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1. 发明申请

US20070226167A1 Systems and methods for clinical decision crawler agent 有权
标题翻译：临床决策爬行器的系统和方法
公开(公告)号：US20070226167A1
公开(公告)日：2007-09-27
申请号：US11389857
申请日：2006-03-27
申请人： Shrikant Deshpande
发明人： Shrikant Deshpande
IPC分类号： G06F15/18
CPC分类号： G16H50/20 , G06F19/00 , G16H40/20
摘要： Certain embodiments of the present invention provide a system for clinical decision support including a crawler agent component. The crawler agent component is adapted to receive a search parameter. The search parameter specifies a criteria for evidence data to be searched for. The crawler agent component is adapted to initiate a search of a plurality of evidence sources based at least in part on the search parameter. The search identifies the evidence data. The evidence data is utilized by the clinical decision support system to provide decision support to a healthcare provider for a patient.
摘要翻译：本发明的某些实施例提供了一种用于临床决策支持的系统，其包括履带代理部件。履带代理部件适于接收搜索参数。搜索参数指定要搜索的证据数据的标准。爬虫代理部件适于至少部分地基于搜索参数来启动对多个证据源的搜索。搜索确定证据数据。证据数据由临床决策支持系统利用，为患者的医疗保健提供者提供决策支持。

2. 发明申请

US20050048066A1 Identification of potential immunodominant acetylcholine receptor alpha subunit 审中-公开
标题翻译：鉴定潜在的免疫显性乙酰胆碱受体α亚基
公开(公告)号：US20050048066A1
公开(公告)日：2005-03-03
申请号：US10240035
申请日：2001-03-30
申请人： Shrikant Deshpande , Edward Spack , Nancy Wehner , Subhashini Arimilli
发明人： Shrikant Deshpande , Edward Spack , Nancy Wehner , Subhashini Arimilli
IPC分类号： A61K38/00 , A61K39/00 , A61P21/04 , A61P37/00 , A61P37/06 , C07K7/08 , C07K14/705 , C07K14/74 , C07K19/00
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention is directed to the treatment of autoimmune diseases, in particular of Myasthenia Gravis. This invention provides novel autoimmune dominant peptides derived from the acetylcholine receptor, as well as methods for preparing the peptides. The present invention further provides complexes comprising these peptides associated with an appropriate major histocompatibility complex (MHC) molecule and methods for making these complexes. The complexes of the present invention can be used therapeutically or prophylactically for treating Myasthenia Gravis.
摘要翻译：本发明涉及治疗自身免疫性疾病，特别是重症肌无力。本发明提供了源自乙酰胆碱受体的新型自身免疫优势肽以及制备肽的方法。本发明还提供了包含与适合的主要组织相容性复合物（MHC）分子相关的这些肽的复合物和制备这些复合物的方法。本发明的复合物可以治疗或预防用于治疗重症肌无力。

3. 发明申请

US20120230998A1 IP-10 ANTIBODIES AND THEIR USES 有权
标题翻译： IP-10抗体及其用途
公开(公告)号：US20120230998A1
公开(公告)日：2012-09-13
申请号：US13478786
申请日：2012-05-23
申请人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
发明人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
IPC分类号： A61K39/395 , A61P25/00 , A61P19/02 , A61P29/00 , A61P1/00 , A61P9/10 , A61P17/00 , A61P11/00 , A61P25/28 , A61K48/00 , A61P13/12 , C12N5/02 , A61P3/10
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译：本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

4. 发明申请

US20100077497A1 IP-10 ANTIBODIES AND THEIR USES 有权
标题翻译： IP-10抗体及其用途
公开(公告)号：US20100077497A1
公开(公告)日：2010-03-25
申请号：US12472877
申请日：2009-05-27
申请人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
发明人： Shrikant DESHPANDE , Haichun HUANG , Mohan SRINIVASAN , Josephine M. CARDARELLI , Changyu WANG , David PASSMORE , Vangipuram RANGAN , Thomas E. LANE , Hans S. KEIRSTEAD , Michael T. LIU
IPC分类号： A01K67/027 , C07K16/18 , A61K39/395 , C12N5/18 , C07H21/04 , C12N15/63 , A61P31/12 , A61P31/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译：本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

5. 发明申请

US20090125555A1 METHOD AND APPARATUS FOR FLEXIBLE ARCHIVING 审中-公开
标题翻译：灵活存档的方法和装置
公开(公告)号：US20090125555A1
公开(公告)日：2009-05-14
申请号：US11940140
申请日：2007-11-14
申请人： Marc Stanis , Seshadri Sekharan Davarapalli , Shrikant Deshpande , Jeff Chu , Robert Grant , Udaya Kumar KV
发明人： Marc Stanis , Seshadri Sekharan Davarapalli , Shrikant Deshpande , Jeff Chu , Robert Grant , Udaya Kumar KV
IPC分类号： G06F17/30
CPC分类号： G06F19/321 , G06F16/51
摘要： Certain embodiments of the present invention provide a system and method for selectively archiving medical imaging data. The method comprises receiving criteria to selectively archive medical imaging data. The criteria may include but is not limited to, for example, one of the following: modality, procedure code, institution, department, physician, data type, patient demographics. The method may also include acquiring medical imaging data. The medical imaging data may have associated information, for example header information or image data. The method may also include comparing the associated information with the criteria. The medical images having associated information that satisfies the criteria is archived and the medical images having associated information that does not satisfy the criteria is discarded.
摘要翻译：本发明的某些实施例提供了一种用于选择性归档医学成像数据的系统和方法。该方法包括接收选择性地归档医学成像数据的标准。标准可以包括但不限于例如以下之一：模态，程序代码，机构，部门，医师，数据类型，患者人口统计学。该方法还可以包括获取医学成像数据。医学成像数据可以具有关联信息，例如标题信息或图像数据。该方法还可以包括将相关联的信息与标准进行比较。归档具有满足标准的关联信息的医学图像，并丢弃具有不满足标准的关联信息的医学图像。

