专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07202277B2 Benzamidine derivatives having anti-inflammatory and immunosuppressive activity 有权
标题翻译：具有抗炎和免疫抑制活性的苯甲脒衍生物
公开(公告)号：US07202277B2
公开(公告)日：2007-04-10
申请号：US10467624
申请日：2002-02-06
申请人： Francesco Makovec , Simona Zanzola , Roberto Artusi , Lucio Claudio Rovati
发明人： Francesco Makovec , Simona Zanzola , Roberto Artusi , Lucio Claudio Rovati
IPC分类号： A61K31/17
CPC分类号： C07D213/40 , C07C257/14 , C07C279/18 , C07C279/36 , C07C335/20 , C07C2601/14 , C07C2603/74 , C07D209/14 , C07D209/40 , C07D277/48
摘要： Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, R1 is selected from an alkyl group having from 1 to 3 carbon atoms and the amino group, unsubstituted or substituted with the nitro group or the methyl group, R2 is selected independently from hydrogen, an alkyl group having from 1 to 4 carbon atoms, the methoxy, ethoxy, propoxy group, a mono-, bi- or tricyclic cycloalkane residue having from 5 to 12 carbon atoms, the adamantyl group, an aryl, naphthyl or heterocyclic group, unsubstituted or substituted with methyl, methoxy, hydroxy, amino or halogen groups, R3 and R4 are selected independently from hydrogen and an alkyl group having from 1 to 3 carbon atoms, R5 represents one or two substituents independently selected from hydrogen and the methyl, methoxyl and hydroxyl groups, n is a whole number from 0 to 6, and the amidine group is in the para or meta position relative to the “-A-NH—” group.
摘要翻译：可以由通式（I）表示的化合物如下所示：

2. 发明申请

US20100120802A1 Novel Anti-Inflammatory and Analgesic Heterocyclic Amidines that Inhibit Nitrogen Oxide (NO) Production 审中-公开
标题翻译：抑制氮氧化物（NO）生产的新型抗炎和止痛性杂环脒
公开(公告)号：US20100120802A1
公开(公告)日：2010-05-13
申请号：US12688298
申请日：2010-01-15
申请人： Francesco MAKOVEC , Antonio Giordani , Roberto Artusi , Stefano Mandelli , Ilario Verpiliq , Simona Zanzola , Lucio Claudio Rovati
发明人： Francesco MAKOVEC , Antonio Giordani , Roberto Artusi , Stefano Mandelli , Ilario Verpiliq , Simona Zanzola , Lucio Claudio Rovati
IPC分类号： A61K31/428 , C07D277/62 , C07D209/18 , C07D215/38 , C07D417/04 , C07D235/18 , C07D263/57 , A61K31/404 , A61K31/47 , A61K31/4184 , A61K31/517 , A61K31/423 , A61P29/00 , A61P37/00 , A61P19/10 , A61P19/02 , A61P25/04 , A61P1/00
CPC分类号： C07D215/06 , C07D209/08 , C07D217/04 , C07D235/08 , C07D235/18 , C07D239/74 , C07D263/57 , C07D277/64 , C07D277/66 , C07D307/79 , C07D333/54 , C07D403/04 , C07D405/04 , C07D409/04 , C07D417/04
摘要： Heterocyclic amidines with anti-inflammatory and analgesic activity that inhibit nitrogen oxide production, of formula (I): in which: G1 and G2 are hydrogen, halogen, hydroxyl, C1-C4 alkoxy, C1-C4 alkyl, and an amidino substituent of formula Q, provided that, for each compound of formula (I), only one of the two substituents G1 or G2 is an amidino substituent of formula Q: and in which the substituents W, Y and X are combined to form 9- or 10-membered bicyclic heteroaromatic derivatives containing up to 2 hetero atoms in the same ring; and Z is an aryl or heteroaryl group, a linear or branched C1-C6 alkyl or alkenyl chain, a C1-C4 alkyl-aryl group or a C1-C4 alkyl-heteroaryl group.
摘要翻译：其中：G1和G2是氢，卤素，羟基，C1-C4烷氧基，C1-C4烷基和式（Ⅳ）的脒基取代基，其具有抑制氮氧化物生成的抗炎和止痛活性的杂环脒; Q，条件是对于每种式（I）化合物，两个取代基G1或G2中只有一个是式Q的脒基取代基，其中取代基W，Y和X被结合形成9-或10- 在同一环中含有至多2个杂原子的二元双环杂芳族衍生物; Z是芳基或杂芳基，直链或支链C 1 -C 6烷基或烯基链，C 1 -C 4烷基 - 芳基或C 1 -C 4烷基 - 杂芳基。

