC-SOD C by being a glycosylation-free mutant. The variants may be produced by recombinant DNA techniques and are useful in the treatment of various diseases.
摘要翻译： PCT No.PCT / DK90 / 00238 Sec。 371日期：1992年5月13日 102（e）日期1992年5月13日PCT提交1990年9月17日PCT公布。公开号WO91 / 04315 1991年4月4日。与重组EC-SOD C相比，具有天然EC-SOD的超氧化物歧化性质并具有修饰（还原或增加的）肝素结合的细胞外超氧化物歧化酶（EC-SOD）变体以及包含这些变体的组合物。 EC-SOD变体是多肽，其包含：1）天然EC-SOD C的氨基酸1-193; 2）基于但不同于重组EC-SOD C的氨基酸部分194-222的氨基酸序列，通过在C-末端被截短或延长，或者通过取代或以其它方式修饰序列的一个或多个氨基酸部分。另一种EC-SOD变体是通过无糖基化突变体与重组EC-SOD C不同的变体。变异体可以通过重组DNA技术产生并且可用于治疗各种疾病。

9. 发明授权

US5248603A Superoxide dismutase 失效
标题翻译：超氧化物歧化酶
公开(公告)号：US5248603A
公开(公告)日：1993-09-28
申请号：US897624
申请日：1992-06-12
申请人： Stefan Marklund , Thomas Edlund
发明人： Stefan Marklund , Thomas Edlund
IPC分类号： A61K38/44 , C07K16/40 , C12N9/02 , C12N15/53
CPC分类号： A61K38/446 , C07K16/40 , C12N9/0089
摘要： A superoxide dismutase originally found in extracellular body fluids and therefore termed extracellular superoxide dismutase (EC-SOD) is prepared by growing a cell line, preferably of mammalian origin, producing EC-SOD and recovering the EC-SOD secreted from the cells or by inserting a DNA sequence encoding EC-SOD into a suitable vector, introducing the recombinant vector into a host cell, growing the cell and recovering the EC-SOD produced.EC-SOD may be used for the prophylaxis or treatment of diseases or disorders associated with the presence or formation of superoxide radicals.
摘要翻译：最初在细胞外体液中发现的超氧化物歧化酶，因此称为细胞外超氧化物歧化酶（EC-SOD）是通过生长优选哺乳动物来源的细胞系产生EC-SOD并回收从细胞分泌的EC-SOD或通过插入将编码EC-SOD的DNA序列转化成合适的载体，将重组载体导入宿主细胞，培养细胞并回收产生的EC-SOD。 EC-SOD可用于预防或治疗与超氧化物基团的存在或形成有关的疾病或病症。

10. 发明申请

US20080050767A1 TRANSGENIC ANIMALS EXPRESSING PRKAG3 失效
标题翻译：表达PRKAG3的转基因动物
公开(公告)号：US20080050767A1
公开(公告)日：2008-02-28
申请号：US11744590
申请日：2007-05-04
申请人： Leif Andersson , Stefan Marklund
发明人： Leif Andersson , Stefan Marklund
IPC分类号： C12N15/00 , C12Q1/02
CPC分类号： C12N9/1205 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2227/108 , A01K2267/03 , A01K2267/0362 , C12N15/8509 , C12N2830/008
摘要： Transgenic non-human animals that express the γ3 subunit of PRKAG are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention, or diagnosis of diseases related to energy metabolism, including obesity, dyslipidemia, insulin resistance syndrome, and type 2 diabetes.
摘要翻译：描述了表达PRKAG的γ3亚基的转基因非人动物，以及使用转基因非人动物作为改善治疗，预防或诊断与能量代谢有关的疾病的模型的方法，包括肥胖，血脂异常，胰岛素耐药综合征和2型糖尿病。

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