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1. 发明授权

US08282961B2 Method of preparing a microcapsule containing unsaturated fatty acids, the microcapsule prepared by the method, and articles containing the microcapsule 有权
标题翻译：制备含有不饱和脂肪酸的微胶囊的方法，通过该方法制备的微胶囊和含有微胶囊的制品
公开(公告)号：US08282961B2
公开(公告)日：2012-10-09
申请号：US12377506
申请日：2007-07-27
申请人： Hong-Sig Sin , Si-Ho Park , Soo-Jong Um , Jong-Hyun Lee , Hee-Jeong Kim , Ha-Lyong Jin , Hyoung-Su Kim
发明人： Hong-Sig Sin , Si-Ho Park , Soo-Jong Um , Jong-Hyun Lee , Hee-Jeong Kim , Ha-Lyong Jin , Hyoung-Su Kim
IPC分类号： A61K9/14
CPC分类号： B01J13/02
摘要： The present invention provides a preparing method of microcapsule containing unsaturated fatty acid comprising the steps of (a) preparing a first coating material by mixing and gelatinating one or more gums selected from the group consisting of xanthan gum, guar gum, and locusbean gum, with poly glycerin esters of fatty acid in sterilized water, adding unsaturated fatty acid to the solution, and homogenizing the solution; (b) preparing a second coating material by mixing and gelatinating starch or modified starch, gelatin or casein, and poly glycerin esters of fatty acid in sterilized water, adding the first coating material prepared in (a) to the solution, and homogenizing the solution; and (c) spraying the second coating material prepared in (b) in cold sterilized water; a microcapsule prepared by the method; and articles containing the microcapsule.The present microcapsule has effects of preventing the oxidation of unsaturated fatty acid and inhibiting offensive smell.
摘要翻译：本发明提供含有不饱和脂肪酸的微胶囊的制备方法，其包括以下步骤：（a）通过将选自由黄原胶，瓜尔胶和路基胶豆胶组成的组中的一种或多种树胶混合并凝胶化而制备第一涂料，在无菌水中的脂肪酸的聚甘油酯，向溶液中加入不饱和脂肪酸，并均化溶液; （b）通过将灭菌水中的淀粉或改性淀粉，明胶或酪蛋白和脂肪酸的聚甘油酯混合并凝胶化制备第二涂料，将（a）中制备的第一涂料添加到溶液中，并使溶液均化 ; 和（c）将（b）中制备的第二涂层材料喷射到冷无菌水中; 通过该方法制备的微胶囊; 和含有微胶囊的物品。本发明的微胶囊具有防止不饱和脂肪酸氧化并抑制异味的作用。

2. 发明授权

US07166744B2 Retinoid derivatives and methods for producing said compounds and anti-cancer pharmaceutical composition comprising said compounds 有权
标题翻译：类视黄醇衍生物和制备所述化合物的方法和包含所述化合物的抗癌药物组合物
公开(公告)号：US07166744B2
公开(公告)日：2007-01-23
申请号：US10239001
申请日：2002-05-29
申请人： Hong-Sig Sin , Soo-Jong Um , Young-Soy Rho , Si-Ho Park , Youn-Ja Kwon , Myoung-Soon Park , Hye-Sook Han , So-Mi Kim , Dong-Myoung Kim , Deok-Kun Oh , Jong-Sup Park , Tae-Sung Bae
发明人： Hong-Sig Sin , Soo-Jong Um , Young-Soy Rho , Si-Ho Park , Youn-Ja Kwon , Myoung-Soon Park , Hye-Sook Han , So-Mi Kim , Dong-Myoung Kim , Deok-Kun Oh , Jong-Sup Park , Tae-Sung Bae
IPC分类号： C07C311/02 , C07C233/01
CPC分类号： C07C403/20 , C07B2200/09 , C07C205/43 , C07C233/10 , C07C233/28 , C07C233/33 , C07C233/44 , C07C233/55 , C07C2601/16 , C07F9/12
摘要： The present invention relates to a novel retinoid derivative compound represented by the formula I: wherein X, R1, R2 and R3 are as defined herein or pharmaceutically acceptalbe salts thereof. Also, the present invention relates to processes for producing the compound of the formula I and to an anti-cancer composition comprising the compound of the formula I. The compound of the formula I according to the present invention exerts high anti-cancer effects while not causing undesirable side effects.
摘要翻译：本发明涉及由式I表示的新型维甲酸衍生物化合物：其中X，R 1，R 2和R 3均为或其药学上可接受的盐。此外，本发明涉及制备式I化合物的方法和包含式I化合物的抗癌组合物。根据本发明的式I化合物发挥高抗癌作用而不是引起不良副作用。

