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1. 发明授权

US07427661B2 Canine IL-5 proteins and fragments thereof 有权
标题翻译：犬IL-5蛋白及其片段
公开(公告)号：US07427661B2
公开(公告)日：2008-09-23
申请号：US11561562
申请日：2006-11-20
申请人： Shumin Yang , Catherine A. McCall , Eric R. Weber
发明人： Shumin Yang , Catherine A. McCall , Eric R. Weber
IPC分类号： C07K14/52 , C12N15/19
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/51 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C12N2799/021
摘要： The present invention relates to canine interleukin-5 proteins; canine interleukin-5 nucleic acid molecules, including those that encode canine interleukin-5 proteins; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬白细胞介素-5蛋白; 犬白细胞介素-5核酸分子，包括编码犬白细胞介素-5蛋白的核酸分子; 针对这种蛋白质产生的抗体; 以及调节这些蛋白质的抑制性化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

2. 发明授权

US07026139B2 Canine IL-13 nucleic acid molecules and fragments thereof 失效
标题翻译：犬IL-13核酸分子及其片段
公开(公告)号：US07026139B2
公开(公告)日：2006-04-11
申请号：US10262439
申请日：2002-09-30
申请人： Shumin Yang
发明人： Shumin Yang
IPC分类号： C12P21/06 , C12N5/00 , C12N15/00 , C12N15/63 , C07H21/02
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C07K16/247 , C12N2799/021
摘要： The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF nucleic acid molecules, including those that encode canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins, respectively; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫科动物CD154，犬白细胞介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF蛋白 ; 对犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫CD154，犬白介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF核酸分子，包括分别编码犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫科动物CD154，犬白介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF蛋白 ; 针对这种蛋白质产生的抗体; 以及调节这些蛋白质的抑制性化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

3. 发明授权

US07385045B2 Canine B7-1 nucleic acid molecules 失效
标题翻译：犬B7-1核酸分子
公开(公告)号：US07385045B2
公开(公告)日：2008-06-10
申请号：US11288047
申请日：2005-11-28
申请人： Shumin Yang , Gek-Kee Sim
发明人： Shumin Yang , Gek-Kee Sim
IPC分类号： C07H21/04 , C12N15/00 , C12N15/11
CPC分类号： C07K14/70521 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51 , C07K14/70532 , C12N2799/021
摘要： The present invention relates to B7 proteins; to B7 nucleic acid molecules, including those that encode such B7 proteins; to antibodies raised against such B7 proteins; and to therapeutic compounds that regulate B7 function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及B7蛋白; 包括B7核酸分子，包括编码这种B7蛋白的那些; 针对这种B7蛋白产生的抗体; 以及调节B7功能的治疗化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

4. 发明授权

US07078506B2 Canineil-4nucleic acid molecules and uses thereof 失效
标题翻译： Canineil-4核酸分子及其用途
公开(公告)号：US07078506B2
公开(公告)日：2006-07-18
申请号：US10218654
申请日：2002-08-13
申请人： Gek-Kee Sim , Shumin Yang , Matthew J. Dreitz , Ramani S. Wonderling
发明人： Gek-Kee Sim , Shumin Yang , Matthew J. Dreitz , Ramani S. Wonderling
IPC分类号： C07H21/02 , C07H21/04 , C12P21/06 , C12N5/00 , C12N15/00 , C12N15/63 , C07K1/00
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/51 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C07K16/247 , C12N2799/021
摘要： The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF nucleic acid molecules, including those that encode canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins, respectively; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫科动物CD154，犬白细胞介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF蛋白 ; 对犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫CD154，犬白介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF核酸分子，包括分别编码犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫科动物CD154，犬白介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF蛋白 ; 针对这种蛋白质产生的抗体; 以及调节这些蛋白质的抑制性化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

5. 发明授权

US06852847B1 Canine and feline B7-2 nucleic acid molecules and uses thereof 失效
标题翻译：犬和猫科B7-2核酸分子及其用途
公开(公告)号：US06852847B1
公开(公告)日：2005-02-08
申请号：US09646561
申请日：1999-03-19
申请人： Gek-Kee Sim , Shumin Yang , Karen S. Sellins
发明人： Gek-Kee Sim , Shumin Yang , Karen S. Sellins
IPC分类号： A61K38/00 , A61K39/00 , A61K48/00 , C07K14/705 , C12N15/12 , C07H21/04 , C12N15/09 , C12N15/63
CPC分类号： C07K14/70521 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51 , C07K14/70532 , C12N2799/021
摘要： The present invention relates to canine and feline B7 proteins; to B7 nucleic acid molecules, including those that encode such B7 proteins; to antibodies raised against such B7 proteins; and to therapeutic compounds that regulate B7 function. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬和猫B7蛋白; 包括B7核酸分子，包括编码这种B7蛋白的那些; 针对这种B7蛋白产生的抗体; 以及调节B7功能的治疗化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