3. 发明申请

US20110118289A1 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW MAO INHIBITORS AND IMIDAZOLINE RECEPTOR LIGANDS 有权
标题翻译： 6-1H-咪唑 - 喹唑啉和喹啉衍生物，新的MAO抑制剂和咪唑啉受体配体
公开(公告)号：US20110118289A1
公开(公告)日：2011-05-19
申请号：US12999862
申请日：2008-06-20
申请人： Antonio Giordani , Marco Lanza , Gianfranco Caselli , Stefano Mandelli , Simona Zanzola , Francesco Makovec , Lucio Claudio Rovati
发明人： Antonio Giordani , Marco Lanza , Gianfranco Caselli , Stefano Mandelli , Simona Zanzola , Francesco Makovec , Lucio Claudio Rovati
IPC分类号： A61K31/517 , C07D401/10 , A61K31/4709 , C07D405/14 , C07D403/10 , A61P25/36
CPC分类号： A61K31/517 , A61K31/4178 , A61K31/485 , C07D401/04 , C07D403/04 , C07D405/14 , A61K2300/00
摘要： The present invention is directed to 6-(1H-imidazo-1-yl)-2-aryl and 2-heteroaryl quinazoline and quinolines derivatives, compounds of formula (I), their pharmaceutical acceptable salts and solvates and corresponding pharmaceutical compositions, that acts as Monoamine Oxidase (MAO) inhibitors and Imidazoline Receptor ligands: wherein: X is independently selected from —CH group or a nitrogen atom (—N), W is independently selected from an aryl group, an heteroaryl group, or a benzocondensed heteroaryl group such as 1,3-benzodioxole, benzofuran, 2,3-dihydrobenzofuran, benzothiophene, 2,3-dihydrobenzothiophene, indole, 2,3-dihydroindole, benzimidazole, benzoxazole, benzothiazole, 2H-3,4-dihydrobenzopyran, [1,4]-benzodioxine, 2,3-dihydro-[1,4]-benzodioxine (1,4-benzodioxan). R1 is independently selected from hydrogen (—H), C1-C4 alkyl, hydroxymethyl (—CH2OH), aminomethyl (—CH2NH2), alkylaminomethyl [CH2NH(R2)], or di-alkylaminomethyl [CH2N(R2)2], trifluoromethyl (—CF3).Compounds of formula (I) elicited a pharmacological profile suitable for the clinical treatment of depression and related disorders, Parkinson disease, drug abuse, and morphine tolerance and dependence.
摘要翻译：本发明涉及6-（1H-咪唑-1-基）-2-芳基和2-杂芳基喹唑啉和喹啉衍生物，式（I）化合物，其药学上可接受的盐和溶剂化物以及相应的药物组合物，其作用作为单胺氧化酶（MAO）抑制剂和咪唑啉受体配体：其中：X独立地选自-CH基或氮原子（-N），W独立地选自芳基，杂芳基或苯并稠合的杂芳基，例如作为1,3-苯并间二氧杂环戊烯，苯并呋喃，2,3-二氢苯并呋喃，苯并噻吩，2,3-二氢苯并噻吩，吲哚，2,3-二氢吲哚，苯并咪唑，苯并恶唑，苯并噻唑，2H-3,4-二氢苯并吡喃，[1,4] 苯并二恶英，2,3-二氢 - [1,4] - 苯并二恶英（1,4-苯并二恶烷）。 R 1独立地选自氢（-H），C 1 -C 4烷基，羟甲基（-CH 2 OH），氨基甲基（-CH 2 NH 2），烷基氨基甲基[CH 2 NH（R 2）]或二烷基氨基甲基[ -CF 3）。式（I）化合物引发适于临床治疗抑郁症和相关疾病，帕金森病，药物滥用和吗啡耐受性和依赖性的药理学特征。

