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1. 发明申请

US20040126841A9 Novel G-protein coupled receptor, HLTEX11 审中-公开
标题翻译：新型G蛋白偶联受体HLTEX11
公开(公告)号：US20040126841A9
公开(公告)日：2004-07-01
申请号：US10367724
申请日：2003-02-19
申请人： SmithKline Beecham Corp.
发明人： Winnie Chan , Derk J. Bergsma , Catherine E. Ellis
IPC分类号： C12P021/02 , C12N005/06 , C07K014/705 , C07H021/04
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K2319/02 , C12N2799/026
摘要： Human HL TEX11 polypeptides and DNA (RNA) encoding such HL TEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HL TEX11 for the treatment of atherosclerosis. inflammatory conditions. and infections. particularly viral infections such as AIDS. among others, among others. are also disclosed. Also disclosed are diagnostic assavs for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HL TEX11 and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人HLTEX11多肽和编码这种HL TEX11的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种HL TEX11来治疗动脉粥样硬化的方法。炎症状况。和感染。特别是艾滋病等病毒感染。等等。也被披露。还公开了用于检测与核酸序列中的突变相关的疾病和改变的多肽浓度的诊断性病例。还公开了用于检测编码HL TEX11的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

2. 发明申请

US20040096888A1 Human pelota homolog 审中-公开
标题翻译：人类pelota同系物
公开(公告)号：US20040096888A1
公开(公告)日：2004-05-20
申请号：US10678274
申请日：2003-10-06
申请人： SmithKline Beecham Corp.
发明人： Jeffrey Richard Jackson , Michael Joseph Hansbury
IPC分类号： C12Q001/68 , C07H021/04 , C12N009/00
CPC分类号： C07K14/4702 , A61K38/00
摘要： 68772 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing 68772 polypeptides and polynucleotides in the design of protocols for the treatment of proliferative diseases such as leukemias, solid tumor cancers and metastases; chronic inflammatory proliferative diseases such as psoriasis and rheumatoid arthritis; proliferative cardiovascular diseases such as restenosis; prolifertive ocular disorders such as diabetic retinopathy; and benign hyperproliferative diseases such as hemangiomas, among others, and diagnostic assays for such conditions.
摘要翻译：公开了68772多肽和多核苷酸以及通过重组技术产生这种多肽的方法。还公开了在设计用于治疗增殖性疾病如白血病，实体瘤癌症和转移瘤的方案中使用68772多肽和多核苷酸的方法; 慢性炎性增生性疾病如牛皮癣和类风湿性关节炎; 增生性心血管疾病如再狭窄; 增生性眼部疾病如糖尿病性视网膜病变; 和良性过度增生性疾病如血管瘤等，以及这些病症的诊断测定。

3. 发明申请

US20030215847A1 Human cartilage glycoprotein 失效
标题翻译：人类软骨糖蛋白
公开(公告)号：US20030215847A1
公开(公告)日：2003-11-20
申请号：US10373802
申请日：2003-02-27
申请人： SmithKline Beecham Corp.
发明人： Robert B. Kirkpatrick , Martin Rosenberg
IPC分类号： C12Q001/68 , G01N033/53 , G01N033/537 , G01N033/543 , C07H021/04 , C12N009/64 , C12P019/34 , C12P021/02 , C12N005/06
CPC分类号： G01N33/6887 , A61K38/00 , C07K14/78 , C07K16/40 , C12N9/2442 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Y302/01014 , G01N2333/924
摘要： Nucleic acid sequences for HC gp-39L are provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.
摘要翻译：提供HC gp-39L的核酸序列。还提供了检测组织重塑蛋白表达改变的方法和诊断组织重塑障碍。

4. 依法登记的发明

USH2153H Association of asthma with polymorphisms in the cysteinyl leukotriene 2 receptor 审中-公开
公开(公告)号：USH2153H
公开(公告)日：2006-04-04
申请号：US13133202
申请日：2002-04-24
申请人： SMITHKLINE BEECHAM CORP
发明人： IGNAR DIANE MICHELE , PILLAI SREEKUMAR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Polymorphisms in the cysteinyl-leukotriene receptor 2 gene and their association with asthma are described.

