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1. 发明授权

US06264971B1 Ocular insert 失效
标题翻译：眼插入
公开(公告)号：US06264971B1
公开(公告)日：2001-07-24
申请号：US09428967
申请日：1999-11-04
申请人： Sohrab Darougar , Dayshad Darougar
发明人： Sohrab Darougar , Dayshad Darougar
IPC分类号： A61F900
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of a drug upon insertion into the upper or lower fornix of the eye. The device comprises an elongate body of a polymeric material including two end portions, wherein the body contains a pharmaceutically active ingredient, and wherein the device has a length of at least 8 mm and a maximum diameter not exceeding 1.9 mm. The device is sufficiently flexible to allow it to bend along the curvature of the eye within the upper or lower fornix upon its being positioned so that the longitudinal axis of the device is generally parallel to the transverse diameter of the eyeball, and the device does not extend onto any visible portion of the eyeball. Each of the end portions of the device is tapered towards the extremities of the device.
摘要翻译：柔性眼部插入装置，其适于在插入到眼睛的上部或下部穹窿中时控制药物的持续释放。该装置包括具有两个端部部分的聚合材料的细长体，其中主体含有药物活性成分，并且其中该装置的长度为至少8mm，最大直径不超过1.9mm。该装置具有足够的柔性，以允许其在定位时沿着上或下穹窿内的眼睛的曲率弯曲，使得装置的纵向轴线大致平行于眼球的横向直径，并且该装置不延伸到眼球的任何可见部分。装置的每个端部朝向装置的末端逐渐变细。

2. 发明申请

US20070168025A1 Artificial cornea 审中-公开
标题翻译：人造角膜
公开(公告)号：US20070168025A1
公开(公告)日：2007-07-19
申请号：US11332105
申请日：2006-01-13
申请人： Sohrab Darougar , Dayshad Darougar
发明人： Sohrab Darougar , Dayshad Darougar
IPC分类号： A61F2/14
CPC分类号： A61F2/142
摘要： The present invention relates to a keratoprosthesis or artificial cornea which is designed as a light weight disc resembling a human cornea. The keratoprosthesis is maintained in the eye after surgery and is preferably adapted to reduce complications after surgery such as infection, rejection or necrosis.
摘要翻译：本发明涉及一种角膜假体或人造角膜，其被设计为类似于人角膜的轻质盘。角膜假体在手术后保持在眼睛中，并且优选适于减少手术后的并发症，例如感染，排斥或坏死。

3. 发明授权

US5395618A Ocular insert with anchoring protrusions 失效
标题翻译：眼插入物与锚定突起
公开(公告)号：US5395618A
公开(公告)日：1995-03-07
申请号：US243915
申请日：1994-05-17
申请人： Sohrab Darougar , Alan L. Weiner
发明人： Sohrab Darougar , Alan L. Weiner
IPC分类号： A61F9/007 , A61F9/00 , A61K9/00 , B82B1/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. The sustained release mechanism may, for example, be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. The protrusions may be of various shapes such as, for example, ribs, screw threads, dimples or bumps, truncated cone-shaped segments or winding braid segments. In a further embodiment, the polymeric material for the body is selected as one which swells in a liquid environment. Thus a device of smaller initial size may be employed. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. The device can be retained in the upper or lower fornix for 7 to 14 days or longer.
摘要翻译：一种柔性眼部插入装置，适于将眼药物的受控持续释放到眼睛中。在一个实施方案中，该装置包括呈杆状或管状形式的聚合物材料的细长体，其包含药物活性成分，并且具有至少两个从身体径向向外延伸的锚定突起。该装置具有至少8mm的长度，并且其主体部分包括突起的直径不超过1.9mm。持续释放机制可以例如通过扩散或渗透或生物侵蚀。插入装置有利地插入眼睛的上部或下部穹窿中，以便凭借穹窿解剖结构独立于眼睛的移动。突起可以是各种形状，例如肋，螺纹，凹坑或凸起，截头圆锥形段或缠绕编织段。在另一个实施方案中，用于身体的聚合物材料选择为在液体环境中溶胀的聚合物材料。因此，可以采用较小初始尺寸的装置。本插入装置的尺寸和构造使得在插入上部或下部穹窿中时，该装置保持离开视野，以便能够在长时间使用时良好地保持在适当位置并且被患者察觉不到。该装置可以保留在上，下穹顶7至14天或更长时间。

4. 发明授权

US5989579A Ocular insert with anchoring protrusions 失效
公开(公告)号：US5989579A
公开(公告)日：1999-11-23
申请号：US934382
申请日：1997-09-19
申请人： Sohrab Darougar , Alan L. Weiner , Padmanabh Pravinchandra Bhatt , Victor Albert Raul , David Clayton Gantner
发明人： Sohrab Darougar , Alan L. Weiner , Padmanabh Pravinchandra Bhatt , Victor Albert Raul , David Clayton Gantner
IPC分类号： A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. The sustained release mechanism may, for example, be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. The protrusions may be of various shapes such as, for example, ribs, screw threads, dimples or bumps, truncated cone-shaped segments or winding braid segments. In a further embodiment, the polymeric material for the body is selected as one which swells in a liquid environment. Thus a device of smaller initial size may be employed. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. The device can be retained in the upper or lower fornix for 7 to 14 days or longer.