4. 发明申请

US20070244170A1 Novel Pyrrole Derivatives with Angiotensin II Antagonist Activity 有权
标题翻译：新型吡咯衍生物与血管紧张素II拮抗剂活性
公开(公告)号：US20070244170A1
公开(公告)日：2007-10-18
申请号：US11568362
申请日：2005-04-27
申请人： Francesco Makovec , Roberto Artusi , Antonio Giordani , Simona Zanzola , Lucio Rovati
发明人： Francesco Makovec , Roberto Artusi , Antonio Giordani , Simona Zanzola , Lucio Rovati
IPC分类号： A61K31/41 , A61P9/12 , C07D207/00 , C07D257/10 , C07D403/10
CPC分类号： C07D403/10
摘要： Compounds which may be represented by the general formula (I) shown below and in which: R1 is a group independently selected from among: CHO, —COOH, —CH2OH R2 is hydrogen or a linear or branched C1-C6 alkyl group R3 is hydrogen or a halogen group selected from among Cl and Br R4 is a linear or branched C3-C5 alkyl group and the pharmaceutically acceptable salts thereof such as the sodium or potassium salt. The compounds exhibit potent and selective All antagonist activity and are useful for the treatment of any disorders in which elevated synthesis of All or overexpression of the AT1 receptor may play a primary pathological role, as in the case of arterial hypertension, congestive cardiac insufficiency, platelet aggregation and disorders associated therewith such as for example myocardial and cerebral infarction, renal ischaemia, venous and arterial thrombosis, peripheral vasculopathy, pulmonary hypertension, diabetes mellitus, diabetic neuropathy, glaucoma and diabetic retinopathy.
摘要翻译：可以由下述通式（I）表示的化合物，其中：R 1是独立地选自：CHO，-COOH，-CH 2， OH R 2是氢或直链或支链C 1 -C 6烷基R 3是氢或选自Cl和Br R 4的卤素基团是直链或支链C 3 -C 5烷基和其药学上可接受的盐例如钠盐或钾盐。所述化合物表现出有效和选择性的所有拮抗剂活性，并且可用于治疗其中AT 1受体的全部或过表达的合成升高可能起主要病理学作用的任何障碍，如在动脉高血压，充血性心功能不全，血小板聚集和与之相关的病症，例如心肌和脑梗塞，肾缺血，静脉和动脉血栓形成，外周血管病变，肺动脉高压，糖尿病，糖尿病性神经病，青光眼和糖尿病性视网膜病变。

