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1. 发明申请

US20160206775A1 Temperature-Insensitive Calcium Phosphate Cements 有权
标题翻译：温度不敏感的磷酸钙水泥
公开(公告)号：US20160206775A1
公开(公告)日：2016-07-21
申请号：US15083701
申请日：2016-03-29
申请人： Skeletal Kinetics LLC
发明人： Sahil Jalota , David C. Delaney , Duran N. Yetkinler
IPC分类号： A61L24/00
CPC分类号： A61L24/0084 , A61K9/0024 , A61K33/42 , A61L2430/02
摘要： Temperature-insensitive calcium phosphate cements and methods of using the same are provided. Aspects of the cements include a dry component having fine and coarse calcium phosphate particulate reactants and a setting fluid which includes a cellulose. The dry component and setting fluid may be combined over a broad temperature range to produce a flowable composition. The resultant flowable composition finds use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.
摘要翻译：提供了温度不敏感的磷酸钙水泥及其使用方法。水泥的方面包括具有细小的和粗糙的磷酸钙颗粒反应物的干组分和包括纤维素的固化液。干组分和凝固流体可以在宽的温度范围内组合以产生可流动的组合物。所得到的可流动组合物可用于各种不同的应用，包括修复硬组织缺陷，例如骨缺损如骨折。

2. 发明申请

US20150374751A1 Implantable, Malleable Calcium Phosphate Compositions and Methods for Making and Using the Same 审中-公开
标题翻译：可植入的，可延展的磷酸钙组合物及其制备和使用方法
公开(公告)号：US20150374751A1
公开(公告)日：2015-12-31
申请号：US14742532
申请日：2015-06-17
申请人： Skeletal Kinetics, LLC
发明人： David C. Delaney , Sahil Jalota , Duran N. Yetkinler
IPC分类号： A61K33/42 , A61L27/12
CPC分类号： A61K33/42 , A61K9/0024 , A61K47/02 , A61L27/12 , A61L27/58 , A61L2430/02
摘要： Implantable, malleable calcium phosphate compositions are provided. The compositions include calcium and phosphate reactants and a non-aqueous liquid carrier. Aspects of the invention also include methods of making and using the compositions, as well as kits that include the compositions. The compositions and methods find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
摘要翻译：提供可植入的可延展的磷酸钙组合物。组合物包括钙和磷酸盐反应物和非水性液体载体。本发明的方面还包括制备和使用组合物的方法，以及包括组合物的试剂盒。组合物和方法可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

3. 发明申请

US20130165540A1 Porous Calcium Phospate Granules and Methods of Making and Using the Same 审中-公开
标题翻译：多孔钙磷酸盐颗粒及其制备和使用方法
公开(公告)号：US20130165540A1
公开(公告)日：2013-06-27
申请号：US13724493
申请日：2012-12-21
申请人： SKELETAL KINETICS, LLC
发明人： David C. Delaney , Sahil Jalota
IPC分类号： C08J9/00 , C01B25/32
CPC分类号： C08J9/0066 , A61L27/12 , A61L27/32 , A61L27/56 , A61L2430/02 , C01B25/32 , C01P2004/32
摘要： Porous calcium phosphate granules and methods of making the same are provided. Embodiments of the methods include producing a solid spherical granule precursor that includes: (i) a calcium phosphate component; and (ii) a porogen component; and (b) removing the porogen component from the solid spherical granule precursor to produce a spherical porous calcium phosphate granule. Granules of the invention find use in a variety of different applications.
摘要翻译：提供多孔磷酸钙颗粒及其制备方法。所述方法的实施方案包括制备固体球形颗粒前体，其包括：（i）磷酸钙组分; 和（ii）致孔剂组分; 和（b）从固体球形颗粒前体中除去致孔剂组分以产生球状多孔磷酸钙颗粒。本发明的颗粒可用于各种不同的应用。

4. 发明授权

US10022471B2 Calcium phosphate cements and methods for using the same 有权
公开(公告)号：US10022471B2
公开(公告)日：2018-07-17
申请号：US13800694
申请日：2013-03-13
申请人： Skeletal Kinetics, LLC
发明人： Brent R. Constantz , David Delaney , Duran N. Yetkinler
IPC分类号： A61L27/12
摘要： Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.

