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1. 发明授权

US07834169B2 P300 histone acetylase inhibitor 有权
标题翻译： P300组蛋白乙酰酶抑制剂
公开(公告)号：US07834169B2
公开(公告)日：2010-11-16
申请号：US10490550
申请日：2002-08-13
申请人： Shuki Mizutani , Takayuki Yamada
发明人： Shuki Mizutani , Takayuki Yamada
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C07K14/47 , C07K14/4703 , C12N2310/14 , G01N2333/91045
摘要： An inhibitor of histone acetyltransferase p300 was isolated from human cDNA library and identified as a nuclear protein composed of 855 amino acid residues. It binds to the cysteine/histidine-rich region of p300, thereby inhibiting the transcriptional activation by p300. It also inhibits the transcription activity of p53, with p300 functioning as a coactivator, and inhibits the discontinuance of cell cycle that relies on p53.
摘要翻译：从人cDNA文库中分离组蛋白乙酰转移酶p300的抑制剂，鉴定为由855个氨基酸残基组成的核蛋白。它与p300的半胱氨酸/组氨酸富集区结合，从而抑制p300的转录激活。它还抑制p53的转录活性，p300作为共激活因子，并抑制依赖于p53的细胞周期的中断。

2. 发明授权

US08309700B2 Inhibitor of histone acetyltransferase, especially p300 失效
标题翻译：组蛋白乙酰转移酶抑制剂，特别是p300
公开(公告)号：US08309700B2
公开(公告)日：2012-11-13
申请号：US12901382
申请日：2010-10-08
申请人： Shuki Mizutani , Takayuki Yamada
发明人： Shuki Mizutani , Takayuki Yamada
IPC分类号： C07H21/04 , C12N15/00
CPC分类号： C12N15/113 , C07K14/47 , C07K14/4703 , C12N2310/14 , G01N2333/91045
摘要： An inhibitor of histone acetyltransferase p300 was isolated from human cDNA library and identified as a nuclear protein composed of 855 amino acid residues. It binds to the cysteine/histidine-rich region of p300, thereby inhibiting the transcriptional activation by p300. It also inhibits the transcription activity of p53, with p300 functioning as a coactivator, and inhibits the discontinuance of cell cycle that relies on p53.
摘要翻译：从人cDNA文库中分离组蛋白乙酰转移酶p300的抑制剂，鉴定为由855个氨基酸残基组成的核蛋白。它与p300的半胱氨酸/组氨酸富集区结合，从而抑制p300的转录激活。它还抑制p53的转录活性，p300作为共激活因子，并抑制依赖于p53的细胞周期的中断。

3. 发明申请

US20120088301A1 FACTOR TAKING PART IN TRANSCRIPTION CONTROL 审中-公开
标题翻译：收购控制部分的因素
公开(公告)号：US20120088301A1
公开(公告)日：2012-04-12
申请号：US13296878
申请日：2011-11-15
申请人： Shuki MIZUTANI , Takayuki Yamada
发明人： Shuki MIZUTANI , Takayuki Yamada
IPC分类号： C12N5/10 , C12N15/85 , C12N15/11
CPC分类号： C07K14/4702
摘要： HDART binds with HDAC (histone deacetylase) and function as a repressor. HDART directly binds with Skip functioning as a transcription co-activator of a nuclear receptor to repress the transcription of the nuclear receptor. Moreover, HDART is one of transcription co-repressors of nuclear receptor, and binds with HDAC thereby enabling intense repression of transcription through the histone deacetylization of HDAC. On the other hand, a dominant negative peptide of HDART can be obtained, and it has been confirmed that this peptide activates transcription contrary to the HDART protein of the full length. Especially, the transcription activity of retinoic acid receptor with this peptide has an activity exceeding all-trans retinoic acid (ATRA).
摘要翻译： HDART与HDAC（组蛋白脱乙酰酶）结合并作为阻遏物起作用。 HDART直接与Skip发挥作用，作为核受体的转录共激活剂，以抑制核受体的转录。此外，HDART是核受体的转录共抑制因子之一，并与HDAC结合，从而通过HDAC的组蛋白脱乙酰化使得能够强烈抑制转录。另一方面，可以获得HDART的显性负性肽，并且已经证实该肽激活与全长的HDART蛋白相反的转录。特别地，视黄酸受体与该肽的转录活性具有超过全反式视黄酸（ATRA）的活性。

4. 发明申请

US20080145928A1 Factor Taking Part in Transcription Control 审中-公开
标题翻译：因素参与转录控制
公开(公告)号：US20080145928A1
公开(公告)日：2008-06-19
申请号：US10522277
申请日：2003-07-25
申请人： Shuki Mizutani , Takayuki Yamada
发明人： Shuki Mizutani , Takayuki Yamada
IPC分类号： C12N5/06 , C07H21/04 , C07K16/00 , C07K16/18 , C07K2/00
CPC分类号： C07K14/4702
摘要： HDART binds with HDAC (histone deacetylase) and function as a repressor. HDART directly binds with Skip functioning as a transcription co-activator of a nuclear receptor to repress the transcription of the nuclear receptor. Moreover, HDART is one of transcription co-repressors of nuclear receptor, and binds with HDAC thereby enabling intense repression of transcription through the histone deacetylization of HDAC. On the other hand, a dominant negative peptide of HDART can be obtained, and it has been confirmed that this peptide activates transcription contrary to the HDART protein of the full length. Especially, the transcription activity of retinoic acid receptor with this peptide has an activity exceeding all-trans retinoic acid (ATRA).
摘要翻译： HDART与HDAC（组蛋白脱乙酰酶）结合并作为阻遏物起作用。 HDART直接与Skip发挥作用，作为核受体的转录共激活剂，以抑制核受体的转录。此外，HDART是核受体的转录共抑制因子之一，并与HDAC结合，从而通过HDAC的组蛋白脱乙酰化使得能够强烈抑制转录。另一方面，可以获得HDART的显性负性肽，并且已经证实该肽激活与全长的HDART蛋白相反的转录。特别地，视黄酸受体与该肽的转录活性具有超过全反式视黄酸（ATRA）的活性。