5. 发明授权

US07145037B2 Adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities, and process for preparing them 有权
标题翻译：具有神经保护，抗抑郁药和抗缺血活性的金刚烷衍生物及其制备方法
公开(公告)号：US07145037B2
公开(公告)日：2006-12-05
申请号：US10931245
申请日：2004-09-01
申请人： Francesco Makovec , Roberto Artusi , Simona Zanzola , Lucio Claudio Rovati
发明人： Francesco Makovec , Roberto Artusi , Simona Zanzola , Lucio Claudio Rovati
IPC分类号： C07C257/00 , C07C279/00 , A61K31/155
CPC分类号： C07C279/36 , C07C257/14 , C07C279/04 , C07C2601/02 , C07C2603/74
摘要： The invention describes compounds represented by the general formula (I) given below: in which: n is an integer between 1 and 4; R1 and R2 are chosen independently from hydrogen and a methyl group; R3 is chosen independently from a linear, branched or cyclic alkyl group containing from 1 to 3 carbon atoms (R3a) and a simple amino group (R3b) or an amino group substituted with a nitro group (R3c) The compounds are useful for treating central nervous system diseases or peripheral neuropathies.
摘要翻译：本发明描述了由下列通式（I）表示的化合物：其中：n为1至4之间的整数; R 1和R 2独立地选自氢和甲基; R 3独立地选自含有1至3个碳原子的直链，支链或环状烷基（R 3a）和简单氨基（R 3b）或被硝基取代的氨基（R 3c）。这些化合物可用于治疗中枢神经系统疾病或周围神经病变。

6. 发明申请

US20050049312A1 Novel adamantane derivatives with neuroprotective, antidepressant and anti-ischaemic activities,and process for preparing them 有权
标题翻译：具有神经保护，抗抑郁药和抗缺血活性的新型金刚烷衍生物及其制备方法
公开(公告)号：US20050049312A1
公开(公告)日：2005-03-03
申请号：US10931245
申请日：2004-09-01
申请人： Francesco Makovec , Roberto Artusi , Simona Zanzola , Lucio Rovati
发明人： Francesco Makovec , Roberto Artusi , Simona Zanzola , Lucio Rovati
IPC分类号： A61P9/10 , A61K31/155 , A61P19/02 , A61P25/02 , A61P25/14 , A61P25/24 , A61P25/28 , A61P29/00 , C07C257/14 , C07C279/04 , C07C279/36 , C07C257/16
CPC分类号： C07C279/36 , C07C257/14 , C07C279/04 , C07C2601/02 , C07C2603/74
摘要： The invention describes compounds represented by the general formula (I) given below: in which: n is an integer between 1 and 4; R1 and R2 are chosen independently from hydrogen and a methyl group; R3 is chosen independently from a linear, branched or cyclic alkyl group containing from 1 to 3 carbon atoms (R3a) and a simple amino group (R3b) or an amino group substituted with a nitro group (R3c) The compounds are useful for treating central nervous system diseases or peripheral neuropathies.
摘要翻译：本发明描述了由下列通式（I）表示的化合物：其中：n为1至4之间的整数; R1和R2独立地选自氢和甲基; R3独立于含有1至3个碳原子（R3a）和简单氨基（R3b）或被硝基取代的氨基（R3c）的直链，支链或环状烷基选择。该化合物可用于治疗中枢神经系统疾病或周围神经病变。

