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1. 发明申请

US20100094007A1 Methods of making cyclic, N-amino functional triamines 有权
标题翻译：制备环状N-氨基功能性三胺的方法
公开(公告)号：US20100094007A1
公开(公告)日：2010-04-15
申请号：US12587338
申请日：2009-10-06
申请人： Stephen W. King , Thomas Z. Srnak , Stefan K. Mierau
发明人： Stephen W. King , Thomas Z. Srnak , Stefan K. Mierau
IPC分类号： C07D241/04
CPC分类号： C07D295/13 , C07D241/04
摘要： The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
摘要翻译：本发明提供了制备环状三胺的策略。包括某些前体和/或某些类型的催化剂的反应介质可以转化为具有改进的转化率和选择性的环状三胺。这些策略可纳入涉及转氨酶和/或还原胺化方案的反应中。在转氨酶的情况下，例如，在合适的催化剂存在下，使用氨基转移引发高级胺的闭环，导致期望的环状三胺具有显着的转化率和产率。在还原胺化的情况下，在合适的催化剂存在下使合适的多官能前体反应也通过环闭合产生环状三胺，具有明显的选择性和转化率。氨基转移和还原胺化方法都可以在比仅使用酸性催化剂时使用的温度更温和的温度下实施。优选的实施方案可以产生通常不含盐副产物的反应混合物。

2. 发明授权

US08492592B2 Low metal loaded, catalyst compositions including acidic mixed metal oxide as support 有权
标题翻译：低金属负载的催化剂组合物，包括作为载体的酸性混合金属氧化物
公开(公告)号：US08492592B2
公开(公告)日：2013-07-23
申请号：US13456444
申请日：2012-04-26
申请人： Stephen W. King , Stefan K. Mierau
发明人： Stephen W. King , Stefan K. Mierau
IPC分类号： C07C209/00 , B01J23/00 , B01J21/00 , B01J20/00
CPC分类号： B01J23/8896 , B01J21/12 , B01J35/008 , B01J35/1014 , B01J35/1019 , B01J37/0201 , C07C209/00
摘要： The invention provides a method of transaminating a reactant with a catalyst composition comprising support and catalyst portions. The support includes an acidic mixed metal oxide including a transitional alumina and a second metal oxide. The transitional alumina can comprise delta or theta alumina, in combination with other transitional phases, or an alpha or gamma alumina. The second metal oxide has a weight percentage less than the weight percentage of alumina. The catalyst portion is 25 weight percent or less of the catalyst composition and is composed of nickel and rhenium. The catalyst portion includes nickel in an amount in the range of 2 to 20 weight percent, based upon total catalyst composition weight, and there is no boron in the catalyst portion. The method provides high activity and selectivity for reactant transamination to a desired product while minimizing the formation of unwanted cyclic products.
摘要翻译：本发明提供了一种用包含载体和催化剂部分的催化剂组合物将反应物转氨的方法。载体包括含有过渡氧化铝和第二金属氧化物的酸性混合金属氧化物。过渡氧化铝可以包含与其它过渡相结合的δ或θ氧化铝，或α或γ氧化铝。第二金属氧化物的重量百分比小于氧化铝的重量百分数。催化剂部分为催化剂组合物的25重量％以下，由镍和铼构成。催化剂部分包括基于总催化剂组合物重量的2-20重量％范围内的量的镍，并且在催化剂部分中不存在硼。该方法提供了对期望产物的反应物转氨酸的高活性和选择性，同时使不期望的环状产物的形成最小化。

