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    • 1. 发明授权
    • Calcium phosphate material
    • 磷酸钙材料
    • US09492585B2
    • 2016-11-15
    • US14367145
    • 2012-12-17
    • Sirakoss Limited
    • Iain Ronald GibsonJanet Mabel Scott SkakleJordan Christopher Conway
    • C01B25/32A61L27/12A61L27/56
    • A61L27/12A61L27/56A61L2400/12C01B25/32C01B25/322C01B25/327
    • The invention relates to porous granular calcium phosphate osteoinductive materials, particularly materials useful in body tissue repair, principally bone repair and bone replacement, and also to the use of such materials and to a method of making such materials. Exemplary materials comprise discrete porous granules each containing crystals of at least one calcium phosphate, wherein (i) at least 90% of said crystals of the granules have a crystal size in the range 10-100 nm, (ii) at least 90% of the pores in the granules have a pore size in the range 10-500 nm, (iii) the average pore size of the pores having pore size in the range 10-500 nm in the granules is in the range 30-90 nm, (iv) the total volume porosity of the granules is at least 50%, and (v) the surface area of the granules is in the range 10-70 m2/g.
    • 本发明涉及多孔粒状磷酸钙骨诱导材料,特别是可用于身体组织修复,主要是骨修复和骨置换的材料,以及这些材料的使用以及制造这种材料的方法。 示例性材料包括各自含有至少一种磷酸钙的晶体的离散多孔颗粒,其中(i)至少90%的所述颗粒晶体的晶体尺寸在10-100nm的范围内,(ii)至少90% 颗粒中的孔具有10-500nm的孔径,(iii)颗粒中孔径在10-500nm范围内的孔的平均孔径在30-90nm的范围内(( iv)颗粒的总体积孔隙率至少为50%,(v)颗粒的表面积在10-70m 2 / g的范围内。