7. 发明授权

US08633208B2 6-1H-imidazo-quinazoline and quinolines derivatives, new MAO inhibitors and imidazoline receptor ligands 有权
标题翻译： 6-1H-咪唑并喹唑啉和喹啉衍生物，新的MAO抑制剂和咪唑啉受体配体
公开(公告)号：US08633208B2
公开(公告)日：2014-01-21
申请号：US12999862
申请日：2008-06-20
申请人： Antonio Giordani , Marco Lanza , Gianfranco Caselli , Stefano Mandelli , Simona Zanzola , Francesco Makovec , Lucio Claudio Rovati
发明人： Antonio Giordani , Marco Lanza , Gianfranco Caselli , Stefano Mandelli , Simona Zanzola , Francesco Makovec , Lucio Claudio Rovati
IPC分类号： A01N43/54 , A01N43/42 , A61K31/517 , A61K31/44 , C07D239/72 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D233/00
CPC分类号： A61K31/517 , A61K31/4178 , A61K31/485 , C07D401/04 , C07D403/04 , C07D405/14 , A61K2300/00
摘要： The present invention is directed to 6-(1H-imidazo-1-yl)-2-aryl and 2-heteroaryl quinazoline and quinolines derivatives, compounds of formula (I), their pharmaceutical acceptable salts and solvates and corresponding pharmaceutical compositions, that acts as Monoamine Oxidase (MAO) inhibitors and Imidazoline Receptor ligands: wherein: X is independently selected from —CH group or a nitrogen atom (—N), W is independently selected from an aryl group, an heteroaryl group, or a benzocondensed heteroaryl group such as 1,3-benzodioxole, benzofuran, 2,3-dihydrobenzofuran, benzothiophene, 2,3-dihydrobenzothiophene, indole, 2,3-dihydroindole, benzimidazole, benzoxazole, benzothiazole, 2H-3,4-dihydrobenzopyran, [1,4]-benzodioxine, 2,3-dihydro-[1,4]-benzodioxine (1,4-benzodioxan). R1 is independently selected from hydrogen (—H), C1-C4 alkyl, hydroxymethyl (—CH2OH), aminomethyl (—CH2NH2), alkylaminomethyl [CH2NH(R2)], or di-alkylaminomethyl [CH2N(R2)2], trifluoromethyl (—CF3). Compounds of formula (I) elicited a pharmacological profile suitable for the clinical treatment of depression and related disorders, Parkinson disease, drug abuse, and morphine tolerance and dependence.
摘要翻译：本发明涉及6-（1H-咪唑-1-基）-2-芳基和2-杂芳基喹唑啉和喹啉衍生物，式（I）化合物，其药学上可接受的盐和溶剂化物以及相应的药物组合物，其作用作为单胺氧化酶（MAO）抑制剂和咪唑啉受体配体：其中：X独立地选自-CH基或氮原子（-N），W独立地选自芳基，杂芳基或苯并稠合的杂芳基，例如作为1,3-苯并间二氧杂环戊烯，苯并呋喃，2,3-二氢苯并呋喃，苯并噻吩，2,3-二氢苯并噻吩，吲哚，2,3-二氢吲哚，苯并咪唑，苯并恶唑，苯并噻唑，2H-3,4-二氢苯并吡喃，[1,4] 苯并二恶英，2,3-二氢 - [1,4] - 苯并二恶英（1,4-苯并二恶烷）。 R 1独立地选自氢（-H），C 1 -C 4烷基，羟甲基（-CH 2 OH），氨基甲基（-CH 2 NH 2），烷基氨基甲基[CH 2 NH（R 2）]或二烷基氨基甲基[ -CF 3）。式（I）化合物引发适于临床治疗抑郁症和相关疾病，帕金森病，药物滥用和吗啡耐受性和依赖性的药理学特征。

8. 发明授权

US08193353B2 6-1H-imidazo-quinazoline and quinolines derivatives, new potent analgesics and anti-inflammatory agents 有权
标题翻译： 6-1H-咪唑并喹唑啉和喹啉衍生物，新型强效止痛剂和抗炎剂
公开(公告)号：US08193353B2
公开(公告)日：2012-06-05
申请号：US13169350
申请日：2011-06-27
申请人： Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
发明人： Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
IPC分类号： C07D239/72
CPC分类号： C07D413/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14
摘要： The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases.
摘要翻译：本发明涉及式I的新颖的6-1H-咪唑-2-芳基和2-杂芳基喹唑啉和喹啉，其相应的盐和溶剂合物，其制备方法和该化合物及相应的药物组合物的用途用于治疗疼痛和炎症相关疾病。除了具有显着的抗炎特性之外，本发明的化合物已经被证明在炎性和神经性疼痛的药理学治疗中都是非常有效的。它们在干扰COX-2和炎性细胞因子表达和产生方面的有效性，也将它们作为有趣的化合物，也用于治疗癌症以及多种炎性疾病。