5. 发明申请

US20040175794A1 Novel integrin ligand ITGL-TSP 审中-公开
标题翻译：新型整合素配体ITGL-TSP
公开(公告)号：US20040175794A1
公开(公告)日：2004-09-09
申请号：US10757450
申请日：2004-01-15
申请人： Human Genome Sciences, Inc. , SmithKline Beecham Corp.
发明人： Zdenka L. Jonak , Stephen H. Trulli , James A. Fornwald , Jonathon A. Terrett , Gregg A. Hastings
IPC分类号： C12N009/16 , C07H021/04
CPC分类号： C12N9/6489 , A61K38/00 , A61K48/00 , C07K14/4702 , C12Q1/37 , G01N33/5011 , G01N33/502 , G01N33/564 , G01N33/57496 , G01N33/6893 , G01N33/6896 , G01N2500/00 , G01N2800/102 , G01N2800/164 , G01N2800/24 , G01N2800/2821 , G01N2800/323
摘要： ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retinopathy), restenosis, Alzheimer's disease and tissue remodeling, among others, and diagnostic assays for such conditions.
摘要翻译：公开了ITGL-TSP多肽和用于通过重组技术产生此类多肽的多核苷酸和方法。还公开了在设计用于治疗血管发生疾病（癌症，癌症，慢性炎症性疾病）的方案中使用ITGL-TSP多肽和多核苷酸的方法，类风湿性关节炎，动脉粥样硬化，黄斑变性，糖尿病性视网膜病变），再狭窄，阿尔茨海默病和组织重塑等，以及用于这些病症的诊断测定。

6. 发明申请

US20040156822A1 Novel chemokine for mobilizing stem cells 审中-公开
标题翻译：用于动员干细胞的新型趋化因子
公开(公告)号：US20040156822A1
公开(公告)日：2004-08-12
申请号：US10803960
申请日：2004-03-19
申请人： Human Genome Sciences, Inc. , SmithKline Beecham Corp.
发明人： John R. White , Louis Pelus , Haodong Li , Brent L. Kreider
IPC分类号： A61K038/19
CPC分类号： C07K14/523 , A61K38/00 , Y10S930/14
摘要： Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided.
摘要翻译：提供用于动员干细胞的新型趋化因子。还提供了移动干细胞的方法。

7. 发明申请

US20040147527A1 Methods of use of gemifloxacin compounds against fluoroquinolone resistant Streptococcus pneumoniae bacteria 审中-公开
标题翻译：使用吉非沙星化合物抗氟喹诺酮抗性肺炎链球菌的方法
公开(公告)号：US20040147527A1
公开(公告)日：2004-07-29
申请号：US10758506
申请日：2004-01-15
申请人： SmithKline Beecham Corp.
发明人： Darrin Bast , Ross J. Davidson , Joyce DeAzavedo , Donald E. Low
IPC分类号： A61K031/496
CPC分类号： A61K31/47
摘要： This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against certain pathogenic bacteria.
摘要翻译：本发明部分地涉及新确定的使用喹诺酮抗生素的方法，特别是针对某些致病细菌的吉米沙星化合物。

8. 发明申请

US20040187865A1 Metered dose inhaler for fluticasone propionate 审中-公开
标题翻译：丙酸氟替卡松计量吸入器
公开(公告)号：US20040187865A1
公开(公告)日：2004-09-30
申请号：US10823533
申请日：2004-04-14
申请人： SmithKline Beecham Corp.
发明人： Ian C. Ashurst , Ignatius Loy Britto , Craig Steven Herman , Li Li-Bovet , Michael Thomas Riebe
IPC分类号： A61M011/00
CPC分类号： B65D83/54 , A61M15/009 , A61M2205/0222
摘要： A metered dose inhaler having all or part of its internal surfaces coated with one or more fluorocarbon polymers, optimally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formation comprising fluticasone propionate or a physiologically acceptable solvate thereof and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.
摘要翻译：一种计量吸入器，其全部或部分内表面涂覆有一种或多种碳氟聚合物，最佳地与一种或多种非碳氟聚合物组合，用于分配包含丙酸氟替卡松或其生理学上可接受的溶剂合物的吸入药物形式，以及碳氟化合物推进剂，任选地与一种或多种其它药理活性剂或一种或多种赋形剂组合。

