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1. 发明授权

US06316470B1 Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands 失效
标题翻译：苄基哌嗪基和哌啶基乙酮衍生物：多巴胺受体亚型特异性配体
公开(公告)号：US06316470B1
公开(公告)日：2001-11-13
申请号：US09608329
申请日：2000-06-29
申请人： Renata Xavier Kover , Silva Terdjanian , Jennifer Tran , Andrew Thurkauf
发明人： Renata Xavier Kover , Silva Terdjanian , Jennifer Tran , Andrew Thurkauf
IPC分类号： A61K314523
CPC分类号： C07D295/15 , C07D209/08 , C07D401/06
摘要： Disclosed are compounds of the formula: or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH; R1, R2 and R3 independently represent organic or inorganic substituents; R4 and R4′ independently represent hydrogen, alkyl or form a ring with the atom to which they are attached; R5 represents hydrogen, alkyl, alkoxy, or alkylthio, and R6 represents hydrogen or alkyl; or R5 and R6 form a ring together with the atoms to which they are attached; and R7, R8, R9, R10, and R11 independently represent hydrogen or alkyl, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
摘要翻译：公开了下式的化合物或其药学上可接受的加成盐，其中：Y表示氧或硫; Z是氮或CH; R 1，R 2和R 3独立地表示有机或无机取代基; R 4和R 4'独立地表示氢，烷基或与它们连接的原子形成环; R 5表示氢，烷基，烷氧基或烷硫基，R6代表氢或烷基; 或R 5和R 6与它们所连接的原子一起形成环; 和R 7，R 8，R 9，R 10和R 11独立地表示氢或烷基，该化合物可用于治疗和/或预防神经心理障碍，包括但不限于精神分裂症，躁狂症，痴呆，抑郁症，焦虑症，强迫行为，药物滥用，帕金森样运动障碍和与使用精神安定药有关的运动障碍。

2. 发明授权

US6084098A Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands 失效
标题翻译：苄基哌嗪基和哌啶基乙酮衍生物：多巴胺受体亚型特异性配体
公开(公告)号：US6084098A
公开(公告)日：2000-07-04
申请号：US259239
申请日：1999-02-26
申请人： Renata Xavier Kover , Silva Terdjanian , Jennifer Tran , Andrew Thurkauf
发明人： Renata Xavier Kover , Silva Terdjanian , Jennifer Tran , Andrew Thurkauf
IPC分类号： C07D209/08 , C07D295/15 , C07D401/06 , C07D403/06
CPC分类号： C07D295/15 , C07D209/08 , C07D401/06
摘要： Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable addition salts thereof wherein: Y represents oxygen or sulfur; Z is nitrogen or CH;R.sub.1, R.sub.2 and R.sub.3 independently represent organic or inorganic substituents;R.sub.4 and R.sub.4 ' independently represent hydrogen, alkyl or form a ring with the atom to which they are attached;R.sub.5 represents hydrogen, alkyl, alkoxy, or alkylthio, and R.sub.6 represents hydrogen or alkyl; or R.sub.5 and R.sub.6 form a ring together with the atoms to which they are attached; andR.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 independently represent hydrogen or alkyl,which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
摘要翻译：公开了下式的化合物或其药学上可接受的加成盐，其中：Y表示氧或硫; Z是氮或CH; R1，R2和R3独立地表示有机或无机取代基; R4和R4'独立地表示氢，烷基或与它们所连接的原子形成环; R5代表氢，烷基，烷氧基或烷硫基，R6代表氢或烷基; 或R 5和R 6与它们所连接的原子一起形成环; 并且R 7，R 8，R 9，R 10和R 11独立地表示氢或烷基，该化合物可用于治疗和/或预防神经心理障碍，包括但不限于精神分裂症，躁狂症，痴呆，抑郁，焦虑，强迫行为，药物滥用，帕金森样运动障碍和与使用精神安定药有关的运动障碍。

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