9. 发明申请

US20090264451A1 6-1H-IMIDAZO-QUINAZOLINE AND QUINOLINES DERIVATIVES, NEW POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS 有权
标题翻译： 6-1H-IMIDAZO-喹唑啉和喹啉衍生物，新的药物和抗炎药物
公开(公告)号：US20090264451A1
公开(公告)日：2009-10-22
申请号：US12376080
申请日：2006-08-03
申请人： Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
发明人： Antonio Giordani , Stefano Mandelli , Ilario Verpilio , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Tiziana Piepoli , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
IPC分类号： A61K31/517 , C07D403/10 , C07D401/10 , C07D405/14 , C07D413/14 , C07D409/14 , A61K31/4709 , A61P29/00 , A61P25/00
CPC分类号： C07D413/14 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14
摘要： The present invention is directed to novel 6-1H-imidazo-2-aryl and 2-heteroaryl quinazoline and quinoline of formula I, corresponding salts and solvates thereof, to a process for their preparation and to the use of this compounds and corresponding pharmaceutical composition for the treatment of pain and inflammatory related disorders. Compounds of the invention have been proven highly effective in the pharmacological treatment of both inflammatory and neuropathic pain, in addition to striking anti-inflammatory properties. Their effectiveness in interfering with COX-2 and inflammatory cytokines expressions and production, highlights them as interesting compounds also for the treatment of cancer in addition to several inflammatory diseases.Formula I:
摘要翻译：本发明涉及式I的新颖的6-1H-咪唑-2-芳基和2-杂芳基喹唑啉和喹啉，其相应的盐和溶剂合物，其制备方法和该化合物及相应的药物组合物的用途用于治疗疼痛和炎症相关疾病。除了具有显着的抗炎特性之外，本发明的化合物已经被证明在炎性和神经性疼痛的药理学治疗中都是非常有效的。它们在干扰COX-2和炎性细胞因子表达和产生方面的有效性，也将它们作为有趣的化合物，也用于治疗癌症以及多种炎性疾病。公式I：

10. 发明申请

US20090227609A1 AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS 有权
标题翻译： 2-异喹啉和喹啉的氨基衍生物; POTENT ANALGESICS和抗炎药物
公开(公告)号：US20090227609A1
公开(公告)日：2009-09-10
申请号：US12376066
申请日：2006-07-31
申请人： Antonio Giordani , Stefano Mandelli , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Teresa Simonetta Fiorentino , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
发明人： Antonio Giordani , Stefano Mandelli , Simona Zanzola , Francesca Tarchino , Gianfranco Caselli , Teresa Simonetta Fiorentino , Silvio Mazzari , Francesco Makovec , Lucio Claudio Rovati
IPC分类号： A61K31/517 , C07D239/72 , C07D215/38 , A61K31/4709 , A61P37/06 , A61P29/00
CPC分类号： C07D405/04
摘要： The present invention concerns novel amidines derivatives of 2-heteroaryl-quinazoline and quinolines of general formula (I), to a process for their preparation, to their pharmaceutical compositions and to the use of these compounds, salts and solvates thereof, along with the corresponding pharmaceutical compositions, for the treatment of pain and inflammatory disorders. Compounds of this invention are extremely potent analgesics, suitable for the treatment of both inflammatory and neuropathic pain. Particularly for the treatment of neuropathic pain the compounds of the invention have been proved largely superior to the standards currently in the clinical use. These compounds are not acting through inhibition of COX or NOS enzymes but are effective in inhibiting inflammatory cytokine production induced by inflammatory stimuli.
摘要翻译：本发明涉及通式（I）的2-杂芳基 - 喹唑啉和喹啉的新型脒衍生物，其制备方法，其药物组合物以及这些化合物，其盐和溶剂合物的用途以及相应的药物组合物，用于治疗疼痛和炎症性疾病。本发明的化合物是非常有效的止痛剂，适用于治疗炎性和神经性疼痛。特别是对于神经性疼痛的治疗，本发明的化合物已被证明在很大程度上优于目前在临床应用中的标准。这些化合物不是通过抑制COX或NOS酶而起作用，而是有效抑制由炎症刺激引起的炎性细胞因子产生。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式