9. 发明申请

US20030148465A1 Novel G-protein coupled receptor, HLTEX11 审中-公开
标题翻译：新型G蛋白偶联受体HLTEX11
公开(公告)号：US20030148465A1
公开(公告)日：2003-08-07
申请号：US10367724
申请日：2003-02-19
申请人： SmithKline Beecham Corp.
发明人： Winnie Chan , Derk J. Bergsma , Catherine E. Ellis
IPC分类号： C12P021/02 , C12N005/06 , C07K014/705 , C07H021/04
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K2319/02 , C12N2799/026
摘要： Human HL TEX11 polypeptides and DNA (RNA) encoding such HL TEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HL TEX11 for the treatment of atherosclerosis. inflammatory conditions. and infections. particularly viral infections such as AIDS. among others, among others. are also disclosed. Also disclosed are diagnostic assavs for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HL TEX11 and for detecting altered levels of the polypeptide in a host.
摘要翻译：公开了人HLTEX11多肽和编码这种HL TEX11的DNA（RNA）和通过重组技术产生这种多肽的方法。还公开了利用这种HL TEX11来治疗动脉粥样硬化的方法。炎症状况。和感染。特别是艾滋病等病毒感染。等等。也被披露。还公开了用于检测与核酸序列中的突变相关的疾病和改变的多肽浓度的诊断性病例。还公开了用于检测编码HL TEX11的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

10. 发明申请

US20030105138A1 Method of treatment for decreasing mortality resulting from congestive heart failure 审中-公开
标题翻译：减少充血性心力衰竭引起的死亡率的治疗方法
公开(公告)号：US20030105138A1
公开(公告)日：2003-06-05
申请号：US10324856
申请日：2002-12-19
申请人： Boehringer Mannheim Pharmaceuticals Corporation- SmithKline Beecham Corp. Limited Partnership No. 1
发明人： Mary Ann Lukas-Laskey , Robert Ruffolo JR. , Neil Howard Shusterman , Gisbert Sponer , Klaus Strein
IPC分类号： A61K031/454 , A61K031/403
CPC分类号： A61K31/403 , A61K31/7048 , A61K2300/00
摘要： A method of treatment using a compound of Formula I: 1 wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl; R3 is hydrogen or lower alkyl of up to 6 carbon atoms; R4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R4 together with R5 can represent nullCH2null0null; X is a valency bond, nullCH2, oxygen or sulfur; Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl; R5 and R6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a nullCONH2null group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or R5 and R6 together represent methylenedioxy; or a pharmaceutically acceptable salt thereof, alone or in conjunction with one or more other therapeutic agents, said agents being selected from the group consisting of ACE inhibitors, diuretics, and digoxin for decreasing mortality resulting from congestive heart failure (CHF) in mammals, particularly humans.
摘要翻译：使用式I化合物的方法：其中：R1是氢，至多6个碳原子的低级烷酰基或选自苯甲酰基和萘甲酰基的芳酰基; R2是氢，至多6个碳原子的低级烷基或选自苄基，苯基乙基和苯基丙基的芳基烷基; R3是氢或最多6个碳原子的低级烷基; R4是氢或至多6个碳原子的低级烷基，或当X是氧时，R4与R5一起可以代表-CH2-0-; X是价键，-CH 2，氧或硫; Ar选自苯基，萘基，茚满基和四氢萘基; R 5和R 6分别选自氢，氟，氯，溴，羟基，至多6个碳原子的低级烷基，-CONH 2 - 基，至多6个碳原子的低级烷氧基，苄氧基，至多6个碳的低级烷硫基原子，低至6个碳原子的低级烷基亚磺酰基和至多6个碳原子的低级烷基磺酰基; 或R5和R6一起表示亚甲二氧基; 特别是用于降低哺乳动物充血性心力衰竭（CHF）引起的死亡率的ACE抑制剂，利尿剂和地高辛，所述药物单独或与一种或多种其它治疗剂联合使用，或其药学上可接受的盐，人类。

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