3. 发明申请

US20120238780A1 LOW METAL LOADED, CATALYST COMPOSITIONS INCLUDING ACIDIC MIXED METAL OXIDE AS SUPPORT 有权
标题翻译：低金属负载，催化剂组合物，包括酸性混合金属氧化物作为支持
公开(公告)号：US20120238780A1
公开(公告)日：2012-09-20
申请号：US13456444
申请日：2012-04-26
申请人： Stephen W. King , Stefan K. Mierau
发明人： Stephen W. King , Stefan K. Mierau
IPC分类号： C07C209/02
CPC分类号： B01J23/8896 , B01J21/12 , B01J35/008 , B01J35/1014 , B01J35/1019 , B01J37/0201 , C07C209/00
摘要： The invention provides a method of transaminating a reactant with a catalyst composition comprising support and catalyst portions. The support includes an acidic mixed metal oxide including a transitional alumina and a second metal oxide. The transitional alumina can comprise delta or theta alumina, in combination with other transitional phases, or an alpha or gamma alumina. The second metal oxide has a weight percentage less than the weight percentage of alumina. The catalyst portion is 25 weight percent or less of the catalyst composition and is composed of nickel and rhenium. The catalyst portion includes nickel in an amount in the range of 2 to 20 weight percent, based upon total catalyst composition weight, and there is no boron in the catalyst portion. The method provides high activity and selectivity for reactant transamination to a desired product while minimizing the formation of unwanted cyclic products.
摘要翻译：本发明提供了一种用包含载体和催化剂部分的催化剂组合物将反应物转氨的方法。载体包括含有过渡氧化铝和第二金属氧化物的酸性混合金属氧化物。过渡氧化铝可以包含与其它过渡相结合的δ或θ氧化铝，或α或γ氧化铝。第二金属氧化物的重量百分比小于氧化铝的重量百分数。催化剂部分为催化剂组合物的25重量％以下，由镍和铼构成。催化剂部分包括基于总催化剂组合物重量的2-20重量％范围内的量的镍，并且在催化剂部分中不存在硼。该方法提供了对期望产物的反应物转氨酸的高活性和选择性，同时使不期望的环状产物的形成最小化。

4. 发明授权

US08187997B2 Low metal loaded, catalyst compositions including acidic mixed metal oxide as support 有权
标题翻译：低金属负载，催化剂组合物包括作为载体的酸性混合金属氧化物
公开(公告)号：US08187997B2
公开(公告)日：2012-05-29
申请号：US12587351
申请日：2009-10-06
申请人： Stephen W. King , Stefan K Mierau
发明人： Stephen W. King , Stefan K Mierau
IPC分类号： B01J23/00 , B01J21/00 , B01J20/00
CPC分类号： B01J23/8896 , B01J21/12 , B01J35/008 , B01J35/1014 , B01J35/1019 , B01J37/0201 , C07C209/00
摘要： The invention provides a catalyst composition composed of a support portion and a catalyst portion. The support portion includes an acidic mixed metal oxide including a transitional alumina and a second metal oxide. The transitional alumina can comprise delta or theta alumina, in combination with other transitional phases, or an alpha or gamma alumina. The second metal oxide has a weight percentage that is less than the weight percentage of alumina. The catalyst portion is 25 weight percent or less of the catalyst composition and is composed of nickel and rhenium. The catalyst portion includes nickel in an amount in the range of 2 to 20 weight percent, based upon total catalyst composition weight, and there is no boron in the catalyst portion.
摘要翻译：本发明提供一种由支撑部分和催化剂部分组成的催化剂组合物。支撑部分包括包含过渡氧化铝和第二金属氧化物的酸性混合金属氧化物。过渡氧化铝可以包含与其它过渡相结合的δ或θ氧化铝，或α或γ氧化铝。第二金属氧化物的重量百分比小于氧化铝的重量百分数。催化剂部分为催化剂组合物的25重量％以下，由镍和铼构成。催化剂部分包括基于总催化剂组合物重量的2-20重量％范围内的量的镍，并且在催化剂部分中不存在硼。

5. 发明授权

US08907088B2 Methods of making cyclic, N-amino functional triamines 有权
标题翻译：制备环状N-氨基功能性三胺的方法
公开(公告)号：US08907088B2
公开(公告)日：2014-12-09
申请号：US13548425
申请日：2012-07-13
申请人： Stephen W. King , Stefan K. Mierau , Thomas Z. Smak
发明人： Stephen W. King , Stefan K. Mierau , Thomas Z. Smak
IPC分类号： C07D295/13 , C07D241/04
CPC分类号： C07D295/13 , C07D241/04
摘要： The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
摘要翻译：本发明提供了制备环状三胺的策略。包括某些前体和/或某些类型的催化剂的反应介质可以转化为具有改进的转化率和选择性的环状三胺。这些策略可纳入涉及转氨酶和/或还原胺化方案的反应中。在转氨酶的情况下，例如，在合适的催化剂存在下，使用氨基转移引发高级胺的闭环，导致期望的环状三胺具有显着的转化率和产率。在还原胺化的情况下，在合适的催化剂存在下使合适的多官能前体反应也通过环闭合产生环状三胺，具有明显的选择性和转化率。氨基转移和还原胺化方法都可以在比仅使用酸性催化剂时使用的温度更温和的温度下实施。优选的实施方案可以产生通常不含盐副产物的反应混合物。