5. 发明申请

US20160030626A1 Rapid Setting High Strength Calcium Phosphate Cements Comprising Cyclodextrins 有权
标题翻译：快速设定高强度磷酸钙水泥，包括环糊精
公开(公告)号：US20160030626A1
公开(公告)日：2016-02-04
申请号：US14817512
申请日：2015-08-04
申请人： Skeletal Kinetics, LLC
发明人： Sahil Jalota , David C. Delaney , Duran N. Yetkinler
IPC分类号： A61L24/00 , A61L24/08
CPC分类号： A61L24/0084 , A61K47/26 , A61L24/08 , A61L2400/10 , C04B12/02 , C04B28/344 , C04B2111/00836 , C04B12/04 , C04B22/064 , C04B24/383
摘要： Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.
摘要翻译：提供快速凝固高强度磷酸钙水泥及其使用方法。水泥的方面包括细和粗磷酸钙颗粒反应物和环糊精，当与固化液组合时，产生可快速成为高强度产品的可流动组合物。可流动组合物可用于各种不同的应用，包括修复硬组织缺陷，例如骨缺损如骨折。

6. 发明申请

US20140202359A1 Rapid Setting High Strength Calcium Phosphate Cements Comprising Cyclodextrins 有权
标题翻译：快速设定高强度磷酸钙水泥，包括环糊精
公开(公告)号：US20140202359A1
公开(公告)日：2014-07-24
申请号：US14163988
申请日：2014-01-24
申请人： Skeletal Kinetics, LLC
发明人： Sahil Jalota , David C. Delaney , Duran N. Yetkinler
IPC分类号： A61K47/26
CPC分类号： A61L24/0084 , A61K47/26 , A61L24/08 , A61L2400/10 , C04B12/02 , C04B28/344 , C04B2111/00836 , C04B12/04 , C04B22/064 , C04B24/383
摘要： Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.
摘要翻译：提供快速凝固高强度磷酸钙水泥及其使用方法。水泥的方面包括细和粗磷酸钙颗粒反应物和环糊精，当与固化液组合时，产生可快速成为高强度产品的可流动组合物。可流动组合物可用于各种不同的应用，包括修复硬组织缺陷，例如骨缺损如骨折。

7. 发明授权

US09827346B2 Rapid setting high strength calcium phosphate cements comprising cyclodextrins 有权
公开(公告)号：US09827346B2
公开(公告)日：2017-11-28
申请号：US14817512
申请日：2015-08-04
申请人： Skeletal Kinetics, LLC
发明人： Sahil Jalota , David C. Delaney , Duran N. Yetkinler
IPC分类号： C04B12/02 , A61L24/00 , C04B28/34 , A61K47/26 , A61L24/08 , C04B111/00
CPC分类号： A61L24/0084 , A61K47/26 , A61L24/08 , A61L2400/10 , C04B12/02 , C04B28/344 , C04B2111/00836 , C04B12/04 , C04B22/064 , C04B24/383
摘要： Rapid setting high strength calcium phosphate cements and methods of using the same are provided. Aspects of the cements include fine and coarse calcium phosphate particulate reactants and a cyclodextrin which, upon combination with a setting fluid, produce a flowable composition that rapidly sets into a high strength product. The flowable compositions find use in a variety of different applications, including the repair of hard tissue defects, e.g., bone defects such as fractures.