5. 发明申请

US20110070653A1 INHIBITOR OF HISTONE ACETYLTRANSFERASE, ESPECIALLY p300 失效
标题翻译：乙酰胆碱酯酶抑制剂，特别是p300
公开(公告)号：US20110070653A1
公开(公告)日：2011-03-24
申请号：US12901382
申请日：2010-10-08
申请人： Shuki MIZUTANI , Takayuki Yamada
发明人： Shuki MIZUTANI , Takayuki Yamada
IPC分类号： C07K14/47 , C07K16/18 , C07H21/00 , C07H21/04 , G01N33/68
CPC分类号： C12N15/113 , C07K14/47 , C07K14/4703 , C12N2310/14 , G01N2333/91045
摘要： An inhibitor of histone acetyltransferase p300 was isolated from human cDNA library and identified as a nuclear protein composed of 855 amino acid residues. It binds to the cysteine/histidine-rich region of p300, thereby inhibiting the transcriptional activation by p300. It also inhibits the transcription activity of p53, with p300 functioning as a coactivator, and inhibits the discontinuance of cell cycle that relies on p53.
摘要翻译：从人cDNA文库中分离组蛋白乙酰转移酶p300的抑制剂，鉴定为由855个氨基酸残基组成的核蛋白。它与p300的半胱氨酸/组氨酸富集区结合，从而抑制p300的转录激活。它还抑制p53的转录活性，p300作为共激活因子，并抑制依赖于p53的细胞周期的中断。

6. 发明授权

US08889408B2 Factor taking part in transcription control 有权
标题翻译：参与转录控制的因子
公开(公告)号：US08889408B2
公开(公告)日：2014-11-18
申请号：US13296878
申请日：2011-11-15
申请人： Shuki Mizutani , Takayuki Yamada
发明人： Shuki Mizutani , Takayuki Yamada
IPC分类号： C12N15/85 , C12N15/11 , C07K14/47
CPC分类号： C07K14/4702
摘要： HDART binds with HDAC (histone deacetylase) and functions as a repressor. HDART directly binds with Skip, which functions as a transcription co-activator of nuclear receptors, to repress the transcription by the nuclear receptor. Moreover, HDART is a transcription co-repressor of nuclear receptors, and binds with HDAC wherein transcription can be strongly repressed through the histone deacetylization of HDAC. On the other hand, a dominant negative peptide of HDART can be obtained, and it has been confirmed that, in contrast with the full-length HDART protein, this peptide activates transcription. In particular, the ability of this peptide to activate transcription by the retinoic acid receptor exceeds that of all-trans retinoic acid (ATRA).
摘要翻译： HDART与HDAC结合（组蛋白脱乙酰酶），起到阻遏物的作用。 HDART与作为核受体的转录共激活子的Skip直接结合，以抑制核受体的转录。此外，HDART是核受体的转录共抑制因子，并与HDAC结合，其中可以通过HDAC的组蛋白脱乙酰化强烈抑制转录。另一方面，可以获得HDART的显性负性肽，并且已经证实，与全长HDART蛋白质相反，该肽激活转录。特别地，该肽激活视黄酸受体转录的能力超过全反式视黄酸（ATRA）的能力。

7. 发明申请

US20050069986A1 P300 histone acetylase inhibitor 有权
标题翻译： P300组蛋白乙酰酶抑制剂
公开(公告)号：US20050069986A1
公开(公告)日：2005-03-31
申请号：US10490550
申请日：2002-08-13
申请人： Shuki Mizutani , Takayuki Yamada
发明人： Shuki Mizutani , Takayuki Yamada
IPC分类号： C07K14/47 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N9/99
CPC分类号： C12N15/113 , C07K14/47 , C07K14/4703 , C12N2310/14 , G01N2333/91045
摘要： An inhibitor of histone acetyltransferase p300 was isolated from human cDNA library and identified as a nuclear protein composed of 855 amino acid residues. It binds to the cysteine/histidine-rich region of p300, thereby inhibiting the transcriptional activation by p300. It also inhibits the transcription activity of p53, with p300 functioning as a coactivator, and inhibits the discontinuance of cell cycle that relies on p53.
摘要翻译：从人cDNA文库中分离组蛋白乙酰转移酶p300的抑制剂，鉴定为由855个氨基酸残基组成的核蛋白。它与p300的半胱氨酸/组氨酸富集区结合，从而抑制p300的转录激活。它还抑制p53的转录活性，p300作为共激活因子，并抑制依赖于p53的细胞周期的中断。

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