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1. 发明申请

US20140024046A1 Exosomal Biomarkers for Cardiovasular Events 审中-公开
标题翻译：用于心血管事件的Exosomal Biomarkers
公开(公告)号：US20140024046A1
公开(公告)日：2014-01-23
申请号：US13995760
申请日：2012-02-17
申请人： Dominique De Kleijn , Gerard Pasterkamp , Leonardus Timmers , Siu Kwan Sze
发明人： Dominique De Kleijn , Gerard Pasterkamp , Leonardus Timmers , Siu Kwan Sze
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to a method of predicting the risk of a subject developing a cardiovascular event, comprising determining the presence of a biomarker that is indicative of the risk of developing a cardiovascular event in an exosome sample from the subject. The exosomes are suitably isolated from a body fluid selected from serum, plasma, blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage fluid, synovial fluid, breast milk, saliva, in particular serum. Alternatively, the exosomes are present in a body fluid, in particular serum. The biomarker is selected from the proteins Vitronectin, Serpin F2, CD14, Cystatin C, Plasminogen, Nidogen 2, Serpin G1 or any combination of two or more of these proteins. The invention further relates to a method of diagnosing the occurrence of acute coronary syndrome in a subject, comprising determining the presence of a biomarker that is indicative of the occurrence of acute coronary syndrome in an exosome sample from the subject. In this method the biomarker is selected from Serpin F2, CD14, Cystatin C or combinations thereof.
摘要翻译：本发明涉及一种预测发展心血管事件的受试者的风险的方法，包括确定生物标志物的存在，所述生物标志物指示在来自受试者的外来体样品中发生心血管事件的风险。外来体合适地从选自血清，血浆，血液，尿液，羊水，恶性腹水，支气管肺泡灌洗液，滑液，母乳，唾液，特别是血清中的体液分离。或者，外来体存在于体液中，特别是血清中。生物标志物选自蛋白质Vitronectin，Serpin F2，CD14，半胱氨酸蛋白酶抑制剂C，纤溶酶原，Nidogen 2，Serpin G1或两种或更多种这些蛋白质的任何组合。本发明还涉及一种诊断受试者中急性冠状动脉综合征发生的方法，包括确定在来自受试者的外来体样品中指示急性冠状动脉综合征发生的生物标志物的存在。在该方法中，生物标志物选自Serpin F2，CD14，半胱氨酸蛋白酶抑制剂C或其组合。

2. 发明申请

US20120309041A1 Determination of Exosomel Biomarkers for Predicting Cardiovascular Events 审中-公开
标题翻译：用于预测心血管事件的Exosomel生物标志物的测定
公开(公告)号：US20120309041A1
公开(公告)日：2012-12-06
申请号：US13516417
申请日：2011-01-07
申请人： Leonardus Timmers , Siu Kwan Sze , Dominicus Paschalis Victor De Kleijn
发明人： Leonardus Timmers , Siu Kwan Sze , Dominicus Paschalis Victor De Kleijn
IPC分类号： G01N33/566 , G01N27/62 , C07K16/18
CPC分类号： G01N33/6893 , G01N2333/78 , G01N2333/8121 , G01N2333/8139 , G01N2800/32 , G01N2800/50
摘要： The present invention relates to a method of predicting the risk of a subject developing a cardiovascular event, comprising determining the presence of a biomarker that is indicative of the risk of developing a cardiovascular event in exosomes from the subject. The exosomes are suitably isolated from a body fluid selected from serum, plasma, blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage fluid, synovial fluid, breast milk, saliva, in particular serum. The biomarker is selected from the proteins Vitronectin, Serpin F2, CD14, Cystatin C, Plasminogen, Nidogen 2 or any combination of two or more of these proteins.
摘要翻译：本发明涉及一种预测发生心血管事件的受试者的风险的方法，包括确定存在指示在受试者的外来体中发生心血管事件的风险的生物标志物。外来体合适地从选自血清，血浆，血液，尿液，羊水，恶性腹水，支气管肺泡灌洗液，滑液，母乳，唾液，特别是血清中的体液分离。生物标志物选自蛋白质Vitronectin，Serpin F2，CD14，半胱氨酸蛋白酶抑制剂C，纤溶酶原，Nidogen2或两种或更多种这些蛋白质的任何组合。

3. 发明申请

US20060261267A1 Composite MALDI matrix material and methods of using it and kits thereof in MALDI 审中-公开
标题翻译：复合MALDI基质材料及其在MALDI中的使用方法及其试剂盒
公开(公告)号：US20060261267A1
公开(公告)日：2006-11-23
申请号：US11133845
申请日：2005-05-20
申请人： Siu Kwan Sze , Lin Hua
发明人： Siu Kwan Sze , Lin Hua
IPC分类号： H01J49/16
CPC分类号： C08F8/30 , H01J49/0418
摘要： The present invention relates to a composite matrix material for Matrix-assisted Laser Desorption/Ionisation (MALDI), a process for preparing the same, and a method of its use in MALDI. The invention also relates to a kit for carrying out MALDI. The matrix material comprises at least one MALDI matrix forming compound and a polymer. The polymer serves as supporting material for the at least one MALDI matrix forming compound to which it is covalently linked.
摘要翻译：本发明涉及用于矩阵辅助激光解吸/电离（MALDI）的复合基质材料，其制备方法及其在MALDI中的应用方法。本发明还涉及用于进行MALDI的试剂盒。基质材料包含至少一种形成MALDI基质的化合物和聚合物。聚合物用作与其共价连接的至少一种形成MALDI基质的化合物的载体材料。

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