3. 发明申请

US20100080851A1 METHOD OF PREPARING A MICROCAPSULE CONTAINING UNSATURATED FATTY ACIDS, THE MICROCAPSULE PREPARED BY THE METHOD, AND ARTICLES CONTAINING THE MICROCAPSULE 有权
标题翻译：制备含有不饱和脂肪酸的微胶囊的方法，由该方法制备的微生物和含有微生物的制品
公开(公告)号：US20100080851A1
公开(公告)日：2010-04-01
申请号：US12377506
申请日：2007-07-27
申请人： Hong-Sig Sin , Si-Ho Park , Soo-Jong Um , Jong-Hyun Lee , Hee-Jeong Kim , Ha-Lyong Jin , Hyoung-Su Kim
发明人： Hong-Sig Sin , Si-Ho Park , Soo-Jong Um , Jong-Hyun Lee , Hee-Jeong Kim , Ha-Lyong Jin , Hyoung-Su Kim
IPC分类号： A61K9/50 , B05D1/02 , A61K31/20 , A61P7/00
CPC分类号： B01J13/02
摘要： The present invention provides a preparing method of microcapsule containing unsaturated fatty acid comprising the steps of (a) preparing a first coating material by mixing and gelatinating one or more gums selected from the group consisting of xanthan gum, guar gum, and locusbean gum, with poly glycerin esters of fatty acid in sterilized water, adding unsaturated fatty acid to the solution, and homogenizing the solution; (b) preparing a second coating material by mixing and gelatinating starch or modified starch, gelatin or casein, and poly glycerin esters of fatty acid in sterilized water, adding the first coating material prepared in (a) to the solution, and homogenizing the solution; and (c) spraying the second coating material prepared in (b) in cold sterilized water; a microcapsule prepared by the method; and articles containing the microcapsule.The present microcapsule has effects of preventing the oxidation of unsaturated fatty acid and inhibiting offensive smell.
摘要翻译：本发明提供含有不饱和脂肪酸的微胶囊的制备方法，其包括以下步骤：（a）通过将选自由黄原胶，瓜尔胶和路基胶豆胶组成的组中的一种或多种树胶混合并凝胶化而制备第一涂料，在无菌水中的脂肪酸的聚甘油酯，向溶液中加入不饱和脂肪酸，并均化溶液; （b）通过将灭菌水中的淀粉或改性淀粉，明胶或酪蛋白和脂肪酸的聚甘油酯混合并凝胶化制备第二涂料，将（a）中制备的第一涂料添加到溶液中，并使溶液均化 ; 和（c）将（b）中制备的第二涂层材料喷射到冷无菌水中; 通过该方法制备的微胶囊; 和含有微胶囊的物品。本发明的微胶囊具有防止不饱和脂肪酸氧化并抑制异味的作用。

4. 发明授权

US07173062B2 Method for the improvement of skin wrinkles using retinyl retinoate 有权
标题翻译：使用视黄醇维生素A改善皮肤皱纹的方法
公开(公告)号：US07173062B2
公开(公告)日：2007-02-06
申请号：US10466514
申请日：2002-01-15
申请人： Young-Soy Roh , Soo-Jong Um , Min-Sook Jeong , Joo-Dong Lee , Hee-Chang Ryoo , Jeong-Kuan Son , Hyo-Jung Kim , Hyuk Kim , Sung-Won Jung , Hye-Sook Han , Si-Ho Park , Seong-Ho Kim
发明人： Young-Soy Roh , Soo-Jong Um , Min-Sook Jeong , Joo-Dong Lee , Hee-Chang Ryoo , Jeong-Kuan Son , Hyo-Jung Kim , Hyuk Kim , Sung-Won Jung , Hye-Sook Han , Si-Ho Park , Seong-Ho Kim
IPC分类号： A61K31/215
CPC分类号： C07C403/24 , A61K8/671 , A61K2800/75 , A61Q19/00 , A61Q19/08 , C07C403/08 , C07C2601/16
摘要： The present invention relates to a method for the improvement of skin wrinkles using retinal retaliate.
摘要翻译：本发明涉及使用视网膜报复物改善皮肤皱纹的方法。

5. 发明授权

US07030265B2 Retinol derivatives, the method of preparations and the uses thereof 有权
标题翻译：视黄醇衍生物，制剂方法及其应用
公开(公告)号：US07030265B2
公开(公告)日：2006-04-18
申请号：US10221428
申请日：2002-01-10
申请人： Hong-Sig Sin , Si-Ho Park , Young-Soy Rho , Soo-Jong Um , Youn-Ja Kwon , Myoung-Soon Park , Hye-Sook Han , Min-Sook Jung , So-Mi Kim-Cho , Dong-Myong Kim , Deok-kun Oh , Jong-Sup Park
发明人： Hong-Sig Sin , Si-Ho Park , Young-Soy Rho , Soo-Jong Um , Youn-Ja Kwon , Myoung-Soon Park , Hye-Sook Han , Min-Sook Jung , So-Mi Kim-Cho , Dong-Myong Kim , Deok-kun Oh , Jong-Sup Park
IPC分类号： C07C69/07 , C07C69/52 , C07C69/527 , C07C69/587
CPC分类号： C07K5/06113 , C07K5/0613
摘要： The present invention relates to novel retinol derivatives, the methods of preparation and the uses thereof. According to the present invention, retinol derivatives comprise carboester linkage between di-, tri-, polypeptide having functional group of COOH and retinol. Retinol derivatives in the present invention comprise carboester linkage between amino acid having functional group of di-COOH and retinol. Retinol derivatives comprise carboester linkage between retinol and the compounds having the function group of COOH and multiple double bonds on carbon chain. Retinol derivatives in the present invention comprise carboester linkage between retinol and the compounds having the functional group of di-COOH and one double bond. Retinol derivatives in the present invention comprise ether linkage between the compounds with OH functional group and retinol.
摘要翻译：本发明涉及新型视黄醇衍生物，其制备方法及其应用。根据本发明，视黄醇衍生物包含具有COOH官能团的二，三，多肽与视黄醇之间的连接。本发明的视黄醇衍生物包含具有二-COOOH官能团的氨基酸与视黄醇之间的连接。视黄醇衍生物包含视黄醇与具有COOH官能团和碳链上多个双键的化合物之间的连结。本发明的视黄醇衍生物包含视黄醇与具有二-COOOH官能团和一个双键的化合物之间的连接。本发明的视黄醇衍生物包括具有OH官能团的化合物与视黄醇之间的醚键。

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