6. 发明授权

US07183080B2 Cannie IL-5 nucleic acid molecules 有权
标题翻译： Cannie IL-5核酸分子
公开(公告)号：US07183080B2
公开(公告)日：2007-02-27
申请号：US10787382
申请日：2004-02-24
申请人： Shumin Yang , Catherine A. McCall , Eric R. Weber
发明人： Shumin Yang , Catherine A. McCall , Eric R. Weber
IPC分类号： C12P21/06 , C07H21/02 , C07H21/04 , C12N5/00 , C12N15/00 , C12N15/63
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/51 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C12N2799/021
摘要： The present invention relates to canine interleukin-5 proteins; canine interleukin-5 nucleic acid molecules, including those that encode canine interleukin-5 proteins; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬白细胞介素-5蛋白; 犬白细胞介素-5核酸分子，包括编码犬白细胞介素-5蛋白的核酸分子; 针对这种蛋白质产生的抗体; 以及调节这些蛋白质的抑制性化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

7. 发明申请

US20090111970A1 CANINE AND FELINE IMMUNOREGULATORY PROTEINS, NUCLEIC ACID MOLECULES, AND USES THEREOF 审中-公开
标题翻译：犬和免疫蛋白免疫蛋白，核酸分子及其用途
公开(公告)号：US20090111970A1
公开(公告)日：2009-04-30
申请号：US12234136
申请日：2008-09-19
申请人： Shumin Yang , Catherine A. McCall , Eric R. Weber
发明人： Shumin Yang , Catherine A. McCall , Eric R. Weber
IPC分类号： C07K4/00 , C07K14/00
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/51 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C12N2799/021
摘要： The present invention relates to canine interleukin-5 proteins; canine interleukin-5 nucleic acid molecules, including those that encode canine interleukin-5 proteins; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬白细胞介素-5蛋白; 犬白细胞介素-5核酸分子，包括编码犬白细胞介素-5蛋白的核酸分子; 针对这种蛋白质产生的抗体; 以及调节这些蛋白质的抑制性化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

8. 再颁专利

USRE40374E1 Canine IL-13 immunoregulatory proteins and uses thereof 有权
标题翻译：犬IL-13免疫调节蛋白及其用途
公开(公告)号：USRE40374E1
公开(公告)日：2008-06-10
申请号：US10918292
申请日：2004-08-13
申请人： Shumin Yang
发明人： Shumin Yang
IPC分类号： A61K45/00 , C07K1/00 , C07H21/04 , C12P21/06
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C07K16/247 , C12N2799/021
摘要： The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF nucleic acid molecules, including those that encode canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins, respectively; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫科动物CD154，犬白细胞介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF蛋白 ; 对犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫CD154，犬白介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF核酸分子，包括分别编码犬白细胞介素-4，犬或猫Flt-3配体，犬或猫CD40，犬或猫科动物CD154，犬白介素-5，犬白细胞介素-13，猫干扰素α和/或猫GM-CSF蛋白 ; 针对这种蛋白质产生的抗体; 以及调节这些蛋白质的抑制性化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

9. 发明申请

US20070141671A1 CANINE IL-5 PROTEINS AND FRAGMENTS THEREOF 有权
标题翻译：犬类IL-5蛋白及其片段
公开(公告)号：US20070141671A1
公开(公告)日：2007-06-21
申请号：US11561562
申请日：2006-11-20
申请人： Shumin Yang , Catherine McCall , Eric Weber
发明人： Shumin Yang , Catherine McCall , Eric Weber
IPC分类号： C12P21/06 , C07H21/04 , C07K14/47 , C07K7/08
CPC分类号： C07K14/475 , A61K38/00 , A61K2039/51 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C12N2799/021
摘要： The present invention relates to canine interleukin-5 proteins; canine interleukin-5 nucleic acid molecules, including those that encode canine interleukin-5 proteins; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.
摘要翻译：本发明涉及犬白细胞介素-5蛋白; 犬白细胞介素-5核酸分子，包括编码犬白细胞介素-5蛋白的核酸分子; 针对这种蛋白质产生的抗体; 以及调节这些蛋白质的抑制性化合物。本发明还包括鉴定和获得这些蛋白质，核酸分子，抗体和抑制性化合物的方法。本发明还包括包含这些蛋白质，核酸分子，抗体和/或抑制化合物的治疗组合物，以及这些治疗组合物在动物体内调节免疫应答的用途。

10. 发明申请

US20060216786A1 Feline interferon-alpha proteins 失效
公开(公告)号：US20060216786A1
公开(公告)日：2006-09-28
申请号：US11369203
申请日：2006-03-06
申请人： Gek-Kee Sim , Shumin Yang , Matthew Dreitz , Ramani Wonderling
发明人： Gek-Kee Sim , Shumin Yang , Matthew Dreitz , Ramani Wonderling
IPC分类号： C07K14/52 , C07K14/535 , C07H21/04 , C12P21/06 , C12N15/86
CPC分类号： C07K14/475 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/5409 , C07K14/5437 , C07K14/56 , C07K14/70575 , C07K14/70578 , C07K16/247 , C12N2799/021
摘要： The present invention relates to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins; to canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF nucleic acid molecules, including those that encode canine interleukin-4, canine or feline Flt-3 ligand, canine or feline CD40, canine or feline CD154, canine interleukin-5, canine interleukin-13, feline interferon alpha, and/or feline GM-CSF proteins, respectively; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.

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