6. 发明申请

US20120277435A1 METHODS OF MAKING CYCLIC, N-AMINO FUNCTIONAL TRIAMINES 有权
标题翻译：制备环状，N-氨基官能三亚胺的方法
公开(公告)号：US20120277435A1
公开(公告)日：2012-11-01
申请号：US13548425
申请日：2012-07-13
申请人： Stephen W. King , Stefan K. Mierau , Thomas Z. Smak
发明人： Stephen W. King , Stefan K. Mierau , Thomas Z. Smak
IPC分类号： C07D241/04
CPC分类号： C07D295/13 , C07D241/04
摘要： The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
摘要翻译：本发明提供了制备环状三胺的策略。包括某些前体和/或某些类型的催化剂的反应物介质可以转化为具有改进的转化率和选择性的环状三胺。这些策略可纳入涉及转氨酶和/或还原胺化方案的反应中。在转氨酶的情况下，例如，在合适的催化剂存在下，使用氨基转移引发高级胺的闭环，导致期望的环状三胺具有显着的转化率和产率。在还原胺化的情况下，在合适的催化剂存在下使合适的多官能前体反应也通过环闭合产生环状三胺，具有明显的选择性和转化率。氨基转移和还原胺化方法都可以在比仅使用酸性催化剂时使用的温度更温和的温度下实施。优选的实施方案可以产生通常不含盐副产物的反应混合物。

7. 发明授权

US08293676B2 Low metal loaded, alumina supported, catalyst compositions and amination process 有权
标题翻译：低金属负载，氧化铝负载，催化剂组合物和胺化方法
公开(公告)号：US08293676B2
公开(公告)日：2012-10-23
申请号：US12587355
申请日：2009-10-06
申请人： Stephen W. King , Stefan K. Mierau
发明人： Stephen W. King , Stefan K. Mierau
IPC分类号： B01J23/00 , B01J21/00
CPC分类号： B01J23/70 , B01J21/12 , B01J23/755 , C07C209/64 , C07C211/14
摘要： The present invention provides catalyst compositions useful for transamination reactions. The catalyst compositions have a catalyst support that includes transitional alumina, use a low metal loading (for example, less than 25 wt. %), and do not require the presence of rhenium. The catalyst compositions are able to advantageously promote transamination of a reactant product (such as the transamination of EDA to DETA) with excellent activity and selectivity, and similar to transaminations promoted using a precious metal-containing catalyst.
摘要翻译：本发明提供了可用于氨基转移反应的催化剂组合物。催化剂组合物具有包括过渡氧化铝的催化剂载体，使用低的金属负载（例如，小于25重量％），并且不需要存在铼。催化剂组合物能够以优异的活性和选择性有利地促进反应物产物的转氨基反应（如EDA的转氨酶），并且类似于使用贵金属的催化剂促进的转氨酶。

8. 发明申请

US20100094008A1 Methods of making cyclic, n-amino functional triamines 有权
标题翻译：制备环状，N-氨基官能的三胺的方法
公开(公告)号：US20100094008A1
公开(公告)日：2010-04-15
申请号：US12587380
申请日：2009-10-06
申请人： Stephen W. King , Thomas Z. Srnak , Stefan K. Mierau
发明人： Stephen W. King , Thomas Z. Srnak , Stefan K. Mierau
IPC分类号： C07D241/04
CPC分类号： C07D295/13 , C07D241/04
摘要： The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
摘要翻译：本发明提供了制备环状三胺的策略。包括某些前体和/或某些类型的催化剂的反应介质可以转化为具有改进的转化率和选择性的环状三胺。这些策略可纳入涉及转氨酶和/或还原胺化方案的反应中。在转氨酶的情况下，例如，在合适的催化剂存在下，使用氨基转移引发高级胺的闭环，导致期望的环状三胺具有显着的转化率和产率。在还原胺化的情况下，在合适的催化剂存在下使合适的多官能前体反应也通过环闭合产生环状三胺，具有明显的选择性和转化率。氨基转移和还原胺化方法都可以在比仅使用酸性催化剂时使用的温度更温和的温度下实施。优选的实施方案可以产生通常不含盐副产物的反应混合物。