8. 发明申请

US20140342013A1 CALCIUM PHOSPHATE CEMENT COMPOSITIONS THAT SET INTO HIGH STRENGTH POROUS STRUCTURES 审中-公开
标题翻译：磷酸钙水泥组合物设置为高强度多孔结构
公开(公告)号：US20140342013A1
公开(公告)日：2014-11-20
申请号：US14213805
申请日：2014-03-14
申请人： Skeletal Kinetics, LLC
发明人： Jiawei He , David C. Delaney
IPC分类号： A61L24/02 , A61L24/00
CPC分类号： A61L24/02 , A61L24/0005 , A61L24/0036 , A61L27/12 , A61L27/3608 , A61L27/446 , A61L27/46 , A61L27/56 , A61L2400/06 , C04B28/34 , C04B2103/42 , C04B2111/00836 , C04B22/143 , C04B12/04 , C04B24/383 , C04B38/0051 , C04B22/16
摘要： Calcium phosphate cement compositions are provided. Aspects of the cement compositions include a dry reactant component comprising a reactive α-tricalcium phosphate component, a multi-size pore forming calcium sulphate dihydrate component and a demineralized bone matrix component. During use, the dry reactant is combined with a setting fluid to produce a sellable composition that sets into a high strength porous product. Aspects of the invention further include the settable compositions themselves as well as kits for preparing the same. Methods and compositions as described herein find use in a variety of applications, including hard tissue repair applications.
摘要翻译：提供了磷酸钙水泥组合物。水泥组合物的方面包括干反应物组分，其包含反应性α-磷酸三钙组分，多尺寸孔形成硫酸钙二水合物组分和脱矿质骨基质组分。在使用过程中，将干燥的反应物与凝固流体混合以产生可成型为高强度多孔产品的可销售组合物。本发明的方面还包括可固化组合物本身以及用于制备它们的试剂盒。本文所述的方法和组合物可用于各种应用，包括硬组织修复应用。

9. 发明申请

US20140010880A1 Tricalcium Phosphate Coarse Particle Compositions and Methods for Making the Same 审中-公开
标题翻译：磷酸三钙粗颗粒组合物及其制备方法
公开(公告)号：US20140010880A1
公开(公告)日：2014-01-09
申请号：US13928211
申请日：2013-06-26
申请人： Skeletal Kinetics LLC
发明人： Sahil Jalota , David C. Delaney , Duran N. Yetkinler
IPC分类号： A61K9/14 , C01B25/32 , A61K47/02
CPC分类号： A61K9/14 , A61K47/02 , A61L27/12 , C01B25/32 , C01B25/327 , C04B12/025 , C04B35/447 , C04B35/6313 , Y10T428/2982
摘要： Methods for preparing a tricalcium phosphate coarse particle composition are provided. Aspects of the methods include converting an initial tricalcium phosphate particulate composition to hydroxyapatite, sintering the resultant hydroxyapatite to produce a second tricalcium phosphate composition and then mechanically manipulating the second tricalcium phosphate composition to produce a tricalcium phosphate coarse particle composition. The subject methods and compositions produced thereby find use in a variety of applications.
摘要翻译：提供了制备磷酸三钙粗颗粒组合物的方法。方法的方面包括将初始磷酸三钙颗粒组合物转化为羟基磷灰石，烧结所得羟基磷灰石以产生第二磷酸三钙组合物，然后机械操作第二磷酸三钙组合物以产生磷酸三钙粗颗粒组合物。由此产生的主题方法和组合物可用于各种应用。

10. 发明申请

US20130273118A1 Calcium Phosphate Cements and Methods for Using the Same 有权
标题翻译：磷酸钙水泥及其使用方法
公开(公告)号：US20130273118A1
公开(公告)日：2013-10-17
申请号：US13800694
申请日：2013-03-13
申请人： Skeletal Kinetics, LLC
发明人： Brent R. Constantz , David Delaney , Duran N. Yetkinler
IPC分类号： A61L27/12
CPC分类号： A61L27/12 , Y10S514/951 , Y10S514/955
摘要： Methods and compositions for producing flowable compositions, e.g. pastes, that set into calcium phosphate products are provided. In the subject methods, dry reactants that include a calcium source and a phosphate source are combined with a setting fluid to produce the flowable composition. A feature of the subject methods is that the dry reactants include a particulate calcium and/or phosphate reactant having a mean particle size of less than about 8 μm and narrow size distribution. Also provided are the compositions themselves as well as kits for use in practicing the subject methods. The subject methods and compositions produced thereby find use in a variety of applications, including the repair of hard tissue defects, e.g., bone defects.
摘要翻译：用于生产可流动组合物的方法和组合物，例如提供了设置成磷酸钙产品的糊剂。在本发明方法中，包括钙源和磷酸盐源的干燥反应物与固化流体组合以产生可流动组合物。本发明方法的特征在于干燥反应物包括平均粒径小于约8μm并具有窄尺寸分布的颗粒状钙和/或磷酸盐反应物。还提供了组合物本身以及用于实践本发明方法的试剂盒。由此产生的主题方法和组合物可用于各种应用，包括修复硬组织缺陷，例如骨缺损。

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