5. 发明授权

US5322691A Ocular insert with anchoring protrusions 失效
标题翻译：眼插入物与锚定突起
公开(公告)号：US5322691A
公开(公告)日：1994-06-21
申请号：US83303
申请日：1993-06-29
申请人： Sohrab Darougar , Alan L. Weiner
发明人： Sohrab Darougar , Alan L. Weiner
IPC分类号： A61F9/007 , A61F9/00 , A61K9/00 , B82B1/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye. In one embodiment, the device includes an elongated body of a polymeric material in the form of a rod or tube containing a pharmaceutically active ingredient and with at least two anchoring protrusions extending radially outwardly from the body. The device has a length of at least 8 mm and the diameter of its body portion including the protrusions does not exceed 1.9 mm. The sustained release mechanism may, for example, be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. The protrusions may be of various shapes such as, for example, ribs, screw threads, dimples or bumps, truncated cone-shaped segments or winding braid segments. In a further embodiment, the polymeric material for the body is selected as one which swells in a liquid environment. Thus a device of smaller initial size may be employed. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. The device can be retained in the upper or lower fornix for 7 to 14 days or longer.
摘要翻译：一种柔性眼部插入装置，适于将眼药物的受控持续释放到眼睛中。在一个实施方案中，该装置包括呈杆状或管状形式的聚合物材料的细长体，其包含药物活性成分，并且具有至少两个从身体径向向外延伸的锚定突起。该装置具有至少8mm的长度，并且其主体部分包括突起的直径不超过1.9mm。持续释放机制可以例如通过扩散或渗透或生物侵蚀。插入装置有利地插入眼睛的上部或下部穹窿中，以便凭借穹窿解剖结构独立于眼睛的移动。突起可以是各种形状，例如肋，螺纹，凹坑或凸起，截头圆锥形段或缠绕编织段。在另一个实施方案中，用于身体的聚合物材料选择为在液体环境中溶胀的聚合物材料。因此，可以采用较小初始尺寸的装置。本插入装置具有的尺寸和构造使得当插入到上或下穹窿中时，该装置保持离开视野，以便能够在长时间使用时良好地保持在适当位置并且被患者察觉不到。该装置可以保留在上，下穹顶7至14天或更长时间。

6. 发明授权

US5147647A Ocular insert for the fornix 失效
标题翻译：眼睑插入物
公开(公告)号：US5147647A
公开(公告)日：1992-09-15
申请号：US626001
申请日：1990-12-12
申请人： Sohrab Darougar
发明人： Sohrab Darougar
IPC分类号： A61F9/00
CPC分类号： A61F9/0017
摘要： A flexible ocular insert device adapted for the controlled sustained release of an ophthalmic drug into the eye, wherein the device includes an elongated cylindrical shaped body having a length of at least 8 mm and with the diameter of its body portion not exceeding 1.9 mm. The sustained release mechanism may be by diffusion or by osmosis or bioerosion. The insert device is advantageously inserted into the upper or lower fornix of the eye so as to be independent of movement of the eye by virtue of the fornix anatomy. In one embodiment of the invention, an insert device having a length of 8 to 25 mm, to suit eyes of different sizes, was employed for use in the lower fornix and a device having a length of 8 to 35 mm was employed for use in the upper fornix. The present insert device is of a size and configuration such that, upon insertion into the upper or lower fornix, the device remains out of the field of vision so as to be well retained in place and imperceptible by a patient over a prolonged period of use. Thus the device can be retained in the upper or lower fornix for 7 to 14 days or longer.
摘要翻译：一种灵活的眼部插入装置，其适用于将眼药物受控地持续释放到眼睛中，其中该装置包括具有至少8mm的长度并且其主体部分的直径不超过1.9mm的细长圆柱形本体。持续释放机制可以通过扩散或通过渗透或生物侵蚀来进行。插入装置有利地插入眼睛的上部或下部穹窿中，以便凭借穹窿解剖结构独立于眼睛的移动。在本发明的一个实施例中，使用长度为8至25mm的插入装置以适合不同尺寸的眼睛，用于下穹窿，并且使用长度为8至35mm的装置用于上穹窿本插入装置具有的尺寸和构造使得当插入到上或下穹窿中时，该装置保持离开视野，以便能够在长时间使用时良好地保持在适当位置并且被患者察觉不到。因此，该装置可以保留在上，下穹顶7至14天或更长时间。

7. 发明授权

US5137030A Diagnostic methods 失效
标题翻译：诊断方法
公开(公告)号：US5137030A
公开(公告)日：1992-08-11
申请号：US415646
申请日：1989-10-02
申请人： Sohrab Darougar
发明人： Sohrab Darougar
IPC分类号： A61B10/00 , A61B10/02 , A61B17/32 , G01N1/28
CPC分类号： A61B10/02 , A61B10/0291 , A61B10/0045 , A61B2010/0074 , A61B2017/320008 , G01N2001/2846
摘要： A probe is provided for collecting mucous tissue samples in vivo particularly from the conjunctiva, the urethra and the cervix. The probe comprises a handle portion and a body portion, which is slotted for scraping tissue into the slots.The tissue sample may then be introduced into an aqueous transport medium comprising sucrose, potassium phosphates, foetal bovine serum, streptomycin, vancomycin and nystatin. The sample may be smeared from the transport medium, with the cells still intact onto a slide, using a cytocentrifuge; and then the smear is assayed for disease, for example disease due to adenovirus, herpes simplex virus or chlamydia.The assay step may include single or multiple immunofluorescent staining.
摘要翻译：提供探针用于在体内收集粘液组织样品，特别是从结膜，尿道和子宫颈。探针包括手柄部分和主体部分，其被开槽以将组织刮擦到狭槽中。然后可以将组织样品引入包含蔗糖，磷酸钾，胎牛血清，链霉素，万古霉素和制霉菌素的水性转运培养基中。可以使用细胞离心机将样品从运输介质中抹去，细胞仍然完整地放在载玻片上; 然后对涂片进行测定疾病，例如由于腺病毒，单纯疱疹病毒或衣原体引起的疾病。测定步骤可以包括单次或多次免疫荧光染色。

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