6. 发明授权

US07152157B2 System and method for dynamic resource configuration using a dependency graph 有权
标题翻译：使用依赖图进行动态资源配置的系统和方法
公开(公告)号：US07152157B2
公开(公告)日：2006-12-19
申请号：US10382427
申请日：2003-03-05
申请人： Richard C. Murphy , Scott M. Carter , Mario G. Ornelas , Shrikant Deshpande
发明人： Richard C. Murphy , Scott M. Carter , Mario G. Ornelas , Shrikant Deshpande
IPC分类号： G06F1/24
CPC分类号： G06F9/5077
摘要： A system and method for predicting whether a dynamic reconfiguration of a resource of a resource domain would be successful, prior to attempting the reconfiguration. A resource domain includes one or more computer resources (e.g., physical, logical and pseudo devices) and a graph management agent configured to maintain a graph representing the resources and dependencies between resources. Vertices of the graph represent resources; edges represent dependencies. A resource domain may also include a set of policies or constraints regarding resources and reconfigurations of resources. An illustrative constraint may specify that a particular resource (e.g., a multi-pathed logical device) must have a minimal number of paths (e.g., two). The graph agent identifies the effect the dynamic reconfiguration operation would have upon the resources and dependencies, and determines whether any constraints would be violated. If no constraints would be violated, the graph management agent may indicate that the reconfiguration would succeed.
摘要翻译：在尝试重新配置之前，用于预测资源域的资源的动态重新配置是否将成功的系统和方法。资源域包括一个或多个计算机资源（例如，物理，逻辑和伪设备）以及图形管理代理，其被配置为维护表示资源的图表和资源之间的依赖关系。图的顶点代表资源; 边缘表示依赖关系。资源域还可以包括关于资源的资源和重新配置的一组策略或约束。说明性的约束可以指定特定资源（例如，多播路逻辑设备）必须具有最小数量的路径（例如，两个）。图形代理识别动态重新配置操作对资源和依赖关系的影响，并确定是否违反任何约束。如果不违反任何限制，则图形管理代理可以指示重新配置将成功。

7. 发明授权

US08945546B2 IP-10 antibodies and their uses 有权
标题翻译： IP-10抗体及其用途
公开(公告)号：US08945546B2
公开(公告)日：2015-02-03
申请号：US13478786
申请日：2012-05-23
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
IPC分类号： A61K39/395 , A61K39/40 , C07K14/52 , C07K16/24 , A61K39/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译：本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

8. 发明申请

US20060251975A1 System and method for retrieving radiographic images 审中-公开
标题翻译：用于检索放射照相图像的系统和方法
公开(公告)号：US20060251975A1
公开(公告)日：2006-11-09
申请号：US11121197
申请日：2005-05-03
申请人： Arvind Taranath , Jeff Chu , Shrikant Deshpande
发明人： Arvind Taranath , Jeff Chu , Shrikant Deshpande
IPC分类号： G03F1/00
CPC分类号： G06F19/321
摘要： Certain embodiments of the present invention provide a method of retrieving radiographic images including interfacing with a storage system containing radiographic images. Some of the radiographic images have data representative of an image modality. A method further includes determining at least one filter corresponding to a filter modality. Each filter may be independently determinable from other filters. Additionally, a method includes pre-fetching at least one radiographic image using the filter, wherein the image modality of the at least one radiographic image corresponds to the filter modality.
摘要翻译：本发明的某些实施例提供一种检索放射照相图像的方法，包括与包含放射照相图像的存储系统的接口。一些放射照相图像具有表示图像模态的数据。方法还包括确定对应于滤波器模态的至少一个滤波器。每个滤波器可以独立地从其他滤波器确定。另外，一种方法包括使用滤波器预取至少一个放射照相图像，其中至少一个放射照相图像的图像模态对应于滤波器模态。

9. 发明授权

US06171590B2 Chemokine receptor peptide for inducing an immune response 失效
标题翻译：趋化因子受体肽用于诱导免疫反应
公开(公告)号：US06171590B2
公开(公告)日：2001-01-09
申请号：US09164186
申请日：1998-09-30
申请人： Maureen Howard , Shrikant Deshpande , Walter Ferlin , Subhashini Arimilli
发明人： Maureen Howard , Shrikant Deshpande , Walter Ferlin , Subhashini Arimilli
IPC分类号： A61K3816
CPC分类号： C07K14/7158 , A61K39/00
摘要： The present invention provides immunogenic oligopeptides derived from the chemokine receptor protein for use in compositions and methods for the treatment, and prevention of inflammatory responses.
摘要翻译：本发明提供衍生自趋化因子受体蛋白的免疫原性寡肽，用于组合物和用于治疗和预防炎性反应的方法。

10. 发明授权

US08258266B2 IP-10 antibodies and their uses 有权
标题翻译： IP-10抗体及其用途
公开(公告)号：US08258266B2
公开(公告)日：2012-09-04
申请号：US12472877
申请日：2009-05-27
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine M. Cardarelli , Changyu Wang , David B. Passmore , Vangipuram Rangan , Thomas E. Lane , Hans S. Keirstead , Michael T. Liu
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C12N5/02 , C12N5/16 , C07K1/00
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译：本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

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