9. 发明授权

US08618108B2 Methods of making cyclic, N-amino functional triamines 有权
标题翻译：制备环状N-氨基功能性三胺的方法
公开(公告)号：US08618108B2
公开(公告)日：2013-12-31
申请号：US12587338
申请日：2009-10-06
申请人： Stephen W. King , Stefan K. Mierau , Thomas Z. Srnak
发明人： Stephen W. King , Stefan K. Mierau , Thomas Z. Srnak
IPC分类号： A61K31/50 , A61K31/501 , A61K31/497 , C07D241/04 , C07D295/00
CPC分类号： C07D295/13 , C07D241/04
摘要： The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
摘要翻译：本发明提供了制备环状三胺的策略。包括某些前体和/或某些类型的催化剂的反应介质可以转化为具有改进的转化率和选择性的环状三胺。这些策略可纳入涉及转氨酶和/或还原胺化方案的反应中。在转氨酶的情况下，例如，在合适的催化剂存在下，使用氨基转移引发高级胺的闭环，导致期望的环状三胺具有显着的转化率和产率。在还原胺化的情况下，在合适的催化剂存在下使合适的多官能前体反应也通过环闭合产生环状三胺，具有明显的选择性和转化率。氨基转移和还原胺化方法都可以在比仅使用酸性催化剂时使用的温度更温和的温度下实施。优选的实施方案可以产生通常不含盐副产物的反应混合物。

10. 发明授权

US08273884B2 Methods of making cyclic, N-amino functional triamines 有权
标题翻译：制备环状N-氨基功能性三胺的方法
公开(公告)号：US08273884B2
公开(公告)日：2012-09-25
申请号：US12587380
申请日：2009-10-06
申请人： Stephen W. King , Thomas Z. Srnak , Stefan K. Mierau
发明人： Stephen W. King , Thomas Z. Srnak , Stefan K. Mierau
IPC分类号： C07D241/04 , C07D295/00
CPC分类号： C07D295/13 , C07D241/04
摘要： The present invention provides strategies for making cyclic triamines. Reactant media including certain precursors and/or certain types of catalysts can be converted into cyclic triamines with improved conversion and selectivity. The strategies can be incorporated into reactions that involve transamination schemes and/or reductive amination schemes. In the case of transamination, for instance, using transamination to cause ring closure of higher amines in the presence of a suitable catalyst leads to desired cyclic triamines with notable conversion and yield. In the case of reductive amination, reacting suitable polyfunctional precursors in the presence of a suitable catalyst also yields cyclic triamines via ring closure with notable selectivity and conversion. Both transamination and reductive amination methodologies can be practiced under much milder temperatures than are used when solely acid catalysts are used. Preferred embodiments can produce reaction mixtures that are generally free of salt by-products.
摘要翻译：本发明提供了制备环状三胺的策略。包括某些前体和/或某些类型的催化剂的反应物介质可以转化为具有改进的转化率和选择性的环状三胺。这些策略可纳入涉及转氨酶和/或还原胺化方案的反应中。在转氨酶的情况下，例如，在合适的催化剂存在下，使用氨基转移引发高级胺的闭环，导致期望的环状三胺具有显着的转化率和产率。在还原胺化的情况下，在合适的催化剂存在下使合适的多官能前体反应也通过环闭合产生环状三胺，具有明显的选择性和转化率。氨基转移和还原胺化方法都可以在比仅使用酸性催化剂时使用的温度更温和的温度下实施。优选的实施方案可以产生通常不含盐副产物的反应混合物。

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